Bone-density tests
It’s worth getting a bone-density test if you’re older or have other risk factors for weak bones, because without it the first sign of osteoporosis is usually a broken bone. Autor: © 2011 American Medical … Leer más
Clinical Practice. Postmenopausal Osteoporosis
N Engl J Med. 2016 Jan 21;374(3):254-62. doi: 10.1056/NEJMcp1513724. Review. Key Clinical Points Postmenopausal Osteoporosis Fractures and osteoporosis are common, particularly among older women, and hip fractures can be devastating. Treatment is generally recommended in … Leer más
Myostatin deficiency partially rescues the bone phenotype of osteogenesis imperfecta model mice
Osteoporos Int. 2016 Jan;27(1):161-70. doi: 10.1007/s00198-015-3226-7. Epub 2015 Jul 16. Myostatin deficiency partially improved the reduced femoral bone biomechanical strength of adult +/oim mice by increasing muscle mass with concomitant improvements in bone microarchitecture and … Leer más
Managing Osteoporosis in Patients on Long-Term Bisphosphonate Treatment: Report of a Task Force of the American Society for Bone and Mineral Research
Osteoporos Int. 2016 Jan;27(1):161-70. doi: 10.1007/s00198-015-3226-7. Epub 2015 Jul 16. Myostatin deficiency partially improved the reduced femoral bone biomechanical strength of adult +/oim mice by increasing muscle mass with concomitant improvements in bone microarchitecture and … Leer más
Managing Osteoporosis in Patients on Long-Term Bisphosphonate Treatment: Report of a Task Force of the American Society for Bone and Mineral Research
J Bone Miner Res. 2016 Jan;31(1):16-35. doi: 10.1002/jbmr.2708. Review. Hence, the Task Force suggests that after 5 years of oral BP or 3 years of intravenous BP, reassessment of risk should be considered. In women … Leer más
Contribution of Quadriceps Weakness to Fragility Fracture: A Prospective Study
J Bone Miner Res. 2016 Jan;31(1):208-14. doi: 10.1002/jbmr.2594. Epub 2015 Aug 4. These data indicate that muscle weakness is an independent determinant of fracture risk in men, but not in women. This sex difference suggests … Leer más
Epidemiology of fractures in type 2 diabetes
Bone. 2016 Jan;82:2-8. doi: 10.1016/j.bone.2015.05.032. Epub 2015 May 29. Review. This article is part of a Special Issue entitled “Bone and diabetes” Autor: Schwartz AV
Implications of exercise-induced adipo-myokines in bone metabolism
The beneficial effects of exercise on bone metabolism depends on the intermittent exposure to myokines which, instead, act as inflammatory/pro-resorptive mediators when chronically elevated; on the other hand, the reduction in the circulating levels of … Leer más
Oxidative stress, autophagy, epigenetic changes and regulation by miRNAs as potential therapeutic targets in osteoarthritis
A deeper knowledge of the mechanisms involved in chondrocyte aging could identify potential targets for the treatment of OA, a prevalent and therapeutic-orphan disease.
New PPARγ partial agonist improves obesity-induced metabolic alterations and atherosclerosis in LDLr-/- mice
GQ-177, a new thiazolidinedione, acts as a partial PPARγ agonist that improves obesity-associated insulin resistance and dyslipidemia with atheroprotective effects in LDLr-/- mice.
