Proc Natl Acad Sci U S A. 2015 Jan 20. pii: 201409857. Thus, activation of osteocytic β-catenin signaling increases both osteoclasts and osteoblasts, leading to bone gain, and is sufficient to activate the Notch pathway. … Leer más
Cell. 2015 Jan 15;160(1-2):269-84. doi: 10.1016/j.cell.2014.11.042. Grem1 expression identifies distinct connective tissue stem cells in both the bone (OCR stem cells) and the intestine (iRSCs). Autor: Worthley DL, Churchill M, Compton JT, Tailor Y, Rao … Leer más
In conclusion, administration of oral and intravenous bisphosphonates was associated with increased bone mineral density at the lumbar spine and total hip over two years in HIV-positive patients. However, none of the included trials were … Leer más
Although interesting data on relief of vasomotor symptoms have been reported for DT56a, further clinical studies with a greater number of cases and a longer period of study are required to correctly identify its indications … Leer más
For most conditions, the available evidence is limited. Special attention should be paid to possible contraindications of drugs used for the treatment of postmenopausal or senile osteoporosis. Bisphosphonates are the most widely used drugs in … Leer más
J Bone Miner Res. 2014 Dec;29(12):2545-51. doi: 10.1002/jbmr.2283 Percentage change from baseline in TH and FN BMD at months 12 and 24 was greater (p < 0.05) in ZOL-treated patients compared with placebo in most subgroups. Treatment-by-subgroup … Leer más
J Bone Miner Res. 2014 Dec;29(12):2529-33. doi: 10.1002/jbmr.2387. Accordingly, this Perspective provides evidence that the “undetermined significance” portion of the MGUS acronym may be best replaced in favor of the term “monoclonal gammopathy of skeletal … Leer más
Journal of Bone and Mineral Research, Vol. 29, No. 12, December 2014, pp 2537–2544. doi: 10.1002/jbmr.2309. The studies found that diffuse matrix damage regions in living cortical bone undergo a direct microstructural and mechanically effective … Leer más
Journal of Bone and Mineral Research, Volume 29, Issue 12, pages 2594–2600. doi: 10.1002/jbmr.2291. In conclusion, the estimated femoral strength from FE analysis of DXA scans is an independent predictor and performs at least as … Leer más
Bone 2014; 73:1-7. doi: 10.1016/j.bone.2014.12.003. Over time, two periods of increased PHPT incidence occurred, one beginning in 1974 (121.7 per 100,000 person-years) and a second peak (86.2 per 100,000 person-years) starting in 1998. The median age of … Leer más
