The aim of this work was to observe the behavior of osteoblast cells cultured in vitro on titanium discs in relation to disc surface roughness and the addition of melatonin to the culture medium.

Among the genes studied, a significant increase in phosphate-regulating neutral endopeptidase, X-linked (PHEX) expression was observed in cells cultured on EP discs. The addition of melatonin increased osteoblast cell proliferation and differentiation, and may favor the osseointegration of dental implants.

Int J Mol Sci. 2017 Apr 13;18(4). pii: E823. doi: 10.3390/ijms18040823.

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Sola-Ruiz MF, Perez-Martinez C, Labaig-Rueda C, Carda C, Martín De Llano JJ