The relative efficacy and harms of balloon kyphoplasty (BK) for treating vertebral compression fractures (VCF) are uncertain. The clinical importance of the greater improvements with BK versus NSM is unclear, may be due to placebo effect, and may not counterbalance short-term AE risks. Outcomes appeared similar between BK and other surgical interventions.Well-conducted randomized trials comparing BK with sham would help resolve remaining ncertainty about the relative benefits and harms of BK.

J Bone Miner Res. 2017 May 17. doi: 10.1002/jbmr.3170. [Epub ahead of print]

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Rodriguez AJ, Fink HA, Mirigian L, Guañabens N, Eastell R, Akesson K, Bauer DC, Ebeling PR