Imminent fracture risk.
The clinical significance of osteoporosis is in the occurrence of fractures and re-fractures. The main risk factor of sustaining a fracture is a previous one, but a recent fracture is a better fracture risk factor … Leer más
Effect of recent spinal cord injury on the OPG/RANKL system and its relationship with bone loss and the response to denosumab therapy
Osteoporos Int. 2017 Jun 4. doi: 10.1007/s00198-017-4090-4 Más información Gifre L, Ruiz-Gaspà S, Carrasco JL, Portell E, Vidal J, Muxi A, Monegal A,Guañabens N, Peris P
Numerical Modelling of Femur Fracture and Experimental Validation Using Bone Simulant
Ann Biomed Eng. 2017 Jun 20. doi: 10.1007/s10439-017-1877-6 Más información Marco M, Giner E, Larraínzar-Garijo R, Caeiro JR, Miguélez MH
Bone Loss After Denosumab: Only Partial Protection with Zoledronate
A case series of six women with postmenopausal osteoporosis who had received continuous denosumab for 7 years and were then given a single infusion of zoledronate (5 mg) is reported. During denosumab treatment, bone mineral density (BMD) … Leer más
Evaluation of the Dietary Intake of Cadmium, Lead and Mercury and Its Relationship with Bone Health among Postmenopausal Women in Spain.
Few studies have investigated the extent to which dietary heavy metals are associated with low bone mineral density. They did not find associations between bone health and the dietary intake of three heavy metals in … Leer más
Mind the (treatment) gap: a global perspective on current and future strategies for prevention of fragility fractures
This narrative review considers the key challenges facing healthcare professionals and policymakers responsible for providing care to populations in relation to bone health. These challenges broadly fall into four distinct themes: (1) case finding and … Leer más
Bone health in Down syndrome
Patients with Down syndrome have a number of risk factors that theoretically could predispose them to osteoporosis. In addition, the bone mass of these people may be affected by their anthropometric and body composition peculiarities. … Leer más
Extracellular calcium promotes bone formation from bone marrow mesenchymal stem cells by amplifying the effects of BMP-2 on SMAD signalling.
Understanding the molecular events that regulate osteoblast differentiation is essential for the development of effective approaches to bone regeneration. In this study, they analysed the osteoinductive properties of extracellular calcium in bone marrow-derived mesenchymal stem … Leer más
Bone density, microarchitecture, and material strength in chronic kidney disease patients at the time of kidney transplantation.
Bone health is assessed by bone mineral density (BMD). Other techniques such as trabecular bone score and microindentation could improve the risk of fracture’s estimation. Our chronic kidney disease (CKD) patients presented worse bone health … Leer más
Association of physical fitness, body composition, cardiometabolic markers and adherence to the Mediterranean diet with bone mineral density in perimenopausal women. The FLAMENCO project.
This study aimed to analyse the association of different components of physical fitness, body composition, cardiometabolic markers and the Mediterranean diet with bone mineral density (BMD) in perimenopausal women, and to test which of these … Leer más
