The diabetic paradox: Bone mineral density and fracture in type 2 diabetes
Endocrinol Nutr. 2016 Nov;63(9):495-501. Autor: Botella Martínez S, Varo Cenarruzabeitia N, Escalada San Martin J, Calleja Canelas A.
Oxidation inhibits PTH receptor signaling and trafficking
Biochem Biophys Res Commun. 2016 Nov 28.Watch Full Movie Online Streaming Online and Download Reactive Oxygen Species (ROS) increase during aging, potentially affecting many tissues including brain, heart, and bone. ROS alter signaling pathways and … Leer más
Diverging results of areal and volumetric bone mineral density in Down syndrome
Osteoporos Int. 2016 Nov 12. Population with Down syndrome (DS) has lower areal BMD, in association with their smaller skeletal size. However, volumetric BMD and other indices of bone microarchitecture, such as trabecular bone score … Leer más
Parathyroid Hormone Polymorphism RS6254 is Associated with the Development and Severity of Osteoporosis in Asymptomatic but not Normocalcemic Hyperparathyroidism
Horm Metab Res. 2016 Nov 11. Autor: Díaz-Soto G, Romero E, Pérez-Castrillón JL, Jauregui OI, de Luis Román D
CathepsinKCre mediated deletion of βcatenin results in dramatic loss of bone mass by targeting both osteoclasts and osteoblastic cells
Sci Rep. 2016 Nov 2;6:36201. doi: 10.1038/srep36201 This study examines the effects of Wnt/βcatenin signaling in mature osteoclasts by generating mice lacking βcatenin in CathepsinK-expressing cells (Ctnnb1(f/f);CtsKCre mice). Their results indicate that the bone phenotype … Leer más
Circulating microRNA Signatures in Patients With Idiopathic and Postmenopausal Osteoporosis and Fragility Fractures
J Clin Endocrinol Metab. 2016 Nov;101(11):4125-4134 Specific serum miRNA profiles are strongly related to bone pathologies. Therefore miRNAs might be directly linked to bone tissue homeostasis. In particular, miR-29b-3p has previously been reported as regulator … Leer más
Distinct Osteomimetic Response of Androgen-Dependent and Independent Human Prostate Cancer Cells to Mechanical Action of Fluid Flow: Prometastatic Implications
Prostate. 2016 Nov 3. doi: 10.1002/pros.23270. Prostate cancer frequently expresses an osteomimetic phenotype, but it is unclear how it is regulated and what biological and clinical implications it confers. MAFF activated osteoblast-like phenotype of prostate … Leer más
Diabetes Drug effects on the skeleton
PUMBE – Calcif Tissue Int (2016). doi:10.1007/s00223-016-0203-x Anti-diabetes medications are crucial for maintaining glucose control and for preventing micro- and macrovascular complications in diabetes. However, they may modulate fracture risk in diabetes in different ways. … Leer más
Effects of chronic lead exposure on bone mineral properties in femurs of growing rats
Toxicology. 2016 Nov 30. pii: S0300-483X(16)30303-1. doi:10.1016/j.tox.2016.11.017. The aim of the present study is to make a more detailed description of the toxic effects of lead intoxication on bone intrinsic material properties as mineral composition, … Leer más
Homocysteine as a Pathological Biomarker for Bone Disease
J Cell Physiol. 2016 Nov 18. doi: 10.1002/jcp.25693. This article reviews the current body of knowledge on regulation of Hcy mediated oxidative stress and its role in bone remodeling, vascular blood flow and progression of … Leer más
