Circulating microRNA Signatures in Patients With Idiopathic and Postmenopausal Osteoporosis and Fragility Fractures

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J Clin Endocrinol Metab. 2016 Nov;101(11):4125-4134

Specific serum miRNA profiles are strongly related to bone pathologies. Therefore miRNAs might be directly linked to bone tissue homeostasis. In particular, miR-29b-3p has previously been reported as regulator of osteogenic differentiation and could serve as a novel marker of bone turnover in osteoporotic patients as a member of a miRNA signature.

A set of 19 miRNAs was differentially regulated in all subjects with low-traumatic fractures. miRNAs were excellent discriminators of patients with fractures, regardless of age and gender.

Autor: R Kocijan, C Muschitz, E Geiger, S Skalicky, A Baierl, R Dormann, F Plachel, X Feichtinger, P Heimel, A Fahrleitner-Pammer, J Grillari, H Redl, H Resch and M Hackl

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