Our data confirm a clinically relevant bone loss associated with aromatase inhibitors (AI) therapy amongst non-users of preventative bisphosphonates. We further report on the importance of BMD monitoring as well as calcium and 25(OH)vitD supplementation … Leer más
Bone. 2016 Mar;84:57-68. doi: 10.1016/j.bone.2015.12.016. Epub 2015 Dec 23. Review. Given the polygenic nature of skeletal diseases like osteoporosis and osteoarthritis, validating the function of additional miRNA-associated SNPs has the potential to enhance our understanding … Leer más
There was no significant difference between suffering a second hip fracture and following osteoporosis treatment, using psychotropic drugs or being institutionalised.
Bone. 2016 Mar;84:279-88. doi: 10.1016/j.bone.2015.12.006. Epub 2015 Dec 17 These data suggest demineralization can occur from within bone through the canalicular system, and that peri-canalicular demineralization occurs not uniformly but directed by individual osteocytes. Blockade … Leer más
Unintentional weight loss at baseline was associated with a significantly increased risk of fracture of the clavicle, wrist, spine, rib, hip, and pelvis for up to 5 years following weight loss. This increase is seen … Leer más
Osteoporos Int. 2016 Mar;27(3):849-52. doi: 10.1007/s00198-015-3453-y. Epub 2015 Dec 14. No abstract available. Clinicians need to rethink the assumption that a patient who has taken an oral bisphosphonate for 5 years or an intravenous therapy … Leer más
Calcidiol is faster and 3-6 times more potent to obtain serum levels of 25(OH)D in the medium to long term.
Osteoporos Int. 2016 Mar;27(3):861-71. doi: 10.1007/s00198-015-3331-7. Epub 2015 Sep 29 Further clinical studies with these medications are needed to fully understand their effects on fracture healing in order to simultaneously treat fragility fractures and underlying … Leer más
J Clin Endocrinol Metab. 2016 Feb;101(2):394-415. doi: 10.1210/jc.2015-2175. Epub 2016 Jan 8. Rickets, osteomalacia, and vitamin D and calcium deficiencies are preventable global public health problems in infants, children, and adolescents. Implementation of international rickets … Leer más
JAMA Intern Med. 2016 Feb 1;176(2):175-83. doi: 10.1001/jamainternmed.2015.7148. Although higher monthly doses of vitamin D were effective in reaching a threshold of at least 30 ng/mL of 25-hydroxyvitamin D, they had no benefit on lower … Leer más
