Although scarce data are available, interesting opportunities are open for a better understanding of the pharmacogenetics of osteoporosis and osteoporotic fractures. They include the reanalysis of data already available from epidemiological studies and clinical trials, … Leer más
Bone. 2014 Sep 28;69C:139-147. doi: 10.1016/j.bone.2014.09.016. [Epub ahead of print] This study examined the role of NPP1 in osteocytes, osteoclasts and cortical bone, using a mouse model lacking NPP1 (Enpp1−/−) he cortical bone from Enpp1−/− … Leer más
J Bone Miner Res. 2014 Oct;29(10):2224-9. doi: 10.1002/jbmr.2248. In conclusion, our study shows that lung cancer screening participants have a substantial vertebral fracture burden. Fractures are more common in current smokers, who also have lower … Leer más
J Bone Miner Res. 2014 Oct;29(10):2131-40. doi: 10.1002/jbmr.2293 In this invited perspective, we highlight the magnitude of the problem across biomedical fields and address the relevance of these concerns to the field of bone and … Leer más
Bone. 2014 Sep;66:146-54 These results demonstrate that RANKL produced by osteocytes contributes to the increased bone resorption and the bone loss caused by secondary hyperparathyroidism, strengthening the evidence that osteocytes are an important target cell … Leer más
JBMR 2014; 29(9) 1993-2003 The results suggest monitoring binding kinetics based on fluorescently labeled bisphosphonates represents a highly sensitive, site-specific method for monitoring changes in bone mineral deposition with the potential for translation into human … Leer más
Bone 2014;66:147-154 The results demonstrate that RANKL produced by osteocytes contributes to the increased bone resorption and the bone loss caused by secondary hyperparathyroidism, strengthening the evidence that osteocytes are an important target cell for … Leer más
Bone. 2014 Jun 14;66C:105-110. doi: 10.1016/j.bone.2014.06.008. [Epub ahead of print]. The femorotibial angle (FTA) of the patients with atypical diaphyseal femoral fracture were significantly larger compared to that of those with not only atypical subtrochanteric … Leer más
Fragility fractures were seen in 4.4 % of SLE patients. All patients with fragility fractures showed osteopenia at BMD. There is a high prevalence of bone loss in SLE patients, since up to 46 % … Leer más
A panel of experts from the Spanish Menopause Society has met to develop usage recommendations based on the best available evidence.
