In patients with prostate carcinoma, estrogen levels influence bone resorption and bone formation whereas androgens may exert actions only in bone resorption. These results suggest that estradiol is the main sex steroid that regulates bone … Leer más
In spite of the fact that this study does not have a large enough sample, our data suggest that HT used in the early years of menopause does not present a long-term protective effect on vertebral … Leer más
A high prevalence of secondary causes of osteoporosis is observed in HIV-infected patients, and its type and cumulative number determine a lower BMD, after adjusting by age and body mass index. Eighty-one percent of human … Leer más
Keeping in mind the premise “living longer, living better”, this commentary is the result of the thoughts, proposals and conclusions obtained after one year working in the framework of this network. Osteoporosis is a worldwide … Leer más
Bone-tissue engineering is a therapeutic target in the field of dental implant and orthopedic surgery. It is therefore essential to find a microenvironment that enhances the growth and differentiation of osteoblasts both from mesenchymal stem … Leer más
Gene candidate and genome-wide association studies have revealed tens of loci of susceptibility for osteoporosis. The results underscore the significance of the LRP5 gene in bone metabolism and emphasize the significance of the replication of … Leer más
Denosumab increased significantly bone mass in all three dual X-ray absorptiometry standard sites, while alendronate did not at total hip. No benefit was observed in men previously treated with alendronate who switched to denosumab treatment. … Leer más
Our results show: (i) retinoic acid affects proliferative and mineralogenic activities in two fish skeletal cell types and (ii) that during phenotype transitions, specific retinoic acid nuclear receptors and bone-related genes are differentially expressed in a … Leer más
The magnitude of the problem of osteoporosis in psoriatic arthritis seems to be mild. To assess the bone mineral density (BMD) and the frequency of osteoporosis and clinical fractures in a large group of Spanish … Leer más
The results highlight the PUFA metabolism differences between uninduced and induced MSC to differentiate into adipocytes and osteoblasts, besides the relevant role of the lipoxygenase gene expression in adipogenesis induction. Autor: Casado-Díaz A, Ferreiro-Vera C, Priego-Capote … Leer más
