Circulating sclerostin levels are significantly increased in patients with prostate cancer and particularly in those receiving androgen deprivation therapy. The inverse relationship between serum sclerostin and testosterone in these patients suggests that androgens are key … Leer más
Keeping in mind the premise «living longer, living better», this commentary is the result of the thoughts, proposals and conclusions obtained after one year working in the framework of this network. Osteoporosis is a worldwide … Leer más
We provide strong and significant evidence from both linkage and association analyses that the SOST gene may affect the strength of the femoral shaft. Future investigations should study the relationship between bone mass formation and … Leer más
Gene candidate and genome-wide association studies have revealed tens of loci of susceptibility for osteoporosis. The results underscore the significance of the LRP5 gene in bone metabolism and emphasize the significance of the replication of … Leer más
In spite of the fact that this study does not have a large enough sample, our data suggest that HT used in the early years of menopause does not present a long-term protective effect on vertebral … Leer más
The results highlight the PUFA metabolism differences between uninduced and induced MSC to differentiate into adipocytes and osteoblasts, besides the relevant role of the lipoxygenase gene expression in adipogenesis induction. Autor: Casado-Díaz A, Ferreiro-Vera C, Priego-Capote … Leer más
Our results show: (i) retinoic acid affects proliferative and mineralogenic activities in two fish skeletal cell types and (ii) that during phenotype transitions, specific retinoic acid nuclear receptors and bone-related genes are differentially expressed in a … Leer más
The results suggest that deletions in the 6p25.1 locus may predispose to higher risk of fracture in a subset of populations of European origin; larger and geographically restricted studies will be needed to confirm this … Leer más
The results suggest that matrix Gla protein genetic variations could predict a higher risk of bone loss and progression of vascular calcification in men. Two matrix Gla protein (MGP) polymorphisms were associated with progression of … Leer más
The impact on the population of the different recommendations is enormous, varying from 17% to 80% of the population over 50 who would be tested Although in men it seems that a clinical rationale exists … Leer más
