The role of wnt signaling and sclerostin in the pathogenesis of glucocorticoid-induced osteoporosis.

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This review describes the most recent data on the effects of glucocorticoids on the Wnt signaling pathway, especially on their antagonists, sclerostin and Dkk-1.

Bone formation is suppressed in glucocorticoid-induced osteoporosis. One of the mechanisms by which glucocorticoids depress bone formation is through their effects on the Wnt/β-catenin signaling pathway, a critical regulator of osteoblastogenesis.

Autor: Guañabens N, Gifre L, Peris P.

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