Lysophosphatidic acid receptor inhibition as a new multipronged treatment for rheumatoid arthritis.

Pharmacological inhibition of LPA1 receptor in the K/BxN serum-transfer arthritis model led to reduction of severity of arthritis involving multiple mechanisms, increased apoptosis, reduced inflammatory mediators and proteins involved in bone remodelling, that show LPA1 as a very promising target in rheumatoid arthritis treatment.

Autor: Orosa B, García S, Martínez P, González A, Gómez-Reino JJ, Conde C.

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