Association of matrix Gla protein gene functional polymorphisms with loss of bone mineral density and progression of aortic calcification.

The results suggest that matrix Gla protein genetic variations could predict a higher risk of bone loss and progression of vascular calcification in men.

Two matrix Gla protein (MGP) polymorphisms were associated with progression of aortic calcification and femoral neck bone loss in men. All these findings were also functionally corroborated in two vascular and bone in vitro systems indicating that MGP genetic variations can be partly responsible of higher risk of bone loss and vascular calcification.

Autor: Tuñón-Le Poultel D, Cannata-Andía JB, Román-García P, Díaz-López JB,

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Lilly
Angelini
Laboratorios Rubió
Grupo Italfármaco
UCB-Pharma
Theramex
Stada