Retinoic acid differentially affects in vitro proliferation, differentiation and mineralization of two fish bone-derived cell lines: different gene expression of nuclear receptors and ECM proteins.

Our results show: (i) retinoic acid affects proliferative and mineralogenic activities in two fish skeletal cell types and (ii) that during phenotype transitions, specific retinoic acid nuclear receptors and bone-related genes are differentially expressed in a cell type-dependent manner.

Autor: Fernández I, Tiago DM, Laizé V, Leonor Cancela M, Gisbert E.

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