The aim of this study was to examine whether alterations caused by diabetes in calcium homeostasis, expression of osteopontin and the microarchitecture of bone are corrected by exposure to vanadium. They conclude that treatment with 3 mg V per d of the glucose lowering agent bis(maltolato)oxovanadium(iv) causes a decrease in osteopontin mRNA, which could favour the normalization of changes in Ca homeostasis and bone microarchitecture, both at the cortical and trabecular levels, caused by diabetes.
Metallomics. 2017 Feb 14. doi: 10.1039/c6mt00272b
Sanchez-Gonzalez C), Moreno L, Lopez-Chaves C, Nebot E, Pietschmann P, Rodriguez-Nogales A, Galvez J, Montes-Bayon M, Sanz-Medel A, Llopis J.