Five Freely Circulating miRNAs and Bone Tissue miRNAs Are Associated With Osteoporotic Fractures

J Bone Miner Res. 2014; 29: 1715‒1717. doi: 10.1002/jbmr.2175.

In conclusion, this study profiled serum miRNAs in osteoporosis and identified 9 miRNAs highly associated with osteoporosis in blood serum. In bone tissue, 6 differentially expressed miRNAs were detectable. Five of these were simultaneously upregulated in the serum samples. Those 5 identified, significantly upregulated circulating miRNAs may provide novel biomarkers for osteoporosis and may play an important role in the pathogenesis of osteoporosisrelated hip fractures

Autor: Seeliger C*, Karpinski K , Haug A , Vester H , Schmitt A , Bauer JA and van Griensven M
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