Bone. 2016 Mar;84:57-68. doi: 10.1016/j.bone.2015.12.016. Epub 2015 Dec 23. Review. Given the polygenic nature of skeletal diseases like osteoporosis and osteoarthritis, validating the function of additional miRNA-associated SNPs has the potential to enhance our understanding … Leer más
Bone. 2016 Mar;84:279-88. doi: 10.1016/j.bone.2015.12.006. Epub 2015 Dec 17 These data suggest demineralization can occur from within bone through the canalicular system, and that peri-canalicular demineralization occurs not uniformly but directed by individual osteocytes. Blockade … Leer más
Osteoporos Int. 2016 Mar;27(3):849-52. doi: 10.1007/s00198-015-3453-y. Epub 2015 Dec 14. No abstract available. Clinicians need to rethink the assumption that a patient who has taken an oral bisphosphonate for 5 years or an intravenous therapy … Leer más
Osteoporos Int. 2016 Mar;27(3):861-71. doi: 10.1007/s00198-015-3331-7. Epub 2015 Sep 29 Further clinical studies with these medications are needed to fully understand their effects on fracture healing in order to simultaneously treat fragility fractures and underlying … Leer más
Chronic abnormal phosphaturia explains, at least in part, progressive bone loss during TDF therapy. These data suggest that tubular dysfunction leads to an altered equilibrium between phosphatemia, phosphaturia and bone as mechanism of progressive BMD … Leer más
Our data confirm a clinically relevant bone loss associated with aromatase inhibitors (AI) therapy amongst non-users of preventative bisphosphonates. We further report on the importance of BMD monitoring as well as calcium and 25(OH)vitD supplementation … Leer más
There was no significant difference between suffering a second hip fracture and following osteoporosis treatment, using psychotropic drugs or being institutionalised.
Unintentional weight loss at baseline was associated with a significantly increased risk of fracture of the clavicle, wrist, spine, rib, hip, and pelvis for up to 5 years following weight loss. This increase is seen … Leer más
Calcidiol is faster and 3-6 times more potent to obtain serum levels of 25(OH)D in the medium to long term.
La Fundación Lilly, en desarrollo de sus objetivos estatutarios y dentro del programa de Apoyo a la Investigación BIOMÉDICA, convoca los Premios Fundación Lilly de Investigación Biomédica Preclínica y Clínica 2016, para investigadores que hayan … Leer más
