This review summarizes the complex pathophysiology of CKD-MBD and outlines which laboratory abnormalities represent biomarkers of disease severity, which laboratory abnormalities are predictors of cardiovascular disease, and which laboratory abnormalities should be considered (direct) uremic … Leer más
According to our results, VDR locus association follows an additive model in which increased genetic risk score for the VDR is directly correlated with AIDS progression rates. Our data supports a role of vitamin-D pathway … Leer más
To further foster this research, the pathway to eventually obtain authorisation from the National Competent Authorities and Research Ethics Committees under the European regulation is reviewed, and the experience of the REBORNE European project offers … Leer más
There are currently substantial developments being made in the understanding of the interplay between bone metabolism and the metabolic system. These insights could potentially lead to the development of new treatment strategies and interventions with … Leer más
Our results demonstrate that: 1) 17β-estradiol (E2) at physiological plasma levels in female rats is neuroprotective in male rats when given at the acute stage of the ischemic challenge; and 2) bazedoxifene acetate at clinically … Leer más
These results reinforce the role of antioxidant pathways and of B-cells in bone metabolism. Furthermore, it shows that a genome-wide gene expression approach in animal models is a useful method for detecting genes associated to … Leer más
Osteocalcin, produced by osteoblasts or released from mineralised bone, interferes with insulin concentrations and sensitivity, and its metabolism is disturbed in kidney disease. These bone-derived humoral factors might place the bone at the centre of … Leer más
Calcif Tissue Int. 2014 Sep;95(3):201-8. doi: 10.1007/s00223-014-9882-3. Epub 2014 Jun 20. After adjusting for age, weight, BMD, smoking, and maternal and family history of fracture, TBS (but not BMD) remained a significant predictor of fracture: … Leer más
Osteoporos Int (2014) 25:2271–2277. doi: 10.1007/s00198-014-2761-y. Epub 2014 Jun 21. Lumbar spine texture analysis using TBS is a risk factor for major osteoporotic fractures and a risk factor for death. Lumbar spine TBS is able … Leer más
J Bone Miner Res 2014; 29:1651-1660. The clinical and radiographic findings of adult patients with persistent hypophosphatasemia resemble those of the adult form of hypophosphatasia. Clinicians should take notice of persistent hypophosphatasemia, consider the diagnosis … Leer más
