Inflammatory factors in the circulation of patients with active rheumatoid arthritis stimulate osteoclastogenesis via endogenous cytokine production by osteoblasts

Osteoporos Int 2014; Oct;25(10):2453-63. doi: 10.1007/s00198-014-2779-1. Epub 2014 Jul 16

The combination of cytokines present in serum of RA patients with active disease might contribute to bone loss by directly inhibiting osteoblast proliferation and differentiation, but especially by enhancing endogenous cyto- kine (i.e., RANKL and IL-6) production by osteoblasts, there- by stimulating osteoclastogenesis.

Autor: Pathak J L, Bravenboer N, Verschueren P , Lems WF, Luyten F P, Klein-Nulend J, Bakker A D.
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