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Denosumab increased significantly bone mass in all three dual X-ray absorptiometry standard sites, while alendronate did not at total hip. No benefit was observed in men previously treated with alendronate who switched to denosumab treatment. … Leer más

Roux-en-Y gastric bypass increased circulating osteopontin levels, while they remained unaltered after sleeve gastrectomy. The increase in osteopontin levels after Roux-en-Y gastric bypass could be related to the increased bone resorption in relation to its … Leer más

Patients with chronic hepatitis C have low bone mass associated with increased bone resorption, and some relationship can be expected between serum aminotransferase levels and the degree of bone mass loss. Bone mass may be … Leer más

Bone 61 (2014) 138–148. This review examines recent developments in the understanding of why the elderly hip becomes fragile. This growing understanding is suggesting novel testable approaches for reducing risk of hip fracture that might translate … Leer más

Calcif Tissue Int. 2014 Jun;94(6):569-79. doi: 10.1007/s00223-014-9851-x. Epub 2014 Apr 1. The objective of this review is to summarize the recent research on bone cells under microgravity conditions based on advances in the field. Autor: … Leer más

Calcif Tissue Int. 2014 Jun;94(6):597-607. doi: 10.1007/s00223-014-9855-6. Epub 2014 Apr 6. These results provide further evidence that PPI use may increase fracture risk in the elderly and highlight the need for clinicians to periodically reassess … Leer más

Mol Endocrinol. 2014 Jul;28(7):1150-65 We conclude that osteocytogenesis is accompanied by changes in gene expression that may be driven by both genetic and epigenetic components. These changes are likely responsible for the osteocyte phenotype and … Leer más

J. Bone Miner Res 2014; 29: 935–943. DOI: 10.1002/jbmr.2092 Conclusions: These findings support further investigation of blosozumab as a potential anabolic therapy for osteoporosis. Autor: McColm J, Hu L, Womack T, Cai Tang C, Chiang … Leer más

Nature. 2014 Feb 13;506(7487):240-4. doi: 10.1038/nature12883. Epub 2014 Jan 15 These findings demonstrate that genetic alterations in osteoblasts can induce acute myeloid leukaemia, identify molecular signals leading to this transformation and suggest a potential novel … Leer más