Oxidative stress has been related to this bone loss, making dietary compounds with antioxidant properties a promising weapon. Male Wistar rats were maintained on diets with fish oil as unique fat source, supplemented or not with coenzyme Q10 (CoQ10). BMD was evaluated in the femur. Serum osteocalcin, osteopontin, receptor activator of nuclear factor-κB ligand, ostroprotegerin, parathyroid hormone, urinary F₂-isoprostanes, and lymphocytes DNA strand breaks were also measured. Reduced oxidative stress associated to CoQ10 supplementation of this n-3 PUFA-rich diet might explain the  higher BMD found in aged rats in this group of animals.

Nutrients. 2017 Feb 22;9(2). pii: E176. doi: 10.3390/nu9020176.

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Varela-López A, Ochoa JJ, Llamas-Elvira JM, López-Frías M, Planells E, Ramirez-Tortosa M, Ramirez-Tortosa CL, Giampieri F, Battino M, Quiles JL.