Since the previous studies showed that anti-citrullinated protein antibodies (ACPA) can induce osteoclasts differentiation and activation, even before arthritis onset, the aim of their study was to determine whether ACPA-positivity is associated with lower bone mineral density (BMD) at baseline visit of a register of early arthritis (EA) patients. The study population comprised 578 patients (80% females) from their EA clinic.

Data reinforce the previous preclinical findings suggesting that the systemic bone loss detected at the initial phases of early ACPA-positive arthritis is independent of inflammatory status and, therefore, could be mediated by ACPA.

Rheumatol Int. 2017 Feb 27. doi: 10.1007/s00296-017-3674-9

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Llorente I, Merino L, Ortiz AM, Escolano E, González-Ortega S,García-Vicuña R, García-Vadillo JA, Castañeda S, González-Álvaro I.