J Clin Endocrinol Metab. 2016 Nov;101(11):4125-4134
Specific serum miRNA profiles are strongly related to bone pathologies. Therefore miRNAs might be directly linked to bone tissue homeostasis. In particular, miR-29b-3p has previously been reported as regulator of osteogenic differentiation and could serve as a novel marker of bone turnover in osteoporotic patients as a member of a miRNA signature.
A set of 19 miRNAs was differentially regulated in all subjects with low-traumatic fractures. miRNAs were excellent discriminators of patients with fractures, regardless of age and gender.
Autor: R Kocijan, C Muschitz, E Geiger, S Skalicky, A Baierl, R Dormann, F Plachel, X Feichtinger, P Heimel, A Fahrleitner-Pammer, J Grillari, H Redl, H Resch and M Hackl