Extra virgin olive oil has positive effects on health. Oleuropein is a polyphenolic compound present in olive-tree leaves, fruits (olives) and olive oil. The effects of oleuropein on the adipogenesis of human bone-marrow mesenchymal stem cells were studied by transcriptomics and differential gene-expression analyses. Their data suggest that mitochondrial activity is reduced by oleuropein, mostly during adipogenic differentiation. These results shed light on oleuropein activity on cells, with potential application as a “nutraceutical” for the prevention and treatment of diseases such as obesity and osteoporosis.
Food Funct. 2017 Feb 28. doi: 10.1039/c7fo00045f.
Casado-Díaz A, Anter J, Müller S, Winter P, Quesada-Gómez JM, Dorado G