Biochemical markers of bone turnover in diabetes patients-a meta-analysis, and a methodological study on the effects of glucose on bone markers

Osteoporos Int. 2014 Jun 25(6):1697-708. doi: 10.1007/s00198-014-2676-7.

In conclusion, we found that diabetes patients have a different bone turnover than non-diabetes patients and the differences in bone turnover are enhanced at menopause. The results from this meta-analysis underscore the need to conduct more re- search within the assessment of fracture risk using bone markers in patients with diabetes. The methodological study conducted in this study showed that it is not likely that bone markers change configuration due to changes in blood glu- cose. Thus, other mechanisms, apart from possible assay variability, may influence the heterogeneity observed for bio- markers in this study