Advanced Glycation End Products, Diabetes, and Bone Strength

Curr Osteoporos Rep. 2016 Dec;14(6):320-326.

Diabetic patients have a higher fracture risk than expected by their bone mineral density (BMD). Poor bone quality is the most suitable and explainable cause for the elevated fracture risk in this population. Advanced glycation end products (AGEs), physically affect the properties of the bone material, one of a component of bone quality, through their accumulation in the bone collagen fibers.

Autor: Yamamoto M, Sugimoto T

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