Sin categoría – Página 86 – SEIOMM, Sociedad Española de Investigación Ósea

Guidelines for the management of asymptomatic primary hyperparathyroidism: summary statement from the Fourth International Workshop

J Clin Endocrinol Metab. 2014 Oct;99(10):3561-9. doi: 10.1210/jc.2014-1413. Epub 2014 Aug 27. In view of new findings since the last International Workshop on the Management of Asymptomatic PHPT, guidelines for management have been revised. The … Leer más

CLINICAL PRESENTATION OF PAGET’S DISEASE: EVALUATION OF A CONTEMPORARY COHORT AND SYSTEMATIC REVIEW

Calcif Tissue Int. 2014 Nov;95(5):385-92. doi: 10.1007/s00223-014-9904-1. Epub 2014 Aug 27. While changes in the mode of presentation of PDB have occurred over recent years, many patients present with complications such as fracture and deformity. … Leer más

Effects of eight-month treatment with ONO-5334, a cathepsin K inhibitor, on bone metabolism, strength and microstructure in ovariectomized cynomolgus monkeys

Bone. 2014 Apr 27;65C:1-8. doi: 10.1016/j.bone.2014.04.023. In microstructural analysis, alendronate suppressed OVX-induced increase in femoral mid-shaft osteonal bone formation rate (BFR) to a level below that recorded in the sham group, whereas ONO-5334 (Catepsin K … Leer más

Inflammatory factors in the circulation of patients with active rheumatoid arthritis stimulate osteoclastogenesis via endogenous cytokine production by osteoblasts

Osteoporos Int 2014; Oct;25(10):2453-63. doi: 10.1007/s00198-014-2779-1. Epub 2014 Jul 16 The combination of cytokines present in serum of RA patients with active disease might contribute to bone loss by directly inhibiting osteoblast proliferation and differentiation, … Leer más

Secular trends in hip fractures worldwide: opposing trends East versus west

J Bone Miner Res. 2014 Aug;29(8):1745-55. doi: 10.1002/jbmr.2218. Data presented here show close parallels between rising rates of urbanization and hip fractures across disparate geographic locations and cultures. Once the proportion of the urban population … Leer más

RECONSIDERATION OF THE RELEVANCE OF MILD WEDGE OR SHORT VERTEBRAL HEIGHT DEFORMITIES ACROSS A BROAD AGE DISTRIBUTION

Osteoporos Int. 2014 Nov;25(11):2609-15. doi: 10.1007/s00198-014-2801-7. Epub 2014 Jul 29. The study demonstrates that mild or wedged vertebral shape changes are rare among younger subjects, suggesting that when these radiographic abnormalities are seen among older … Leer más

Five Freely Circulating miRNAs and Bone Tissue miRNAs Are Associated With Osteoporotic Fractures

J Bone Miner Res. 2014; 29: 1715‒1717. doi: 10.1002/jbmr.2175. In conclusion, this study profiled serum miRNAs in osteoporosis and identified 9 miRNAs highly associated with osteoporosis in blood serum. In bone tissue, 6 differentially expressed … Leer más

The effect of olive oil on osteoporosis prevention.

Published evidence suggests that olive oil phenols can be beneficial by preventing the loss of bone mass. It has been demonstrated that they can modulate the proliferative capacity and cell maturation of osteoblasts by increasing … Leer más

Osteocyte control of bone remodeling: is sclerostin a key molecular coordinator of the balanced bone resorption–formation cycles?

Osteoporosis International 2014; 25: 2685-2700. doi: 10.1002/biof.1186. The osteocyte network plays a central role in directing bone response either to mechanical loading, or to unloading, leading correspondingly to bone formation or resorption. This review shows … Leer más

Influence of Vitamin D Status on the Effect of Statins on Bone Mineral Density and Bone Turnover Markers in Postmenopausal Women.

Women on statins and serum 25OHD levels above 20 ng/mL have greater BMD and less bone resorption than those without either of the factors. Differences, however, are not significant in women with only one of … Leer más