Distinct Osteomimetic Response of Androgen-Dependent and Independent Human Prostate Cancer Cells to Mechanical Action of Fluid Flow: Prometastatic Implications

Prostate. 2016 Nov 3. doi: 10.1002/pros.23270.

Prostate cancer frequently expresses an osteomimetic phenotype, but it is unclear how it is regulated and what biological and clinical implications it confers.  MAFF activated osteoblast-like phenotype of prostate cancer cells and altered their responses to osteocyte soluble factors.