07Mar 2013

Vitamin D insufficiency has deleterious consequences on health outcomes. In elderly or postmenopausal women, it may exacerbate osteoporosis.

Introduction

Few subjects have been the source of as much discussion in the medical community in recent years as vitamin D. Lack of vitamin D has well known direct effects on bone health. This occurs via the deregulation of calcium homeostasis and increased serum parathyroid hormone (PTH), which negatively affects bone remodeling by increasing bone resorption1–3. Continue reading

04Mar 2013

Para los afectados por enfermedades óseas, como la osteoporosis, es fundamental la práctica de ejercicio físico tanto para prevenir su avance como para minimizar los riesgos de fractura.

Un ejercicio físico adaptado a sus especiales necesidades, como el que les brinda el método Pilates, que les procura múltiples beneficios. “Se trata de una actividad física sin riesgo de caídas o golpes, que hace trabajar los músculos y ayuda a compensar el desequilibrio entre reabsorción y formación del tejido óseo”, explica Emilie Baudoin, experta en Pilates en Divina Pastora Seguros. Continue reading

04Mar 2013

Angels Martinez-Ferrer MD1, Jordi Blasco MD2, Josep L Carrasco3, Juan Macho PhD2, Luis San Román MD2, Antonio López Rueda MD2, Ana Monegal PhD1, Nuria Guañabens PhD4, Pilar Peris PhD4,

Abstract

We have recently observed an increased risk for vertebral fractures (VF) in a randomized controlled trial comparing the analgesic effect of vertebroplasty (VP) versus conservative treatment in symptomatic VF. The aim of the present study was to evaluate the risk factors related to the development of VF after VP in these patients.

We evaluated risk factors including age, gender, bone mineral density, the number, type and severity of vertebral deformities at baseline, the number of vertebral bodies treated, the presence and location of disk cement leakage, bone remodeling (determining bone turnover markers) and 25 hydroxyvitamin D (25OHD) levels at baseline in all patients.Twenty-nine radiologically new VF were observed in 17/57 patients undergoing VP, 72% adjacent to the VP. Patients developing VF after VP showed an increased prevalence of 25OHD deficiency (< 20 ng/ml) and higher PINP values. 25OHD levels < 20ng/ml was the principal factor related to the development of VF after VP in multivariate analysis (RR,15.47; 95% CI,2.99-79.86, P<0.0001), whereas age >80 years (RR,3.20;95%CI,1.70-6.03, P=0.0007) and glucocorticoid therapy (RR,3.64;95%CI,1.61-8.26,P=0.0055) constituted the principal factors in the overall study population. Increased risk of VF after VP was also associated with cement leakage into the inferior disk (RR,6.14;95%CI,1.65-22.78, P=0.044) and >1 vertebral body treated during VP (RR,4.19; 95% CI,1.03-34.3, P=0.044).

In conclusion, nearly 30% of patients with osteoporotic VF treated with VP had a new VF after the procedure. Age, especially over 80 years, the presence of inferior disk cement leakage after the procedure, the number of cemented vertebrae and low 25OHD serum levels were related to the development of new VF in these patients; the latter indicating the need to correct vitamin D deficiency prior to performing VP. © 2013 American Society for Bone and Mineral Research.

26Feb 2013

Zaragoza, 13 feb (EFE).- Un estudio de la Universidad de Zaragoza vincula la práctica competitiva de ciclismo con mayor riesgo de osteoporosis y el decrecimiento en salud ósea,

El trabajo, desarrollado por el grupo de investigación Genud (Growth, Exercise, Nutrition and Development) de la Universidad de Zaragoza, ha sido publicado recientemente en la revista «BMC medicine» y también incluido en el compendio «Advances in Sport Nutrition, Exercise and Medicine».

Continue reading

12Feb 2013

El premio consiste en una dotación de 50.000 euros y una obra de un escultor español contemporáneo.

Banco Sabadell otorga este premio con objeto de reconocer la excelencia de personas jóvenes, con una importante trayectoria en el campo de la búsqueda biomédica y ciencias de la salud, que destaquen en su especialidad por su capacidad de innovación. El premio consiste en una dotación de 50.000 euros y una obra de un escultor español contemporáneo. La de esta edición es del barcelonés Sergi Aguilar, considerado uno de los principales artistas españoles de su generación.

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05Feb 2013

Se abre el plazo de presentación de candidaturas para la nueva edición de los Premios Fundación Pfizer de Investigación en las siguientes categorías:

Investigación Básica.
Investigación Clínica o Salud Pública.
Investigación para profesionales sanitarios en fase de especialización

Podrán optar aquellos trabajos de investigación biomédica que hayan sido publicados durante 2012, en revistas contenidas en el Science Citation Index. Los trabajos deberán haberse realizado en instituciones españolas públicas o privadas. También se aceptarán trabajos realizados en entidades españolas en colaboración con instituciones extranjeras. Continue reading

01Feb 2013

XXV Convocatoria de Becas para Ampliación de Estudios en el Extranjero en Ciencias de la Vida y de la Materia

Presentación

La Fundación Ramón Areces tiene como objetivo fundamental el patrocinio de proyectos de investigación científica y técnica en España a través de Concursos Nacionales, la formación de jóvenes investigadores, así como el fomento y desarrollo de la educación y de la cultura en general. Continue reading

01Feb 2013

Authors: Sahana, H.; Khajuria, Deepak Kumar; Razdan, Rema; Mahapatra, D. Roy; Bhat, M.R.; Suresh, Sarasija; Rao, R. Ramachandra; Mariappan, L.

Abstract:

A superior drug formulation capable of achieving efficient osteogenesis is in imperative demand for the treatment of osteoporosis. In the present study we investigated the potential of using novel risedronate-hydroxyapatite (HA) nanoparticle based formulation in an animal model of established osteoporosis. Nanoparticles of HA loaded with risedronate (NHLR) of various sizes (80-130 nm) were generated for bone targeted drug delivery. Three months after ovariectomy, 36 ovariectomized (OVX) rats were divided into 6 equal groups and treated with various doses of NHLR (500, 350 and 250 μg/kg intravenous single dose) and sodium risedronate (500 μg/kg, intravenous single dose). Untreated OVX and sham OVX served as controls. One month after drug administration, the left tibia and femur were tested for bone mechanical properties and histology, respectively. In the right femur, bone density was measured by method based on Archimedes principle and bone porosity analyses were performed using X-ray imaging. NHLR (250 μg/kg) showed a significant increase in bone density and reduced bone porosity when compared with OVX control. Moreover, NHLR (250 μg/kg) significantly increased bone mechanical properties and bone quality when compared with OVX control. The results strongly suggest that the NHLR, which is a novel nanoparticle based formulation, has a therapeutic advantage over risedronate sodium monotherapy for the treatment of osteoporosis in a rat model of postmenopausal osteoporosis.

Document Type: Research article

DOI: http://dx.doi.org/10.1166/jbn.2013.1482

Publication date: 2013-02-01

11Ene 2013

Opportunities for ECTS to communicate information about their 50th Annivesary Congress.

Abstract deadline: 28 January 2013

To ensure that your research is part of ECTS 2013, you will need to submit your abstract by the 28 January 2013 via the ECTS website. http://www.ectscongress.org/2013/prog/abstract.htm
Why submit your abstract to ECTS 2013?

  • Long-standing congress of highest scientific quality (50th anniversary in 2013)
  • Good balance of basic science and clinical content
  • Abstracts will be published online
  • High percentage of submitted abstracts selected as oral presentations (average of over 15%)
  • The ECTS is a registered charity and uses any surplus income on the provision of grants, awards and training courses
  • The ECTS is supportive of new investigators, providing grants and awards for scientists and clinicians within 10 years of attaining their PhD/MD

Please note that any abstract that has been presented in an oral session at any other congress can also be submitted as a poster to the ECTS.

08Ene 2013

Could wood be a practical replacement for bone? Researchers from the National Research Council of Italy (CNR) writing in a forthcoming issue of the International Journal of Healthcare Technology and Management …

Biloine W. Young • Fri, December 21st, 2012

Could wood be a practical replacement for bone? Researchers from the National Research Council of Italy (CNR) writing in a forthcoming issue of the International Journal of Healthcare Technology and Management suggest that it can. It turns out that the structure of some woods at the microscopic level is very close to that of natural bone; both have unique biomechanical properties such as high strength and lightness.

Two researchers in Italy, Ugo Finardi (Institute for Economic Research on Firms and Growth-CERIS-CNR, and University of Torino), and Simone Sprio (Institute of Science and Technology for Ceramics – ISTEC-CNR), have carried out a case study on the implications of a new technology recently developed by the Research Group on Biomaterials of ISTEC. In that work, the researchers, Anna Tampieri, Simone Sprio and Andrea Ruffini, used a nanotechnological approach to transform rattan wood into hierarchically organized implants. Continue reading