Notch1 and Notch2 expression in osteoblast precursors regulates femoral microarchitecture

Bone 2014; 62:22-28

Notch1 and Notch2 inactivation increased porosity and reduced thickness of cortical bone. These effects were modest and more evident in 3 and 6 month old female than in male mice of the same age. In conclusion, Notch1 and Notch2 expression in osteoblast precursors regulates cancellous bone volume and microarchitecture.