OSTEOCYTES MEDIATE THE ANABOLIC ACTIONS OF CANONICAL Wnt/β-catenin SIGNALING IN BONE

Proc Natl Acad Sci U S A. 2015 Jan 20. pii: 201409857.

Thus, activation of osteocytic β-catenin signaling increases both osteoclasts and osteoblasts, leading to bone gain, and is sufficient to activate the Notch pathway. These findings demonstrate disparate outcomes of β-catenin activation in osteocytes versus osteoblasts and identify osteocytes as central target cells of the anabolic actions of canonical Wnt/β-catenin signaling in bone.

Autor: Tu X,Delgado-Calle J,Condon KW,Maycas M,Zhang H,Carlesso N,Taketo M,Burr DB,Plotkin LI,Bellido T.
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