Bone mineral density was similar between HIV-infected patients aged 20-30 years than in age- and gender-matched controls. However, lower femoral T-scores and higher rate of osteopenia and osteoporosis were seen in HIV-infected men.
Therapy with protease inhibitors, nadir CD4 counts, and fat and lean mass were predictive factors of peak bone mass. Given that these patients will be living with HIV infection for many years, every effort should be made to modify risk factors.
