The selective estrogen receptor modulator, bazedoxifene, reduces ischemic brain damage in male rat.

Our results demonstrate that: 1) 17β-estradiol (E2) at physiological plasma levels in female rats is neuroprotective in male rats when given at the acute stage of the ischemic challenge; and 2) bazedoxifene acetate at clinically relevant plasma levels mimics the neuroprotective action of E2 and could be, therefore, a candidate in stroke treatment.

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