J Bone Miner Res, (2014) 29; 787–795
The findings represent the first demonstration, using a direct in vivo measure of BMS, of compromised bone material properties in patients with T2D. Further, our results confirm previous studies demonstrating low bone turnover in patients with T2D and highlight the potential detrimental effects of prolonged hyperglycemia on bone quality. Thus, the skeleton needs to be recognized as another important target tissue subject to diabetic complications.
Autor: J N Farr,1 M T Drake,1 S Amin,2 L J Melton III,3 L K McCready,1 Sundeep Khosla1