Presenta tu candidatura a los Premios ESCEO-IOF para Jóvenes Investigadores
Ya está abierto el plazo para presentar las solicitudes a los Premios ESCEO – IOF que se otorgan a jóvenes investigadores por sus contribuciones en el campo de la investigación ósea y mineral en la reunión anual WCO-IOF-ESCEO 2025 en Roma, Italia. Valor del premio y requisitos Se distribuirán 20 becas de 1.000 euros cada…
REVISTA DE OSTEOPOROSIS Y METABOLISMO MINERAL VOLUMEN 16. NÚM. 2.
Ya está disponible el nuevo número de la ROMM del 2024 En el siguiente enlace podéis encontrar la versión en español e inglés:
“Métodos de determinación y valores deseables de la Vitamina D”, disponible el vídeo
El Dr. José Manuel Quesada Gómez (Servicio de Endocrinología. Hospital Reina Sofía. Córdoba) y el profesor Feliciano Priego Capote (Profesor Titular del Departamento de Química Analítica de la Universidad de Córdoba) han impartido la hasta el momento última sesión en línea de la SEIOMM. Con la colaboración del Dr. José Luis Pérez Castrillón como moderador,…
Lo mejor del año en investigación clínica sobre metabolismo óseo, con la Dra. Pilar Peris en el podcast “Somos la SEIOMM”
En esta tercera entrega del podcast “Somos la SEIOMM” hablamos con la doctora Pilar Peris. Especialista en Reumatología del Servicio de Reumatología del Hospital Clínico de Barcelona, la doctora Peris nos resumirá Lo Mejor del Año en Metabolismo Óseo. Las comunicaciones de Investigación CLÍNICA presentadas en el XXVI Congreso de la SEIOMM. Puede descargar aquí…
Registro REFRA (Proyecto FLS Excellence): lo más relevante de los pacientes incorporados al Registro
La SEIOMM les ofrece en esta infografía un resumen de lo más relevante de los pacientes incorporados al Registro REFRA, como parte del Proyecto FLS Excellence. Toda la información se irá actualizando periódicamente. Puede descargar la infografía en este enlace: ÚLTIMA ACTUALIZACIÓN Actualización 3 de octubre de 2022. 5.393 pacientes incluidos en nuestro registro REFRA.
Resolución de solicitudes para el Proyecto FLS Excellence: aceptadas 13 solicitudes
Finalizado el plazo de acceso al Proyecto FLS Excellence SEIOMM/FEIOMM 2022-2023, el pasado 27 de mayo de 2022, se han aceptado 13 de las solicitudes presentadas al cumplir con los criterios de selección requeridos. Desde el Comité Científico y Ejecutivo agradecemos el interés de todas las FLS participantes en este proyecto, y a las no…
El Bone Site 2022 reúne a expertos en metabolismo óseo los días 3 y 4 de junio en Madrid de forma presencial y por streaming
Llega el Bone Site 2022, una iniciativa que cumple este año su segunda edición y que está pensada para debatir los retos y avances en el manejo de la osteoporosis. El Bone Site 2022 contará con un programa científico de actualidad y con la participación de expertos nacionales e internacionales en metabolismo óseo. SEIOMM avala…
Cuida tu Salud, un proyecto europeo que busca promover un envejecimiento saludable
CuidaTuSalud es un proyecto europeo que busca concienciar sobre la importancia de promover un envejecimiento saludable “especialmente a partir de los 65 años”, según AMGEN, promotor de esta plataforma educativa sobre salud ósea y cardiovascular. Todos los materiales educativos de #ProtectYourLife #CuidaTuSalud se encuentran disponibles en este enlace: http://bit.ly/PULCuidaTuSalud Aquí, desde un enfoque científico validado, se…
La Vitamina D a partir de los 65 años, podcast “ÓSEO MARTES” de SEIOMM con la Dra. Cristina Carbonell
En mayores de 65 años el mantenimiento de ciertos niveles de Vitamina D es fundamental para el adecuado metabolismo del hueso. Ese es el mensaje central del primer ÓSEO MARTES, una iniciativa que SEIOMM ha puesto en marcha, con la colaboración de Gebro Pharma, y con la Dra. Cristina Carbonell (Especialista en Medicina Familiar y…
El Comité Científico del Proyecto FLS-Excellence comunica la resolución de solicitudes
El Comité ha tenido en cuenta para la adjudicación los criterios especificados en la convocatoria.
Convocadas las Becas FEIOMM-UCB-AMGEN a los mejores trabajos sobre unidades de coordinación de fractura o FLS
La cuantía total de las becas es de 10.000 euros. El plazo de solicitud finaliza el 30 de septiembre de 2020 a las 24 horas.
Combination therapies in the treatment of osteoporosis
Combination therapies in the treatment of osteoporosis
Off-label uses of denosumab in metabolic bone diseases
Bone. 2019 Dec;129:115048. doi:10.1016/j.bone.2019.115048 Polyzos SA, Makras P, Tournis S, Anastasilakis AD
Trends in Prescribing Menopausal Hormone Therapy and Bisphosphonates in Australia and Manitoba, Canada and Adherence to Recommendations
J Womens Health (Larchmt). 2019 Dec 31. doi:10.1089/jwh.2019.7828. Salagame U, Kliewer EV, Demers A, Banks E, Velentzis LS, Goldsbury D, Egger S,Leslie WD, Canfell K.
Involvement of the gut microbiota and barrier function in glucocorticoid induced osteoporosis
J Bone Miner Res. 2019 Dec 30. doi: 10.1002/jbmr.3947. Schepper JD, Collins F, Rios-Arce ND, Kang HJ, Schaefer L, Gardinier JD,Raghuvanshi R, Quinn RA, Britton R, Parameswaran N, McCabe LR.
Noncoding RNA miR-205-5p mediates osteoporosis pathogenesis and osteoblast differentiation by regulating RUNX2
Noncoding RNA miR-205-5p mediates osteoporosis pathogenesis and osteoblast differentiation by regulating RUNX2
Changes in vascular calcification and bone mineral density in calcium supplement users from the Canadian Multi-center Osteoporosis Study (CaMOS)
Changes in vascular calcification and bone mineral density in calcium supplement users from the Canadian Multi-center Osteoporosis Study (CaMOS)
Treating osteoporotic osteoarthritis, or the art of cutting a balding man’s hair
Treating osteoporotic osteoarthritis, or the art of cutting a balding man’s hair
3D culture modelling: An emerging approach for Translational Cancer Research in Sarcomas
3D culture modelling: An emerging approach for Translational Cancer Research in Sarcomas
Biphasic Hydrogels Integrating Mineralized and Anisotropic Features for Interfacial Tissue Engineering
Biphasic Hydrogels Integrating Mineralized and Anisotropic Features for Interfacial Tissue Engineering
Strontium-releasing mesoporous bioactive glasses with anti-adhesive zwitterionic surface as advanced biomaterials for bone tissue regeneration
Strontium-releasing mesoporous bioactive glasses with anti-adhesive zwitterionic surface as advanced biomaterials for bone tissue regeneration
In-vitro comparison of hydroxyapatite coatings obtained by cold spray and conventional thermal spray technologies
In-vitro comparison of hydroxyapatite coatings obtained by cold spray and conventional thermal spray technologies
Fracture risk assessment in the general population in Spain by FRAX® algorithm. EPISER2016 study.
Fracture risk assessment in the general population in Spain by FRAX® algorithm. EPISER2016 study.
Muscular Fitness Mediates the Association between 25-Hydroxyvitamin D and Areal Bone Mineral Density in Children with Overweight/Obesity.
Muscular Fitness Mediates the Association between 25-Hydroxyvitamin D and Areal Bone Mineral Density in Children with Overweight/Obesity.
Vitamin D, menopause, and aging: quo vadis? Climacteric.
Vitamin D, menopause, and aging: quo vadis? Climacteric.
Bone Mineral Metabolism Status, Quality of Life, and Muscle Strength in Older People. Nutrients.
Bone Mineral Metabolism Status, Quality of Life, and Muscle Strength in Older People. Nutrients.
Smoking and Alcohol Intake but Not Muscle Strength in Young Men Increase Fracture Risk at Middle Age: A Cohort Study Linked to the Swedish National Patient Registry.
Smoking and Alcohol Intake but Not Muscle Strength in Young Men Increase Fracture Risk at Middle Age: A Cohort Study Linked to the Swedish National Patient Registry.
Targeting Macrophages: Friends or Foes in Disease? Front Pharmacol.
Targeting Macrophages: Friends or Foes in Disease? Front Pharmacol.
Spanish National Hip Fracture Registry (RNFC): First-year results and comparison with other registries and prospective multi-centric studies from Spain].
Spanish National Hip Fracture Registry (RNFC): First-year results and comparison with other registries and prospective multi-centric studies from Spain].
Cholecalciferol and calcifediol for vitamin D supplementation.
Cholecalciferol and calcifediol for vitamin D supplementation.
Long term effects on biochemical bone markers of a single infusion of zoledronic acid in Paget disease of bone.
Long term effects on biochemical bone markers of a single infusion of zoledronic acid in Paget disease of bone.
Relationship between 1,25-Dihydroxyvitamin D and Body Composition in Middle-Aged Sedentary Adults: The FIT-AGEING Study. Nutrients
Relationship between 1,25-Dihydroxyvitamin D and Body Composition in Middle-Aged Sedentary Adults: The FIT-AGEING Study. Nutrients
The use of microindentation for the study of bone properties in type 1 diabetes mellitus patients.
The use of microindentation for the study of bone properties in type 1 diabetes mellitus patients.
Osteopenia and Osteoporosis in Patients with Bronchiectasis: Association with Respiratory Parameters, Body Composition, Muscle Strength and Bone Remodeling Biomarkers.
Osteopenia and Osteoporosis in Patients with Bronchiectasis: Association with Respiratory Parameters, Body Composition, Muscle Strength and Bone Remodeling Biomarkers.
Increased Fracture Risk in Women Treated With Aromatase Inhibitors Versus Tamoxifen: Beneficial Effect of Bisphosphonates.
Increased Fracture Risk in Women Treated With Aromatase Inhibitors Versus Tamoxifen: Beneficial Effect of Bisphosphonates.
Analysis of bone impairment by 3D DXA hip measures in patients with primary hyperparathyroidism: a pilot study.
Analysis of bone impairment by 3D DXA hip measures in patients with primary hyperparathyroidism: a pilot study.
East-west gradient in hip fracture incidence in Spain:how much can we explain by following the pattern of risk factors?
East-west gradient in hip fracture incidence in Spain:how much can we explain by following the pattern of risk factors?
Atopic eczema and fracture risk in adults: A population-based cohort study.
Atopic eczema and fracture risk in adults: A population-based cohort study.
Assessment on patient outcomes of primary hip replacement: an interrupted time series analysis from ‘The National Joint Registry of England and Wales’.
Assessment on patient outcomes of primary hip replacement: an interrupted time series analysis from ‘The National Joint Registry of England and Wales’.
Prevalence and mortality of individuals with X-linked hypophosphataemia: a United Kingdom real world data analysis.
Prevalence and mortality of individuals with X-linked hypophosphataemia: a United Kingdom real world data analysis.
Impact of risk minimisation measures on the use of strontium ranelate in Europe: a multi-national cohort study in 5 EU countries by the EU-ADR Alliance.
Impact of risk minimisation measures on the use of strontium ranelate in Europe: a multi-national cohort study in 5 EU countries by the EU-ADR Alliance.
Inequalities in prescription rates of anti-osteoporosis drugs in primary care in England: Apractice-level prescribing data analysis in 2013-2018.
Inequalities in prescription rates of anti-osteoporosis drugs in primary care in England: Apractice-level prescribing data analysis in 2013-2018.
Silicon substituted hydroxyapatite/VEGF scaffolds stimulate bone regeneration in osteoporotic sheep.
Silicon substituted hydroxyapatite/VEGF scaffolds stimulate bone regeneration in osteoporotic sheep.
Bile acids and bilirubin effects on osteoblastic gene profile.Implications in the pathogenesis of osteoporosis in liver diseases.
Bile acids and bilirubin effects on osteoblastic gene profile.Implications in the pathogenesis of osteoporosis in liver diseases.
Efficacy and safety of denosumab vs.bisphosphonates in postmenopausal women previously treated with oral bisphosphonates.
Efficacy and safety of denosumab vs.bisphosphonates in postmenopausal women previously treated with oral bisphosphonates.
Algorithm for the management of patients at low, high and very high risk of osteoporotic fractures.
Algorithm for the management of patients at low, high and very high risk of osteoporotic fractures.
Multi-Material Dual Gradient 3D Printing for Osteogenic Differentiation and Spatial Segregation.
Multi-Material Dual Gradient 3D Printing for Osteogenic Differentiation and Spatial Segregation.
Balancing benefits and risks in the era of biologics.
Balancing benefits and risks in the era of biologics.
Endothelial Progenitor Cells Do Not Originate From the Bone Marrow.
Endothelial Progenitor Cells Do Not Originate From the Bone Marrow.
Psychotropic medications and proton pump inhibitors and the risk of fractures in the teriparatide versus risedronate VERO clinical trial.
Psychotropic medications and proton pump inhibitors and the risk of fractures in the teriparatide versus risedronate VERO clinical trial.
Algorithm for the Use of Biochemical Markers of Bone Turnover in the Diagnosis, Assessment and Follow-Up of Treatment for Osteoporosis.
Algorithm for the Use of Biochemical Markers of Bone Turnover in the Diagnosis, Assessment and Follow-Up of Treatment for Osteoporosis.
Denosumab or romosozumab therapy and risk of cardiovascular events in patients with primary osteoporosis: Systematic review and meta- analysis.
Denosumab or romosozumab therapy and risk of cardiovascular events in patients with primary osteoporosis: Systematic review and meta- analysis.
Ten years change in post-fracture care for hip fracture patients.
Ten years change in post-fracture care for hip fracture patients.
Zoledronate for the Prevention of Bone Loss in Women Discontinuing Denosumab Treatment. A Prospective 2-Year Clinical Trial.
Zoledronate for the Prevention of Bone Loss in Women Discontinuing Denosumab Treatment. A Prospective 2-Year Clinical Trial.
Periostin and sclerostin levels in individuals with spinal cord injury and their relationship with bone mass, bone turnover, fracture and osteoporosis status.
Periostin and sclerostin levels in individuals with spinal cord injury and their relationship with bone mass, bone turnover, fracture and osteoporosis status.
A multicenter, randomized, rater-blinded, parallel-group, phase 3 study to compare the efficacy, safety, and immunogenicity of biosimilar RGB-10 and reference once-daily teriparatide in patients with osteoporosis.
A multicenter, randomized, rater-blinded, parallel-group, phase 3 study to compare the efficacy, safety, and immunogenicity of biosimilar RGB-10 and reference once-daily teriparatide in patients with osteoporosis.
Effects of Therapeutic Doses of Celecoxib on Several Physiological Parameters of Cultured Human Osteoblasts
Effects of Therapeutic Doses of Celecoxib on Several Physiological Parameters of Cultured Human Osteoblasts
The osteocyte: A multifunctional cell within the bone
The osteocyte: A multifunctional cell within the bone
Hip fractures following denosumab discontinuation: three clinical cases reports
Hip fractures following denosumab discontinuation: three clinical cases reports
A subset of low density granulocytes is associated with vascular calcification in chronic kidney disease patients
A subset of low density granulocytes is associated with vascular calcification in chronic kidney disease patients
Fracture liaison service and mortality in elderly hip fracture patients: a prospective cohort study
Fracture liaison service and mortality in elderly hip fracture patients: a prospective cohort study
Analysis of volumetric BMD in people with Down syndrome using DXA-based 3D modeling
Analysis of volumetric BMD in people with Down syndrome using DXA-based 3D modeling
Zoledronate in the prevention of Paget’s (ZiPP): protocol for a randomised trial of genetic testing and targeted zoledronic acid therapy to prevent SQSTM1-mediated Paget’s disease of bone
Zoledronate in the prevention of Paget’s (ZiPP): protocol for a randomised trial of genetic testing and targeted zoledronic acid therapy to prevent SQSTM1-mediated Paget’s disease of bone
Radiofrequency echographic multi-spectrometry for the in-vivo assessment of bone strength: state of the art-outcomes of an expert consensus meeting organized by the European Society for Clinical and Economic Aspects of Osteoporosis,Osteoarthritis and Musculoskeletal Diseases (ESCEO)
Radiofrequency echographic multi-spectrometry for the in-vivo assessment of bone strength: state of the art-outcomes of an expert consensus meeting organized by the European Society for Clinical and Economic Aspects of Osteoporosis,Osteoarthritis and Musculoskeletal Diseases (ESCEO)
Changes in Bone Mineral Density in Patients with Type 2 Diabetes After Different Bariatric Surgery Procedures and the Role of Gastrointestinal Hormones
Changes in Bone Mineral Density in Patients with Type 2 Diabetes After Different Bariatric Surgery Procedures and the Role of Gastrointestinal Hormones
Handling Parathormone Receptor Type 1 in Skeletal Diseases: Realities and Expectations of Abaloparatide
Handling Parathormone Receptor Type 1 in Skeletal Diseases: Realities and Expectations of Abaloparatide
Osteostatin Inhibits Collagen-Induced Arthritis by Regulation of Immune Activation, Pro-Inflammatory Cytokines, and Osteoclastogenesis
Osteostatin Inhibits Collagen-Induced Arthritis by Regulation of Immune Activation, Pro-Inflammatory Cytokines, and Osteoclastogenesis
Synthesis and in vivo evaluation of a scaffold containing wollastonite/β-TCP for bone repair in a rabbit tibial defect model
Synthesis and in vivo evaluation of a scaffold containing wollastonite/β-TCP for bone repair in a rabbit tibial defect model
Is vitamin-D supplementation not useful in patients at risk of fractures and falls?
Is vitamin-D supplementation not useful in patients at risk of fractures and falls?
Determinants, consequences and potential solutions to poor adherence to anti-osteoporosis treatment: results of an expert group meeting organized by the European Society for Clinical and Economic Aspects of Osteoporosis, Osteoarthritis and Musculoskeletal Diseases (ESCEO) and the International Osteoporosis Foundation (IOF).
Determinants, consequences and potential solutions to poor adherence to anti-osteoporosis treatment: results of an expert group meeting organized by the European Society for Clinical and Economic Aspects of Osteoporosis, Osteoarthritis and Musculoskeletal Diseases (ESCEO) and the International Osteoporosis Foundation (IOF).
Phosphate disorders and clinical management of hypophosphatemia and hyperphosphatemia
Phosphate disorders and clinical management of hypophosphatemia and hyperphosphatemia
RESOLUCION Becas FEIOMM INSCRIPCIÓN al XXIV CONGRESO GIRONA 2019
RESOLUCIÓN BECAS FEIOMM INSCRIPCIÓN XXIV CONGRESO SEIOMM 2019_GIRONA
Madrid, a 30 de septiembre de 2019
Finalizado el plazo para el envío de solicitudes para acceder a una de las 11 Becas FEIOMM dirigida a Jóvenes Investigadores, para la inscripción al XXIV Congreso SEIOMM 2019_ GIRONA, se adjunta la lista de solicitantes admitidos y no admitidos para su evaluación:
CONVOCATORIA BECAS FEIOMM INSCRIPCIÓN 2019
CONVOCATORIA 10 Becas FEIOMM INSCRIPCIÓN al XXIV CONGRESO GIRONA 2019 Madrid, a 10 de septiembre de 2019 La Fundación Española de Investigación Ósea y del Metabolismo Mineral (FEIOMM) convoca 10 Becas como ayuda a jóvenes investigadores para la asistencia al XXIV CONGRESO NACIONAL SEIOMM que se celebrará en Girona del 16 al 18 de octubre de 2019. Pueden consultar las bases…
Jornada Resolviendo dudas del día a día en la PREVENCIÓN DE FRACTURAS POR FRAGILIDAD
Queríamos informarles de que el próximo 3 de octubre tendrá lugar en el Ilustre Colegio de Médicos de Alicante la jornada de formación dirigida a Médicos Especialistas en Medicina Familiar y Comunitaria, que lleva por título: “Resolviendo dudas del día a día en la PREVENCIÓN DE FRACTURAS POR FRAGILIDAD”, la cual viene avalada por su Sociedad.
PROLIA® (DENOSUMAB): POSIBLE RIESGO DE FRACTURAS VERTEBRALES MÚLTIPLES TRAS LA SUSPENSIÓN DEL TRATAMIENTO
Se han notificado casos de fracturas, algunas múltiples, tras la suspensión del tratamiento con Prolia® (denosumab). LINK a AEMPS LINK PDF Nota informativa Se recuerda que Prolia® únicamente se debe de utilizar en pacientes con elevado riesgo de fracturas y se recomienda a los profesionales sanitarios considerar, antes de comenzar a tratar al paciente, la posible aparición…
CONVOCATORIA BECAS FEIOMM INVESTIGACIÓN 2019
La Fundación Española de Investigación Ósea y del Metabolismo Mineral (FEIOMM), convoca 6 BECAS de 7.000 € cada una para promocionar la investigación básica, clínica y traslacional en el campo del metabolismo mineral y óseo. BASES de la CONVOCATORIA aquí Fecha Límite domingo 29 de septiembre de 2019 REQUISÍTOS Ser miembro asociado ordinario o de pleno derecho de la…
Bisphosphonate treatment changes regional distribution of trabecula microstructure in human lumbar vertebrae
2019 Jul 4;127:482-487. doi: 10.1016/j.bone.2019.07.003 PubMed PMID: 31280018. Vom Scheidt A, Hemmatian H, Püschel K, Krause M, Amling M, Busse B. Bone.
Increased risk of osteoporotic fracture in community-dwelling elderly men 20 or more years after gastrectomy: The Fujiwara-kyo Osteoporosis Risk in Men (FORMEN) Cohort Study
2019 Jun 26;127:250-259. doi: 10.1016/j.bone.2019.06.014 PubMed PMID: 31254731 Iki M, Fujita Y, Kouda K, Yura A, Tachiki T, Tamaki J, Sato Y, Moon JS, Hamada M, Kajita E, Okamoto N, Kurumatani N Bone.
Bone-Forming and Antiresorptive Effects of Romosozumab in Postmenopausal Women With Osteoporosis: Bone Histomorphometry and Microcomputed Tomography Analysis After 2 and 12 Months of Treatment
2019 Jun 24. doi: 10.1002/jbmr.3735. PMID: 31233639 Chavassieux P, Chapurlat R, Portero-Muzy N, Roux JP, Garcia P, Brown JP, Libanati C, Boyce RW, Wang A, Grauer A J Bone Miner Res. Más información: https://www.ncbi.nlm.nih.gov/pubmed/31233639
Low vitamin D status is associated with impaired bone quality and increased risk of fracture-related hospitalization in older Australian women.
Res. 2019 Jun 24. doi: 10.1002/jbmr.3818 PMID: 31233633 Zhu K, Lewis JR, Sim M, Prince RL J Bone Miner Más información: https://www.ncbi.nlm.nih.gov/pubmed/31233633
Effects of zoledronic acid on vertebral shape of children and adolescents with osteogenesis imperfecta
2019 Jun 16;127:164-171. doi: 10.1016/j.bone.2019.06.011 PMID: 31216496 Li LJ, Zheng WB, Zhao DC, Yu W, Wang O, Jiang Y, Xia WB, Li M Bone. Más información: https://www.ncbi.nlm.nih.gov/pubmed/31216496
The next step after anti-osteoporotic drug discontinuation: an up-to-date review of sequential treatment
Endocrine. 2019 Jun;64(3):441-455. doi: 10.1007/s12020-019-01919- Guañabens N, Moro-Álvarez MJ, Casado E, Blanch-Rubió J, Gómez-Alonso C, Díaz-Guerra GM, Del Pino-Montes J, Díaz de Lamadrid CV, Peris P, Muñoz-Torres M; SEIOMM Working Group https://www.ncbi.nlm.nih.gov/pubmed/30963388
Bone Protective Effect of Extra-Virgin Olive Oil Phenolic Compounds by Modulating Osteoblast Gene Expression
Nutrients. 2019 Jul 25;11(8). pii: E1722. doi: 10.3390/nu11081722. Melguizo-Rodríguez L, Manzano-Moreno FJ, Illescas-Montes R, Ramos-Torrecillas J, Luna-Bertos E, Ruiz C, García-Martínez O. https://www.ncbi.nlm.nih.gov/pubmed/31349732
Vitamin D and cardio-metabolic risk factors in overweight adults: an overview of evidence
Curr Pharm Des. 2019 Jul 21. doi:10.2174/1381612825666190722103919. Valer-Martinez A, Martinez JA, Sayon-Orea C, Galvano F, Grosso G, Bes-Rastrollo M. https://www.ncbi.nlm.nih.gov/pubmed/31333117
Diagnostic Value of Mid-Thigh and Mid-Calf Bone, Muscle, and Fat Mass in Osteosarcopenia: A Pilot Study
Calcif Tissue Int. 2019 Jul 10. doi: 10.1007/s00223-019-00582-5. Bani Hassan E, Phu S, Vogrin S, Escobedo Terrones G, Pérez X, Rodriguez-Sanchez I, Duque G. https://www.ncbi.nlm.nih.gov/pubmed/31292687
Immune Function and Diversity of Osteoclasts in Normal and Pathological Conditions
Front Immunol. 2019 Jun 19;10:1408. doi: 10.3389/fimmu.2019.01408. eCollection 2019. Review. Madel MB, Ibáñez L, Wakkach A, de Vries TJ, Teti A, Apparailly F, Blin-Wakkach C. https://www.ncbi.nlm.nih.gov/pubmed/31275328
Bone mineral density and bone mineral content among female elite athletes
Bone. 2019 Jul 1. pii: S8756-3282(19)30262-5. doi: 10.1016/j.bone.2019.06.030. Bellver M, Del Rio L, Jovell E, Drobnic F, Trilla A. https://www.ncbi.nlm.nih.gov/pubmed/31271933
Parathyroid Hormone-Related Protein (PTHrP) Accelerates Soluble RANKL Signals for Downregulation of Osteogenesis of Bone Mesenchymal Stem Cells
J Clin Med. 2019 Jun 12;8(6). pii: E836. doi: 10.3390/jcm8060836 Elango J, Rahman SU, Henrotin Y, de Val JEMS, Bao B, Wang S, Li B, Wu W. https://www.ncbi.nlm.nih.gov/pubmed/31212822
Epidemiological, Clinical and Genetic Study of Hypophosphatasia in A Spanish Population: Identification of Two Novel Mutations in The Alpl Gene
Sci Rep. 2019 Jul 2;9(1):9569. doi: 10.1038/s41598-019-46004-2. García-Fontana C, Villa-Suárez JM, Andújar-Vera F, González-Salvatierra S, Martínez-Navajas G, Real PJ, Gómez Vida JM, de Haro T, García-Fontana B, Muñoz-Torres M. https://www.ncbi.nlm.nih.gov/pubmed/31267001
Associations between bone impact microindentation and clinical risk factors for fracture
Endocrinology. 2019 Jul 16. pii: en.2019-00415. doi:10.1210/en.2019-00415. Rufus-Membere P, Holloway-Kew KL, Diez-Perez A, Kotowicz MA, Pasco JA. https://www.ncbi.nlm.nih.gov/pubmed/31310275
Cost-Effectiveness of the Screening for the Primary Prevention of Fragility Hip Fracture in Spain Using FRAX(®)
Calcif Tissue Int. 2019 Jun 6. doi: 10.1007/s00223-019-00570-9. Martin-Sanchez M, Comas M, Posso M, Louro J, Domingo L, Tebé C, Castells X, Espallargues M. https://www.ncbi.nlm.nih.gov/pubmed/31172231
The secreted matrix protein mindin increases prostate tumor progression and tumor-bone crosstalk via ERK 1/2 regulation
Carcinogenesis. 2019 Jul 20;40(7):828-839. doi: 10.1093/carcin/bgz105 Ardura JA, Gutiérrez-Rojas I, Álvarez-Carrión L, Rodríguez-Ramos MR, Pozuelo JM, Alonso V. https://www.ncbi.nlm.nih.gov/pubmed/31168562
Erythropoietin modulates bone marrow stromal cell differentiation
Bone Researchvolume 7, Article number: 21 (2019) Sukanya Suresh, Luis Fernandez de Castro, Soumyadeep Dey, Pamela G. Robey & Constance Tom Noguchi https://www.nature.com/articles/s41413-019-0060-0
Vitamin D supplementation and musculoskeletal health. A controversial necessity
Med Clin (Barc). 2019 Jul 19. pii: S0025-7753(19)30419-1. doi:10.1016/j.medcli.2019.05.010. Quesada Gómez JM, Nogues X, Sosa Henríquez M, Bouillon R. https://www.ncbi.nlm.nih.gov/pubmed/31331670
Cost-effectiveness of pharmacological fracture prevention for osteoporosis as prescribed in clinical practice in France, Germany, Italy, Spain, and the United Kingdom
Osteoporos Int. 2019 Jul 3. doi: 10.1007/s00198-019-05064-w Svedbom A, Hadji P, Hernlund E, Thoren R, McCloskey E, Stad R, Stollenwerk B. https://www.ncbi.nlm.nih.gov/pubmed/31270592
Epidemiology/Quality of Life Working Group. Fracture risk following intermission of osteoporosis therapy
Osteoporos Int. 2019 Jun 7. doi: 10.1007/s00198-019-05002-w Dennison EM, Cooper C, Kanis JA, Bruyère O, Silverman S, McCloskey E,Abrahamsen B, Prieto-Alhambra D, Ferrari S; IOF https://www.ncbi.nlm.nih.gov/pubmed/31175404
Age-Related Changes and Effects of Bisphosphonates on Bone Turnover and Disease Progression in Fibrous Dysplasia of Bone
J Bone Miner Res. 2019 Apr;34(4):653-660. doi: 10.1002/jbmr.3649 Florenzano P, Pan KS, Brown SM, Paul SM, Kushner H, Guthrie LC, de Castro LF, Collins MT, Boyce AM. https://www.ncbi.nlm.nih.gov/pubmed/30645769
Periostin and sclerostin levels in individuals with spinal cord injury and their relationship with bone mass, bone turnover, fracture and osteoporosis status
2019 Jul 24. pii: S8756-3282(19)30293-5. doi: 10.1016/j.bone.2019.07.019. PubMed PMID: 31351195. Maïmoun L, Bouallègue FB, Gelis A, Aouinti S, Mura T, Philibert P, Souberbielle JC, Piketty M, Garnero P, Mariano-Goulart D, Fattal C Bone. https://www.ncbi.nlm.nih.gov/pubmed/31351195
Vitamin D, Autoimmune Disease and Rheumatoid Arthritis
2019 Jul 8. doi:10.1007/s00223-019-00577-2] PubMed PMID: 31286174. Harrison SR, Li D, Jeffery LE, Raza K, Hewison M. Calcif Tissue Int. https://www.ncbi.nlm.nih.gov/pubmed/31286174
Bone metabolism, bone mineral density and low-energy fractures 10 years after Roux-en-Y gastric bypass
2019 Jul 16;127:436-445. doi: 10.1016/j.bone.2019.07.014 PubMed PMID: 31323430. Blom-Høgestøl IK, Hewitt S, Chahal-Kummen M, Brunborg C, Gulseth HL, Kristinsson JA, Eriksen EF, Mala T Bone. https://www.ncbi.nlm.nih.gov/pubmed/31323430
The effects of mechanically loaded osteocytes and inflammation on bone remodeling in a bisphosphonate-induced environment
2019 Jul 10;127:460-473. doi: 10.1016/j.bone.2019.07.008. PubMed PMID: 31301402. George EL, Truesdell SL, Magyar AL, Saunders MM. Bone. https://www.ncbi.nlm.nih.gov/pubmed/31301402
High-serum phosphate and parathyroid hormone distinctly regulate bone loss and vascular calcification in experimental chronic kidney disease
Nephrol Dial Transplant. 2019 Jun 1;34(6):934-941. doi:10.1093/ndt/gfy287. Carrillo-López N, Panizo S, Alonso-Montes C, Martínez-Arias L, Avello N, Sosa P, Dusso AS, Cannata-Andía JB, Naves-Díaz M. https://www.ncbi.nlm.nih.gov/pubmed/30189026
Women With Pregnancy and Lactation-Associated Osteoporosis (PLO) Have Low Bone Remodeling Rates at the Tissue Level
Res. 2019 Jul 26. doi: 10.1002/jbmr.3750. PubMed PMID: 31348548. Cohen A, Kamanda-Kosseh M, Dempster DW, Zhou H, Müller R, Goff E, Colon I, Bucovsky M, Stubby J, Nickolas TL, Stein EM, Recker RR, Lappe JM, Shane E. J Bone Miner https://www.ncbi.nlm.nih.gov/pubmed/31348548
RESOLUCIÓN BECAS FEIOMM ASBMR 2019
Puedes descargar el ACTA aquí. Dado que el número de solicitantes admitidos es superior al de becas ofertadas y siguiendo las bases establecidas, las BECAS han sido ADJUDICADAS a: GONZALO ALLO MIGUEL, por su trabajo: “Serum 25 hydroxyvitamin D levels, Trabecular Bone Score and Bone Mineral Density in patients with Differentiated Thyroid Cancer and TSH suppression therapy” EDUARDO MARTÍN GUERRERO, por su…
The next step after anti-osteoporotic drug discontinuation: an up-to-date review of sequential treatment.
Endocrine. 2019 Jun;64(3):441-455. doi: 10.1007/s12020-019-01919-8. Guañabens N, Moro-Álvarez MJ, Casado E, Blanch-Rubió J, Gómez-Alonso C, Díaz-Guerra GM, Del Pino-Montes J, Díaz de Lamadrid CV, Peris P, Muñoz-Torres M; SEIOMM Working Group.
Rabbit as model for osteoporosis research.
J Bone Miner Metab. 2019 May 13. doi:10.1007/s00774-019-01007-x. Permuy M, López-Peña M, Muñoz F, González-Cantalapiedra A.
Effects of long-term treatment of denosumab on bone mineral density: insights from an in-silico model of bone mineralization.
Bone. 2019 May 2;125:87-95. doi: 10.1016/j.bone.2019.04.022. Martínez-Reina J, Pivonka P.
The impact of hip fracture on health-related quality of life and activities of daily living: the SPARE-HIP prospective cohort study.
Arch Osteoporos. 2019 May 29;14(1):56. doi: 10.1007/s11657-019-0607-0. Prieto-Alhambra D, Moral-Cuesta D, Palmer A, Aguado-Maestro I, Bardaji MFB, Brañas F, Bueno GA, Caeiro-Rey JR, Cano IA, Barres-Carsi M, Delgado LG, Salomó-Domènech M, Etxebarria-Foronda I, Ferrer BL, Mills S, Herrando LE, Mifsut D, Evangelista LDR, Nogués X, Perez-Coto I, Blasco JM, Martín-Hernández C, Kessel H, Serra JT,…
Trabecular bone score and bone remodeling markers identify perimenopausal women at high risk of bone loss.
https://www.ncbi.nlm.nih.gov/pubmed/31141196Clin Endocrinol (Oxf). 2019 May 29. doi: 10.1111/cen.14042 Gutierrez-Buey G, Restituto P, Botella S, Monreal I, Colina I, Rodríguez-Fraile M, Calleja A, Varo N.
Assessment of early therapy discontinuation and health-related quality of life in breast cáncer patients treated with aromatase inhibitors: B-ABLE cohort study.
Breast Cancer Res Treat. 2019 May 24. doi: 10.1007/s10549-019-05289-7. Pineda-Moncusí M, Servitja S, Tusquets I, Diez-Perez A, Rial A, Cos ML,Campodarve I, Rodriguez-Morera J, Garcia-Giralt N, Nogués X.
Prevalent vertebral fractures and minor vertebral deformities analyzed by vertebral fracture assessment (VFA) increases the risk of incident fractures in postmenopausal women: the FRODOS study
Osteoporos Int. 2019 May 23. doi:10.1007/s00198-019-04962-3. Kanterewicz E, Puigoriol E, Rodríguez Cros JR, Peris P. https://www.ncbi.nlm.nih.gov/pubmed/31123788
Collagen Peptide Upregulates Osteoblastogenesis from Bone Marrow Mesenchymal Stem Cells through MAPK- Runx2.
Cells. 2019 May 11;8(5). pii: E446. doi: 0.3390/cells8050446 Elango J, Robinson J, Zhang J, Bao B, Ma N, de Val JEMS, Wu W.
Nanoparticles to Knockdown Osteoporosis-Related Gene and Promote Osteogenic Marker Expression for Osteoporosis Treatment.
ACS Nano. 2019 May 28;13(5):5451-5464. doi:10.1021/acsnano.9b00241. Mora-Raimundo P, Lozano D, Manzano M, Vallet-Regí M.
Tartrate-resistant acid phosphatase 5b, but not periostin, is useful for assessing Paget’s disease of bone.
Bone. 2019 Jul;124:132-136. doi:10.1016/j.bone.2019.04.023. Guañabens N, Filella X, Florez H, Ruiz-Gaspá S, Conesa A, Peris P, Monegal A, Torres F. https://www.ncbi.nlm.nih.gov/pubmed/31051316
Effect of weight loss on bone metabolism in postmenopausal obese women with osteoarthritis.
https://www.ncbi.nlm.nih.gov/pubmed/31006614Obes Res Clin Pract. 2019 Apr 18. pii:S1871-403X(18)30428-9. doi:10.1016/j.orcp.2019.03.002 López-Gómez JJ, Izaola-Jauregui O, Primo-Martín D, Torres-Torres B,Gómez-Hoyos E, Ortolá-Buigues A, Martín-Ferrero MÁ, Pérez-Castrillón JL, De Luis-Román DA. https://www.ncbi.nlm.nih.gov/pubmed/31006614
Bone development and remodeling in metabolic disorders.
J Inherit Metab Dis. 2019 Apr 3. doi: 10.1002/jimd.12097. Serra-Vinardell J, Roca-Ayats N, De-Ugarte L, Vilageliu L, Balcells S,Grinberg D.
Osteostatin potentiates the bioactivity of mesoporous glass scaffolds containing Zn(2+) ions in human mesenchymal stem cells.
Acta Biomater. 2019 Apr 15;89:359-371. doi: 10.1016/j.actbio.2019.03.033. Heras C, Sanchez-Salcedo S, Lozano D, Peña J, Esbrit P, Vallet-Regi M,Salinas AJ. https://www.ncbi.nlm.nih.gov/pubmed/30890462
Aplidin (plitidepsin) is a novel anti-myeloma agent with potent anti-resorptive activity mediated by direct effects on osteoclasts.
Oncotarget. 2019 Apr 12;10(28):2709-2721. doi: 10.18632/oncotarget.26831. eCollection 2019 Apr 12. Delgado-Calle J, Kurihara N, Atkinson EG, Nelson J, Miyagawa K, Galmarini CM, Roodman GD, Bellido T.
Comparison of Risk of Osteoporotic Fracture in Denosumab vs Alendronate Treatment Within 3 Years of Initiation.
JAMA Netw Open. 2019 Apr 5;2(4):e192416. doi:10.1001/jamanetworkopen.2019.2416. Pedersen AB, Heide-Jørgensen U, Sørensen HT, Prieto-Alhambra D, Ehrenstein V.
A role for autophagy in bone biology.
Nat Rev Endocrinol. 2019 May . doi: 10.1038/s41574-019-0223-5. Starling S.
2019_ PREMIO RUBIO APOYO A LA REVISTA DE LA SEIOMM (ROMM)
Revista de Osteoporosis y Metabolismo Mineral 2019_Bases de la CONVOCATORIAAnexo 1 Estimados socios, La SEIOMM vuelve a convocar por segundo año consecutivo el PREMIO RUBIO APOYO A LA REVISTA DE LA SEIOMM, dotado con 1.000 euros, para el asociado que más cite a la ROMM desde revistas indexadas y con factor de impacto.
CONVOCATORIA BECAS FEIOMM ASBMR 2019
La Fundación Española de Investigación Ósea y del Metabolismo Mineral FEIOMM convoca 5 Becas para la presentación de trabajos científicos en ASBMR 2019 que se celebrará en Orlando, Florida, (USA) del 20 al 23 de septiembre de 2019. Puedes consultar las bases de la convocatoria en el siguiente link: “BECAS y PREMIOS” BASES DE LA CONVOCATORIA ASBMR 2019 *Las solicitudes se…
PREMIO FEIOMM A LA MEJOR PUBLICACIÓN SOBRE VITAMINA D – Patrocinado por Gebro
Estimados socios/as, La FEIOMM (Fundación Española de Investigación Ósea y del Metabolismo Mineral), gracias a la colaboración de GEBRO Pharma convoca un premio dotado con 1.000 euros para el mejor trabajo sobre vitamina D publicado en una revista científica de ámbito nacional o internacional. 2019_Bases de la CONVOCATORIA
Vitamin D Receptor Polymorphism and DHCR7 Contribute to the Abnormal Interplay Between Vitamin D and Lipid Profile in Rheumatoid Arthritis.
Sci Rep. 2019 Feb 22;9(1):2546. doi:10.1038/s41598-019-38756-8. Rodríguez-Carrio J, Alperi-López M, Naves-Díaz M, Dusso A, López P, Ballina-García FJ, Cannata-Andía JB, Suárez A.
Discrimination of osteoporosis-related vertebral fractures by DXA-derived 3D measurements: a retrospective case-control study.
Osteoporos Int. 2019 Feb 15. doi: 10.1007/s00198-019-04894-y López Picazo M, Humbert L, Di Gregorio S, González Ballester MA, Del Río Barquero LM.
Trabecular bone score in active or former smokers with and without COPD.
PLoS One. 2019 Feb 1;14(2):e0209777. doi: 10.1371/journal.pone.0209777. eCollection 2019. González J, Rodríguez-Fraile M, Rivera P, Restituto P, Colina I, Calleja MLD, Alcaide AB, Campo A, Bertó J, Seijo LM, Pérez T, Zulueta J, Varo N, de-Torres JP.
Metabolomics reveals citric acid secretion in mechanically-stimulated osteocytes is inhibited by high glucose
Sci Rep. 2019 Feb 19;9(1):2295. doi: 10.1038/s41598-018-38154-6 Villaseñor A, Aedo-Martín D, Obeso D, Erjavec I, Rodríguez-Coira J, Buendía I, Ardura JA, Barbas C, Gortazar AR.
Proof of Concept on Functionality Improvement of Mesenchymal Stem-Cells, in Postmenopausal Osteoporotic Women Treated with Teriparatide (PTH1-34), After Suffering Atypical Fractures
Calcif Tissue Int. 2019 Feb 6. doi: 10.1007/s00223-019-00533-0. Casado-Díaz A, Dorado G, Giner M, Montoya MJ, Navarro-Valverde C, Díez-Pérez A, Quesada-Gómez JM.
Trabecular Bone Score, Bone Mineral Density and Bone Markers in Patients with Primary Hyperparathyroidism 2 Years After Parathyroidectomy. Horm Metab Res.
2019 Mar;51(3):186-190. doi: 10.1055/a-0850-8679. Miguel GA, Carranza FH, Rodríguez JCR, Ramos MA, Pablos DL, Herrero EF, Díaz-Guerra GM.
Calcimimetics maintain bone turnover in uremic rats despite the concomitant decrease in parathyroid hormone concentration.
Kidney Int. 2019 Mar 12. pii:S0085-2538(19)30043-2. doi: 10.1016/j.kint.2018.12.015. Díaz-Tocados JM, Rodríguez-Ortiz ME, Almadén Y, Pineda C, Martínez-Moreno JM, Herencia C, Vergara N, Pendón-Ruiz de Mier MV, Santamaría R, Rodelo-Haad C,Casado-Díaz A, Lorenzo V, Carvalho C, Frazão JM, Felsenfeld AJ, Richards WG, Aguilera-Tejero E, Rodríguez M, López I, Muñoz-Castañeda JR.
Stopping Denosumab
https://www.ncbi.nlm.nih.gov/pubmed/30659428Curr Osteoporos Rep. 2019 Feb;17(1):8-15. doi: 10.1007/s11914-019-00502-4. Review. PMID: 30659428 Lamy O, Stoll D, Aubry-Rozier B, Rodriguez EG.
Functional characterization of the C7ORF76 genomic region, a prominent GWAS signal for osteoporosis in 7q21.3. Bone.
2019 Mar 14;123:39-47. doi:10.1016/j.bone.2019.03.014. Roca-Ayats N, Martínez-Gil N, Cozar M, Gerousi M, Garcia-Giralt N, Ovejero D, Mellibovsky L, Nogués X, Díez-Pérez A, Grinberg D, Balcells S.
Bone age as a correction factor for the analysis of trabecular bone score (TBS) in children.
Arch Osteoporos. 2019 Feb 27;14(1):26. doi:10.1007/s11657-019-0573-6. Guagnelli MA, Winzenrieth R, Lopez-Gonzalez D, McClung MR, Del Rio L, Clark P.
Spontaneous vertebral fractures after denosumab discontinuation: A case collection and review of the literature.
Semin Arthritis Rheum. 2019 Feb 15. pii: S0049-0172(18)30700-5. doi:10.1016/j.semarthrit.2019.02.007. Florez H, Ramírez J, Monegal A, Guañabens N, Peris P.
Targeting of chondrocyte plasticity via connexin43 modulation attenuates celular senescence and fosters a pro-regenerative environment in osteoarthritis.
Cell Death Dis. 2018 Dec 5;9(12):1166. doi: 10.1038/s41419-018-1225-2. Varela-Eirín M, Varela-Vázquez A, Guitián-Caamaño A, Paíno CL, Mato V, Largo R, Aasen T, Tabernero A, Fonseca E, Kandouz M, Caeiro JR, Blanco A, Mayán MD.
Bone-Healing Pattern on the Surface of Titanium Implants at Cortical and Marrow Compartments in Two Topographic Sites: an Experimental Study in Rabbits.
Materials (Basel). 2018 Dec 27;12(1). pii: E85.doi: 10.3390/ma12010085. Soto-Peñaloza D, Caneva M, Viña-Almunia J, Martín-de-Llano JJ, Peñarrocha-Oltra D, Peñarrocha-Diago M.
Feasibility and tolerability of bone impact microindentation testing: a cross-sectional, population-based study in Australia.
BMJ Open. 2018 Dec 22;8(12):e023959. doi: 10.1136/bmjopen-2018-023959. Rufus-Membere P, Holloway-Kew KL, Diez-Perez A, Kotowicz MA, Pasco JA.
Trabecular bone score and bone mineral density in patients with postsurgical hypoparathyroidism after total thyroidectomy for differentiated thyroid carcinoma.
Surgery. 2018 Dec 13. pii: S0039-6060(18)30750-5. doi: 10.1016/j.surg.2018.10.034. Iglesias SG, Dominguez MLM, Herrero EF, Martinez-Pueyo JI, Arroba CM, Diaz-Guerra GM, Hawkins Carranza F.
Association between brown adipose tissue and bone mineral density in humans.
Int J Obes (Lond). 2018 Dec 5. doi: 10.1038/s41366-018-0261-4. Sanchez-Delgado G, Martinez-Tellez B, Garcia-Rivero Y, Acosta FM, Alcantara JMA, Amaro-Gahete FJ, Llamas-Elvira JM, Gracia-Marco L, Ruiz JR.
Role of Bone Morphogenetic Protein 2 Polymorphisms in Bone Mineral Density after the Start of Treatment with Atorvastatin.
Basic Clin Pharmacol Toxicol. 2018 Dec;123(6):766-769. doi:10.1111/bcpt.13086. Usategui-Martín R, Vega G, Abad-Manteca L, Ruiz-Mambrilla M, Calero-Paniagua I, Dueñas-Laita A, Pérez-Castrillón JL.
Efficacy, cost, and aspects to take into account in the treatment of osteoporosis in the elderly.
Rev Esp Geriatr Gerontol. 2018 Dec 31. pii: S0211-139X(18)30716-9. doi: 10.1016/j.regg.2018.11.007. Review. Sáez-López P, Etxebarria-Foronda I, Mesa Lampre MP, Alonso García N, Sánchez Hernández N.
Comparison of BMD Changes and Bone Formation Marker Levels 3 Years After Bisphosphonate Discontinuation: FLEX and HORIZON-PFT Extension I Trials.
J Bone Miner Res. 2018 Dec 7. doi: 10.1002/jbmr.3654. [Epub ahead of print] DOI: 10.1002/jbmr.3654 -PMID: 30536713 Kim TY(1)(2), Bauer DC(1)(3), McNabb BL(1), Schafer AL(1)(3)(2), Cosman F(4)(5), Black DM(3), Eastell R(6).
One Year of Romosozumab Followed by Two Years of Denosumab Maintains Fracture Risk Reductions: Results of the FRAME Extension Study.
J Bone Miner Res. 2018 Dec 3. doi: 10.1002/jbmr.3622. [Epub ahead of print] DOI: 10.1002/jbmr.3622 -PMID: 30508316 Lewiecki EM(1), Dinavahi RV(2), Lazaretti-Castro M(3), Ebeling PR(4), Adachi JD(5), Miyauchi A(6), Gielen E(7), Milmont CE(2), Libanati C(8), Grauer A(2).
Hip fracture rates and time trends in use of anti-osteoporosis medications in Denmark for the period 2005 to 2015: Missed opportunities in fracture prevention.
Bone. 2018 Dec 21;120:476-481. doi: 10.1016/j.bone.2018.12.016. [Epub ahead of print] DOI: 10.1016/j.bone.2018.12.016 -PMID: 30583122 Abrahamsen B(1), Skjødt MK(2), Vestergaard P(3). https://www.ncbi.nlm.nih.gov/pubmed/30583122
Acute hypercalcemia and excessive bone resorption following anti-RANKL withdrawal: Case report and brief literature review.
Bone. 2018 Dec 17;120:482-486. doi: 10.1016/j.bone.2018.12.012. [Epub ahead of print] DOI: 10.1016/j.bone.2018.12.012 -PMID: 30572144 Roux S(1), Massicotte MH(2), Huot Daneault A(3), Brazeau-Lamontagne L(4), Dufresne J(5).
Effect of Sarcopenia on Postoperative Mortality in Osteoporotic Hip Fracture Patients.
J Bone Metab. 2018 Nov;25(4):227-233. doi: 10.11005/jbm.2018.25.4.227. Epub 2018 DOI: 10.11005/jbm.2018.25.4.227 -PMCID: PMC6288605 -PMID: 30574467 Kim YK, Yi SR, Lee YH, Kwon J, Jang SI, Park SH. https://www.ncbi.nlm.nih.gov/pubmed/30574467
Urinary Incontinences Are Related with Fall and Fragility Fractures in Elderly Population: Nationwide Cohort Study.
J Bone Metab. 2018 Nov;25(4):267-274. doi: 10.11005/jbm.2018.25.4.267. Epub 2018 DOI: 10.11005/jbm.2018.25.4.267 -PMCID: PMC6288612 -PMID: 30574471 Kim HJ, Kim JW, Jang SN, Kim KD, Yoo JI, Ha YC. https://www.ncbi.nlm.nih.gov/pubmed/30574471
Fracture Prevention with Zoledronate in Older Women with Osteopenia.
N Engl J Med. 2018 Dec 20;379(25):2407-2416. doi: 10.1056/NEJMoa1808082. Epub 2018 Oct 1. DOI: 10.1056/NEJMoa1808082 -PMID: 30575489 [Indexed for MEDLINE] Reid IR(1), Horne AM(1), Mihov B(1), Stewart A(1), Garratt E(1), Wong S(1), Wiessing KR(1), Bolland MJ(1), Bastin S(1), Gamble GD(1). https://www.ncbi.nlm.nih.gov/pubmed/30575489
RESOLUCIÓN BECAS FEIOMM-3rd HERBERT FLEISCH WORKSHOP
Finalizado el plazo para el envío de solicitudes para acceder a una de las 3 Becas FEIOMM, dirigida a Jóvenes Investigadores, para asistir al 3rd HERBERT FLEISCH WORKSHOP que tendrá lugar del 17-19 de marzo en la ciudad de Brujas (Bélgica), y que consistirán en inscripción, viaje y alojamiento, se adjunta la lista de solicitantes admitidos y…
Demineralized Bone Matrix Coating Si-Ca-P Ceramic Does Not Improve the Osseointegration of the Scaffold.
Materials (Basel). 2018 Sep 1;11(9). pii: E1580. doi: 10.3390/ma11091580. Parrilla-Almansa A, García-Carrillo N, Ros-Tárraga P, Martínez CM, Martínez-Martínez F, Meseguer-Olmo L, De Aza PN.
Fracture risk in type 2 diabetic patients: A clinical prediction tool based on a large population-based cohort
PLoS One. 2018 Sep 7;13(9):e0203533. doi: 10.1371/journal.pone.0203533. eCollection 2018. Martínez-Laguna D, Tebé C, Nogués X, Kassim Javaid M, Cooper C, Moreno V,Diez-Perez A, Collins GS, Prieto-Alhambra D.. https://www.ncbi.nlm.nih.gov/pubmed/30192850
High-serum phosphate and parathyroid hormone distinctly regulate bone loss and vascular calcification in experimental chronic kidney disease.
Nephrol Dial Transplant. 2018 Sep 5. Carrillo-López N, Panizo S, Alonso-Montes C, Martínez-Arias L, Avello N, Sosa P, Dusso AS, Cannata-Andía JB, Naves-Díaz M.
High risk and probability of progression to osteoporosis at 10 years in HIV-infected individuals: the role of PIs.
J Antimicrob Chemother. 2018 Sep 1;73(9):2452-2459. Negredo E, Langohr K, Bonjoch A, Pérez-Alvárez N, Estany C, Puig J, Rosales J, Echeverría P, Clotet B, Gómez G.
Linking of psoriasis with osteopenia and osteoporosis: A cross-sectional study.
Indian J Dermatol Venereol Leprol. 2018 Sep 17. Martinez-Lopez A, Blasco-Morente G, Giron-Prieto MS, Arrabal-Polo MA, Luque-Valenzuela M, Luna-Del Castillo JD, Tercedor-Sanchez J, Arias-Santiago S.
Impact of the implementation of a Fracture Liaison Service on pharmaceutical expenses for osteoporosis compared to an area without an FLS.
Negrín M. Expert Rev Pharmacoecon Outcomes Res. 2018 Sep 6:1-7. Naranjo A, Ojeda-Bruno S, Saavedra A, Molina A, https://www.ncbi.nlm.nih.gov/pubmed/30129375
Variants in cardiac GATA genes associated with bicuspid aortic valve.
Rodríguez I. Eur J Clin Invest. 2018 Sep 19:e13027. Alonso-Montes C, Martín M, Martínez-Arias L, Coto E, Naves-Díaz M, Morís C, Cannata-Andía JB
Advances in the treatment of hypoparathyroidism with PTH 1-34.
Bone. 2018 Sep 21. pii: S8756-3282(18)30358-2. doi: 10.1016/j.bone.2018.09.018. DOI: 10.1016/j.bone.2018.09.018 -PMID: 30243992 Winer KK(1).
Serum 25-hydroxyvitamin D levels and incident falls in older women.
Osteoporos Int. 2018 Sep 25. doi: 10.1007/s00198-018-4705-4. DOI: 10.1007/s00198-018-4705-4 -PMID: 30255229 Uusi-Rasi K(1), Patil R(2)(3), Karinkanta S(2), Tokola K(2), Kannus P(2)(4)(5), Lamberg-Allardt C(6), Sievänen H(2).
The risk of subsequent osteoporotic fractures is decreased in subjects experiencing fracture while on denosumab: results from the FREEDOM and FREEDOM Extension studies
Osteoporos Int. 2018 Sep 22. doi: 10.1007/s00198-018-4687-2. Kendler DL, Chines A, Brandi ML, Papapoulos S, Lewiecki EM, Reginster JY, Muñoz Torres M, Wang A, Bone HG..
Impact of prescription drugs on second fragility fractures among US Medicare patients.
Osteoporos Int. 2018 Sep 19. doi: 10.1007/s00198-018-4697-0. DOI: 10.1007/s00198-018-4697-0 PMID: 30232537 Munson JC(1)(2)(3), Bynum JPW(4)(5)(6)(7), Bell JE(4)(8), McDonough C(9), Wang Q(4), Tosteson T(4)(10), Tosteson ANA(4)(5). https://www.ncbi.nlm.nih.gov/pubmed/30232537
Secular trends of hip fractures in France: impact of changing characteristics of the background population.
Osteoporos Int. 2018 Sep 13. doi: 10.1007/s00198-018-4666-7. DOI: 10.1007/s00198-018-4666-7 – PMID: 30215115 Garofoli R(1), Maravic M(1)(2), Ostertag A(3), Cohen-Solal M(4)(5). https://www.ncbi.nlm.nih.gov/pubmed/30215115
Bone management in hematologic stem cell transplant recipients
Foundation Committee of Scientific Advisors Working Group on Cancer and Bone Disease.. Osteoporos Int. 2018 Sep 3. Kendler DL, Body JJ, Brandi ML, Broady R, Cannata-Andia J, Cannata-Ortiz MJ, El Maghraoui A, Guglielmi G, Hadji P, Pierroz DD, de Villiers TJ, Rizzoli R, Ebeling PR; International Osteoporosis https://www.ncbi.nlm.nih.gov/pubmed/30178158
Bone mineral density and vertebral fractures and their relationship with pulmonary dysfunction in patients with chronic obstructive pulmonary disease.
Osteoporos Int. 2018 Jul 25. doi: 10.1007/s00198-018-4643-1. DOI: 10.1007/s00198-018-4643-1 -PMID: 30043107 Munhoz da Rocha Lemos Costa T(1), Costa FM(2), Hoffman Jonasson T(3), Aguiar Moreira C(3), Boguszewski CL(3), Cunha Borges JL(4), Zeghbi Cochenski Borba V(3). https://www.ncbi.nlm.nih.gov/pubmed/30043107
Incidence, risk factors, and fracture healing of atypical femoral fractures: a multicenter case-control study.
Osteoporos Int. 2018 Jul 23. doi: 10.1007/s00198-018-4640-4. DOI: 10.1007/s00198-018-4640-4 -PMID: 30039251 Lim SJ(1), Yeo I(2), Yoon PW(3), Yoo JJ(4), Rhyu KH(5), Han SB(6), Lee WS(7), Song JH(8), Min BW(9), Park YS(10).
Incident fracture is associated with a period of accelerated loss of hip BMD: the Study of Osteoporotic Fractures.
Osteoporos Int. 2018 Jul 10. doi: 10.1007/s00198-018-4606-6. DOI: 10.1007/s00198-018-4606-6 -PMID: 29992510 Christiansen BA(1), Harrison SL(2), Fink HA(3), Lane NE(4); Study of Osteoporotic Fractures Research Group.
Long-term oral bisphosphonates delay healing after tooth extraction: a single institutional prospective study.
Osteoporos Int. 2018 Oct;29(10):2315-2321. doi: 10.1007/s00198-018-4621-7. DOI: 10.1007/s00198-018-4621-7 – PMID: 29967931 Shudo A(1), Kishimoto H(2), Takaoka K(2), Noguchi K(2).
Hypovitaminosis D: comparison between patients with hip fracture and patients with vertebral fractures.
Osteoporos Int. 2018 Jun 23. doi: 10.1007/s00198-018-4582-x. DOI: 10.1007/s00198-018-4582-x -PMID: 29934647 Giordano S(1), Proietti A(2), Bisaccia T(2), Caso P(2), Martocchia A(2), Falaschi P(2), Tafaro L(2).
Do sarcopenia and/or osteoporosis increase the risk of frailty? A 4-year observation of the second and third ROAD study surveys.
Osteoporos Int. 2018 Jun 21. doi: 10.1007/s00198-018-4596-4. DOI: 10.1007/s00198-018-4596-4 -PMID: 29931626 Yoshimura N(1), Muraki S(2), Oka H(3), Iidaka T(2), Kodama R(4), Horii C(4), Kawaguchi H(5), Nakamura K(6), Akune T(6), Tanaka S(4). https://www.ncbi.nlm.nih.gov/pubmed/29931626
Screening for Osteoporosis to Prevent Fractures: US Preventive Services Task Force Recommendation Statement.
JAMA. 2018 Jun 26;319(24):2521-2531. doi: 10.1001/jama.2018.7498. DOI: 10.1001/jama.2018.7498 -PMID: 29946735 [Indexed for MEDLINE] US Preventive Services Task Force, Curry SJ(1), Krist AH(2)(3), Owens DK(4)(5), Barry MJ(6), Caughey AB(7), Davidson KW(8), Doubeni CA(9), Epling JW Jr(10), Kemper AR(11), Kubik M(12), Landefeld CS(13), Mangione CM(14), Phipps MG(15), Pignone M(16)(17), Silverstein M(18), Simon MA(19), Tseng CW(20)(21), WongJB(22).
Screening to Prevent Osteoporotic Fractures: Updated Evidence Report and Systematic Review for the US Preventive Services Task Force.
JAMA. 2018 Jun 26;319(24):2532-2551. doi: 10.1001/jama.2018.6537. DOI: 10.1001/jama.2018.6537 -PMID: 29946734 [Indexed for MEDLINE] Viswanathan M(1)(2), Reddy S(1)(2), Berkman N(1)(2), Cullen K(1)(2), Middleton JC(2)(3), Nicholson WK(4), Kahwati LC(1)(2). https://www.ncbi.nlm.nih.gov/pubmed/29946734
Factors associated with proximal femur fracture determined in a large cadaveric cohort.
Bone. 2018 Nov;116:196-202. doi: 10.1016/j.bone.2018.08.005. Epub 2018 Aug 8. DOI: 10.1016/j.bone.2018.08.005 -PMID: 30096469 Dragomir-Daescu D(1), Rossman TL(2), Rezaei A(3), Carlson KD(3), Kallmes DF(4), Skinner JA(4), Khosla S(5), Amin S(6). https://www.ncbi.nlm.nih.gov/pubmed/30096469
Long term time trends in use of medications associated with risk of developing osteoporosis: Nationwide data for Denmark from 1999 to 2016.
Bone. 2018 Aug 29. pii: S8756-3282(18)30324-7. doi: 10.1016/j.bone.2018.08.019. DOI: 10.1016/j.bone.2018.08.019 – PMID: 30172013 Skjødt MK(1), Ostadahmadli Y(2), Abrahamsen B(3). https://www.ncbi.nlm.nih.gov/pubmed/30172013
27-hydroxycholesterol, an endogenous SERM, and risk of fracture in postmenopausal women: A nested case-cohort study in the Women’s Health Initiative.
J Bone Miner Res. 2018 Aug 23. doi: 10.1002/jbmr.3576. DOI: 10.1002/jbmr.3576 – PMID: 30138538 Chang PY(1), Feldman D(1), Stefanick ML(1), McDonnell DP(2), Thompson BM(3), McDonald JG(3), Lee JS(1)(4). https://www.ncbi.nlm.nih.gov/pubmed/30138538
Teriparatide Treatment Increases Mineral Content and Volume in Cortical and Trabecular Bone of Iliac Crest: A Comparison of Infrared Imaging With X-Ray-Based Bone Assessment Techniques.
J Bone Miner Res. 2018 Aug 13. doi: 10.1002/jbmr.3565. DOI: 10.1002/jbmr.3565 -PMID: 30102789 Paschalis EP(1), Krege JH(2), Gamsjaeger S(1), Eriksen EF(3), Burr DB(4), Disch DP(2), Stepan JJ(5), Fahrleitner-Pammer A(6), Klaushofer K(1), Marin F(2), PavoI(2). https://www.ncbi.nlm.nih.gov/pubmed/30102789
Activation of RANK/RANKL/OPG Pathway Is Involved in the Pathophysiology of Fibrous Dysplasia and Associated With Disease Burden.
J Bone Miner Res. 2018 Nov 29. doi: 10.1002/jbmr.3602. [Epub ahead of print] de Castro LF(1), Burke AB(1)(2), Wang HD(1)(3), Tsai J(1)(2), Florenzano P(1)(4), Pan KS(1)(3), Bhattacharyya N(1), Boyce AM(1), Gafni RI(1), Molinolo AA(5), Robey PG(6), Collins MT(1). DOI: 10.1002/jbmr.3602 -PMID: 30496606 https://www.ncbi.nlm.nih.gov/pubmed/30496606
Characteristics of Self-Reported Sleep and the Risk of Falls and Fractures: The Women’s Health Initiative (WHI).
J Bone Miner Res. 2018 Nov 21. doi: 10.1002/jbmr.3619. Cauley JA(1), Hovey KM(2), Stone KL(3)(4), Andrews CA(5), Barbour KE(6), Hale L(7)(8), Jackson RD(9), Johnson KC(10), LeBlanc ES(11), Li W(12), Zaslavsky O(13), Ochs-Balcom H(2), Wactawski-Wende J(2), Crandall CJ(14). DOI: 10.1002/jbmr.3619 -PMID: 30461066
Poor Vitamin K Status Is Associated With Low Bone Mineral Density and Increased Fracture Risk in End-Stage Renal Disease.
J Bone Miner Res. 2018 Nov 14. doi: 10.1002/jbmr.3608. [Epub ahead of print] Evenepoel P(1)(2), Claes K(1)(2), Meijers B(1)(2), Laurent M(3), Bammens B(1)(2), Naesens M(1)(2), Sprangers B(1)(2), Pottel H(4), Cavalier E(5), Kuypers D(1)(2). DOI: 10.1002/jbmr.3608 -PMID: 30427544 https://www.ncbi.nlm.nih.gov/pubmed/30427544
Adding Lateral Spine Imaging for Vertebral Fractures to Densitometric Screening: Improving Ascertainment of Patients at High Risk of Incident Osteoporotic Fractures.
J Bone Miner Res. 2018 Nov 5. doi: 10.1002/jbmr.3595. [Epub ahead of print] Prince RL(1)(2), Lewis JR(1)(3)(4), Lim WH(1)(5), Wong G(3), Wilson KE(6), Khoo BC(1)(7), Zhu K(1)(2), Kiel DP(8), Schousboe JT(9). DOI: 10.1002/jbmr.3595 -PMID: 30395687
Physical activity across adulthood and bone health in later life: the 1946 British birth cohort.
J Bone Miner Res. 2018 Oct 22. doi: 10.1002/jbmr.3607. [Epub ahead of print] Muthuri SG(1), Ward KA(2)(3), Kuh D(1), Elhakeem A(4), Adams JE(5), Cooper R(1). DOI: 10.1002/jbmr.3607 -PMID: 30347128
Association Between Alendronate and All-Cause Mortality and Cardiovascular Mortality Among Hip Fracture: An Alternative Explanation.
J Bone Miner Res. 2018 Oct;33(10):1906-1907. doi: 10.1002/jbmr.3570. Epub 2018 Sep 6. Tran TS(1), Nguyen TV(1)(2). DOI: 10.1002/jbmr.3570 -PMID: 30106496
Serum 25-Hydroxyvitamin D and Intact Parathyroid Hormone Influence Muscle Outcomes in Children and Adolescents.
J Bone Miner Res. 2018 Nov;33(11):1940-1947. doi: 10.1002/jbmr.3550. Epub 2018 Aug 27. Wright CS(1)(2), Laing EM(2), Pollock NK(3), Hausman DB(2), Weaver CM(4), Martin BR(4), McCabe GP(5), Peacock M(6), Warden SJ(1), Hill Gallant KM(4)(6), Lewis RD(2). DOI: 10.1002/jbmr.3550 -PMID: 30001469
Vitamin D Supplementation in Elderly Black Women Does Not Prevent Bone Loss: A Randomized Controlled Trial.
J Bone Miner Res. 2018 Nov;33(11):1916-1922. doi: 10.1002/jbmr.3521. Epub 2018 Jul 19. Aloia J(1), Fazzari M(1), Islam S(1), Mikhail M(1), Shieh A(1), Katumuluwa S(1), Dhaliwal R(1), Stolberg A(1), Usera G(1), Ragolia L(1). DOI: 10.1002/jbmr.3521 -PMID: 29905969
Bone mineral density response rates are greater in patients treated with abaloparatide compared with those treated with placebo or teriparatide: Results from the ACTIVE phase 3 trial.
Bone. 2018 Oct 22;120:137-140. doi: 10.1016/j.bone.2018.10.015 Miller PD(1), Hattersley G(2), Lau E(3), Fitzpatrick LA(4), Harris AG(5), Williams GC(4), Hu MY(4), Riis BJ(6), Russo L(7), Christiansen C(6). DOI: 10.1016/j.bone.2018.10.015 -PMID: 30359763
Administration of teriparatide for four years cyclically compared to two years daily in treatment Naïve and alendronate treated women.
Bone. 2018 Oct 21;120:246-253. doi: 10.1016/j.bone.2018.10.020. Cosman F(1), Nieves JW(2), Roimisher C(3), Neubort S(3), McMahon DJ(3), Dempster DW(4), Lindsay R(5). DOI: 10.1016/j.bone.2018.10.020 -PMID: 30355512
Denosumab effects on bone density and turnover in postmenopausal women with low bone mass with or without previous treatment.
Bone. 2018 Oct 4;120:44-49. doi: 10.1016/j.bone.2018.10.001. Tsourdi E(1), Makras P(2), Rachner TD(1), Polyzos S(3), Rauner M(1), Mandanas S(4), Hofbauer LC(5), Anastasilakis AD(6). DOI: 10.1016/j.bone.2018.10.001 -PMID: 30292818
Alterations in non-type I collagen biomarkers in osteogenesis imperfecta.
Bone. 2018 Oct 2;120:70-74. doi: 10.1016/j.bone.2018.09.024 Nicol L(1), Morar P(2), Wang Y(3), Henriksen K(4), Sun S(4), Karsdal M(4), Smith R(5), Nagamani SCS(6), Shapiro J(7), Lee B(6), Orwoll E(8). DOI: 10.1016/j.bone.2018.09.024 -PMID: 30290234
The trabecular bone score: Relationships with trabecular and cortical microarchitecture measured by HR-pQCT and histomorphometry in patients withchronic kidney disease.
Bone. 2018 Nov;116:215-220. doi: 10.1016/j.bone.2018.08.006. Epub 2018 Aug 8. Ramalho J(1), Marques IDB(1), Hans D(2), Dempster D(3), Zhou H(4), Patel P(5), Pereira RMR(6), Jorgetti V(7), Moyses RMA(8), Nickolas TL(9). DOI: 10.1016/j.bone.2018.08.006 -PMID: 30098418
Longitudinal changes in bone parameters in young girls with anorexia nervosa.
Bone. 2018 Nov;116:22-27. doi: 10.1016/j.bone.2018.03.022. Epub 2018 Mar 27. Shepherd S(1), Kyriakou A(1), Shaikh MG(1), McDevitt H(1), Oakley C(2), Thrower M(2), Ahmed SF(1), Mason A(3). DOI: 10.1016/j.bone.2018.03.022 -PMID: 29601899
Abaloparatide is an Effective Treatment Option for Postmenopausal Osteoporosis: Review of the Number Needed to Treat Compared with Teriparatide.
Calcif Tissue Int. 2018 Nov;103(5):540-545. doi: 10.1007/s00223-018-0450-0. Epub 2018 Jun 27. Reginster JY(1), Hattersley G(2), Williams GC(3), Hu MY(3), Fitzpatrick LA(3), Lewiecki EM(4). DOI: 10.1007/s00223-018-0450-0 -PMCID: PMC6182596 PMID: 29951742 https://www.ncbi.nlm.nih.gov/pubmed/29951742
Associations between sedentary time, physical activity and bone health among older people using compositional data analysis.
PLoS One. 2018 Oct 22;13(10):e0206013. doi: 10.1371/journal.pone.0206013.eCollection 2018. Rodríguez-Gómez I, Mañas A, Losa-Reyna J, Rodríguez-Mañas L, Chastin SFM, Alegre LM, García-García FJ, Ara I.
In situ gel-forming system for dual BMP-2 and 17β-estradiol controlled release for bone regeneration in osteoporotic rats.
Drug Deliv Transl Res. 2018 Oct;8(5):1103-1113. doi:10.1007/s13346-018-0574-9. Segredo-Morales E, Reyes R, Arnau MR, Delgado A, Évora C. https://www.ncbi.nlm.nih.gov/pubmed/30105738
Nutritional deficiencies and bone metabolism after endobarrier in obese type 2 patients with diabetes.
Eur J Clin Nutr. 2018 Oct;72(10):1447-1450. doi:10.1038/s41430-017-0074-x. Vilarrasa N, Fabregat A, Toro S, Gordejuela AG, Casajoana A, Montserrat M, Garrido P, López-Urdiales R, Virgili N, Planas-Vilaseca A, Simó-Servat A, Pujol J.
Efficacy of a multidisciplinary approach on postoperative morbidity and mortality of elderly patients with hip fracture.
J Clin Anesth. 2018 Oct 1;53:11-19. doi:10.1016/j.jclinane.2018.09.029. Reguant F, Arnau A, Lorente JV, Maestro L, Bosch J.
Fall-risk increasing drugs and prevalence of polypharmacy in older patients discharged from an Orthogeriatric Unit after a hip fracture.
Aging Clin Exp Res. 2018 Oct 1. doi: 10.1007/s40520-018-1046-2. [Epub ahead of print] Correa-Pérez A, Delgado-Silveira E, Martín-Aragón S, Rojo-Sanchís AM,Cruz-Jentoft AJ. https://www.ncbi.nlm.nih.gov/pubmed/30276631
Comparative anti-fracture effectiveness of different oral anti-osteoporosis therapies based on “real-world” data: a meta-analysis of propensity-matched cohort findings from the UK Clinical Practice
Clin Epidemiol. 2018 Oct 9;10:1417-1431. doi: 10.2147/CLEP.S164112. eCollection 2018. Khalid S, Calderon-Larrañaga S, Hawley S, Ali MS, Judge A, Arden N, van Staa T, Cooper C, Javaid MK, Prieto-Alhambra D. Research Database and the Catalan SIDIAP Database. https://www.ncbi.nlm.nih.gov/pubmed/30349390
A home-based tele-rehabilitation protocol for patients with hip fracture called @ctivehip.
Res Nurs Health. 2018 Nov 16. doi:10.1002/nur.21922 Ortiz-Piña M, Salas-Fariña Z, Mora-Traverso M, Martín-Martín L,Galiano-Castillo N, García-Montes I, Cantarero-Villanueva I, Fernández-Lao C, Arroyo-Morales M, Mesa-Ruíz A, Castellote-Caballero Y, Salazar-Graván S, Kronborg L, Martín-Matillas M, Ariza-Vega P.
Feasibility of 3D-printed models of the proximal femur to real bone: a cadaveric study.
Hip Int. 2018 Nov 13:1120700018811553. doi:10.1177/1120700018811553. Sallent A, Seijas R, Pérez-Bellmunt A, Oliva E, Casasayas O, Escalona C, Ares O. https://www.ncbi.nlm.nih.gov/pubmed/30421629
Intercellular communication via gap junction channels between chondrocytes and bone cells
Biochim Biophys Acta Biomembr. 2018 Dec;1860(12):2499-2505. Carpintero-Fernandez P, Gago-Fuentes R, Wang HZ, Fonseca E, Caeiro JR, Valiunas V, Brink PR, Mayan MD.
Hip fractures in the oldest old. Comparative study of centenarians and nonagenarians and mortality risk
Factors. Injury. 2018 Sep 26. pii: S0020-1383(18)30547-3. Barceló M, Francia E, Romero C, Ruiz D, Casademont J, Torres OH.
Effects of teriparatide on hip and upper limb fractures in patients with osteoporosis: A systematic review and meta-analysis.
Bone. 2018 Sep 27;120:1-8. Díez-Pérez A, Marin F, Eriksen EF, Kendler DL, Krege JH, Delgado-Rodríguez M.
Bone health evaluation one year after aromatase inhibitors completion
Bone. 2018 Dec;117:54-59. Pineda-Moncusí M, Servitja S, Casamayor G, Cos ML, Rial A, Rodriguez-Morera J, Tusquets I, Diez-Perez A, Garcia-Giralt N, Nogués X.
Influence of demographic and clinical characteristics of elderly patients with a hip fracture on mortality: A retrospective, total cohort study in North-East Spain.
Bone. 2018 Dec;117:123-129. Cancio JM, Vela E, Santaeugènia S, Clèries M, Inzitari M, Ruiz D.
Assessing bone quality through mechanical properties in postmenopausal trabecular bone.
Injury. 2018 Sep;49 Suppl 2:S3-S10. doi: 10.1016/j.injury.2018.07.035. Toledano M, Toledano-Osorio M, Guerado E, Caso E, Osorio E, Osorio R.
In-hospital care, complications, and 4-month mortality following a hip or proximal femur fracture: the Spanish registry of osteoporotic femur fractures prospective cohort study.
Osteoporos. 2018 Sep 14;13(1):96. doi: 10.1007/s11657-018-0515-8. Prieto-Alhambra D, Reyes C, Sainz MS, González-Macías J, Delgado LG, Bouzón CA, Gañan SM, Miedes DM, Vaquero-Cervino E, Bardaji MFB, Herrando LE, Baztán FB, Ferrer BL, Perez-Coto I, Bueno GA, Mora-Fernandez J, Doñate TE, Blasco JM,Aguado-Maestro I, Sáez-López P, Doménech MS, Climent-Peris V, Rodríguez ÁD,Sardiñas HK, Gómez ÓT, Serra…
2018_PREMIOS ITALFARMACO
El Jurado, compuesto por los Moderadores de las sesiones de comunicaciones orales y posters y el Comité Científico del XXIII Congreso de la SEIOMM celebrado en Granada, del 7 al 9 de noviembre de 2018; Ha otorgado los Premios Italfarmaco 2018 a las mejores comunicaciones Orales y Póster. Descarga ACTA
RESOLUCIÓN BECAS FEIOMM INVESTIGACIÓN 2018
Granada, a 9 de noviembre de 2018 La Junta Directiva de la SEIOMM/FEIOMM, atendiendo a las valoraciones emitidas por el Comité Científico para la Investigación con el fin de resolver la adjudicación de las Becas FEIOMM de INVESTIGACIÓN 2018 para promover la investigación clínica, básica y traslacional en el campo de la patología metabólica ósea,…
PROGRAMA Pre_Congreso HOT TOPICS ASBMR 2018
MIÉRCOLES 7 NOVIEMBRE 10.30 – 14.00 h Palacio de Congresos de Granada Os presentamos el PROGRAMA HOT TOPICS ASBMR 2018 Descarga el PROGRAMA En esta actividad, que tendrá lugar durante el próximo congreso anual de nuestra sociedad en Granada, se resumirán los principales simposiums plenarios así como las comunicaciones orales y pósters más relevantes que se…
High Irisin levels in non-diabetic HIV-infected males are associated with insulin resistance, non-alcoholic fatty liver disease, and subclinical atherosclerosis.
Clin Endocrinol (Oxf). 2018 Jun 26. Moreno-Perez O, Reyes-Garcia R, Muñoz-Torres M, Merino E, Boix V, Reus S, Giner L, Alfayate R, Garcia-Fontana B, Sanchez-Paya J, Picó A, Portilla J.
Bone-conditioned medium contributes to initiation and progression of osteogenesis by exhibiting synergistic TGF-β1/BMP-2 activity
Int J Oral Sci. 2018 Jun 12;10(2):20 Moreno-Perez O, Reyes-Garcia R, Muñoz-Torres M, Merino E, Boix V, Reus S, Giner L, Alfayate R, Garcia-Fontana B, Sanchez-Paya J, Picó A, Portilla J.
High risk and probability of progression to osteoporosis at 10 years in HIV-infected individuals: the role of PIs
Antimicrob Chemother. 2018 Jun 1 Negredo E, Langohr K, Bonjoch A, Pérez-Alvárez N, Estany C, Puig J, Rosales J, Echeverría P, Clotet B, Gómez G.. J
Cortical and trabecular bone analysis of professional dancers using 3D-DXA: a case-control study.
J Sports Sci. 2018 Jun 18:1-8. Freitas L, Amorim T, Humbert L, Fonollá R, Flouris AD, Metsios GS, Jamurtas AZ, Koutedakis Y.
Higher Levels of Serum 25-Hydroxyvitamin D Are Related to Improved Glucose Homeostasis in Women with Postmenopausal
Osteoporosis. J Womens Health (Larchmt). 2018 Jun 6. Ávila-Rubio V, García-Fontana B, Novo-Rodríguez C, Cantero-Hinojosa J, Reyes-García R, Muñoz-Torres M. https://www.ncbi.nlm.nih.gov/pubmed/29874115
Real-world antidiabetic drug use and fracture risk in 12,277 patients with type 2 diabetes mellitus: a nested case-control study
Osteoporos Int. 2018 Jun 2. Losada E, Soldevila B, Ali MS, Martínez-Laguna D, Nogués X, Puig-Domingo M, Díez-Pérez A, Mauricio D, Prieto-Alhambra D. https://www.ncbi.nlm.nih.gov/pubmed/29860664
Abnormal bone turnover in individuals with low serum alkaline phosphatase
Osteoporos Int. 2018 Jun 12. López-Delgado L, Riancho-Zarrabeitia L, García-Unzueta MT, Tenorio JA, García-Hoyos M, Lapunzina P, Valero C, Riancho JA. https://www.ncbi.nlm.nih.gov/pubmed/29947871
Bone mineral density and vertebral fractures in patients with systemic lupus erythematosus: A systematic review and meta-regression
PLoS One. 2018 Jun 13;13(6):e0196113. Mendoza-Pinto C, Rojas-Villarraga A, Molano-González N, Jiménez-Herrera EA,León-Vázquez ML, Montiel-Jarquín Á, García-Carrasco M, Cervera R.
Eph/Ephrin-mediated stimulation of human bone marrow mesenchymal stromal cells correlates with changes in cell adherence and increased cell death
Stem Cell Res Ther. 2018 Jun 26;9(1):172. Alfaro D, Zapata AG. https://www.ncbi.nlm.nih.gov/pubmed/29941036
Circulating levels of sclerostin are associated with cardiovascular mortality
PLoS One. 2018 Jun 21;13(6):e0199504. Novo-Rodríguez C, García-Fontana B, Luna-Del Castillo JD, Andújar-Vera F, Ávila-Rubio V, García-Fontana C, Morales-Santana S, Rozas-Moreno P, Muñoz-Torres M. https://www.ncbi.nlm.nih.gov/pubmed/29928063
Higher dietary glycemic index and glycemic load values increase the risk of osteoporotic fracture in the PREvención con DIeta MEDiterránea (PREDIMED)-Reus trial
Am J Clin Nutr. 2018 Jun 1;107(6):1035-1042 García-Gavilán JF, Bulló M, Camacho-Barcia L, Rosique-Esteban N,Hernández-Alonso P, Basora J, Martínez-González MA, Estruch R, Fitó M, Salas-Salvadó J. https://www.ncbi.nlm.nih.gov/pubmed/29746627
Second Hip Fracture: Incidence, Trends and Predictors
Calcif Tissue Int. 2018 Jun;102(6):619-626. Mazzucchelli R, Pérez-Fernández E, Crespí N, García-Vadillo A, Rodriguez,Caravaca G, Gil de Miguel A, Carmona L.
Variations in osteoporosis medication utilization. A population-based ecological cross-sectional study in the region of Valencia, Spain
PLoS One. 2018 Jun 21;13(6):e0199086. Sanfélix-Gimeno G, Juliá-Sanchis ML, Librero J, Peiró S, García-Sempere A. https://www.ncbi.nlm.nih.gov/pubmed/29927952
Trends in hip fracture in patients with rheumatoid arthritis: results from the Spanish National Inpatient Registry over a 17-year period (1999-2015)
RMD Open. 2018 Jun 4;4(1):e000671. Mazzucchelli R, Pérez Fernandez E, Crespí-Villarías N, Quirós-Donate J, García Vadillo A, Espinosa M, Peña M, Macía-Villa C, Morell-Hita JL, Martinez-Prada C,Villaverde V, Morado Quiroga I, Guzón-Illescas O, Barbadillo C, Fernández Prada M, Godoy H, Herranz Varela A, Galindo Izquierdo M, Rodriguez Caravaca G. TREND-AR study. https://www.ncbi.nlm.nih.gov/pubmed/29955384
Atlases with Arcuate Foramen present cortical bone thickening that may contribute to a lower fracture risk
World Neurosurg. 2018 Jun 5. pii:S1878-8750(18)31174-4. Sanchis-Gimeno JA, Llido S, Guede D, Nalla S, Martinez-Soriano F, Blanco-Perez E, Caeiro JR. https://www.ncbi.nlm.nih.gov/pubmed/29883825
Low trabecular bone score in postmenopausal women with differentiated thyroid carcinoma after long-term TSH suppressive therapy
Endocrine. 2018 Jul 16. doi: 10.1007/s12020-018-1671-8. De Mingo Dominguez ML, Guadalix Iglesias S, Martin-Arriscado Arroba C, López Alvarez B, Martínez Diaz-Guerra G, Martinez-Pueyo JI, Ferrero Herrero E, Hawkins Carranza F. https://www.ncbi.nlm.nih.gov/pubmed/30014437
SOX6 rs7117858 polymorphism is associated with osteoporosis and obesity-related phenotypes
Eur J Clin Invest. 2018 Jul 30:e13011. doi: 10.1111/eci.13011. Correa-Rodríguez M, Schmidt-RioValle J, Rueda-Medina B.
Olive Oil Consumption and Bone Microarchitecture in Spanish Women
Nutrients. 2018 Jul 26;10(8). pii: E968. doi:10.3390/nu10080968. PubMed PMID: 30049982 Roncero-Martín R, Aliaga Vera I, Moreno-Corral LJ, Moran JM, Lavado-Garcia JM, Pedrera-Zamorano JD, Pedrera-Canal M. https://www.ncbi.nlm.nih.gov/pubmed/30049982
Effects of osteoporosis drug treatments on cortical and trabecular bone in the femur using DXA-based 3D modeling
Osteoporos Int. 2018 Jul 4. doi:10.1007/s00198-018-4624-4 Winzenrieth R, Humbert L, Di Gregorio S, Bonel E, García M, Del Rio L.
Beyond orthogeriatric co-management model:benefits of implementing a process management system for hip fracture
Arch Osteoporos. 2018 Jul 25;13(1):81. doi: 10.1007/s11657-018-0497-6. Brañas F, Ruiz-Pinto A, Fernández E, Del Cerro A, de Dios R, Fuentetaja L,Cebrián L, Larrainzar-Garijo R.
Common and rare variants of WNT16, DKK1 and SOST and their relationship with bone mineral density
Sci Rep. 2018 Jul 19;8(1):10951. doi: 10.1038/s41598-018-29242-8. Martínez-Gil N, Roca-Ayats N, Monistrol-Mula A, García-Giralt N, Díez-Pérez A,Nogués X, Mellibovsky L, Grinberg D, Balcells S.
Influence Of Angiogenic Mediators And Bone Remodelling In Paget´s Disease Of Bone
Int J Med Sci. 2018 Jul 30;15(11):1210-1216. doi: 10.7150/ijms.26580. eCollection 2018. Fuentes-Calvo I, Usategui-Martín R, Calero-Paniagua I, Moledo-Pouso C, García-Ortiz L, Pino-Montes JD, González-Sarmiento R, Martínez-Salgado C. https://www.ncbi.nlm.nih.gov/pubmed/30123059
Medical diagnostic methods applied to a medieval female with vitamin D deficiency from the north of Spain
Int J Paleopathol. 2018 Sep;22:109-120. doi:10.1016/j.ijpp.2018.07.007 Alonso-Llamazares C, Gómez C, García-Manrique P, Pardiñas AF, López B.
Serum 25-Hydroxyvitamin D in Obese Spanish Adults: the Camargo Cohort Study
Obes Surg. 2018 Aug 1. doi: 10.1007/s11695-018-3430-6. Olmos JM, Hernández JL, Pariente E, Martínez J, González-Macías J.
Influence of Physical Activity on Bone Mineral Content and Density in Overweight and Obese Children with Low Adherence to the Mediterranean Dietary Pattern
Nutrients. 2018 Aug 12;10(8). pii: E1075. doi: 10.3390/nu10081075 Muñoz-Hernandez V, Arenaza L, Gracia-Marco L, Medrano M, Merchan Ramirez E, D Martinez Avila W, Oses M, R Ruiz J, B Ortega F, Labayen I.
Oral bisphosphonate prescription and non-adherence at 12 months in patients with hip fractures treated in an acute geriatric unit
Osteoporos Int. 2018 Aug 3. doi: 10.1007/s00198-018-4622-6. Gamboa A, Duaso E, Marimón P, Sandiumenge M, Escalante E, Lumbreras C, Tarrida A.
Hepatic fat content and bone mineral density in children with overweight/obesity
Pediatr Res. 2018 Aug 6. doi: 10.1038/s41390-018-0129-2. Labayen I, Ruiz JR, Arenaza L, Medrano M, Tobalina I, Gracia-Marco L, Ortega FB, Rodriguez-Vigil B.
Repercussion of nonsteroidal anti-inflammatory drugs on the gene expression of human osteoblasts
PeerJ. 2018 Aug 14;6:e5415. doi: 10.7717/peerj.5415. eCollection 2018. Melguizo-Rodríguez L, Costela-Ruiz VJ, Manzano-Moreno FJ, Illescas-Montes R, Ramos-Torrecillas J, García-Martínez O, Ruiz C.
Short-term association between outdoor air pollution and osteoporotic hip fracture
Osteoporos Int. 2018 Aug 9. doi: 10.1007/s00198-018-4605-7. Mazzucchelli R, Crespi Villarias N, Perez Fernandez E, Durban Reguera ML, Garcia-Vadillo A, Quiros FJ, Guzon O, Rodriguez Caravaca G, Gil de Miguel A.
CONVOCATORIA BECAS FEIOMM INVESTIGACIÓN 2018
La Fundación Española de Investigación Ósea y del Metabolismo Mineral (FEIOMM), convoca 6 BECAS de 6.000€ cada una para promocionar la investigación básica, clínica y traslacional en el campo del metabolismo mineral y óseo. BASES de la CONVOCATORIA. Las solicitudes se remitirán a la secretaría de la FEIOMM / SEIOMM, por correo electrónico (seiomm@seiomm.org) en un único archivo pdf antes del miércoles 10 de octubre…
Estrogen therapy for osteoporosis in the modern era
Osteoporos Int. 2018 May;29(5):1049-1055. doi: 10.1007/s00198-018-4414-z. Epub 2018 Mar 8. Review. PubMed PMID: 29520604. Levin VA, Jiang X, Kagan R. https://www.ncbi.nlm.nih.gov/pubmed/29520604
Targeted inhibition of sclerostin for post-menopausal osteoporosis therapy: A critical assessment of the mechanism of action
Eur J Pharmacol. 2018 May 5;826:39-47. doi: 10.1016/j.ejphar.2018.02.028. Epub 2018 Feb 22. Review. PubMed PMID: 29476877. Bhattacharyya S, Pal S, Chattopadhyay N.
Osteoporosis in Rheumatic Diseases: Anti-rheumatic Drugs and the Skeleton
Calcif Tissue Int. 2018 May;102(5):607-618. doi: 10.1007/s00223-018-0401-9. Epub 2018 Feb 22. Review. PubMed PMID: 29470611. Dubrovsky AM, Lim MJ, Lane NE. https://www.ncbi.nlm.nih.gov/pubmed/29470611
Mammalian target of rapamycin as a therapeutic target in osteoporosis
J Cell Physiol. 2018 May;233(5):3929-3944. doi: 10.1002/jcp.26161. Epub 2017 Sep 28. Review. PubMed PMID: 28834576. Shen G, Ren H, Qiu T, Zhang Z, Zhao W, Yu X, Huang J, Tang J, Liang, Yao Z, Yang Z, Jiang X.
Assessment and management of bone health in women with oestrogen receptor-positive breast cancer receiving endocrine therapy: Position statement of the Endocrine Society of Australia, the Australian and New Zealand Bone & Mineral Society, the Australasian Menopause Society and the Clinical Oncology Society of Australia.
Clin Endocrinol (Oxf). 2018 May 9. doi: 10.1111/cen.13735. [Epub ahead of print] Review. PubMed PMID: 29741296. Grossmann M, Ramchand SK, Milat F, Vincent A, Lim E, Kotowicz MA, Hicks J,Teede H.
Interventions to Prevent Falls in Older Adults: Updated Evidence Report and Systematic Review for the US Preventive Services Task Force.
JAMA. 2018 Apr 24;319(16):1705-1716. doi: 10.1001/jama.2017.21962. Review. PubMed PMID: 29710140. Guirguis-Blake JM, Michael YL, Perdue LA, Coppola EL, Beil TL.
Vitamin D, Calcium, or Combined Supplementation for the Primary Prevention of Fractures in Community-Dwelling Adults: US Preventive Services Task Force Recommendation Statement.
JAMA. 2018 Apr 17;319(15):1592-1599. doi: 10.1001/jama.2018.3185. PubMed PMID: 29677309. US Preventive Services Task Force, Grossman DC, Curry SJ, Owens DK, Barry MJ, Caughey AB, Davidson KW, Doubeni CA, Epling JW Jr, Kemper AR, Krist AH, Kubik M, Landefeld S, Mangione CM, Silverstein M, Simon MA, Tseng CW.
Vitamin D, Calcium, or Combined Supplementation for the Primary Prevention of Fractures in Community-Dwelling Adults: Evidence Report and Systematic Review for the US Preventive Services Task Force
JAMA. 2018 Apr 17;319(15):1600-1612. doi: 10.1001/jama.2017.21640. Review. PubMed PMID: 29677308. Kahwati LC, Weber RP, Pan H, Gourlay M, LeBlanc E, Coker-Schwimmer M,Viswanathan M.
Glucocorticoids, Inflammation and Bone
Calcif Tissue Int. 2018 May;102(5):592-606. doi: 10.1007/s00223-017-0335-7. Epub 2018 Jan 8. Review. PubMed PMID: 29313071. Güler-Yüksel M, Hoes JN, Bultink IEM, Lems WF.
Inhibition of VEGF gene expression in osteoblast cells by different NSAIDs
Arch Oral Biol. 2018 Aug;92:75-78. doi: 10.1016/j.archoralbio.2018.05.006. Epub 2018 May 9. PubMed PMID Manzano-Moreno FJ, Costela-Ruiz VJ, Melguizo-Rodríguez L, Illescas-Montes R,García-Martínez O, Ruiz C, Ramos-Torrecillas J.
Increased prevalence of asymptomatic vertebral fractures in HIV-infected patients over 50 years of age.
Arch Osteoporos. 2018 May 8;13(1):56. doi: 10.1007/s11657-018-0464-2. PubMed PMID Llop M, Sifuentes WA, Bañón S, Macia-Villa C, Perez-Elías MJ, Rosillo M,Moreno S, Vázquez M, Casado JL.
Increased bone resorption in hemophilia.Blood
Rev. 2018 May 25. pii: S0268-960X(17)30152-2. doi:10.1016/j.blre.2018.05.002. [Epub ahead of print] Review. PubMed PMID Rodriguez-Merchan EC, Valentino LA.
Gaucher disease and chronic myeloid leukemia: first reported patient receiving enzyme replacement and tyrosine kinase inhibitor therapies simultaneously
Clin Case Rep. 2018 Mar 15;6(5):887-892. eCollection 2018 May. Noya M, Andrade-Campos M, Irun P, López de Frutos L, López-Fernandez M,Giraldo P.
Role of Toll-Like Receptor 4 on Osteoblast Metabolism and Function
Front Physiol. 2018 May 8;9:504. doi: 10.3389/fphys.2018.00504. eCollection 2018. Review. Alonso-Pérez A, Franco-Trepat E, Guillán-Fresco M, Jorge-Mora A, López V, Pino J, Gualillo O, Gómez R.
Cost of osteoporotic hip fracture in Spain per Autonomous Region
Rev Esp Cir Ortop Traumatol. 2018 May 21. pii: S1888-4415(18)30067-5. Bartra A, Caeiro JR, Mesa-Ramos M, Etxebarría-Foronda I, Montejo J, Carpintero P, Sorio-Vilela F, Gatell S, Canals L; en representación de los investigadores del estudio PROA.
RESOLUCIÓN CONVOCATORIA BECAS FEIOMM ASBMR 2018
Madrid, a 17 de julio de 2018 Finalizado el plazo para el envío de solicitudes para acceder a las Becas FEIOMM ASBMR 2018 para la presentación de trabajos de investigación en el Congreso de la ASBMR 2018 que se celebrará en Montréal, Quebec, (CANADA) del 28 de septiembre al 1 de octubre de 2018. Descarga el Acta resolución…
CONVOCATORIA 11 BECAS FEIOMM INSCRIPCIÓN al XXIII Congreso SEIOMM 2018_Granada
La Fundación Española de Investigación Ósea y del Metabolismo Mineral (FEIOMM) convoca 11 Becas como ayuda a jóvenes investigadores para la asistencia al XXIII CONGRESO NACIONAL SEIOMM que se celebrará en Granada del 7 al 9 de noviembre de 2018. ** Este año volvemos a convocar 11 becas en lugar de 10 gracias a la gentileza del Dr. Manuel…
Is calcifediol better than cholecalciferol for vitamin D supplementation?
Osteoporos Int. 2018 Apr 30. doi:10.1007/s00198-018-4520 Quesada-Gomez JM, Bouillon R. https://www.ncbi.nlm.nih.gov/pubmed/29713796
Nutritional Status and Nutritional Treatment Are Related to Outcomes and Mortality in Older Adults with Hip Fracture.
Nutrients. 2018 Apr 30;10(5).pii: E555. doi: 10.3390/nu10050555. Malafarina V, Reginster JY, Cabrerizo S, Bruyère O, Kanis JA, Martinez JA, Zulet MA. https://www.ncbi.nlm.nih.gov/pubmed/29710860
Prevalence of and risk factors for low bone mineral density in Spanish treated HIV-infected patients.
PLoS One. 2018 Apr 30;13(4):e0196201. doi: 10.1371/journal.pone.0196201. eCollection 2018. Cervero M, Torres R, Agud JL, Alcázar V, Jusdado JJ, García-Lacalle C, Moreno S. https://www.ncbi.nlm.nih.gov/pubmed/29709013
Homocysteine levels are associated with bone resorption in pre-frail and frail Spanish women: The Toledo Study for Healthy Aging.
Exp Gerontol. 2018 Apr 26;108:201-208. doi:10.1016/j.exger.2018.04.019 Álvarez-Sánchez N, Álvarez-Ríos AI, Guerrero JM, García-García FJ, Rodríguez-Mañas L, Cruz-Chamorro I, Lardone PJ, Carrillo-Vico A.
Validation of Musculoskeletal Ultrasound in the Assessment of Experimental Gout Synovitis
Ultrasound Med Biol. 2018 Apr 24. pii: S0301-5629(18)30127-3. doi:10.1016/j.ultrasmedbio.2018.03.018. Naredo E, Medina JP, Pérez-Baos S, Mediero A, Herrero-Beaumont G, Largo R.
Effects of Daily Intake of Calcium and Vitamin D-Enriched Milk in Healthy Postmenopausal Women: A Randomized, Controlled, Double-Blind Nutritional Study.
J Womens Health (Larchmt). 2018 May;27(5):561-568. doi: 10.1089/jwh.2017.6655. Reyes-Garcia R, Mendoza N, Palacios S, Salas N, Quesada-Charneco M,Garcia-Martin A, Fonolla J, Lara-Villoslada F, Muñoz-Torres M.
Sost deficiency leads to reduced mechanical strains at the tibia midshaft in strain-matched in vivo loading experiments in mice
J R Soc Interface. 2018 Apr;15(141). pii: 20180012. doi: 10.1098/rsif.2018.0012. PubMed Albiol L, Cilla M, Pflanz D, Kramer I, Kneissel M, Duda GN, Willie BM, Checa S. https://www.ncbi.nlm.nih.gov/pubmed/29669893
Gut Microbiome and Bone
Joint Bone Spine. 2018 Apr 11. pii: S1297-319X(18)30061-7. doi:10.1016/j.jbspin.2018.02.008. Ibáñez L, Rouleau M, Wakkach A, Blin-Wakkach C.
Polymorphisms in genes implicated in base excision repair (BER) pathway are associated with susceptibility to Paget’s disease of bone.
Bone. 2018 7;112:19-23. doi: 10.1016/j.bone.2018.04.003. Usategui-Martín R, Gutiérrez-Cerrajero C, Jiménez-Vázquez S, Calero-Paniagua I, García-Aparicio J, Corral-Gudino L, Del Pino-Montes J, González-Sarmiento R.
Differential Mortality and the Excess Rates of Hip Fracture Associated With Type 2 Diabetes: Accounting for Competing Risks in Fracture Prediction Matters.
J Bone Miner Res. 2018 Apr 6. doi: 10.1002/jbmr.3435. Tebé C, Martinez-Laguna D, Moreno V, Cooper C, Diez-Perez A, Collins GS,Prieto-Alhambra D.
Multi-Scale Approach for the Evaluation of Bone Mineralization in Strontium Ranelate-Treated Diabetic Rats.
Biol Trace Elem Res. 2018 Apr 5. doi: 10.1007/s12011-018-1322-1. Álvarez-Lloret P, Fernández JM, Molinuevo MS, Lino AB, Ferretti JL, Capozza RF, Cortizo AM, McCarthy AD.
Change in the profile of traumatic spinal cord injury over 15 years in Spain.
Scand J Trauma Resusc Emerg Med. 2018 Apr 5;26(1):27. doi:10.1186/s13049-018-0491-4. Bárbara-Bataller E, Méndez-Suárez JL, Alemán-Sánchez C, Sánchez-Enríquez J, Sosa-Henríquez M.
Effect of phenolic extracts from different extra-virgin olive oil varieties on osteoblast-like cells
PLoS One. 2018 Apr 26;13(4):e0196530. doi: 10.1371/journal.pone.0196530.eCollection 2018 Melguizo-Rodríguez L, Ramos-Torrecillas J, Manzano-Moreno FJ, Illescas-Montes R, Rivas A, Ruiz C, De Luna-Bertos E, García-Martínez O
Identifying Potential Therapeutics for Osteoporosis by Exploiting the Relationship between Mevalonate Pathway and Bone Metabolism.
Wan Hasan WN, Chin KY, Jolly JJ, Abd Ghafar N, Soelaiman IN. Endocr Metab Immune Disord Drug Targets. 2018 Apr 23. doi: 10.2174/1871530318666180423122409. [Epub ahead of print] PubMed PMID: 29683099.
Effects of Long-term Denosumab on Bone Histomorphometry and Mineralization in Women With Postmenopausal Osteoporosis.
Dempster DW, Brown JP, Fahrleitner-Pammer A, Kendler D, Rizzo S, Valter I, Wagman RB, Yin X, Yue SV, Boivin G. J Clin Endocrinol Metab. 2018 Apr 16. doi: 10.1210/jc.2017-02669. [Epub ahead of print] PubMed PMID: 29672714.
Bisphosphonate therapy for spinal osteoporosis in Hajdu-Cheney syndrome – new data and literature review.
Pittaway JFH, Harrison C, Rhee Y, Holder-Espinasse M, Fryer AE, Cundy T, Drake WM, Irving MD. Orphanet J Rare Dis. 2018 Apr 4;13(1):47. doi: 10.1186/s13023-018-0795-5. PubMed PMID: 29618366; PubMed Central PMCID: PMC5885380.
Denosumab: A Unique Perspective on Adherence and Cost-effectiveness Compared With Oral Bisphosphonates in Osteoporosis Patients.
Morizio P, Burkhart JI, Ozawa S. Ann Pharmacother. 2018 Apr 1:1060028018768808. doi: 10.1177/1060028018768808. [Epub ahead of print] PubMed PMID: 29616561.
Mesenchymal Stem Cells-Derived Exosomes: A Possible Therapeutic Strategy for Osteoporosis.
Li Y, Jin D, Xie W, Wen L, Chen W, Xu J, Ding J, Ren D, Xiao Z. Curr Stem Cell Res Ther. 2018;13(5):362-368. doi: 10.2174/1574888X13666180403163456. PubMed PMID: 29623851. https://www.ncbi.nlm.nih.gov/pubmed/29623851
Therapy of Endocrine Disease: Denosumab vs bisphosphonates for the treatment of postmenopausal osteoporosis.
Anastasilakis AD, Polyzos SA, Makras P. Eur J Endocrinol. 2018 Jul;179(1):R31-R45. doi: 10.1530/EJE-18-0056. Epub 2018 Apr 24. Review. PubMed PMID: 29691303.
Vitamin D and Calcium Supplements for Preventing Fractures.
JAMA. 2018 Apr 17;319(15):1630. doi: 10.1001/jama.2018.3892. PubMed PMID: 29677304. Jin J.
Effect of risedronate on femoral periprosthetic bone loss following total hip replacement: A systematic review and meta-analysis.
Medicine (Baltimore). 2018 Apr;97(17):e0379. doi: 10.1097/MD.0000000000010379. Review. Ren L, Wang W. PubMed PMID: 29702983; PubMed Central PMCID: PMC5944478. https://www.ncbi.nlm.nih.gov/pubmed/29702983
Vertebral Fracture: Diagnostic Difficulties of a Major Medical Problem.
Res. 2018 Apr;33(4):553-559. doi: 10.1002/jbmr.3404. Epub 2018 Mar 5. PubMed PMID: 29419882. Szulc P. J Bone Miner https://www.ncbi.nlm.nih.gov/pubmed/29419882
Sábado 7 de julio fin_CONVOCATORIA BECAS FEIOMM ASBMR 2018
La Fundación Española de Investigación Ósea y del Metabolismo Mineral FEIOMM convoca 5 Becas para la presentación de trabajos científicos en ASBMR 2018 que se celebrará en Montréal, Quebec, (CANADA) del 28 de septiembre al 1 de octubre de 2018. Dichas becas cubrirán inscripción, viaje y alojamiento. La aceptación de la beca implica la conformidad…
Effects of multicomponent training on lean and bone mass in postmenopausal and older women: a systematic review
Menopause. 2018 Mar;25(3):346-356. doi:10.1097/GME.0000000000000975 Marín-Cascales E, Alcaraz PE, Ramos-Campo DJ, Rubio-Arias JA.
The effects of denosumab and alendronate on glucocorticoid-induced osteoporosis in patients with glomerular disease: A randomized, controlled trial.
PLoS One. 2018 Mar 15;13(3):e0193846. doi: 10.1371/journal.pone.0193846. eCollection 2018. PubMed PMID: 29543887; PubMed Central PMCID: PMC5854344. Iseri K, Iyoda M, Watanabe M, Matsumoto K, Sanada D, Inoue T, Tachibana S, Shibata T.
Effects of denosumab on bone mineral density in Japanese women with osteoporosis treated with aromatase inhibitors for breast cancer.
J Bone Miner Metab. 2018 Mar 8. doi: 10.1007/s00774-018-0917-0. [Epub ahead of print] PubMed PMID: 29520506. Nakatsukasa K, Koyama H, Ouchi Y, Sakaguchi K, Fujita Y, Matsuda T, Kato M, Konishi E, Taguchi T.
Combination therapy of anabolic agents and bisphosphonates on bone mineral density in patients with osteoporosis: a meta-analysis of randomised controlled trials.
BMJ Open. 2018 Mar 1;8(3):e015187. doi: 10.1136/bmjopen-2016-015187. PubMed PMID: 29500198; PubMed Central PMCID: PMC5855398. Lou S, Lv H, Li Z, Zhang L, Tang P.
MANAGEMENT OF ENDOCRINE DISEASE: Atypical femoral fractures: risks and benefits of long-term treatment of osteoporosis with anti-resorptive therapy.
Eur J Endocrinol. 2018 Mar;178(3):R81-R87. doi: 10.1530/EJE-17-1002. Epub 2018 Jan 16. Review. PubMed PMID: 29339529. Adler RA.
Changes of Circulating MicroRNAs in Response to Treatment With Teriparatide or Denosumab in Postmenopausal Osteoporosis.
J Clin Endocrinol Metab. 2018 Mar 1;103(3):1206-1213. doi: 10.1210/jc.2017-02406. PubMed PMID: 29309589. Anastasilakis AD, Makras P, Pikilidou M, Tournis S, Makris K, Bisbinas I, Tsave O, Yovos JG, Yavropoulou MP.
Denosumab: A Review in Postmenopausal Osteoporosis. Drugs Aging.
2018 Feb;35(2):163-173. doi: 10.1007/s40266-018-0525-7. Erratum in: Drugs Aging. 2018 Mar 9;:. PubMed PMID: 29435849. Deeks ED. https://www.ncbi.nlm.nih.gov/pubmed/29435849
Effect of osteoporosis medication on changes in bone mineral density and bone turnover markers after 24-month administration of daily teriparatide: comparison among minodronate, raloxifene, and eldecalcitol.
J Bone Miner Metab. 2018 Mar;36(2):221-228. doi: 10.1007/s00774-017-0829-4. Epub 2017 Mar 14. PubMed PMID: 28293779. Nakatoh S.
The Quest for Osteoporosis Mechanisms and Rational Therapies: How Far We’ve Come, How Much Further We Need to Go.
J Bone Miner Res. 2018 Mar;33(3):371-385. doi: 10.1002/jbmr.3400. Epub 2018 Feb 22. PubMed PMID: 29405383. Manolagas SC.
Mediterranean diet, diet quality, and bone mineral content in adolescents: the HELENA study.
Osteoporos Int. 2018 Mar 5. doi: 10.1007/s00198-018-4427-7 Julián C, Huybrechts I, Gracia-Marco L, González-Gil EM, Gutiérrez Á, González-Gross M, Marcos A, Widhalm K, Kafatos A, Vicente-Rodríguez G, Moreno LA.
Cross-talk between primary osteocytes and bone marrow macrophages for osteoclastogenesis upon collagen treatment.
Sci Rep. 2018 Mar 28;8(1):5318. doi: 10.1038/s41598-018-23532-x. Elango J, Sanchez C, de Val JEMS, Henrotin Y, Wang S, Motaung KSCM, Guo R, Wang C, Robinson J, Regenstein JM, Bao B, Wu W.
Osseointegration mechanisms: a proteomic approach.
J Biol Inorg Chem. 2018 May;23(3):459-470. doi: 10.1007/s00775-018-1553-9. Araújo-Gomes N, Romero-Gavilán F, García-Arnáez I, Martínez-Ramos C, Sánchez-Pérez AM, Azkargorta M, Elortza F, de Llano JJM, Gurruchaga M, Goñi I, Suay J. https://www.ncbi.nlm.nih.gov/pubmed/29572572
Denosumab mid-term densitometric gain in postmenopausal osteoporosis women in clinical practice: comment on “Variability of denosumab densitometric response in postmenopausal osteoporosis.
Rheumatol Int. 2018 Jun;38(6):1161-1162. doi: 10.1007/s00296-018-4007-3. Torrente-Segarra V, Roig-Vilaseca D.
MURCIA _Jornada Formativa AP sobre la Prevención de Fracturas por Fragilidad
Desde SEIOMM/FEIOMM en colaboración con AMGEN y Ferrer os presentamos:
MURCIA_ Jueves, 17 mayo de 2018
“Jornadas formativas para Médicos de Familia”
Resolviendo dudas del día a día en la PREVENCIÓN DE FRACTURAS POR FRAGILIDAD

Teriparatide for treatment of patients with bisphosphonate-associated atypical fracture of the femur.
Osteoporos Int. 2018 Feb;29(2):501-506. doi: 10.1007/s00198-017-4286-7. Epub 2017 Oct 30. Greenspan SL, Vujevich K, Britton C, Herradura A, Gruen G, Tarkin I, Siska P, Hamlin B, Perera S.
Remodeling- and Modeling-Based Bone Formation With Teriparatide Versus Denosumab: A Longitudinal Analysis From Baseline to 3 Months in the AVA Study.
J Bone Miner Res. 2018 Feb;33(2):298-306. Dempster DW, Zhou H, Recker RR, Brown JP, Recknor CP, Lewiecki EM, Miller PD, Rao SD, Kendler DL, Lindsay R, Krege JH, Alam J, Taylor KA, Melby TE, Ruff VA.
TNFα blockade mediates bone protection in antigen-induced arthritis by reducing osteoclast precursor supply.
Bone. 2018 Feb; 107:56-65 Uster S, Matos Coelho F, Aeberli D, Stein JV, Hofstetter W, Engelhardt R, Seitz M.
Bone-Targeted Therapies in Cancer-Induced Bone Disease.
Calcif Tissue Int 2018 2018 Feb;102(2):227-250. doi: 10.1007/s00223-017-0353-5. Epub 2017 Oct 27. Sousa S, Clézardin P
Exercise to improve functional outcomes in persons with osteoporosis: a systematic review and meta-analysis.
Osteoporos Int. 2018 Feb;29(2):265-286. doi: 10.1007/s00198-017-4339-y. Epub 2018 Jan 6. Varahra A, Rodrigues IB, MacDermid JC, Bryant D, Birmingham T.
Twelve years of experience with miglustat in the treatment of type 1 Gaucher disease: The Spanish ZAGAL project
Blood Cells Mol Dis. 2018 Feb;68:173-179. doi:10.1016/j.bcmd.2016.10.017 Giraldo P, Andrade-Campos M, Alfonso P, Irun P, Atutxa K, Acedo A, Barez A, Blanes M, Diaz-Morant V, Fernández-Galán MA, Franco R, Gil-Cortes C, Giner V, Ibañez A, Latre P, Loyola I, Luño E, Hernández-Martin R, Medrano-Engay B, Puerta J, Roig I, de la Serna J, Salamero O,…
Osteoporosis in chronic liver disease
Liver Int. 2018 Feb 26. doi: 10.1111/liv.13730 Guañabens N, Parés A
Bone density, microarchitecture and tissue quality after 1 year of treatment with tenofovir disoproxil fumarate
AIDS. 2018 Feb 8. doi:10.1097/QAD.0000000000001780 Güerri-Fernández R, Lerma-Chippirraz E, Fernandez Marron A, García-Giralt N, Villar-García J, Soldado J, González-Mena A, Guelar A, Díez-Pérez A, Brown TT, Knobel H.
Long-chain omega-3 polyunsaturated fatty acid dietary intake is positively associated with bone mineral density in normal and osteopenic Spanish women.
PLoS One. 2018 Jan 5;13(1):e0190539. doi: 10.1371/journal.pone.0190539. eCollection 2018. Lavado-García J, Roncero-Martin R, Moran JM, Pedrera-Canal M, Aliaga I,Leal-Hernandez O, Rico-Martin S, Canal-Macias ML.
Study of fall risk-increasing drugs in elderly patients before and after a bone fracture
Postgrad Med J. 2018 Feb;94(1108):76-80. doi: 10.1136/postgradmedj-2017-135129. Beunza-Sola M, Hidalgo-Ovejero ÁM, Martí-Ayerdi J, Sánchez-Hernández JG,Menéndez-García M, García-Mata S.
Osteoblastic cell response on high-rough titanium coatings by cold spray
J Mater Sci Mater Med. 2018 Feb 1;29(3):19. doi: 10.1007/s10856-018-6026-8. Vilardell AM, Cinca N, Garcia-Giralt N, Dosta S, Cano IG, Nogués X, Guilemany JM. https://www.ncbi.nlm.nih.gov/pubmed/29392501
Spanish National Hip Fracture Registry (SNHFR): a description of its objectives, methodology and implementation
Rev Esp Geriatr Gerontol. 2018 Feb 6.pii: S0211-139X(18)30001-5. doi:10.1016/j.regg.2017.12.001 Sáez-López P, González-Montalvo JI, Ojeda-Thies C, Mora-Fernández J,Muñoz-Pascual A, Cancio JM, Tarazona FJ, Pareja T, Gómez-Campelo P,Montero-Fernández N, Alarcón T, Mesa-Lampre P, Larrainzar R, Duaso E, Gil-Garay E, Diéz-Pérez A, Prieto-Alhambra D, Queipo-Matas R, Otero-Puime A; participantsin the RNFC.
Effects of abaloparatide on bone mineral density and risk of fracture in postmenopausal women aged 80 years or older with osteoporosis.
Menopause. 2018 Feb 16. doi: 10.1097/GME.0000000000001080. [Epub ahead of print]. McClung MR, Harvey NC, Fitzpatrick LA, Miller PD, Hattersley G, Wang Y, Cosman F. https://www.ncbi.nlm.nih.gov/pubmed/29462094
The Cost-Effectiveness of Screening in the Community to Reduce Osteoporotic Fractures in Older Women in the UK: Economic Evaluation of the SCOOP Study.
J Bone Miner Res. 2018 Feb 22. doi: 10.1002/jbmr.3381. [Epub ahead of print] Turner DA, Khioe RFS, Shepstone L, Lenaghan E, Cooper C, Gittoes N, Harvey NC, Holland R, Howe A, McCloskey E, O’Neill TW, Torgerson D, Fordham R; SCOOP Study Team.
Prospective and Multicenter Evaluation of Outcomes for Quality of Life and Activities of Daily Living for Balloon Kyphoplasty in the Treatment of Vertebral Compression Fractures: The EVOLVE Trial.
Neurosurgery. 2018 Mar 14. doi: 10.1093/neuros/nyy017. [Epub ahead of print] Beall DP, Chambers MR, Thomas S, Amburgy J, Webb JR Jr, Goodman BS, Datta DK, Easton RW, Linville D 2nd, Talati S, Tillman JB
Bone Loss After Romosozumab/Denosumab: Effects of Bisphosphonates.
Calcif Tissue Int. 2018 Feb 14. doi: 10.1007/s00223-018-0404-6. [Epub ahead of print] Horne AM, Mihov B, Reid IR.
Abaloparatide-SC improves trabecular microarchitecture as assessed by trabecular bone score (TBS): a 24-week randomized clinical trial.
Bilezikian JP, Hattersley G, Fitzpatrick LA, Harris AG, Shevroja E, Banks K, Leder BZ, Zanchetta JR, Hans D. Osteoporos Int. 2018 Feb;29(2):323-328. doi: 10.1007/s00198-017-4304-9. Epub 2017 Nov 22.
RESOLUCIÓN solicitudes PROYECTO SEIOMM_FLS EXCELLENCE
RESOLUCIÓN solicitudes PROYECTO SEIOMM_FLS EXCELLENCE Finalizado el plazo del envío de solicitudes para acceder al Proyecto FLS Excellence y una vez reunido el Comité Científico del Proyecto para su valoración, en función de los criterios especificados en la convocatoria, según baremo, han sido adjudicadas las 6 FLS que a continuación se detallan: Descarga aquí la…
Proyecto SEIOMM-3D-SHAPER – Symposium SEIOMM-3D-SHAPER (precongreso ECTS 2018)
Proyecto SEIOMM-3D-SHAPER LINK Bases Proyecto Symposium SEIOMM-3D-SHAPER (precongreso ECTS 2018) Analyzing the Proximal Femur in 3D from Hip DXA Scan ¡Aprende sobre 3D-SHAPER y obtén una licencia de software de prueba gratuita! Si estas interesado inscríbete antes del viernes 4 de mayo de 2018 en seiomm@seiomm.org con tu nombre e institución. La inscripción es gratuita….
PREMIO RUBIÓ APOYO A LA REVISTA DE LA SEIOMM
La Junta Directiva de la SEIOMM, ha decidido crear el PREMIO RUBIÓ APOYO A LA REVISTA DE LA SEIOMM, dotado con 1.000 euros, para el asociado que más cite a la ROMM desde revistas indexadas y con factor de impacto. Bases de la CONVOCATORIA Anexo 1
MADRID Jornada Formativa AP sobre la Prevención de Fracturas por Fragilidad
Desde SEIOMM/FEIOMM en colaboración con AMGEN y Ferrer os presentamos:
MADRID Viernes, 6 abril de 2018
“Jornadas formativas para Médicos de Familia”
Resolviendo dudas del día a día en la PREVENCIÓN DE FRACTURAS POR FRAGILIDAD

High-potency statins but not all statins decrease the risk of new-onset osteoporotic fractures: a nationwide population-based longitudinal cohort study.
Clin Epidemiol. 2018 Jan 18;10:159-165. Lin TK, Liou YS, Lin CH, Chou P, Jong GP. https://www.ncbi.nlm.nih.gov/pubmed/29403315
Protective Effect of Denosumab on Bone in Older Women with Primary Hyperparathyroidism.
J Am Geriatr Soc. 2018 Jan 24. doi: 10.1111/jgs.15250 Eller-Vainicher C, Palmieri S, Cairoli E, Goggi G, Scillitani A, Arosio M, Falchetti A, Chiodini I. https://www.ncbi.nlm.nih.gov/pubmed/29364518
Effects of Teriparatide Compared with Risedronate on the Risk of Fractures in Subgroups of Postmenopausal Women with Severe Osteoporosis: The VERO Trial.
J Bone Miner Res. 2018 Jan 12. doi: 10.1002/jbmr.3384. [Epub ahead of print] Geusens P, Marin F, Kendler DL, Russo LA, Zerbini CA, Minisola S, Body JJ, Lespessailles E, Greenspan SL, Bagur A, Stepan JJ, Lakatos P, Casado E, Moericke R, López-Romero P, Fahrleitner-Pammer A. https://www.ncbi.nlm.nih.gov/pubmed/29329484
Treatment-Related Changes in Bone Turnover and Fracture Risk Reduction in Clinical Trials of Anti-Resorptive Drugs: A Meta-Regression.
J Bone Miner Res. 2018 Jan 10. doi: 10.1002/jbmr.3355. [Epub ahead of print] Bauer DC, Black DM, Bouxsein ML, Lui LY, Cauley JA, de Papp AE, Grauer A, Khosla S, McCulloch CE, Eastell R; Foundation for the National Institutes of Health (FNIH) Bone Quality Project. https://www.ncbi.nlm.nih.gov/pubmed/29318649
Protein Kinase G Activation Reverses Oxidative Stress and Restores Osteoblast Function and Bone Formation in Male Mice With Type 1 Diabetes.
Diabetes. 2018 Jan 4. pii: db170965. doi: 10.2337/db17-0965. [Epub ahead of print] Kalyanaraman H, Schwaerzer G, Ramdani G, Castillo F, Scott BT, Dillmann W, Sah RL, Casteel DE, Pilz RB. https://www.ncbi.nlm.nih.gov/pubmed/29301852
Trabecular Bone Score in Obese and Non-obese Subjects with Primary Hyperparathyroidism Before and After Parathyroidectomy.
J Clin Endocrinol Metab. 2018 Jan 24. doi: 10.1210/jc.2017-02169. [Epub ahead of print] Donovan Tay YK, Cusano NE, Rubin MR, Williams J, Omeragic B, Bilezikian JP.
Co-morbidities only account for a small proportion of excess mortality after fracture: a record linkage study of individual fracture types.
J Bone Miner Res. 2018 Jan 4. doi: 10.1002/jbmr.3374. [Epub ahead of print] Chen W, Simpson JM, March LM, Blyth FM, Bliuc D, Tran T, Nguyen TV, Eisman JA, Center JR.
Incidence of unexpected positive histology in kyphoplasty.
Eur Spine J. 2018 Jan 5. doi: 10.1007/s00586-017-5458-z. [Epub ahead of print] Nowak S, Müller J, Schroeder HWS, Müller JU. https://www.ncbi.nlm.nih.gov/pubmed/29305658
Inhibiting Cellular Senescence: A New Therapeutic Paradigm for Age-Related Osteoporosis.
J Clin Endocrinol Metab. 2018 Feb 7. doi: 10.1210/jc.2017-02694. [Epub ahead of print] Khosla S, Farr JN, Kirkland JL.
Fractures Related to Tenofovir: A Case/Noncase Study in the European Pharmacovigilance Database.
Am J Ther. 2018 Jan 8. doi:10.1097/MJT.0000000000000718. García MG, Larrinaga-Torrontegui U, Eduardo Martinez E, Lertxundi U, Palacios-Zabalza I, Aguirre C.
Vitamin D: Classic and Novel Actions
Ann Nutr Metab. 2018 Jan 18;72(2):87-95. doi: 10.1159/000486536. Gil Á, Plaza-Diaz J, Mesa MD
Parathyroid hormone-related protein exhibits antioxidant features in osteoblastic cells through its N-terminal and osteostatin domains.
Bone Joint Res. 2018 Jan;7(1):58-68. doi:10.1302/2046-3758.71.BJR-2016-0242.R2. Portal-Núñez S, Ardura JA, Lozano D, Martínez de Toda I, De la Fuente M, Herrero-Beaumont G, Largo R, Esbrit P.
Nutritional deficiencies and bone metabolism after endobarrier in obese type 2 patients with diabetes.
Eur J Clin Nutr. 2018 Jan 19. doi: 10.1038/s41430-017-0074-x. Vilarrasa N, Fabregat A, Toro S, Gordejuela AG, Casajoana A, Montserrat M, Garrido P, López-Urdiales R, Virgili N, Planas-Vilaseca A, Simó-Servat A, Pujol J.
MMP14 is a novel target of PTH signaling in osteocytes that controls resorption by regulating soluble RANKL production.
FASEB J. 2018 Jan 17:fj201700919RRR. doi: 10.1096/fj.201700919RRR. Delgado-Calle J, Hancock B, Likine EF, Sato AY, McAndrews K, Sanudo C, Bruzzaniti A, Riancho JA, Tonra JR, Bellido T.
Long-chain omega-3 polyunsaturated fatty acid dietary intake is positively associated with bone mineral density in normal and osteopenic Spanish women
PLoS One. 2018 Jan 5;13(1):e0190539. doi: 10.1371/journal.pone.0190539. eCollection 2018. PubMed Lavado-García J, Roncero-Martin R, Moran JM, Pedrera-Canal M, Aliaga I, Leal-Hernandez O, Rico-Martin S, Canal-Macias ML.
Usefulness of the Trabecular Bone Score for assessing the risk of osteoporotic fracture.
Rev Clin Esp. 2018 Jan 9. pii: S0014-2565(17)30294-1. doi: 10.1016/j.rce.2017.12.005. Redondo L, Puigoriol E, Rodríguez JR, Peris P, Kanterewicz E.
Time to parathyroid function recovery in patients with protracted hypoparathyroidism after total thyroidectomy.
Eur J Endocrinol. 2018 Jan;178(1):105-113. doi: 10.1530/EJE-17-0589. Epub 2017 Oct 24. Villarroya-Marquina I, Sancho J, Lorente-Poch L, Gallego-Otaegui L, Sitges-Serra A
High Serum Retinol as a Relevant Contributor to Low Bone Mineral Density in Postmenopausal Osteoporotic Women.
Calcif Tissue Int. 2018 Jan 2. doi: 10.1007/s00223-017-0379-8. [Epub ahead of print] Navarro-Valverde C, Caballero-Villarraso J, Mata-Granados JM, Casado-Díaz A, Sosa-Henríquez M, Malouf-Sierra J, Nogués-Solán X, Rodríguez-Mañas L, Cortés-Gil X, Delgadillo-Duarte J, Quesada-Gómez JM.
PROYECTOS SEIOMM
RESOLUCIÓN solicitudes PROYECTO SEIOMM_FLS EXCELLENCE_
Finalizado el plazo del envío de solicitudes para acceder al Proyecto FLS Excellence y una vez reunido el Comité Científico del Proyecto para su valoración, en función de los criterios especificados en la convocatoria, según baremo, han sido adjudicadas las 6 FLS que a continuación se detallan:
1.- FLS ANOIA D´IGUALADA _ Consorcio Sanitario del Anoia – Igualada – Barcelona
Solicitante: Dr. Enric Duaso Magaña
2.- FLS BADALONA SERVEIS ASSISTENCIALS_ Centre Sociosaniatrio El Carme. Badalona Serveis Assistencials – Badalona – Barcelona
Solicitante: Dr. Jose Manuel Cancio Trujillo
3.- FLS HOSPITAL DEL MAR_ Hospital del Mar _ Barcelona
Solicitante: Dr. Xavier Nogues Solan
4.- FLS HOSPITAL UNIVERSITARIO VIRGEN MACARENA_ Hospital Virgen Macarena _ Sevilla
Solicitantes: Dra. Mª José Montoya García – Dr. F. Jesús Olmo Montes
5.- FLS CLÍNICO SAN CARLOS_ Hospital clínico San Carlos _ Madrid
Solicitante: Dr. Jesus Mora Fernández
6.- FLS HOSPITAL SON LLÀTZER_ Hospital de Son Llàtzer _ Palma _Islas Baleares
Solicitante: Dr. Bartolomé Lladó Ferrer
Y para que así conste, en Madrid, a 10 de abril de 2018.
Comité Científico Proyecto FLS Excellence
Normativa para Proyectos SEIOMM
Un Proyecto SEIOMM es aquel proyecto de investigación diseñado por socios de la SEIOMM, por la Junta Directiva o por agentes externos a la misma, cuyo contenido o desarrollo es juzgado por la Junta Directiva como de interés para la Sociedad.
Clinical profile and long-term follow-up of 32 patients with postoperative permanent hypoparathyroidism.
Gland Surg. 2017 Dec;6(Suppl 1):S3-S10. doi:10.21037/gs.2017.11.10. Lorente-Poch L, Sancho JJ, Carballo L, Sitges-Serra A. Más información
Bone morphogenetic protein-9/activin-like kinase 1 axis a new target for hepatic regeneration and fibrosis treatment in liver injury.
Hepatobiliary Surg Nutr. 2017 Dec;6(6):414-416. doi: 10.21037/hbsn.2017.11.02. Marí M, Morales A. Más información
Implication of osteoprotegerin and sclerostin in axial spondyloarthritis cardiovascular disease: study of 163 Spanish patients
Clin Exp Rheumatol. 2017 Dec 15 Genre F, Rueda-Gotor J, Remuzgo-Martínez S, Corrales A, Ubilla B, Mijares V,Fernández-Díaz C, Portilla V, Blanco R, Hernández JL, Llorca J, López-Mejías R, González-Gay MA. Más información
Prevalence and risk factors for osteoporosis and fractures in axial spondyloarthritis: A systematic review and meta-analysis.
Semin Arthritis Rheum. 2017 Dec 7. pii: S0049-0172(17)30649-2. doi: 10.1016/j.semarthrit.2017.12.001. Ramírez J, Nieto-González JC, Curbelo Rodríguez R, Castañeda S, Carmona L. Más información
The RSPO3 gene as genetic markers for bone mass assessed by quantitative ultrasound in a population of young adults.
Ann Hum Genet. 2017 Dec 12. doi: 10.1111/ahg.12235 Correa-Rodríguez M, Schmidt Rio-Valle J, Rueda-Medina B. Más información
Trends in incidence of proximal humerus fractures, surgical procedures and outcomes among elderly hospitalized patients with and without type 2 diabetes in Spain (2001-2013).
BMC Musculoskelet Disord. 2017 Dec 11;18(1):522. doi: 10.1186/s12891-017-1892-7 Martinez-Huedo MA, Jiménez-García R, Mora-Zamorano E, Hernández-Barrera V,Villanueva-Martinez M, Lopez-de-Andres A. Más información
Trabecular Bone Score Valuable in Bone Microstructure Assessment after Gastric Bypass in Women with Morbid Obesity?
Nutrients. 2017 Dec 2;9(12). pii: E1314. doi:10.3390/nu9121314 Marengo AP, Guerrero Pérez F, San Martín L, Monseny R, Casajoana A, Valera R, Virgili N, Simó Servat A, Prats A, Gómez-Vaquero C, Vilarrasa N. Is Más información
Bisphosphonates for Paget’s disease of bone in adults
Cochrane Database Syst Rev. 2017 Dec 1;12:CD004956. doi: 10.1002/14651858.CD004956.pub3. Review Corral-Gudino L, Tan AJ, Del Pino-Montes J, Ralston SH. Más información
Hyperphosphatemia induces senescence in human endothelial cells by increasing endothelin-1 production.
Aging Cell. 2017 Dec;16(6):1300-1312. doi:10.1111/acel.12664. Olmos G, Martínez-Miguel P, Alcalde-Estevez E, Medrano D, Sosa P,Rodríguez-Mañas L, Naves-Diaz M, Rodríguez-Puyol D, Ruiz-Torres MP, López-Ongil S. Más información
Preventing future fractures: effectiveness of an orthogeriatric fracture liaison service compared to an outpatient fracture liaison service and the standard management in patients with hip fracture.
Arch Osteoporos. 2017 Dec 11;12(1):112. doi: 10.1007/s11657-017-0373-9 Naranjo A, Fernández-Conde S, Ojeda S, Torres-Hernández L, Hernández-Carballo C, Bernardos I, Rodríguez S, Laynez P. Más información
Risk of venous thromboembolism among users of different anti-osteoporosis drugs: a population-based cohort analysis including over 200,000 participants from Spain and the UK.
Osteoporos Int. 2017 Dec 3. doi:10.1007/s00198-017-4308-5. Martín-Merino E, Petersen I, Hawley S, Álvarez-Gutierrez A, Khalid S,Llorente-Garcia A, Delmestri A, Javaid MK, Van Staa TP, Judge A, Cooper C,Prieto-Alhambra D. Más información
Atypical Fracture of the Sternum After Long-Term Alendronate Plus Cholecalciferol Treatment: A Case Report.
Drug Saf Case Rep.2017 Dec;4(1):5. doi: 10.1007/s40800-017-0046-z. Martín Arias LH, García Ortega P, Sáinz Gil M, Navarro García E, Treceño Lobato C, Delgado Armas V. Más información
Association Between Calcium or Vitamin D Supplementation and Fracture Incidence in Community-Dwelling Older Adults: A Systematic Review and Meta-analysis.
JAMA. 2017 Dec 26;318(24):2466-2482. doi: 10.1001/jama.2017.19344. Zhao JG, Zeng XT, Wang J, Liu L Más información
Screening in the community to reduce fractures in older women (SCOOP): a randomised controlled trial.
Lancet. 2017 Dec 15. pii: S0140-6736(17)32640-5. doi: 10.1016/S0140-6736(17)32640-5. [Epub ahead of print] Shepstone L, Lenaghan E, Cooper C, Clarke S, Fong-Soe-Khioe R, Fordham R, Gittoes N, Harvey I, Harvey N, Heawood A, Holland R, Howe A, Kanis J, Marshall T, O’Neill T, Peters T, Redmond N, Torgerson D, Turner D, McCloskey E; SCOOP Study Team…
Hormone Therapy for the Primary Prevention of Chronic Conditions in Postmenopausal Women: Evidence Report and Systematic Review for the US Preventive Services Task Force.
JAMA. 2017 Dec 12;318(22):2234-2249. doi: 10.1001/jama.2017.16952. Review Gartlehner G, Patel SV, Feltner C, Weber RP, Long R, Mullican K, Boland E, Lux L, Viswanathan M. Más información
Cost-utility analysis of fracture risk assessment using microRNAs compared with standard tools and no monitoring in the Austrian female population.
Bone. 2017 Dec 18;108:44-54. doi: 10.1016/j.bone.2017.12.017. [Epub ahead of print] Walter E, Dellago H, Grillari J, Dimai HP, Hackl M. Más información
Bone quality changes associated with aging and disease: a review.
Ann N Y Acad Sci. 2017 Dec;1410(1):93-106. doi: 10.1111/nyas.13572. Review Boskey AL, Imbert L. Más información
The risk of fragility fractures in new users of dipeptidyl peptidase-4 inhibitors compared to sulfonylureas and other anti-diabetic drugs: A cohort study.
Diabetes Res Clin Pract. 2017 Dec 16;136:159-167. doi: 10.1016/j.diabres.2017.12.008. [Epub ahead of print] Gamble JM, Donnan JR, Chibrikov E, Twells LK, Midodzi WK, Majumdar SR. Más información
A dedicated Fracture Liaison Service telephone program and use of bone turnover markers for evaluating 1-year persistence with oral bisphosphonates.
Osteoporos Int. 2017 Dec 19. doi: 10.1007/s00198-017-4340-5. [Epub ahead of print. van den Berg P, van Haard PMM, van der Veer E, Geusens PP, van den Bergh JP, Schweitzer DH Más información
Effect of Combination Folic Acid, Vitamin B6 , and Vitamin B12 Supplementation on Fracture Risk in Women: A Randomized, Controlled Trial.
J Bone Miner Res. 2017 Dec;32(12):2331-2338. doi: 10.1002/jbmr.3229. Stone KL, Lui LY, Christen WG, Troen AM, Bauer DC, Kado D, Schambach C, Cummings SR, Manson JE. Más información
Adult Paget’s disease of bone: a review.
Rheumatology (Oxford). 2017 Dec 1;56(12):2050-2059. doi: 10.1093/rheumatology/kew430. Review. Paul Tuck S, Layfield R, Walker J, Mekkayil B, Francis R Más información
Quality of life for up to 18 months after low-energy hip, vertebral, and distal forearm fractures-results from the ICUROS.
Osteoporos Int. 2017 Dec 11. doi: 10.1007/s00198-017-4317-4. Svedbom A, Borgstöm F, Hernlund E, Ström O, Alekna V, Bianchi ML, Clark P,Curiel MD, Dimai HP, Jürisson M, Kallikorm R, Lember M, Lesnyak O, McCloskey E,Sanders KM, Silverman S, Solodovnikov A, Tamulaitiene M, Thomas T, Toroptsova N, Uusküla A, Tosteson ANA, Jönsson B, Kanis JA. Más información
Advantages of care for patients with hip fractures in the acute geriatric unit: Hip study Anoia.
Geriatr Gerontol Int. 2017 Nov 15. doi: 10.1111/ggi.13191. Duaso E, Formiga F, Marimón P, Sandiumenge M, Salgado MT, Murga V, Gamboa A, Rodriguez C, Castellà J, Escalante E, Lumbreras C, Tarrida A, Sellarès R. Más información
Effects of Cyclosporine, Tacrolimus, and Rapamycin on Osteoblasts.
Transplant Proc. 2017 Nov;49(9):2219-2224. doi: 10.1016/j.transproceed.2017.07.005. Martín-Fernández M, Rubert M, Montero M, de la Piedra C. Más información
Spanish consensus on treat to target for osteoporosis.
Osteoporos Int. 2017 Nov 24. doi: 10.1007/s00198-017-4310-y. Nogués X, Nolla JM, Casado E, Jódar E, Muñoz-Torres M, Quesada-Gómez JM,Canals L, Balcells M, Lizán L. Más información
Validation of fragility fractures in primary care electronic medical records: A population-based study.
Reumatol Clin. 2017 Nov 28. pii: S1699-258X(17)30272-3. doi: 10.1016/j.reuma.2017.10.013. Martinez-Laguna D, Soria-Castro A, Carbonell-Abella C, Orozco-López P, Estrada-Laza P, Nogues X, Díez-Perez A, Prieto-Alhambra D. Más información
Update on osteoporosis treatment.
Med Clin (Barc). 2017 Nov 24. pii: S0025-7753(17)30818-7. doi:10.1016/j.medcli.2017.10.019 Nogués X, Martinez-Laguna D. Más información
Advances in the evaluation of bone health in kidney transplant patients.
Nefrologia. 2017 Nov 11.pii: S0211-6995(17)30103-0. doi: 10.1016/j.nefro.2017.04.002 Pérez-Sáez MJ, Prieto-Alhambra D, Díez-Pérez A, Pascual J. Más información
The risk of eating disorders and bone health in young adults: the mediating role of body composition and fitness.
Eat Weight Disord. 2017 Nov 13. doi:10.1007/s40519-017-0458-x Garrido-Miguel M, Torres-Costoso A, Martínez-Andrés M, Notario-Pacheco B,Díez-Fernández A, Álvarez-Bueno C, García-Prieto JC, Martínez-Vizcaíno V. Más información
Fragility Fractures & Their Impact on Older People.
Best Pract Res Clin Rheumatol. 2017 Apr;31(2):169-191. doi:10.1016/j.berh.2017.10.001 Sànchez-Riera L, Wilson N. Más información
Epidemiology of Imperfect Osteogenesis: a Rare Disease in the Valencia Region
Rev Esp Salud Publica. 2017 Nov 28;91. pii: e201711045 Gimeno-Martos S, Pérez-Riera C, Guardiola-Vilarroig S, Cavero-Carbonell C. Más información
Correlation between mandibular bone density and skeletal bone density in a Catalonian postmenopausal population.
Oral Surg Oral Med Oral Pathol Oral Radiol. 2017 Nov 29. pii:S2212-4403(17)31106-9. doi: 10.1016/j.oooo.2017.10.003 Estrugo-Devesa A, Segura-Egea J, García-Vicente L, Schemel-Suárez M,Blanco-Carrrión Á, Jané-Salas E, López-López J. Más información
Effect of Sex Steroids on the Bone Health of Transgender Individuals: A Systematic Review and Meta-Analysis
The Journal of Clinical Endocrinology & Metabolism, Volume 102, Issue 11, 1 November 2017, Pages 3904–3913, https://doi.org/10.1210/jc.2017-01642 Naykky Singh-Ospina Spyridoula Maraka Rene Rodriguez-Gutierrez Caroline Davidge-Pitts Todd B Nippoldt Larry J Prokop Mohammad Hassan Murad Más información
Effect of a rare genetic variant of TM7SF4 gene on osteoclasts of patients with Paget’s disease of bone.
BMC Med Genet. 2017 Nov 16;18(1):133. doi: 10.1186/s12881-017-0495-3. Laurier E, Amiable N, Gagnon E, Brown JP, Michou L. Más información
Total Hip Bone Area Affects Fracture Prediction With FRAX® in Canadian White Women.
J Clin Endocrinol Metab. 2017 Nov 1;102(11):4242-4249. doi: 10.1210/jc.2017-01327. Leslie WD, Lix LM, Majumdar SR, Morin SN, Johansson H, Odén A, McCloskey EV, Kanis JA. Más información
The Effect of Intentional Weight Loss on Fracture Risk in Persons With Diabetes: Results From the Look AHEAD Randomized Clinical Trial.
J Bone Miner Res. 2017 Nov;32(11):2278-2287. doi: 10.1002/jbmr.3214 Johnson KC, Bray GA, Cheskin LJ, Clark JM, Egan CM, Foreyt JP, Garcia KR, Glasser S, Greenway FL, Gregg EW, Hazuda HP, Hergenroeder A, Hill JO, Horton ES, Jakicic JM, Jeffery RW, Kahn SE, Knowler WC, Lewis CE, Miller M, Montez MG, Nathan DM, Patricio JL, Peters…
Trabecular bone score (TBS): Method and applications.
Bone. 2017 Nov;104:66-72. doi: 10.1016/j.bone.2017.01.035. Martineau P, Leslie WD. Más información
24-hour profile of serum sclerostin and its association with bone biomarkers in men.
Osteoporos Int. 2017 Nov;28(11):3205-3213. doi: 10.1007/s00198-017-4162-5. Swanson C, Shea SA, Wolfe P, Markwardt S, Cain SW, Munch M, Czeisler CA, Orwoll ES, Buxton OM. Más información
Skeletal Dysplasias: What Every Bone Health Clinician Needs to Know.
Curr Osteoporos Rep. 2017 Oct;15(5):419-424. doi: 10.1007/s11914-017-0392-x. Nikkel SM. Más información
Osteoporosis treatment: recent developments and ongoing challenges.
Lancet Diabetes Endocrinol. 2017 Nov;5(11):898-907. doi: 10.1016/S2213-8587(17)30188-2 Khosla S, Hofbauer LC. Más información
Identification of a novel locus on chromosome 2q13, which predisposes to clinical vertebral fractures independently of bone density.
Ann Rheum Dis. 2017 Nov 23. pii: annrheumdis-2017-212469. doi: 10.1136/annrheumdis-2017-212469 Alonso N, Estrada K, Albagha OME, Herrera L, Reppe S, Olstad OK, Gautvik KM,Ryan NM, Evans KL, Nielson CM, Hsu YH, Kiel DP, Markozannes G, Ntzani EE, Evangelou E, Feenstra B, Liu X, Melbye M, Masi L, Brandi ML, Riches P, Daroszewska A, Olmos JM,…
8ºARC EN OSTEOPOROSIS 2018
www.arcosteoporosis.com Una vez más, un grupo de reconocidos expertos en osteoporosis presentarán las comunicaciones más relevantes de los principales congresos del año 2017 y aportarán todos sus conocimientos para responder a las preguntas planteadas por los asistentes. A través de esta web y de nuestra cuenta de Twitter (@arcosteoporosis) iremos actualizando todas las novedades de…
Analysis of the evolution of cortical and trabecular bone compartments in the proximal femur after spinal cord injury by 3D-DXA
Osteoporos Int. 2017 Oct 17. doi: 10.1007/s00198-017-4268-9 Gifre L, Humbert L, Muxi A, Del Rio L, Vidal J, Portell E, Monegal A, Guañabens N, Peris P Más información
Osteoarthritis: Chondroitin sulfate – CONCEPT clear, uncertainties unchanged
Nat Rev Rheumatol. 2017 Oct;13(10):576-577. doi:10.1038/nrrheum.2017.131 Herrero-Beaumont G, Largo R Más información
Concordance between direct and indirect measurements of free 25-OH vitamin D
Clin Chim Acta.2017 Oct 19;475:169-171. doi: 10.1016/j.cca.2017.10.016 Peris P, Filella X, Monegal A, Guañabens N, Foj L, Bonet M, Boquet D, Casado E, Cerdá D, Erra A, Gómez-Vaquero C, Martínez S, Montalá N Más información
Primary hyperparathyroidism
Med Clin (Barc). 2017 Oct 6. pii: S0025-7753(17)30647-4. doi: 10.1016/j.medcli.2017.07.020 Muñoz-Torres M, García-Martín A Más información
Effect of 2 years of endurance and high-impact training on preventing osteoporosis in postmenopausal women: randomized clinical trial
Menopause. 2017 Oct 16. doi: 10.1097/GME.0000000000001005 García-Gomáriz C, Blasco JM, Macián-Romero C, Guillem-Hernández E, Igual-Camacho C Más información
Impact of an osteoporosis specialized unit on bone health in breast cancer survivals treated with aromatase inhibitors
Reumatol Clin. 2017 Oct 11. pii: S1699-258X(17)30229-2. doi:10.1016/j.reuma.2017.08.005 Martínez P, Galve E, Arrazubi V, Sala MÁ, Fernández S, Pérez CE, Arango JF,Torre I Más información
Bone Mass Assessment in a Cohort of Adults With Down Syndrome: A Cross-Sectional Study
Intellect Dev Disabil. 2017 Oct;55(5):315-324. doi:10.1352/1934-9556-55.5.315 Costa R, De Miguel R, García C, de Asúa DR, Castañeda S, Moldenhauer F, Suárez C Más información
Analysis of SNP-SNP interactions and bone quantitative ultrasound parameter in early adulthood
BMC Med Genet. 2017 Oct 3;18(1):107. doi:10.1186/s12881-017-0468-6 Correa-Rodríguez M, Viatte S, Massey J, Schmidt-RioValle J, Rueda-Medina B,Orozco G Más información
Degradation of extracelular matrix regulates osteoblast migration: A microfluidic-based study
Bone. 2017 Oct 26. pii: S8756-3282(17)30391-5. doi: 10.1016/j.bone.2017.10.025 Movilla N, Borau C, Valero C, García-Aznar JM Más información
Lipid profile and bone mineral density in heavy alcoholics
Clin Nutr. 2017 Oct 16. pii: S0261-5614(17)31368-7. doi:10.1016/j.clnu.2017.10.008 Martín-González C, González-Reimers E, Quintero-Platt G, Cabrera-García P, Romero-Acevedo L, Gómez-Rodríguez MÁ, Rodríguez Gaspar M, Martínez-Martínez D,Santolaria-Fernández F Más información
Biomechanics, obesity, and osteoarthritis.The role of adipokines: when the levee breaks.
J Orthop Res. 2017 Oct 28. doi:10.1002/jor.23788 Francisco V, Pérez T, Pino J, López V, Franco E, Alonso A, Gonzalez-Gay MA,Mera A, Lago F, Gómez R, Gualillo O Más información
Bone mineral density in familial partial lipodystrophy
Clin Endocrinol (Oxf). 2017 Oct 27. doi: 10.1111/cen.13504 Fernández-Pombo A, Ossandon-Otero JA, Guillín-Amarelle C, Sánchez-Iglesias S, Castro AI, González-Méndez B, Rodríguez-García S, Rodriguez-Cañete L, Casanueva FF, Araújo-Vilar D Más información
PTH Reloaded: A New Evolutionary Perspective
Front Physiol. 2017 Oct 9;8:776. doi:10.3389/fphys.2017.00776. eCollection 2017 Review Suarez-Bregua P, Cal L, Cañestro C, Rotllant J Más información
Obesity status influences the relationship among serum osteocalcin, iron stores and insulin sensitivity
Clin Nutr. 2017 Oct 6. pii: S0261-5614(17)31361-4. doi:10.1016/j.clnu.2017.10.001 Xifra G, Moreno-Navarrete JM, Moreno M, Ricart W, Fernández-Real JM Más información
Parathyroid hormone inhibits Notch signaling in osteoblasts and osteocytes
Bone. 2017 Oct;103:159-167. doi: 10.1016/j.bone.2017.06.027 Parathyroid hormone (PTH) and Notch receptors regulate bone formation by governing the function of osteoblastic cells. To determine whether PTH interacts with Notch signaling as a way to control osteoblast function, we tested the effects of PTH on Notch activity in osteoblast- and osteocyte-enriched cultures. Induction of Notch signaling in…
Vertebral Fractures Following Discontinuation of Denosumab: a Post-hoc Analysis of the Randomized Placebo-controlled FREEDOM Trial and its Extension
J Bone Miner Res. 2017 Nov 4. doi: 10.1002/jbmr.3337 Denosumab reduces bone resorption and vertebral and nonvertebral fracture risk. Denosumab discontinuation increases BTMs 3 months after a scheduled dose is omitted, reaching above-baseline levels by 6 months, and decreases BMD to baseline levels by 12 months. We analyzed the risk of new or worsening vertebral…
Muscle functions and bone strength are impaired in adolescents with type 1 diabetes
Bone. 2018 Jan;106:22-27. doi: 10.1016/j.bone.2017.10.005 Sarcopenia and osteoporosis are among the late complications of type 1 diabetes (T1D) in adults. The aim of this study was to assess volumetric bone mineral density (BMD) and dynamic muscle function in adolescents with T1D and to assess the clinical and biochemical predictors of their musculoskeletal system. METHODS: Ninety-five…
Risk and associates of incident hip fracture in type 1 diabetes: The Fremantle Diabetes Study
Diabetes Res Clin Pract. 2017 Oct 18;134:153-160. doi:10.1016/j.diabres.2017.10.011 AIMS: To determine the relative risk of incident hip fracture in patients with type 1 diabetes and matched controls and to compare hip fracture rates in age- and sex-matched patients with type 1 versus type 2 diabetes. METHODS: Longitudinal observational study of 121 adults with type 1…
Genetic and epigenetic factors influencing vitamin D status
J Cell Physiol. 2017 Oct 14. doi: 10.1002/jcp.26216 The global prevalence of vitamin D deficiency appears to be increasing, and the impact of this on human health is important because of the association of vitamin D insufficiency with increased risk of osteoporosis, cardiovascular disease and some cancers. There are few studies on the genetic factors…
Concise Review: Musculoskeletal Stem Cells to Treat Age-Related Osteoporosis
Stem Cells Transl Med. 2017 Oct;6(10):1930-1939. doi: 10.1002/sctm.17-0054 Age-related (type-II) osteoporosis is a common and debilitating condition driven in part by the loss of bone marrow (BM) mesenchymal stromal cells (MSC) and their osteoblast progeny, leading to reduced bone formation. Current pharmacological regiments targeting age-related osteoporosis do not directly treat the disease by increasing bone…
Entrevista a Dr. Josep Blanch Rubio por TVE en el Día Mundial de la Osteroporosis
Entrevista que TVE hace al presidente SEIOMM el Día Mundial de la #osteoporosis Entrevista TVE
Effect of Surgery Versus Observation: Skeletal 5-Year Outcomes in a Randomized Trial of Patients With Primary HPT (the SIPH Study)
J Bone Miner Res. 2017 Sep;32(9):1907-1914. doi: 10.1002/jbmr.3177. Epub 2017 Jul 7. The objective was to study the effect of parathyroidectomy (PTX) compared with observation (OBS) on bone mineral density (BMD) in g/cm2 and T-scores and on biochemical markers of bone turnover (P1NP and CTX-1) in a prospective randomized controlled study of patients with mild…
Romosozumab or Alendronate for Fracture Prevention in Women with Osteoporosis
N Engl J Med. 2017 Sep 11. doi: 10.1056/NEJMoa1708322. [Epub ahead of print] We enrolled 4093 postmenopausal women with osteoporosis and a fragility fracture and randomly assigned them in a 1:1 ratio to receive monthly subcutaneous romosozumab (210 mg) or weekly oral alendronate (70 mg) in a blinded fashion for 12 months, followed by open-label…
Targeting cellular senescence prevents age-related bone loss in mice
Nat Med. 2017 Sep;23(9):1072-1079. doi: 10.1038/nm.4385. Epub 2017 Aug 21. Aging is associated with increased cellular senescence, which is hypothesized to drive the eventual development of multiple comorbidities. Here we investigate a role for senescent cells in age-related bone loss through multiple approaches. In particular, we used either genetic (i.e., the INK-ATTAC ‘suicide’ transgene encoding…
Discontinuation of Denosumab therapy for osteoporosis: A systematic review and position statement by ECTS
2017 Aug 5;105:11-17. doi: 10.1016/j.bone.2017.08.003. [Epub ahead of print] Review. CONCLUSION: There appears to be an increased risk of multiple vertebral fractures after discontinuation of denosumab although strong evidence for such an effect and for measures to prevent the occurring bone loss is lacking. Clinicians and patients should be aware of this potential risk. Based…
Discrepancy between bone density and bone material strength index in three siblings with Camurati-Engelmann disease
Osteoporos Int. 2017 Aug 25. doi: 10.1007/s00198-017-4198-6. Herrera S, Soriano R, Nogués X, Güerri-Fernandez R, Grinberg D, García-Giralt N, Martínez-Gil N, Castejón S, González-Lizarán A, Balcells S, Diez-Perez A. Más información
Non-synonymous WNT16 polymorphisms alleles are associated with different osteoarthritis phenotypes
Rheumatol Int. 2017 Aug 1. doi: 10.1007/s00296-017-3783-5. García-Ibarbia C, Neila S, Garcés C, Alonso MA, Zarrabeitia MT, Valero C, Ortiz F, Riancho JA. Más información
Expression profiling of microRNAs in human bone tissue from postmenopausal women
Hum Cell. 2017 Sep 20. doi: 10.1007/s13577-017-0181-y. De-Ugarte L, Serra-Vinardell J, Nonell L, Balcells S, Arnal M, Nogues X, Mellibovsky L, Grinberg D, Diez-Perez A, Garcia-Giralt N Más información
Sclerostin: an Emerging Target for the Treatment of Cancer-Induced Bone Disease
Curr Osteoporos Rep. 2017 Sep 27. doi: 10.1007/s11914-017-0403-y. McDonald MM, Delgado-Calle J Más información
Comparison of total, free and bioavailable 25-OH vitamin D determinations to evaluate its biological activity in healthy adults: the LabOscat study
Osteoporos Int. 2017 Aug;28(8):2457-2464. doi: 10.1007/s00198-017-4062-8. Peris P, Filella X, Monegal A, Guañabens N( Foj L, Bonet M,Boquet D, Casado E, Cerdá D, Erra A, Gómez-Vaquero C, Martínez S, Montalá N, Pittarch C, Kanterewicz E, Sala M, Suris X, Carrasco JL; LabOscat Study Group. Collaborators: Larrosa M, Nolla JM, Roig-Vilaseca D. Más información
Secular trends of use of anti-osteoporotic treatments in Spain: A population-based cohort study including over 1.5million people and more tan 12years of follow-up
2017 Sep 8;105:292-298. doi: 10.1016/j.bone.2017.08.031. Martín-Merino E, Huerta-Álvarez C, Prieto-Alhambra D, Álvarez-Gutiérrez A, Montero-Corominas D. Más información
Is osteocyte Klotho bad for bone health?
Kidney Int. 2017 Sep;92(3):540-543. doi: 10.1016/j.kint.2017.04.012. Moysés RMA, Dusso A. Más información
Bone mineral density and vitamin D status in systemic lupus erythematosus (SLE): A systematic review
Autoimmun Rev. 2017 Sep 9. pii: S1568-9972(17)30235-5doi:10.1016/j.autrev.2017.09.011. Salman-Monte TC, Torrente-Segarra V, Vega-Vidal AL, Corzo P,Castro-Dominguez F, Ojeda F, Carbonell-Abelló J Más información
The effect of 12-month participation in osteogenic and non-osteogenic sports on bone development in adolescent male athletes. The PRO-BONE study
J Sci Med Sport. 2017 Sep 1. pii: S1440-2440(17)31023-X. doi:10.1016/j.jsams.2017.08.018. Vlachopoulos D, Barker AR, Ubago-Guisado E, Ortega FB, Krustrup P,Metcalf B, Castro Pinero J, Ruiz JR Knapp KM, Williams CA, Moreno LA, Gracia-Marco L. Más información
Exposed necrotic bone in 183 patients with bisphosphonate-related osteonecrosis of the jaw: Associated clinical characteristics
Med Oral Patol Oral Cir Bucal. 2017 Sep 1;22(5):e582-e585. doi:10.4317/medoral.22133. Bagan L, Jiménez Y, Leopoldo M, Murillo-Cortes J, Bagan J. Más información
Primary and secondary non-adherence to osteoporotic medications after hip fracture in Spain. The PREV2FO population-based retrospective cohort study
Sci Rep. 2017 Sep 18;7(1):11784. doi: 10.1038/s41598-017-10899-6. García-Sempere A, Hurtado I, Sanfélix-Genovés J,Rodríguez-Bernal CL, Gil Orozco R, Peiró S, Sanfélix-Gimeno G. Más información
Epidemiology of osteoporotic fractures in Andalusia, Spain, from 2000-2010
Med Clin (Barc). 2017 . pii: S0025-7753(17)30628-0. doi:10.1016/j.medcli.2017.06.070 Aguilar Del Rey FJ, Pérez González O. Más información
El 20 de octubre se celebra el Día Mundial de la Osteoporosis
El 20% de las personas con fractura de cadera fallece al cabo de un año
- De las personas que no fallecen, el 40 por ciento tiene problemas para caminar por sí mismas y el 59 por ciento todavía requiere de ayuda pasado un año
- Una de cada seis mujeres y uno de cada diez hombres mayores de 70 años sufrirá una fractura osteoporótica
- El tratamiento de la osteoporosis reduce entre un 50 y un 70 por ciento el riesgo de fractura
- Más información y vídeo de la campaña en http://www.amgen.es/osteoporosis/
SEVILLA_ 2º Curso de Osteoporosis y otras Enfermedades Metabólicas Óseas para Médicos Residente_SEIOMM
2º Curso de Osteoporosis y otras Enfermedades Metabólicas Óseas para Médicos Residentes en SEVILLA organizado por la SEIOMM/FEIOMM DESCARGA AQUÍ EL PROGRAMA
Sesión científica. SEIOMM-SERPE
www.seiommalexionlive.com Miércoles 25 de octubre de 2017 17:00-18:15 SESIÓN CIENTÍFICA. SEIOMM-SERPE: ENFERMEDADES METABÓLICAS ÓSEAS RARAS EN NIÑOS Y ADULTOS Moderadores: Roger Bouillon, Esmeralda Núñez Cuadros Diagnóstico y tratamiento del hipoparatiroidismo. Claudio Marcocci Nuevas…
PROGRAMA_ASBMR 2017: Best Topics
PROGRAMA ASBMR 2017: Best Topics La FEIOMM, con el patrocinio de Lilly, organiza una actividad científica previa al XXII Congreso de la SEIOMM 2017, en la ciudad de Elche, a la cual estás invitado.
Expression profiling of microRNAs in human bone tissue from postmenopausal women
Hum Cell. 2017 Sep 20. doi: 10.1007/s13577-017-0181-y De-Ugarte L, Serra-Vinardell J, Nonell L, Balcells S, Arnal M, Nogues X, Mellibovsky L, Grinberg D, Diez-Perez A, Garcia-Giralt N Más información
Sclerostin: an Emerging Target for the Treatment of Cancer-Induced Bone Disease
Curr Osteoporos Rep. 2017 Sep 27. doi: 10.1007/s11914-017-0403-y McDonald MM, Delgado-Calle J Más información
Comparison of total, free and bioavailable 25-OH vitamin D determinations to evaluate its biological activity in healthy adults: the LabOscat study
Osteoporos Int. 2017 Aug;28(8):2457-2464. doi: 10.1007/s00198-017-4062-8 Peris P, Filella X, Monegal A, Guañabens N( Foj L, Bonet M,Boquet D, Casado E, Cerdá D, Erra A, Gómez-Vaquero C, Martínez S, Montalá N, Pittarch C, Kanterewicz E, Sala M, Suris X, Carrasco JL; LabOscat Study Group. Collaborators: Larrosa M, Nolla JM, Roig-Vilaseca D. Más Información
Is osteocyte Klotho bad for bone health?
Kidney Int. 2017 Sep;92(3):540-543. doi: 10.1016/j.kint.2017.04.012 Moysés RMA, Dusso A. Más información
Bone mineral density and vitamin D status in systemic lupus erythematosus (SLE): A systematic review
Autoimmun Rev. 2017 Sep 9. pii: S1568-9972(17)30235-5doi:10.1016/j.autrev.2017.09.011. Salman-Monte TC, Torrente-Segarra V, Vega-Vidal AL, Corzo P,Castro-Dominguez F, Ojeda F, Carbonell-Abelló J Más información
The effect of 12-month participation in osteogenic and non-osteogenic sports on bone development in adolescent male athletes. The PRO-BONE study
J Sci Med Sport. 2017 Sep 1. pii: S1440-2440(17)31023-X. doi:10.1016/j.jsams.2017.08.018. Vlachopoulos D, Barker AR, Ubago-Guisado E, Ortega FB, Krustrup P,Metcalf B, Castro Pinero J, Ruiz JR Knapp KM, Williams CA, Moreno LA, Gracia-Marco L. Más información
Exposed necrotic bone in 183 patients with bisphosphonate-related osteonecrosis of the jaw: Associated clinical characteristics
Med Oral Patol Oral Cir Bucal. 2017 Sep 1;22(5):e582-e585. doi:10.4317/medoral.22133. Bagan L, Jiménez Y, Leopoldo M, Murillo-Cortes J, Bagan J. Más información
Primary and secondary non-adherence to osteoporotic medications after hip fracture in Spain. The PREV2FO population-based retrospective cohort study
Sci Rep. 2017 Sep 18;7(1):11784. doi: 10.1038/s41598-017-10899-6. García-Sempere A, Hurtado I, Sanfélix-Genovés J,Rodríguez-Bernal CL, Gil Orozco R, Peiró S, Sanfélix-Gimeno G. Más información
Epidemiology of osteoporotic fractures in Andalusia, Spain, from 2000-2010
Med Clin (Barc). 2017 . pii: S0025-7753(17)30628-0. doi:10.1016/j.medcli.2017.06.070 Aguilar Del Rey FJ, Pérez González O. Más información
Effect of Surgery Versus Observation: Skeletal 5-Year Outcomes in a Randomized Trial of Patients With Primary HPT (the SIPH Study)
J Bone Miner Res. 2017 Sep;32(9):1907-1914. doi: 10.1002/jbmr.3177. Epub 2017 Jul 7. The objective was to study the effect of parathyroidectomy (PTX) compared with observation (OBS) on bone mineral density (BMD) in g/cm2 and T-scores and on biochemical markers of bone turnover (P1NP and CTX-1) in a prospective randomized controlled study of patients with mild…
Romosozumab or Alendronate for Fracture Prevention in Women with Osteoporosis
N Engl J Med. 2017 Sep 11. doi: 10.1056/NEJMoa1708322. [Epub ahead of print] We enrolled 4093 postmenopausal women with osteoporosis and a fragility fracture and randomly assigned them in a 1:1 ratio to receive monthly subcutaneous romosozumab (210 mg) or weekly oral alendronate (70 mg) in a blinded fashion for 12 months, followed by open-label…
CONVOCATORIA BECAS FEIOMM INVESTIGACIÓN 2017
La Fundación Española de Investigación Ósea y del Metabolismo Mineral (FEIOMM), convoca 6 BECAS de 6.000€ cada una para promocionar la investigación básica, clínica y traslacional en el campo del metabolismo mineral y óseo.
REQUISITOS:
CONVOCATORIA 11 BECAS FEIOMM INSCRIPCIÓN al XXII Congreso SEIOMM 2017_Elche
La Fundación Española de Investigación Ósea y del Metabolismo Mineral (FEIOMM) convoca 11 BECAS como ayuda a jóvenes investigadores para la asistencia al XXII CONGRESO NACIONAL SEIOMM que se celebrará en Elche del 25 al 27 de octubre de 2017.
Romosozumab (sclerostin monoclonal antibody) versus teriparatide in postmenopausal women with osteoporosis transitioning from oral bisphosphonate therapy: a randomised, open-label, phase 3 trial.
Lancet. 2017 Jul 26. doi: 10.1016/S0140-6736(17)31613-6. Más información Langdahl BL, Libanati C, Crittenden DB, Bolognese MA, Brown JP, Daizadeh NS,Dokoupilova E, Engelke K, Finkelstein JS, Genant HK, Goemaere S, Hyldstrup L, Jodar-Gimeno E, Keaveny TM, Kendler D, Lakatos P, Maddox J, Malouf J, Massari FE,Molina JF, Ulla MR, Grauer A.
10 years of denosumab treatment in postmenopausal women with osteoporosis:results from the phase 3 randomised FREEDOM trial and open-label extension
Lancet Diabetes Endocrinol. 2017 Jul;5(7):513-523. doi:10.1016/S2213-8587(17)30138-9. Epub 2017 May 22 Más información Bone HG, Wagman RB, Brandi ML, Brown JP, Chapurlat R, Cummings SR, Czerwiński E, Fahrleitner-Pammer A, Kendler DL, Lippuner K, Reginster JY, Roux C, Malouf J, Bradley MN, Daizadeh NS, Wang A, Dakin P, Pannacciulli N, Dempster DW, Papapoulos S.
European Society for Clinical and Economic Aspects of Osteoporosis, Osteoarthritis and Musculoskeletal Diseases (ESCEO). Identification and management of patients at increased risk of osteoporotic fracture: outcomes of an ESCEO expert consensus meeting
Osteoporos Int. 2017 Jul;28(7):2023-2034. doi: 10.1007/s00198-017-4009-0. Epub 2017 Apr 27 Más información Kanis JA, Cooper C, Rizzoli R, Abrahamsen B, Al-Daghri NM, Brandi ML,Cannata-Andia J, Cortet B, Dimai HP, Ferrari S, Hadji P, Harvey NC, Kraenzlin M, Kurth A, McCloskey E, Minisola S, Thomas T, Reginster JY
Identification of hypophosphatasia in a clinical setting: Clinical manifestations and diagnostic recommendations in adult patients.
Med Clin (Barc). 2017 Jul 26. pii:S0025-7753(17)30527-4. doi: 10.1016/j.medcli.2017.06.040 Más información Guañabens N, Blanch J, Martínez-Díaz-Guerra G, Muñoz Torres M.
One and two-year persistence with different anti-osteoporosis medications: a retrospective cohort study.
Osteoporos Int. 2017 Jul 16. doi:10.1007/s00198-017-4144-7. Más información Reyes C, Tebe C, Martinez-Laguna D, Ali MS, Soria-Castro A, Carbonell C, Prieto-Alhambra D.
Unexpected Bone Formation Produced by RANKL Blockade
Trends Endocrinol Metab. 2017 Jul 19. pii: S1043-2760(17)30086-3. doi:10.1016/j.tem.2017.06.003 Más información Portal-Núñez S, Mediero A, Esbrit P, Sánchez-Pernaute O, Largo R, Herrero-Beaumont G
Assessment of Bone Health in Patients With Type 1 Gaucher Disease Using Impact Microindentation.
J Bone Miner Res. 2017 Jul;32(7):1575-1581. doi: 10.1002/jbmr.3121. Epub 2017 May 11. Más información Herrera S, Pérez-López J, Moltó-Abad M, Güerri-Fernández R, Cabezudo E,Novelli S, Esteve J, Hernández A, Roig I, Solanich X, Prieto-Alhambra D, Nogués X, Díez-Pérez A.
Excess of all-cause mortality after a fracture in type 2 diabetic patients: a population-based cohort study.
Osteoporos Int. 2017 Jul 25. doi: 10.1007/s00198-017-4096-y. Más información Martinez-Laguna D, Nogues X, Abrahamsen B, Reyes C, Carbonell-Abella C, Diez-Perez A, Prieto-Alhambra D.
Do 6 months of whole-body vibration training improve lean mass and bone mass acquisition of adolescent swimmers?
Arch Osteoporos. 2017 Dec;12(1):69. doi: 10.1007/s11657-017-0362-z Más información Gómez-Bruton A, González-Agüero A, Matute-Llorente A, Julián C, Lozano-Berges G, Gómez-Cabello A, Casajús JA, Vicente-Rodríguez G
Hypophosphatasia: Clinical manifestations, diagnostic recommendations and therapeutic options.
An Pediatr (Barc). 2017 Jul 15. pii: S1695-4033(17)30223-0. doi: 10.1016/j.anpedi.2017.06.004 Más información Martos-Moreno GA, Calzada J, Couce ML, Argente J.
New insights into human farnesyl pyrophosphate synthase inhibition by second-generation bisphosphonate drugs.
J Comput Aided Mol Des. 2017 Jul;31(7):675-688. doi: 10.1007/s10822-017-0034-5. Epub 2017 Jun 19. Más información Fernández D, Ramis R, Ortega-Castro J, Casasnovas R, Vilanova B, Frau J
Regenerating Bone via Multifunctional Coatings: The Blending of Cell Integration and Bacterial Inhibition Properties on the Surface of Biomaterials.
ACS Appl Mater Interfaces. 2017 Jul 5;9(26):21618-21630. doi: 10.1021/acsami.7b03127 Más información Hoyos-Nogués M, Velasco F, Ginebra MP, Manero JM, Gil FJ, Mas-Moruno C
Comparison of the osteogenic, adipogenic, chondrogenic and cementogenic differentiation potential of periodontal ligament cells cultured on different biomaterials.
Mater Sci Eng C Mater Biol Appl. 2017 Jul 1;76:1075-1084.doi: 10.1016/j.msec.2017.03.213. Epub 2017 Mar 24 Más información Barrera-Ortega CC, Hoz-Rodríguez L, Arzate H, Fonseca-García A, Pérez-Alvarez J, Rodil SE.
Tibiotalocalcaneal fusion with a cemented coated retrograde nail as a salvage procedure for infected ORIF of the ankle.
Rev Esp Cir Ortop Traumatol. 2017 Jul 3. pii: S1888-4415(17)30068-1. doi: 10.1016/j.recot.2017.04.004. Más información Herrera-Pérez M, Boluda-Mengod J, Gutierrez-Morales MJ, Pais-Brito JL.
Do topical applications of bisphosphonates improve bone formation in oral implantology? A systematic review.
Med Oral Patol Oral Cir Bucal. 2017 Jul 1;22(4):e512-e519 Más información Lozano-Carrascal N, Salomó-Coll O, Hernández-Alfaro F, Gehrke SA, Gargallo-Albiol J, Calvo-Guirado JL.
Biodegradable PCL/fibroin/hydroxyapatite porous scaffolds prepared by supercritical foaming for bone regeneration.
Int J Pharm. 2017 Jul 15;527(1-2):115-125. doi: 10.1016/j.ijpharm.2017.05.038 Más información Diaz-Gomez L, García-González CA, Wang J, Yang F, Aznar-Cervantes S, Cenis JL,Reyes R, Delgado A, Évora C, Concheiro A, Alvarez-Lorenzo C
Bone Density, Microarchitecture, and Tissue Quality After Long-Term Treatment With Tenofovir/Emtricitabine or Abacavir/Lamivudine.
J Acquir Immune Defic Syndr. 2017 Jul 1;75(3):322-327. doi: 10.1097/QAI.0000000000001396 Más información Güerri-Fernández R, Molina-Morant D, Villar-García J, Herrera S, González-Mena A, Guelar A, Trenchs-Rodríguez M, Díez-Pérez A, Knobel
Effects of growth hormone treatment on growth late, bone, and mineral metabolism of young rats with uremia induced by adenine
Pediatr Res. 2017 Jul;82(1):148-154. doi: 10.1038/pr.2017.95. Más información Claramunt D, Gil-Peña H, Fuente R, García-López E, Hernández Frías O, Ordoñez FA, Rodríguez-Suárez J, Santos F.
Discrepancy between bone density and bone material strength index in three siblings with Camurati-Engelmann disease
Osteoporos Int. 2017 Aug 25. doi: 10.1007/s00198-017-4198-6 Herrera S, Soriano R, Nogués X, Güerri-Fernandez R, Grinberg D, García-Giralt N, Martínez-Gil N, Castejón S, González-Lizarán A, Balcells S, Diez-Perez Más información
Non-synonymous WNT16 polymorphisms alleles are associated with different osteoarthritis phenotypes
Rheumatol Int. 2017 Aug 1. doi: 10.1007/s00296-017-3783-5 García-Ibarbia C, Neila S, Garcés C, Alonso MA, Zarrabeitia MT, Valero C, Ortiz F, Riancho JA. Más información
Targeting cellular senescence prevents age-related bone loss in mice
Nat Med. 2017 Sep;23(9):1072-1079. doi: 10.1038/nm.4385. Epub 2017 Aug 21. Aging is associated with increased cellular senescence, which is hypothesized to drive the eventual development of multiple comorbidities. Here we investigate a role for senescent cells in age-related bone loss through multiple approaches. In particular, we used either genetic (i.e., the INK-ATTAC ‘suicide’ transgene encoding…
Discontinuation of Denosumab therapy for osteoporosis: A systematic review and position statement by ECTS
2017 Aug 5;105:11-17. doi: 10.1016/j.bone.2017.08.003. [Epub ahead of print] Review. CONCLUSION: There appears to be an increased risk of multiple vertebral fractures after discontinuation of denosumab although strong evidence for such an effect and for measures to prevent the occurring bone loss is lacking. Clinicians and patients should be aware of this potential risk. Based…
The Effect of Abaloparatide-SC on Fracture Risk Is Independent of Baseline FRAX Fracture Probability: A Post Hoc Analysis of the ACTIVE Study.
Daily subcutaneous (SC) injections of the investigational drug abaloparatide-SC (80 mcg) for 18 months significantly decrease the risk of vertebral and nonvertebral fracture compared with placebo in postmenopausal women. We examined the efficacy of abaloparatide-SC as a function of baseline fracture risk, assessed using the FRAX tool. A total of 821 women randomized to placebo…
Treatment of Low Bone Density or Osteoporosis to Prevent Fractures in Men and Women: A Clinical Practice Guideline Update From the American College of Physicians.
This guideline updates the 2008 American College of Physicians (ACP) recommendations on treatment of low bone density and osteoporosis to prevent fractures in men and women. This guideline is endorsed by the American Academy of Family Physicians. The ACP Clinical Guidelines Committee based these recommendations on a systematic review of randomized controlled trials; systematic reviews;…
Osteoporosis Treatment Efficacy for Men: A Systematic Review and Meta-Analysis.
Randomized clinical trials that evaluated the efficacy of a treatment for osteoporosis or low bone mineral density for adult men and reported fracture outcomes. Twenty-four articles reporting results for 22 studies (including 4,868 male participants) met strict inclusion criteria. Fixed-effects meta-analyses using the Mantel-Haenszel method demonstrated significantly lower risk of vertebral fractures with alendronate (relative…
Long-Term Randomized Trial of Intensive Versus Symptomatic Management in Paget’s Disease of Bone: The PRISM-EZ Study.
It has been suggested that normalization of bone turnover may improve clinical outcome in Paget’s disease of bone (PDB) by preventing complications such as fractures and the development of osteoarthritis. Here we investigated the long-term effects of a treatment strategy that aimed to normalize bone turnover in PDB with that of symptomatic treatment. The study…
Imminent fracture risk.
The clinical significance of osteoporosis is in the occurrence of fractures and re-fractures. The main risk factor of sustaining a fracture is a previous one, but a recent fracture is a better fracture risk factor than fracture history. The role of the recency of fracture has been shown for both vertebral and non-vertebral fracture risk….
Effect of recent spinal cord injury on the OPG/RANKL system and its relationship with bone loss and the response to denosumab therapy
Osteoporos Int. 2017 Jun 4. doi: 10.1007/s00198-017-4090-4 Más información Gifre L, Ruiz-Gaspà S, Carrasco JL, Portell E, Vidal J, Muxi A, Monegal A,Guañabens N, Peris P
Numerical Modelling of Femur Fracture and Experimental Validation Using Bone Simulant
Ann Biomed Eng. 2017 Jun 20. doi: 10.1007/s10439-017-1877-6 Más información Marco M, Giner E, Larraínzar-Garijo R, Caeiro JR, Miguélez MH
Correction of 25-OH-vitamin D deficiency improves control of secondary hyperparathyroidism and reduces the inflammation in stable haemodialysis patients.
2017 Jun 30. pii: S0211-6995(17)30131-5. doi: .1016/j.nefro.2017.05.008. Más información Nogués X, Prieto-Alhambra D, Güerri-Fernández R, Garcia-Giralt N, Rodriguez-Morera J, Cos L, Mellibovsky L, Pérez AD.
Normative data for quantitative calcaneal ultrasound in Young males and females
Am J Hum Biol. 2017 Jun 27. doi: 10.1002/ajhb.23030 Más información Correa-Rodríguez M, González-Jiménez E, García PA, Rueda-Medina B,Schmidt-RioValle J
Tofacitinib restores the inhibition of reverse cholesterol transport induced by inflammation: understanding the lipid paradox associated with rheumatoid arthritis
Br J Pharmacol. 2017 Jun 23. doi:10.1111/bph.13932 Más información Pérez-Baos S, Barrasa JI, Gratal P, Larrañaga-Vera A, Prieto-Potin I,Herrero-Beaumont G, Largo R
Insulin use and Excess Fracture Risk in Patients with Type 2 Diabetes: A Propensity-Matched cohort analysis
Sci Rep. 2017 Jun 19;7(1):3781. doi: 10.1038/s41598-017-03748-z Más información Losada-Grande E, Hawley S, Soldevila B, Martinez-Laguna D, Nogues X, Diez-Perez A, Puig-Domingo M, Mauricio D, Prieto-Alhambra D
Prevalence of osteoporosis, estimation of probability of fracture and bone metabolism study in patients with newly diagnosed prostate cancer in the health area of Lugo.
Aten Primaria. 2017 Jun 16. pii: S0212-6567(16)30272-4. doi:10.1016/j.aprim.2017.03.006 Más información Miguel-Carrera J, García-Porrua C, de Toro Santos FJ, Picallo-Sánchez
Dietary antioxidant quality score (DAQs) is associated with bone mass assessed by calcaneal quantitative ultrasound in young women
Nutr Hosp. 2017 Jun 5;34(3):613-618. doi:10.20960/nh.468 Más información Correa Rodríguez M, Schmidt-RioValle J, Rueda-Medina B
Mechanical characterization via nanoindentation of the woven bone developed during bone transport
J Mech Behav Biomed Mater. 2017 Jun 1;74:236-244. doi:10.1016/j.jmbbm.2017.05.031 Más información Mora-Macías J, Pajares A, Miranda P, Domínguez J, Reina-Romo E
Osteogenic potential of platelet-rich plasma in dental stem-cell cultures
Br J Oral Maxillofac Surg. 2017 Jun 13. pii: S0266-4356(17)30157-2. doi: 10.1016/j.bjoms.2017.05.005 Más información Otero L, Carrillo N, Calvo-Guirado JL, Villamil J, Delgado-Ruíz RA
Madrid Cohort of HIV-Infected Children and Adolescents Integrated in the Pediatric Branch of the Spanish National AIDS Research Network (CoRISpe). Low Bone Mineral Density in Vertically HIV-infected Children and Adolescents: Risk Factors and the Role of T-cell Activation and Senescence
Pediatr Infect Dis J. 2017 Jun;36(6):578-583 Más información Jiménez B, Sainz T, Díaz L, Mellado MJ, Navarro ML, Rojo P, González-Tomé MI, Prieto L, Martínez J, de José MI, Ramos JT, Muñoz-Fernandez MÁ
The value of hypercalciuria in patients with osteopenia versus osteoporosis
Urolithiasis.2017 Jun;45(3):279-283. doi: 10.1007/s00240-016-0909-2 Más información Girón-Prieto MS, Del Carmen Cano-García M, Poyatos-Andújar A, Arias-Santiago S, de Haro-Muñoz T, Arrabal-Martín M, Arrabal-Polo MÁ
Bone Density,Microarchitecture, and Tissue Quality Long-term After Kidney Transplant
Transplantation. 2017 Jun;101(6):1290-1294. doi: 10.1097/TP.0000000000001328 Más información Pérez-Sáez MJ, Herrera S, Prieto-Alhambra D, Nogués X, Vera M, Redondo-Pachón D, Mir M, Güerri R, Crespo M, Díez-Pérez A, Pascual J
Cortical and Trabecular Bone Analysis of Patients With High Bone Mass From the Barcelona Osteoporosis Cohort Using 3-Dimensional Dual-Energy X-ray Absorptiometry: A Case-Control Study
J Clin Densitom. 2017 Jun 22. pii:S1094-6950(17)30065-3. doi: 10.1016/j.jocd.2017.05.012 Más información Orduna G, Humbert L, Fonolla R, Romera J, Cos ML, Rial A, Nogués X, Diez-Perez A, Mellibovsky L
Fracture during oral bisphosphonate therapy is associated with deteriorated bone material strength index.
2017 Jun 24;103:64-69. doi: 10.1016/j.bone.2017.06.018 Más información Nogués X, Prieto-Alhambra D, Güerri-Fernández R, Garcia-Giralt N, Rodriguez-Morera J, Cos L, Mellibovsky L, Pérez AD.
ACTA RESOLUCIÓN CONVOCATORIA BECAS FEIOMM ASBMR 2017
Finalizado el plazo para el envío de solicitudes para acceder a las Becas FEIOMM ASBMR 2017 para la presentación de trabajos de investigación en el Congreso de la ASBMR 2017 en Denver, se adjunta la lista de solicitudes remitidas para su evaluación. Descarga Documentación
GGPS1 Mutation and Atypical Femoral Fractures with Bisphosphonates
N Engl J Med. 2017 May 4;376(18):1794-1795. doi: 10.1056/NEJMc1612804 Más información Roca-Ayats N, Balcells S, Garcia-Giralt N, Falcó-Mascaró M, Martínez-Gil N, Abril JF, Urreizti R, Dopazo J, Quesada-Gómez JM, Nogués X, Mellibovsky L, Prieto-Alhambra D, Dunford JE, Javaid MK, Russell RG, Grinberg D, Díez-Pérez A.
Pain, quality of life and safety outcomes of kyphoplasty for vertebral compression fractures: report of a task force of the American Society for Bone and Mineral Research
The relative efficacy and harms of balloon kyphoplasty (BK) for treating vertebral compression fractures (VCF) are uncertain. The clinical importance of the greater improvements with BK versus NSM is unclear, may be due to placebo effect, and may not counterbalance short-term AE risks. Outcomes appeared similar between BK and other surgical interventions.Well-conducted randomized trials comparing…
New Insights Into the Local and Systemic Functions of Sclerostin: Regulation of Quiescent Bone Lining Cells and Beige Adipogenesis in Peripheral Fat Depots
J Bone Miner Res. 2017 May;32(5):889-891. doi: 10.1002/jbmr.3141. Epub 2017 Apr 6. Más información Delgado-Calle J, Bellido T.
Anti-senescence and Anti-inflammatory Effects of the C-terminal Moiety of PTHrP Peptides in OA Osteoblasts.
Osteoarthritis (OA) is characterized by degenerative changes in the whole joint leading to physical disability in the elderly population. This condition is associated with altered bone metabolism in subchondral areas suggesting that therapeutic strategies aimed at modifying bone cell metabolism may be of interest. The three PTHrP peptides favored osteoblastic function although the C-terminal domain…
Responses to Treatment With Teriparatide in Patients With Atypical Femur Fractures Previously Treated With Bisphosphonates
If oversuppression of bone turnover explained the association between bisphosphonate use and atypical subtrochanteric femur fractures (AFF), this could be reversed with anabolic treatment such as teriparatide. They conducted a prospective, open-label study in patients previously treated with bisphosphonates who sustained AFF, examining the response to 24-month treatment with teriparatide on bone mineral density (BMD),…
Bone disease in diabetes: another manifestation of microvascular disease?
Type 1 and type 2 diabetes are generally accepted to be associated with increased bone fracture risk. However, the pathophysiological mechanisms of diabetic bone disease are poorly understood, and whether the associated increased skeletal fragility is a comorbidity or a complication of diabetes remains under debate. Although there is some indication of a direct deleterious…
Bone Loss After Denosumab: Only Partial Protection with Zoledronate
A case series of six women with postmenopausal osteoporosis who had received continuous denosumab for 7 years and were then given a single infusion of zoledronate (5 mg) is reported. During denosumab treatment, bone mineral density (BMD) in the spine increased 18.5% (P = 0.006), and total hip BMD by 6.9% (P = 0.03). Post-zoledronate BMDs were measured 18-23 months after treatment,…
Evaluation of the Dietary Intake of Cadmium, Lead and Mercury and Its Relationship with Bone Health among Postmenopausal Women in Spain.
Few studies have investigated the extent to which dietary heavy metals are associated with low bone mineral density. They did not find associations between bone health and the dietary intake of three heavy metals in postmenopausal women. Dietary intake of the measured heavy metals were within the recommended values. Int J Environ Res Public Health….
Mind the (treatment) gap: a global perspective on current and future strategies for prevention of fragility fractures
This narrative review considers the key challenges facing healthcare professionals and policymakers responsible for providing care to populations in relation to bone health. These challenges broadly fall into four distinct themes: (1) case finding and management of individuals at high risk of fracture, (2) public awareness of osteoporosis and fragility fractures, (3) reimbursement and health…
Bone health in Down syndrome
Patients with Down syndrome have a number of risk factors that theoretically could predispose them to osteoporosis. In addition, the bone mass of these people may be affected by their anthropometric and body composition peculiarities. In general terms, studies in adults with Down syndrome reported that these people have lower areal bone mineral density (g/cm(2))…
Extracellular calcium promotes bone formation from bone marrow mesenchymal stem cells by amplifying the effects of BMP-2 on SMAD signalling.
Understanding the molecular events that regulate osteoblast differentiation is essential for the development of effective approaches to bone regeneration. In this study, they analysed the osteoinductive properties of extracellular calcium in bone marrow-derived mesenchymal stem cell (BM-MSC) differentiation. Data suggest that Ca2+ and BMP-2 cooperate and promote an autocrine/paracrine osteogenic feed-forward loop. On the whole,…
Bone density, microarchitecture, and material strength in chronic kidney disease patients at the time of kidney transplantation.
Bone health is assessed by bone mineral density (BMD). Other techniques such as trabecular bone score and microindentation could improve the risk of fracture’s estimation. Our chronic kidney disease (CKD) patients presented worse bone health (density, microarchitecture, mechanical properties) than controls. More than BMD should be done to evaluate patients at risk of fracture. CONCLUSIONS:…
Association of physical fitness, body composition, cardiometabolic markers and adherence to the Mediterranean diet with bone mineral density in perimenopausal women. The FLAMENCO project.
This study aimed to analyse the association of different components of physical fitness, body composition, cardiometabolic markers and the Mediterranean diet with bone mineral density (BMD) in perimenopausal women, and to test which of these components are independently associated with BMD. The sample comprised 197 perimenopausal women (52.6 ± 4.5 years). Sports Sci. 2017 May;35(9):880-887. doi: 10.1080/02640414.2016.1196825. Más…
Executive summary of the consensus document on osteoporosis in HIV-infected individuals.
Osteoporosis has become an emerging comorbid condition in people living with HIV (PLWH). The increase in survival and the progressive aging of PLWH will make this complication more frequent in the near future. In addition to the traditional risk factors affecting the general population, factors directly or indirectly associated with HIV infection, including antiretroviral therapy,…
BRCA1 haploinsufficiency cell-autonomously activates RANKL expression and generates denosumab-responsive breast cancer-initiating cells.
Denosumab, a monoclonal antibody to the receptor activator of nuclear factor-κB ligand (RANKL), might be a novel preventative therapy for BRCA1-mutation carriers at high risk of developing breast cancer. They propose that breast epithelium-specific mono-allelic inactivation of BRCA1 might suffice to cell-autonomously generate RANKL-addicted, denosumab-responsive CSC-like states. The convergent addiction to a hyperactive RANKL/RANK axis…
Servier dejará de comercializar Protelos en el mes de septiembre
Protelos (ranelato de estroncio), medicamento autorizado por la Comisión Europea en 2004 y comercializado por Laboratorios Servier, tanto en España como en el resto de Europa, se dejará de distribuir a partir del 31 de agosto 2017. Este fármaco está actualmente indicado para el tratamiento de la osteoporosis severa en mujeres posmenopáusicas y en hombres…
Effect of age and gender on serum periostin: Relationship to cortical measures, bone turnover and hormones.
Periostin is an extracellular matrix protein, and in bone is expressed most highly in the periosteum. It increases bone formation through osteoblast differentiation, cell adhesion, Wnt signalling and collagen cross-linking. We hypothesised that serum periostin would be high at times of life when cortical modeling is active, in early adulthood and in older age, and…
MC4R-dependent suppression of appetite by bone-derived lipocalin 2.
Bone has recently emerged as a pleiotropic endocrine organ that secretes at least two hormones, FGF23 and osteocalcin, which regulate kidney function and glucose homeostasis, respectively. These findings have raised the question of whether other bone-derived hormones exist and what their potential functions are. Here we identify, through molecular and genetic analyses in mice, lipocalin…
Patients’ preferences for anti-osteoporosis drug treatment: a cross-European discrete choice experiment.
This study has as objectives: To estimate the preferences of osteoporotic patients for medication attributes, and analyse data from seven European countries. In total, 1124 patients completed the experiment, with a sample of between 98 and 257 patients per country. They found statistically significant differences in patients’ preferences for anti-osteoporosis medications between countries, especially for…
Bone density, microarchitecture and tissue quality following long-term treatment with tenofovir/emtricitabine or abacavir/lamivudine.
HIV infection has been associated with reduced bone mineral density (BMD). Antiretroviral therapy has a deleterious effect on BMD, but its effect on bone fragility is not clear. Long-term treatment with TDF-FTC leads to impaired bone health, not only in terms of BMD, but also in terms of bone quality, another determinant of overall bone…
Swimming and peak bone mineral density: A systematic review and meta-analysis.
This meta-analysis aims to determine the effects of regular swimming on bone mineral density (BMD) in young adults (18-30 years). Young adult swimmers present similar BMD values than CG and lower values than HIGH. J Sports Sci. 2017 Apr 10:1-13. doi: 10.1080/02640414.2017.1307440 Más información Gomez-Bruton A, Montero-Marín J, González-Agüero A, Gómez-Cabello A, García-Campayo J, Moreno…
Cytocompatibility assessment of Ti-Zr-Pd-Si-(Nb) alloys with low Young’s modulus, increased hardness, and enhanced osteoblast differentiation for biomedical applications.
Ti-based alloys have increased importance for biomedical applications due to their excellent properties. In particular, the two recently developed TiZrPdSi(Nb) alloys, with a predominant β-Ti phase microstructure, have good mechanical properties, such as a relatively low Young’s modulus and high hardness. Results suggest that the TiZrPdSi(Nb) alloys can be considered as excellent candidates for orthopaedical…
The Usefulness of Bone Biomarkers for Monitoring Treatment Disease: A Comparative Study in Osteolytic and Osteosclerotic Bone Metastasis Models.
The skeleton is the most common site of colonization by metastatic cancers. Zoledronic acid (ZA) has been shown to be effective for the treatment of bone metastases regardless of whether the bone lesions are osteolytic or osteoblastic. Biochemical markers of bone turnover may be useful tools to quantify the degree of bone remodeling in the…
Bilateral insufficiency hip fractures after bariatric surgery.
Bariatric surgery is one of the most common surgeries within developed countries due to the increase in morbid obesity that has been observed in the past decades.The short-term alterations in the metabolism of calcium and vitamin D are well known after these procedures; however, the clinical and biochemical consequences may not be detected for years…
The Use of the Fracture Risk Assessment (FRAX®) Tool in Predicting Risk of Fractures in Patients With Inflammatory Bowel Disease: A Systematic Review.
Inflammatory bowel disease (IBD), which includes Crohn’s disease and ulcerative colitis, is associated with an increased prevalence of osteoporosis and osteopenia. They aim to evaluate the use of the World Health Organization Fracture Risk Assessment (FRAX®) tool in these patients to assess 10-yr risk of fracture. J Clin Densitom. 2017 Apr – Jun;20(2):180-187. doi: 10.1016/j.jocd.2016.08.010….
A retrospective cohort study of concomitant ipsilateral extra-capsular and intra-capsular fractures of the proximal femur. Are they casual findings or an undervalued reality?
Fractures of the proximal femur constitute a major public health problem, with an annual incidence in Spain of 7.6 cases per 1000 inhabitants over 65 years of age. Between May 2010 and December 2016, 33 (median age, 86 years-old) of the 2625 hip fractures were classified as simultaneous extra- and intra-capsular ipsilateral fractures. CONCLUSION: The…
Adequacy of treatment for osteoporosis in primary prevention. Quantitative and qualitative study
Quantitative study: To assess the prevalence of inadequacy of treatment for osteoporosis in primary prevention (OPP) in women aged 60-74years. Aten Primaria. 2017 Apr 14. pii: S0212-6567(16)30378-X. doi:10.1016/j.aprim.2017.01.007. Más información Vedia Urgell C, Massot Mesquida M, Valles Fernandez R, Garcia Vicente JA, Franzi Siso A, Muñoz Ortiz L, Vilaró Jaques L, Bosch Peligero M.
Behavior of Human Osteoblast Cells Cultured on Titanium Discs in Relation to Surface Roughness and Presence of Melatonin.
The aim of this work was to observe the behavior of osteoblast cells cultured in vitro on titanium discs in relation to disc surface roughness and the addition of melatonin to the culture medium. Among the genes studied, a significant increase in phosphate-regulating neutral endopeptidase, X-linked (PHEX) expression was observed in cells cultured on EP…
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Home Again (2017) Duration 97 mins Genre Comedy, Drama. In Cinemas September 7, 2017 Language English. Country United States of America. Plot For Home Again Movie ‘Home Again’ was released in September 7, 2017 in genre Comedy. Hallie Meyers-Shyer was directed this movie and starring by Reese Witherspoon. This movie tell story about Life for…
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Home Again (2017) Duration 97 mins Genre Comedy, Drama. In Cinemas September 7, 2017 Language English. Country United States of America. Plot For Home Again Movie ‘Home Again’ was released in September 7, 2017 in genre Comedy. Hallie Meyers-Shyer was directed this movie and starring by Reese Witherspoon. This movie tell story about Life for…
Streaming Full Movie Home Again (2017) Online
Home Again (2017) Duration 97 mins Genre Comedy, Drama. In Cinemas September 7, 2017 Language English. Country United States of America. Plot For Home Again ‘Home Again’ is a movie genre Comedy, was released in September 7, 2017. Hallie Meyers-Shyer was directed this movie and starring by Reese Witherspoon. This movie tell story about Life…
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Molecular gates in mesoporous bioactive glasses for the treatment of bone tumors and infection.
Mesoporous bioactive glasses are recently gaining importance thanks to their bone regenerative properties.Moreover, the mesoporous nature of these materials makes them suitable for drug delivery applications, opening new lines in the field of bone therapies. Acta Biomater. 2017 Mar 1;50:114-126. Más información Polo L Gómez-Cerezo N, Aznar E, Vivancos JL, Sancenón F, Arcos D, Vallet-Regí…
Lithogenic factors in postmenopausal women with osteoporotic fracture.
The aim of this study was to show the presence of phosphorus and calcium metabolism disorders and the presence of urine lithogenic factors in women with osteoporotic fracture without previous urinary lithiasis. A cross-sectional study including 55 women with osteoporotic fracture surgically treated in the Trauma Department. CONCLUSIONS: Women with osteoporotic fracture showed several lithogenic…
Generation and characterization of two immortalized human osteoblastic cell lines useful for epigenetic studies.
Different model systems using osteoblastic cell lines have been developed to help understand the process of bone formation. Here, we report the establishment of two human osteoblastic cell lines obtained from primary cultures upon transduction of immortalizing genes. The resulting cell lines had no major J Bone Miner Metab. 2017 Mar;35(2):150-160. doi: 10.1007/s00774-016-0753-z. Epub 2016…
BRCA1 haploinsufficiency cell-autonomously activates RANKL expression and generates denosumab-responsive breast cancer-initiating cells.
Denosumab, a monoclonal antibody to the receptor activator of nuclear factor-κB ligand (RANKL), might be a novel preventative therapy for BRCA1-mutation carriers at high risk of developing breast cancer. They tested the alternative but not mutually exclusive hypothesis that BRCA1 deficiency might cell-autonomously activate RANKL expression to generate cellular states with cancer stem cell (CSC)-like…
The effectiveness of a basic exercise intervention to improve strength and balance in women with osteoporosis.
OBJECTIVE: To determine the effects of a simple exercise program on the balance and strength of postmenopausal women with osteoporosis.CONCLUSION: The present study demonstrates that a physical exercise program based on balance and strength exercises, carried out with simple and readily available equipment, is capable of significantly improving the strength and balance of women with…
Opportunistic screening for osteoporosis by routine CT in Southern Europe.
Abdominal CT images obtained for other reasons can identify patients with osteoporosis BMD without additional radiation exposure or cost. Uncalibrated values at L1 can detect more osteoporosis patients with spinal compression fractures than DXA in oncologic patients. Osteoporos Int. 2017 Mar;28(3):983-990. doi: 10.1007/s00198-016-3804-3. Epub 2017 Jan 20. Más información Alacreu E, Moratal D, Arana E
Paget’s Disease of Bone: Approach to Its Historical Origins.
Paget’s disease of bone is the second most common bone disease after osteoporosis. It is characterized by focal regions of highly exaggerated bone remodeling, with abnormalities in all phases of the remodeling process. This study aims to investigate the hypothesis of a possible British origin of Paget’s disease of bone by studying the worldwide geographic…
MicroRNAs in bone diseases.
MicroRNAs are small, noncoding single-stranded RNAs that have emerged as important posttranscriptional regulators of gene expression, with an essential role in vertebrate development and different biological processes. This review highlights the recent advances in the function of miRNAs and their roles in bone remodeling and bone diseases. MicroRNAs (miRNAs) are a class of small (∼22…
Durability of Response to Zoledronate Treatment and Competing Mortality in Paget’s Disease of Bone
There has been a marked secular trend in recent decades toward patients with Paget’s disease presenting at a greater age and having less extensive skeletal involvement. Over a similar time frame more potent bisphosphonates with a long duration of effect have been developed, raising the prospect of many patients needing only once in a lifetime…
Hypophosphatasia: An overview For 2017.
Hypophosphatasia (HPP) is the inborn-error-of-metabolism that features low serum alkaline phosphatase (ALP) activity (hypophosphatasemia) caused by loss-of-function mutation(s) of the gene that encodes the tissue-nonspecific isoenzyme of ALP (TNSALP). Autosomal recessive or autosomal dominant inheritance from among >300 TNSALP (ALPL) mutations largely explains HPP’s remarkably broad-ranging severity. TNSALP mutation analysis BlueHost优惠码 is essential for recurrence…
The effect of patient age at intervention on risk of implant revision after total replacement of the hip or knee: a population-based cohort study.
Total joint replacements for end-stage osteoarthritis of the hip and knee are cost-effective and demonstrate significant clinical improvement.However, robust population based lifetime-risk data for implant revision are not available to aid patient decision making, which is a particular problem in young patient groups deciding on best-timing for surgery. The study used novel methodology to investigate…
Effects of Sex and Notch Signaling on the Osteocyte Cell Pool.
Osteocytes play a fundamental role in mechanotransduction and skeletal remodeling. Sex is a determinant of skeletal structure, and female C57BL/6J mice have increased osteoblast number in cancellous bone when compared to male mice. Activation of Notch in the skeleton causes profound cell-context dependent changes in skeletal 嘉盛外汇 physiology. the aim of this study was to…
Cost-Effectiveness of Orthogeriatric and Fracture Liaison Service Models of Care for Hip Fracture Patients: A Population-Based Study.
Fracture liaison services are recommended as a model of best practice for organizing patient care and secondary fracture prevention for hip fracture patients, although variation exists in how such services are structured. There is considerable uncertainty as to which model is most cost-effective and should therefore be mandated. This study evaluated the cost- effectiveness of…
Reducing Undercarboxylated Osteocalcin With Vitamin K Supplementation Does Not Promote Lean Tissue Loss or Fat Gain Over 3 Years in Older Women and Men: A Randomized Controlled Trial.
Osteocalcin (OC) is a vitamin K-dependent protein synthesized during bone formation. Mice injected with the undercarboxylated form of OC (ucOC) had more skeletal muscle mass and less fat mass than sham-treated controls, suggesting a unique metabolic role for ucOC. UcOC decreases in response to vitamin K supplementation. Our objective was to determine the effect of…
Biologic therapies and bone loss in rheumatoid arthritis.
Treatment with biologic drugs is associated with the decrease in bone loss. Studies with anti-TNF blocking agents show preservation or increase in spine and hip BMD and also a better profile of bone markers. Most of these studies were performed with infliximab. Only three epidemiological studies analyzed the effect on fractures after anti-TNF blocking top…
Anti-citrullinated protein antibodies are associated with decreased bone mineral density: baseline data from a register of early arthritis patients
Since the previous studies showed that anti-citrullinated protein antibodies (ACPA) can induce osteoclasts differentiation and activation, even before arthritis onset, the aim of their study was to determine 嘉盛外汇 whether ACPA-positivity is associated with lower bone mineral density (BMD) at baseline visit of a register of early arthritis (EA) patients. The study population comprised 578…
Influence of anti-TNF therapy on bone metabolism in patients with inflammatory bowel disease
Eur J Intern Med. 2017 Feb 3. pii: S0953-6205(17)30062-6. doi:10.1016/j.ejim.2017.01.024. Más información Castro B, Rivero M, Crespo J, Riancho JA, Valero C.
Transcriptomic analyses of the anti-adipogenic effects of oleuropein in human mesenchymal stem cells.
Extra virgin olive oil has positive effects on health. Oleuropein is a polyphenolic compound present in olive-tree leaves, fruits (olives) and olive oil. The effects of oleuropein on the adipogenesis of human bone-marrow mesenchymal stem cells were studied by transcriptomics and differential gene-expression analyses. Their data suggest that mitochondrial activity is reduced by oleuropein, mostly…
Serum from postmenopausal women treated with a by-product of olive-oil extraction process stimulates osteoblastogenesis and inhibits adipogenesis in human mesenchymal stem-cells (MSC).
Aging may enhance both oxidative stress and bone-marrow mesenchymal stem-cell (MSC) differentiation into adipocytes. That reduces osteoblastogenesis, thus favoring bone-mass loss and fracture, representing an important worldwide health-issue, mainly in countries with aging populations. Intake of antioxidant products may help to retain bone-mass density. Exp Gerontol. 2017 Feb 3;90:71-78. doi: 10.1016/j.exger.2017.01.024. Más información Casado-Díaz A,…
Clinical experience with microindentation in vivo in humans.
Densitometry and imaging techniques are currently used in clinical settings to measure bone quantity and spatial structure. Recently, Reference Point Indentation has opened the possibility of directly assessing the mechanical characteristics of cortical bone in living individuals, adding a new dimension to the assessment of bone strength. Bone. 2017 Feb;95:175-182. doi: 10.1016/j.bone.2016.11.003. Más información Herrera…
Trochanteric hip fracture during cardioversion therapy. A case report.
Trochanteric hip fractures in elderly patients with osteoporosis are commonly caused by low energy trauma. The cardioversion therapy is an extremely rare cause of this type of fracture.They report the case of a woman with hip fracture after cardioversion. CONCLUSION: The propofol sedation should be complemented with skeletal muscle relaxants in the cardioversion therapy to…
Challenges of bone tissue engineering in orthopaedic patients.
Bone defects may impede normal biomechanics and the structural stability of bone as an organ. In many cases, the correction of bone defects requires extensive surgical intervention involving the use of bone-grafting techniques and other procedures in which healing is slow, there is a high risk of infection and considerable pain is provoked – with…
Age-Related Loss in Bone Mineral Density of Rats Fed Lifelong on a Fish Oil-Based Diet Is Avoided by Coenzyme Q10 Addition.
Oxidative stress has been related to this bone loss, making dietary compounds with antioxidant properties a promising weapon. Male Wistar rats were maintained on diets with fish oil as unique fat source, supplemented or not with coenzyme Q10 (CoQ10). BMD was evaluated in the femur. Serum osteocalcin, osteopontin, receptor activator of nuclear factor-κB ligand, ostroprotegerin,…
Effect of vanadium on calcium homeostasis, osteopontin mRNA expression, and bone microarchitecture in diabetic rats.
The aim of this study was to examine whether alterations caused by diabetes in calcium homeostasis, expression of osteopontin and the microarchitecture of bone are corrected by exposure to vanadium. They conclude that treatment with 3 mg V per d of the glucose lowering agent bis(maltolato)oxovanadium(iv) causes a decrease in osteopontin mRNA, which could favour…
Risk of bone tumors in children and residential proximity to industrial and urban areas: New findings from a case-control study.
Few epidemiologic studies have explored risk factors for bone tumors in children, and the role of environmental factors needs to be analyzed. The objective of this study was to ascertain the association between residential proximity to vigrx plus official website industrial plants and urban areas and risk of bone tumors in children, taking into account…
ECTS Curso de formación de doctorado 2017 – Inscripciones abiertas
Curso ECTS Formación PhD 2017 Las inscripciones para la 11 ECTS doctorado Curso de Formación ya están abiertas. Haga clic aquí para registrarse y descubre lo que puede esperar de Programa y altavoces. El ECTS doctorado curso de formación, destinado a promover el conocimiento general de la investigación hueso para investigadores jóvenes, se encuentra ahora…
Connexin37 deficiency alters organic bone matrix, cortical bone geometry, and increases Wnt/β-catenin signaling
Deletion of connexin (Cx) 37 in mice leads to increased cancellous bone mass due to defective osteoclast differentiation. Paradoxically; however, Cx37-deficient mice exhibit reduced cortical thickness accompanied by higher bone strength,suggesting a contribution of Cx37 to bone matrix composition. Thus, we investigated whether global deletion of Cx37 alters the composition of phentermine organic bone extracellular…
Orientation of whole bone samples of small rodents matters during bending tests.
The influence of the orientation of rat bones on their mechanical response is analyzed in this research. 28 femora obtained from 14 Sprague-Dawley rats. This result confirms that the mechanical properties of the bone tissue depend on its position in the cross-section and provides a reliable explanation to understand the response of the bones when…
Evidence on the analgesic role of bisphosphonates and denosumab in the treatment of pain due to bone metastases: A systematic review within the European Association for Palliative Care guidelines project
Bisphosphonates and denosumab are well-established therapies to reduce the frequency and severity of skeletal-related events in patients with bone metastasis. However, the analgesic effect of these medications on bone pain is uncertain.Watch movie online The Transporter Refueled (2015) Evidence to support an analgesic role for bisphosphonates and denosumab is weak. Bisphosphonates and denosumab appear to…
Bone Structure and Geometric Properties at the Radius and Tibia in Adolescent Endurance-Trained Cyclists.
OBJECTIVE: To describe cortical and trabecular volumetric bone mineral density (vBMD), bone mineral content (BMC), cross-sectional area (CSA), and bone strength indexes (BSIs) in adolescent endurance-trained cyclists (CYC) and compare them with controls (CON). CONCLUSIONS: Adolescent CYC in this study showed lower values of BMC and vBMD at determined sites of the radius and tibia…
3D-DXA: Assessing the Femoral Shape, the Trabecular Macrostructure and the Cortex in 3D from DXA images
The 3D distribution of the cortical and trabecular bone mass in the proximal femur is a critical component in determining fracture resistance that is not taken into account in clinical routine Dual-energy X-ray Absorptiometry (DXA) examination. Models and measurements provided by the “3D-DXA” software algorithm were evaluated using a database of 157 study subjects, by…
Prevalence of vertebral fracture and densitometric osteoporosis in Spanish adult men: The Camargo Cohort Study.
The aim of this study was to assess the prevalence of densitometric osteoporosis and vertebral fractures in Spanish men aged ≥50 years, and to study how the relationship between them may change depending on how osteoporosis is diagnosed. A community-based population of 1003 men aged ≥50 years was studied. Bone mineral density (BMD) was measured by DXA…
Extra virgin olive oil consumption reduces the risk of osteoporotic fractures in the PREDIMED trial.
The incidence of osteoporotic fractures is lower in countries in the Mediterranean basin. Virgin olive oil, a key component of the Mediterranean Diet (MDiet), with recognised beneficial effects on metabolism and cardiovascular health, may decrease the risk of osteoporotic fractures. The aim to this study was to explore the effect of chronic consumption of total…
Primary and Secondary Prevention of Hip Fragility Fracture in Teruel Health Sector, Aragon, Spain
The objective was to analyze primary and secondary interventions carried out in individuals diagnosed with femur fragility fracture at Teruel in 2014. CONCLUSIONS: Primary pharmacologic prevention and assessment of osteoporosis or risk of fracture are unfrequent in our health district.. Although pharmacologic treatment is prescribed more frequently in Teruel than in other areas after a…
Deprescribing long-term treatments with bisphosphonates for osteoporosis in primary care in the Basque Country (Spain)
To evaluate the impact of a multifactorial intervention to promote bisphosphonate deprescription after over 5 years of use (BF5y) in a health care organisation (HCO) in Gipuzkoa (Spain) and to compare it with the standard intervention in other HCOs in the Basque Health Service-Osakidetza.CONCLUSIONS: Standard and multifactorial interventions are very effective in reducing unnecessary treatments…
High Glucose Alters the Secretome of Mechanically Stimulated Osteocyte-like Cells Affecting Osteoclast Precursor Recruitment and Differentiation
Diabetes mellitus (DM) induces bone deterioration, while mechanical stimulation promotes osteocyte-driven bone formation. We aimed to evaluate the interaction of acute exposure (24h) to high glucose (HG) with both the pro-survival effect conferred to osteocytic MLO-Y4 cells and osteoblastic MC3T3-E1 cells by mechanical stimulation and the interaction of these cells with osteoclast precursor RAW264.7 cells….
Relationship between spinal osteoarthritis and vertebral fractures in men older than 50 years: data from the Camargo Cohort Study
Spinal osteoarthritis has been suggested as a risk factor for vertebral fractures. However, results are conflicting: most of the data are focused on the lumbar region, and referred to postmenopausal women, whereas data for men are scarce. The aim of this study is to assess the relationship between spinal osteoarthritis and vertebral fractures in men…
Geographic variation in secondary fracture prevention after a hip fracture during
Fragility fractures of the hip have a major impact on the lives of patients and their families. This study highlights significant geographical variation in secondary fracture prevention with even the highest performing regions failing the majority of patients despite robust evidence supporting the benefits of diagnosis and treatment. CONCLUSIONS: Significant geographic differences exist in prescribing…
Primary hyperparathyroidism: review and recommendations on evaluation, diagnosis, and management. A Canadian and international consensus.
This review presents the current state of the art in the diagnosis and management of PHPT and updates the Canadian Position paper on PHPT. An overview of the impact of PHPT on the skeleton and other target organs is presented with international consensus. Differences in the international presentation of this condition are also summarized. Más…
Effect of Longer-Interval vs Standard Dosing of Zoledronic Acid on Skeletal Events in Patients With Bone Metastases: A Randomized Clinical Trial.
Among patients with bone metastases due to breast cancer, prostate cancer, or multiple myeloma, the use of zoledronic acid every 12 weeks compared with the standard dosing interval of every 4 weeks did not result in an increased risk of skeletal events over 2 years. This longer interval may be an acceptable treatment option. Más…
Effects of Romosozumab Compared With Teriparatide on Bone Density and Mass at the Spine and Hip in Postmenopausal Women With Low Bone Mass.
Results: romosozumab significantly increased integral vBMD and BMC at the lumbar spine and total hip from baseline, and compared with placebo and teriparatide (all p < 0.05). Trabecular vertebral vBMD improved significantly and similarly from baseline (p < 0.05) with both romosozumab (18.3%) and teriparatide (20.1%), whereas cortical vertebral vBMD gains were larger with romosozumab compared with teriparatide (13.7% versus 5.7%, p < 0.0001). Trabecular hip…
Effect of Osteoprotegerin and Dickkopf-Related Protein 1 on Radiological Progression in Tightly Controlled Rheumatoid Arthritis
PLoS One. 2016 Dec 2;11(12):e0166691Watch Full Movie Online Streaming Online and Download The aim of this study is to analyze the association between circulating osteoprotegerin (OPG)and Dickkopf-related protein 1 (DKK-1) and radiological progression in patients with tightly controlled rheumatoid arthritis (RA).
Treatment of menopausal symptoms. New era with new options or new options for menopausal symptoms after 15 years of WHI study
Minerva Ginecol. 2016 Dec 14. Menopausal symptoms include vasomotor symptoms (VMS), vulvar-vaginal atrophy, and loss of bone mass associated with an increased risk of fracture. This article reviews treatment options and provides treatment algorithms for women with menopausal symptoms.
Fibrous dysplasia. Clinical review and therapeutic management
Med Clin (Barc). 2016 Dec 16;147(12):547-553 Fibrous dysplasia is a skeletal disorder that is associated with a wide spectrum of clinical manifestations. Although the treatment of choice is based on bisphosphonates, the therapeutic efficacy of these agents in the control of disease activity remains uncertain. This article reviews the current data available on the treatment…
Molecular mechanisms in bone mechanotransduction
Histol Histopathol. 2016 Dec 16:11858. Bone is one of the most adaptable tissues in the body as it is continuously subjected to load bearing. Mechanical stimulation is necessary for the development of the skeleton.In this review, we discuss the complexity and well-orchestrated events that occur in bone mechanotransduction, focusing on osteocyte viability as an important…
Impact of obesity on bone metabolism
Endocrinol Nutr. 2016 Dec;63(10):551-559. High weight is a protective factor against osteoporosis and risk of fracture. In obesity, however, where overweight is associated to excess fat, this relationship does not appear to be so clear, excess weight has sometimes been associated to decreased bone mass. Autor: López-Gómez JJ, Pérez Castrillón JL, de Luis Román DA
Parathyroid Hormone Polymorphism RS6254 is Associated with the Development and Severity of Osteoporosis in Asymptomatic but not Normocalcemic Hyperthyroidism
Horm Metab Res. 2016 Dec;48(12):828-833. Although normocalcemic and asymptomatic hyperparathyroidism (HPT) are becoming more common, they remain only partially understood. Parathyroid hormone (PTH) polymorphisms have been associated with disease severity in classical HPT. The aim of the present study was to evaluate the clinical effect of PTH polymorphism (rs6254) in normocalcemic and asymptomatic HPT. A…
Gender-associated comorbidities in rheumatoid arthritis and their impact on outcome: data from GENIRA
Rheumatol Int. 2016 Dec 16. GENIRA [Gender in Rheumatoid Arthritis (RA)] is a comprehensive project aimed at studying gender differences in RA patients and how these differences impact on these patient outcomes. Women with RA present significantly worse disability and QOL outcomes than men; these differences can be explained by female gender-associated comorbidities such as…
Switching from a ritonavir-boosted PI to dolutegravir as an alternative strategy in virologically suppressed HIV-infected individuals
Antimicrob Chemother. 2016 Dec 20. pii: dkw504. doi: 10.1093/jac/dkw504. Switching from PIs to dolutegravir in virologically suppressed HIV-infected individuals has not been assessed. The principal aim was to assess the evolution of bone mineral density (BMD) when switching from a ritonavir-boosted PI to dolutegravir in HIV-infected patients with osteopenia or osteoporosis. CONCLUSIONS: Dolutegravir + Kivexa(®) was safe…
Advanced Glycation End Products, Diabetes, and Bone Strength
Curr Osteoporos Rep. 2016 Dec;14(6):320-326. Diabetic patients have a higher fracture risk than expected by their bone mineral density (BMD). Poor bone quality is the most suitable and explainable cause for the elevated fracture risk in this population. Advanced glycation end products (AGEs), physically affect the properties of the bone material, one of a component…
The Activity of Adiponectin in Bone
Calcif Tissue Int. 2016 Dec 7Watch Full Movie Online Streaming Online and Download The adipokine adiponectin affects multiple target tissues and plays important roles in glucose metabolism and whole-body energy homeostasis. Circulating adiponectin levels in obese people are lower than in non-obese, and increased serum adiponectin is associated with weight loss. Results of these studies…
Treatment Sequence Matters: Anabolic and Antiresorptive Therapy for Osteoporosis
J Bone Miner Res. 2016 Dec 7. doi: 10.1002/jbmr.3051.Watch movie online The Transporter Refueled (2015) The majority of osteoporosis medications are antiresorptive agents, which reduce the rate of bone remodeling. Within this group are the bisphosphonates, which inhibit protein prenylation in the mature osteoclast, reducing osteoclast capacity to resorb bone(1) and denosumab, a monoclonal antibody…
Genetic Variants Associated with Circulating Parathyroid Hormone
J Am Soc Nephrol. 2016 Dec 7 Parathyroid hormone (PTH) is a primary calcium regulatory hormone. Elevated serum PTH concentrations in primary and secondary hyperparathyroidism have been associated with bone disease, hypertension, and in some studies, cardiovascular mortality. Genetic causes of variation in circulating PTH concentrations are incompletely understood. This study performed a genome-wide association…
Circulating microRNA Signatures in Patients With Idiopathic and Postmenopausal Osteoporosis and Fragility Fractures
J Clin Endocrinol Metab. 2016 Nov;101(11):4125-4134 Specific serum miRNA profiles are strongly related to bone pathologies. Therefore miRNAs might be directly linked to bone tissue homeostasis. In particular, miR-29b-3p has previously been reported as regulator of osteogenic differentiation and could serve as a novel marker of bone turnover in osteoporotic patients as a member of…
Diabetes Drug effects on the skeleton
PUMBE – Calcif Tissue Int (2016). doi:10.1007/s00223-016-0203-x Anti-diabetes medications are crucial for maintaining glucose control and for preventing micro- and macrovascular complications in diabetes. However, they may modulate fracture risk in diabetes in different ways. The purpose of this review is to provide a comprehensive overview of the effect of these medications on bone metabolism…
Homocysteine as a Pathological Biomarker for Bone Disease
J Cell Physiol. 2016 Nov 18. doi: 10.1002/jcp.25693. This article reviews the current body of knowledge on regulation of Hcy mediated oxidative stress and its role in bone remodeling, vascular blood flow and progression of bone disease. This article is protected by copyright. All rights reserved. Autor: Behera J, Bala J, Nuru M, Tyagi SC,…
Vitamin D Deficiency — Is There Really a Pandemic
New England Journal of Medicine, November 10, 2016 Vol. 375 No. 19, p 1817-1820.J.E. The claim that large proportions of North American and other populations are deficient in vitamin D is based on misinterpretation and misapplication of the Institute of Medicine reference values for nutrients — misunderstandings that can adversely affect patient care. Autor: Manson, P.M….
Effects of Teriparatide Compared with Risedronate on Recovery After Pertrochanteric Hip Fracture: Results of a Randomized, Active-Controlled,Double-Blind Clinical Trial at 26 Weeks
J Bone Joint Surg Am. 2016 Nov 16;98(22):1868-1878. Osteoporosis drugs might affect fracture-healing. We therefore studied the effects of teriparatide in comparison with risedronate on recovery after pertrochanteric hip fractures. Teriparatide was associated with less pain and a shorter time to complete the TUG test between 6 and 26 weeks compared with risedronate. Other fracture-recovery…
Use of hormone therapy for menopausal symptoms and quality of life in breast cancer survivors. Safe and ethical?
Gynecol Endocrinol. 2016 Nov Breast cancer is the most prevalent cancer in women and presently. Over this issue Reviews the available evidence of the use of HT and tibolone in women treated for breast cancer. Autor: Garrido Oyarzún MF, Castelo-Branco C
A reproducible method for the isolation and expansion of ovine mesenchymal stromal cells from bone marrow for use in regenerative medicine preclinical studies
J Tissue Eng Regen Med. 2016 Nov 18. doi: 10.1002/term.2254 The use of multipotent mesenchymal stromal cells (MSCs) as candidate medicines for treating a variety of pathologies is based on their qualities as either progenitors for the regeneration of damaged tissue or producers of a number of molecules with pharmacological properties. The osteogenic potential of…
TBS and BMD at the end of AI-therapy: A prospective study of the B-ABLE cohort
Bone. 2016 Nov;92:1-8. doi: 10.1016/j.bone.2016.08.008. PubMed PMID: 27519968 Autor: María RS, Marta PM, Sonia S, Natalia GG, Tamara M, Ignasi T, Maria MG, Jaime RM, Adolfo DP, Joan A, Xavier N.
Bone mineral density in anorexia nervosa: Only weight and menses recovery?
Endocrinol Nutr. 2016 Nov; 63(9):458-465. Autor: Jáuregui-Lobera I, Bolaños-Ríos P, Sabaté J.
Comments on: The effect of prolonged breast-feeding on the development of postmenopausal osteoporosis in population with insufficient calcium intake and vitamin D level
Osteoporos Int. 2016 Nov; 27(11):3391.Watch Full Movie Online Streaming Online and Download Autor: Moran JM, Pedrera-Zamorano JD.
Bone remodeling markers as lithogenic risk factors in patients with osteopenia-osteoporosis
Int Urol Nephrol. 2016 Nov;48(11):1777-1781 Autor: Girón-Prieto MS, Arias-Santiago S, Del Carmen Cano-García M, Poyatos-Andújar A, de Haro-Muñoz T, Abad-Menor F, Quesada-Charneco M, Arrabal-Polo MÁ, Arrabal-Martín M
The diabetic paradox: Bone mineral density and fracture in type 2 diabetes
Endocrinol Nutr. 2016 Nov;63(9):495-501. Autor: Botella Martínez S, Varo Cenarruzabeitia N, Escalada San Martin J, Calleja Canelas A.
Oxidation inhibits PTH receptor signaling and trafficking
Biochem Biophys Res Commun. 2016 Nov 28.Watch Full Movie Online Streaming Online and Download Reactive Oxygen Species (ROS) increase during aging, potentially affecting many tissues including brain, heart, and bone. ROS alter signaling pathways and constitute potential therapeutic targets to limit oxidative damaging effects in aging-associated diseases. The role of oxidation on PTHR signaling and…
Diverging results of areal and volumetric bone mineral density in Down syndrome
Osteoporos Int. 2016 Nov 12. Population with Down syndrome (DS) has lower areal BMD, in association with their smaller skeletal size. However, volumetric BMD and other indices of bone microarchitecture, such as trabecular bone score (TBS) and calcaneal ultrasound (QUS), were normal. CONCLUSIONS: Areal BMD is reduced in DS, but it seems to be related…
Parathyroid Hormone Polymorphism RS6254 is Associated with the Development and Severity of Osteoporosis in Asymptomatic but not Normocalcemic Hyperparathyroidism
Horm Metab Res. 2016 Nov 11. Autor: Díaz-Soto G, Romero E, Pérez-Castrillón JL, Jauregui OI, de Luis Román D
CathepsinKCre mediated deletion of βcatenin results in dramatic loss of bone mass by targeting both osteoclasts and osteoblastic cells
Sci Rep. 2016 Nov 2;6:36201. doi: 10.1038/srep36201 This study examines the effects of Wnt/βcatenin signaling in mature osteoclasts by generating mice lacking βcatenin in CathepsinK-expressing cells (Ctnnb1(f/f);CtsKCre mice). Their results indicate that the bone phenotype of Ctnnb1(f/f);CtsKCre animals combines a cell-autonomous effect in the mature osteoclast with indirect effects due to the additional targeting of…
Distinct Osteomimetic Response of Androgen-Dependent and Independent Human Prostate Cancer Cells to Mechanical Action of Fluid Flow: Prometastatic Implications
Prostate. 2016 Nov 3. doi: 10.1002/pros.23270. Prostate cancer frequently expresses an osteomimetic phenotype, but it is unclear how it is regulated and what biological and clinical implications it confers. MAFF activated osteoblast-like phenotype of prostate cancer cells and altered their responses to osteocyte soluble factors. Autor: González Á, García de Durango C, Alonso V, Bravo…
Effects of chronic lead exposure on bone mineral properties in femurs of growing rats
Toxicology. 2016 Nov 30. pii: S0300-483X(16)30303-1. doi:10.1016/j.tox.2016.11.017. The aim of the present study is to make a more detailed description of the toxic effects of lead intoxication on bone intrinsic material properties as mineral composition, morphology and microstructural characteristics. Autor: Álvarez-Lloret P, Lee CM, Conti MI, Terrizzi AR, González-López S,Martínez MP.
The role of serum osteoprotegerin and receptor-activator of nuclear factor-Κb ligand in metabolic bone disease of women after obesity surgery
J Bone Miner Metab. 2016 Nov;34(6):655-661.Watch Full Movie Online Streaming Online and Download Metabolic bone disease may appear as a complication of obesity surgery. These data show that the osteoprotegerin and receptor-activator of nuclear factor-κB ligand system is associated with bone markers and bone mineral density at the lumbar spine after obesity surgery Autor: Balsa…
Can acetazolamide be used to treat diseases involving increased bone mineral density?
DOI: 10.5582/irdr.2016.01067 PMCID: PMC5116865 PMID: 27904825 Sclerosing bone dysplasias are a series of clinically and genetically heterogeneous diseases characterized by functional failure of the osteoclasts in bone resorption, leading to an excessive amount of bone mineral density (BMD) which could have serious clinical consequences. We treated three children affected with seriously high levels of BMD…
Biologic therapies and bone loss in rheumatoid arthritis
Osteoporos Int. 2016 Oct 31. [Epub ahead of print] DOI: 10.1007/s00198-016-3769-2 PMID: 27796445 [PubMed – as supplied by publisher] In this review, the authors present the best evidence available regarding bone loss in RA patients. The more recent knowledge of the cytokines’ interplay in the inflamed synovial membrane and its close relation to osteoclast development…
Role and mechanism of action of sclerostin in bone
Bone. 2016 Oct 12. pii: S8756-3282(16)30297-6. doi: 10.1016/j.bone.2016.10.007. [Epub ahead of print] PubMed PMID: 27742498. Autor: Delgado-Calle J, Sato AY, Bellido T.
Parathyroid Hormone Polymorphism RS6254 is Associated with the Development and Severity of Osteoporosis in Asymptomatic but not Normocalcemic Hyperthyroidism
Horm Metab Res. 2016 Oct 18. [Epub ahead of print] PubMed PMID: 27756092. Autor: Díaz-Soto G, Romero E, Pérez-Castrillón JL, Jauregui OI, de Luis Román D.
Osteoporotic Hip Fracture in Spain: A Prospective, 12-Month, Observational Study
Calcif Tissue Int. 2016 Oct 14. [Epub ahead of print] PubMed PMID: 27738719. Autor: Caeiro JR, Bartra A, Mesa-Ramos M, Etxebarría Í, Montejo J, Carpintero P, Sorio F, Gatell S, Farré A, Canals L; PROA investigators
Higher bone mass in prepubertal and peripubertal female footballers
Eur J Sport Sci. 2016 Oct;16(7):877-83. doi: 10.1080/17461391.2016.1144794. PubMed PMID: 26902531. Autor: Plaza-Carmona M, Vicente-Rodríguez G, Gómez-Cabello A, Martín-García M, Sánchez-Sánchez J, Gallardo L, Ara I.
In vitro colonization of stratified bioactive scaffolds by pre-osteoblast cells.
Acta Biomater. 2016 Oct 15;44:73-84. doi: 10.1016/j.actbio.2016.08.014. PubMed PMID: 27521495. Autor: Gómez-Cerezo N, Sánchez-Salcedo S, Izquierdo-Barba I, Arcos D, Vallet-Regí M.
Efficacy of statins for osteoporosis: a systematic review and meta-analysis
Osteoporos Int. 2016 Nov 25. This meta-analysis assessed the efficacy of statins on the risk of fracture, bone mineral density (BMD), and the markers of bone metabolism by collecting data from 33 clinical trials. They found that statin treatment was associated with bone metabolism. And statins seemed to be more effective on male patients with…
Goal-Directed Treatment for Osteoporosis: A Progress Report from the ASBMR-NOF Working Group on Goal-Directed Treatment for Osteoporosis
J Bone Miner Res. 2016 Nov 19. doi: 10.1002/jbmr.3039. The American Society for Bone and Mineral Research and the United States National Osteoporosis Foundation (NOF) formed a working group to develop principles of goal-directed treatment and identify gaps that need to be filled to implement this approach. With goal-directed treatment, a treatment goal would first…
Association of Muscle Weakness with Post-Fracture Mortality in Older Men and Women: A 25 Year Prospective Study
J Bone Miner Res. 2016 Nov 11. doi: 10.1002/jbmr.3037. Osteoporotic fracture increases the risk of premature mortality. Muscle weakness is associated with both increased fracture risk and low BMD. However, the role of muscle strength in post-fracture mortality is not well understood. This study examines the change of muscle strength measured at quadriceps (QS) before…
Nanocrystallinity effects on osteoblast and osteoclast response to silicon substituted hydroxyapatite (SiHA)
Nanocrystallinity of SiHA affects the cell/biomaterial interface inducing bone cell apoptosis by loss of cell anchorage (anoikis), delaying osteoclast-like cell differentiation and decreasing the resorptive activity of this cell type. These results suggest the potential use of nano-SiHA biomaterial for preventing bone resorption in treatment of osteoporotic bone.
Oral Microbiota, Periodontal Status and Osteoporosis in Postmenopausal Women
Osteoporosis did not influence the prevalence of periodontitis among postmenopausal women. The presence of periodontopathogenic bacteria was not sufficient to confirm disease. A preventive maintenance program for postmenopausal women, particularly osteoporotic women, who are at greater risk of tooth loss, could minimize the potential effects of bone loss on periodontal tissues.Watch Cyberbully (2015) Full Movie…
Biologic therapies and bone loss in rheumatoid arthritis
Osteoporos Int. 2016 Oct 31. [Epub ahead of print] DOI: 10.1007/s00198-016-3769-2 PMID: 27796445 [PubMed – as supplied by publisher] In this review, the authors present the best evidence available regarding bone loss in RA patients. The more recent knowledge of the cytokines’ interplay in the inflamed synovial membrane and its close relation to osteoclast development…
Protection From Glucocorticoid-Induced Osteoporosis by Anti-Catabolic Signaling in the Absence of Sost/Sclerostin
J Bone Miner Res 2016, 31: 1791–1802. doi: 10.1002/jbmr.2869 PubMed PMID: 27163932Watch Full Movie Online Streaming Online and Download In the context of glucocorticoid excess, activation of Wnt/β-catenin signaling by Sost/sclerostin deficiency sustains bone integrity by opposing bone catabolism despite markedly reduced bone formation and increased apoptosis. This crosstalk between glucocorticoids and Wnt/β-catenin signaling could…
Vitamin D Storage in Adipose Tissue of Obese and Normal Weight Women
J Bone Miner Res 2016 DOI: 10.1002/jbmr.2979 PubMed PMID: 27542960 First published: 24 October 2016 In summary, although obese women (OB) had significantly greater total vitamin D stores than non-obese control (C), the relationship between serum 25OHD and fat vitamin D and the overall pattern of distribution of vitamin D between the omental and subcutaneous…
Resolución Becas FEIOMM Investigación 2016
Reunido el Jurado formado por el Comité Científico de la Seiomm, con el fin de resolver la adjudicación de las Becas FEIOMM de INVESTIGACIÓN 2016 para promover la investigación clínica, básica y traslacional en el campo de la patología metabólica ósea, se acuerda conceder dichas Becas dotadas con 6.000 € (seis mil) cada una a…
Premio FHOEMO – SEIOMM 2016
PERSISTENCIA A 2 AÑOS ENTRE USUARIAS DE DISTINTOS FÁRMACOS ANTI-OSTEOPORÓTICOS: ESTUDIO DE COHORTES DE BASE POBLACIONAL. Investigador Principal: Carlen Reyes. Colaboradores: Cristian Tebe, Daniel Prieto-Alhambra. Ver resolución aquí.
PREMIOS ITALFÁRMACO-SEIOMM 2016
XXI Congreso SEIOMM – Gran Canaria 2016. El jurado, compuesto por los moderadores de las sesiones de comunicaciones orales y pósters y el Comité Científico del XXI Congreso de la SEIOMM, ha otorgado los Premios Italfármaco 2016 a los siguientes trabajos
Acta Premio Joven Investigador 2015
ANALISIS GENÓMICO Y FUNCIONAL DE LAS CÉLULAS MESENQUIMALES DE PACIENTES CON FRACTURAS DE CADERA. ALVARO DEL REAL Mejor comunicación presentada por un investigador socio menor de 35 años: Dra.Blanca Torrubia
Cortical Bone Porosity: What Is It, Why Is It Important, and How Can We Detect It?
Curr Osteoporos Rep. 2016 Oct;14(5):187-98. doi: 10.1007/s11914-016-0319-y. DOI: 10.1007/s11914-016-0319-y PMID: 27623679 [PubMed – in process] Cortical porosity is important because of its impact on bone material and mechanical properties as well as its role in the remodeling process. This review aims to provide an overview of what this level of porosity is, why it is…
Potentially inappropriate prescribing in older Spanish population according to STOPP/START criteria (STARTREC study)
n our Health Region, at least 50% of the population aged 70 or older has one or more potentially inappropriate prescribing (PIP), according to STOPP/START criteria. According to STOPP, the most common drugs identified are benzodiazepines, non-steroidal anti-inflammatory drugs and proton pump inhibitors; according to START, osteoporosis treatments, antiplatelet agents, statins, metformin and beta blockers….
Cost-effectiveness of orthogeriatric and fracture liaison service models of care for hip fracture patients: A population based study
Irrespective of how patients were stratified in terms of their age, sex, and Charlson co-morbidity score at index hip fracture, our results suggest that introducing an orthogeriatrician-led or a nurse-led FLS is cost-effective when compared to usual care. Although, considerable uncertainty remains concerning which of the models of care should be preferred, introducing an orthogeriatrician-led…
The Use of the WHO Facture Risk Assessment (FRAX®) Tool in Predicting Risk of Fractures in Patients With Inflammatory Bowel Disease: A Systematic Review
The FRAX tool has been limitedly used in patients with IBD; however, the evidence currently available only shows a modest increase in the 10-yr risks of bone fracture and does not support unequivocally the need for specific interventions.Roblox HackBigo Live Beans HackYUGIOH DUEL LINKS HACKPokemon Duel HackRoblox HackPixel Gun 3d HackGrowtopia HackClash Royale Hackmy cafe…
Novel biological markers of bone: from bone metabolism to bone physiology
Rheumatology (Oxford). 2016 Oct;55(10):1714-25. Epub 2016 Jan 20. DOI: 10.1093/rheumatology/kev410 PMID: 26790456 [PubMed – in process] Traditional BTMs have been used for years to help with fracture risk prediction and in particular for treatment monitoring. Clinical use of the new biochemical markers has not been established so far. Their relationship with fracture risk is still…
Osteocytic signalling pathways as therapeutic targets for bone fragility
Nat Rev Endocrinol. 2016 Oct;12(10):593-605. Epub 2016 May 27. DOI: 10.1038/nrendo.2016.71 PMID: 27230951 [PubMed – in process] Osteocytes are differentiated osteoblasts that become surrounded by matrix during the process of bone formation. Acquisition of the osteocyte phenotype is achieved by profound changes in gene expression. The discovery of mutations in human osteocytic genes has contributed,…
Bisphosphonates for steroid-induced osteoporosis
Cochrane Database Syst Rev. 2016 Oct 5;10:CD001347. Review. PMID: 27706804Watch Full Movie Online Streaming Online and Download There was high-certainty evidence that bisphosphonates are beneficial in reducing the risk of vertebral fractures with data extending to 24 months of use. There was low-certainty evidence that bisphosphonates may make little or no difference in preventing nonvertebral…
HIV infection and bone disease
J Intern Med. 2016 Oct;280(4):350-8. doi: 10.1111/joim.12520. Epub 2016 Jun 6. DOI: 10.1111/joim.12520 PMID: 27272530 [PubMed – in process] The success of antiretroviral therapy in treating HIV infection has greatly prolonged life expectancy in affected individuals, transforming the disease into a chronic condition. A number of HIV-associated non-AIDS comorbidities have emerged in the ageing HIV-infected…
Safety and efficacy of vertebroplasty for acute painful osteoporotic fractures (VAPOUR): a multicentre, randomised, double-blind, placebo-controlled trial
Lancet. 2016 Oct 1;388(10052):1408-1416. doi: 10.1016/S0140-6736(16)31341-1. PMID: 27544377 Vertebroplasty is superior to placebo intervention for pain reduction in patients with acute osteoporotic spinal fractures of less than 6 weeks’ in duration. These findings will allow patients with acute painful fractures to have an additional means of pain management that is known to be effective. Autor:…
The roles of vascular endothelial growth factor in bone repair and regeneration
Bone. 2016 Oct;91:30-8. doi: 10.1016/j.bone.2016.06.013. Epub 2016 Jun 25. Review. This review (i) summarizes the roles of VEGF at different stages of bone repair, including the phases of inflammation, endochondral ossification, intramembranous ossification during callus formation and bone remodeling; (ii) discusses different mechanisms underlying the effects of VEGF on osteoblast function, including paracrine, autocrine and…
A randomized, double-blind, multicenter, placebo-controlled study to evaluate the efficacy and safety of oral salmon calcitonin in the treatment of osteoporosis in postmenopausal women taking calcium and vitamin D
Bone. 2016 Oct;91:122-9. doi: 10.1016/j.bone.2016.07.019. Epub 2016 Jul 25. Due to the lack of efficacy in preventing fractures, the development of the orally formulated calcitonin was terminated despite the promising results in earlier studies. Autor: Henriksen K, Byrjalsen I, Andersen JR, Bihlet AR, Russo LA, Alexandersen P, Valter I, Qvist P, Lau E, Riis BJ,…
Longer Duration of Diabetes Strongly Impacts Fracture Risk Assessment: The Manitoba BMD Cohort
J Clin Endocrinol Metab. 2016 Nov;101(11):4489-4496. Diabetes is a FRAX-independent risk factor for MOF only in women with a long duration of diabetes, but diabetes increases hip fracture risk, regardless of duration. Those with diabetes longer than 10 years are at particularly high risk of fracture, and this elevated risk is currently underestimated by FRAX….
Antibacterial silk fibroin/nanohydroxyapatite hydrogels with silver and gold nanoparticles for bone regeneration
On the basis of the aforementioned observations, these hydrogels are very attractive for bone tissue engineering.
Influence of high glucose and advanced glycation end-products (ages) levels in human osteoblast-like cells gene expression
Our data indicates an altered bone remodelling rate in the Type 2 diabetes mellitus group, which may, at least partially, explain the reduced bone strength and increased incidence of non-traumatic fractures in diabetic patients
Deprescribing long-term treatments with bisphosphonates for osteoporosis in primary care in the Basque Country (Spain)
tandard and multifactorial interventions are very effective in reducing unnecessary treatments with bisphosphonates. The multifactorial intervention is more effective than the standard one, although more complex to implement
Effects of a moderately high-protein diet and interval aerobic training combined with strength-endurance exercise on markers of bone metabolism, microarchitecture and turnover in obese Zucker rats
The combination of interventions may be effective to enhance trabecular bone microarchitecture and BMD, and has a partial impact on cortical bone in obese rats. Nevertheless, they do not induce any alteration on the bone turnover markers.
TBS and BMD at the end of AI-therapy: A prospective study of the B-ABLE cohort
AI therapy induces significant decreases in TBS, comparable to BMD loss. BP-treated patients maintained TBS values, whereas BMD increased. AI treatment leads to deterioration of bone microarchitecture, which seems to be attenuated by BP therapy.
Objectively Verified Parental Hip Fracture Is an Independent Risk Factor for Fracture: a Linkage Analysis of 478,792 Parents and 261,705 Offspring
J Bone Miner Res. 2016 Sep;31(9):1753-9. doi: 10.1002/jbmr.2849. Epub 2016 Apr 30. Parental Hip Fracture (HF) increased the risk for offspring Major Osteoporotic Fracture (MOF) and HF but not when parental HF occurred after age 80 years. This suggests a more nuanced approach for clinicians trying to stratify fracture risk, and illustrates the enormous potential…
Triglyceride Levels and Fracture Risk in Midlife Women: Study of Women’s Health Across the Nation (SWAN)
J Clin Endocrinol Metab. 2016 Sep;101(9):3297-305. doi: 10.1210/jc.2016-1366. Epub 2016 Jun 13. CONCLUSIONS: Midlife women with high fasting plasma TG had an increased risk of incident nontraumatic fracture. Secondary Abstract: Midlife women with fasting plasma triglyceride (TG) of at least 300 mg/dl had 2.5-fold greater hazards of fracture in 2 years later and onward, compared…
Links Between the Microbiome and Bone
J Bone Miner Res. 2016 Sep;31(9):1638-46. doi: 10.1002/jbmr.2887. Epub 2016 Jul 26. Despite these challenges, an understanding of the mechanisms by which the gut microbiome affects bone has the potential to provide insights into the dissociation between fracture risk and bone mineral density in patients including those with obesity, diabetes, or inflammatory bowel disease. In…
Potential Usefulness of BMD and Bone Turnover Monitoring of Zoledronic Acid Therapy Among Women With Osteoporosis: Secondary Analysis of Randomized Controlled Trial Data
J Bone Miner Res. 2016 Sep;31(9):1767-73. doi: 10.1002/jbmr.2847. Epub 2016 Apr 25. In conclusion, serum PINP is potentially useful in monitoring response to zoledronic acid. Further research is needed to evaluate the effects of monitoring PINP on treatment decisions and other clinically relevant outcomes. Autor: Bell KJ, Hayen A, Glasziou P, Irwig L, Eastell R,…
Convocatoria BECAS FEIOMM INVESTIGACIÓN 2016
La Fundación Española de Investigación Ósea y del Metabolismo Mineral (FEIOMM), convoca 6 BECAS de 6.000€ cada una para promocionar la investigación básica, clínica y traslacional en el campo del metabolismo mineral y óseo. Consulte las bases de la convocatoria aquí.
Effect of Abaloparatide vs Placebo on New Vertebral Fractures in Postmenopausal Women With Osteoporosis: A Randomized Clinical Trial
JAMA. 2016 Aug 16;316(7):722-33. doi: 10.1001/jama.2016.11136. Among postmenopausal women with osteoporosis, the use of subcutaneous abaloparatide, compared with placebo, reduced the risk of new vertebral and nonvertebral fractures over 18 months. Further research is needed to understand the clinical importance of RD, the risks and benefits of abaloparatide treatment, and the efficacy of abaloparatide vs…
Sun Exposure Behavior, Seasonal Vitamin D Deficiency, and Relationship to Bone Health in Adolescents
J Clin Endocrinol Metab. 2016 Aug;101(8):3105-13. doi: 10.1210/jc.2016-1559. Epub 2016 May 26. Sun exposure levels failed to provide adequate vitamin D, with approximately one-quarter of adolescents insufficient even at summer peak. Seasonal vitamin D deficiency was prevalent and those affected had low BMD. Recommendations on vitamin D acquisition are indicated in this age-group. Autor: Farrar…
Denosumab or Zoledronic Acid in Postmenopausal Women With Osteoporosis Previously Treated With Oral Bisphosphonates
J Clin Endocrinol Metab. 2016 Aug;101(8):3163-70. doi: 10.1210/jc.2016-1801. Epub 2016 Jun 6 In postmenopausal women with osteoporosis previously treated with oral bisphosphonates, denosumab was associated with greater BMD increases at all measured skeletal sites and greater inhibition of bone remodeling compared with ZOL. Autor: Miller PD, Pannacciulli N, Brown JP, Czerwinski E, Nedergaard BS, Bolognese…
Effects of antidepressants on postmenopausal bone loss – A 5-year longitudinal study from the OSTPRE cohort
Bone. 2016 Aug;89:25-31. doi: 10.1016/j.bone.2016.05.003. Epub 2016 May 11. In conclusion, the use of SSRIs seems to accelerate postmenopausal bone loss in a dose-response manner. Associations between TCA and other antidepressant use and bone loss may also exist. Thus, the possibility of increased risk of osteoporosis should be considered when prescribing antidepressants for postmenopausal women….
Daily Intake of Milk Enriched with n-3 Fatty Acids, Oleic Acid, and Calcium Improves Metabolic and Bone Biomarkers in Postmenopausal Women
In postmenopausal women with moderate cardiovascular risk, dietary supplementation with a dairy drink enriched with fatty acids (EPA+DHA), oleic acid, minerals, and vitamins induces a positive effect on cardiovascular risk and parameters of bone metabolism. Its regular consumption may be a useful nutritional support for postmenopausal women.
Prevention of Bone Loss in a Model of Postmenopausal Osteoporosis through Adrenomedullin Inhibition
We propose the use of AM inhibitors for the treatment of osteoporosis and other conditions leading to the loss of bone mass.
The role of daily physical activity and nutritional status on bone turnover in cystic fibrosis: a cross-sectional study
BMI and the daily time spent on moderate PA were found to be correlated with femoral neck BMD in CF patients. The association between daily PA and biochemical markers of bone formation suggests that the level of daily PA may be linked to bone health in this patient group.
The adipokine lipocalin-2 in the context of the osteoarthritic osteochondral junction
LCN2 is an important catabolic adipokine in osteoblast and chondrocyte metabolism that is regulated by differentiation, inflammation and catabolic and anabolic stimuli, and LCN2 expression in chondrocytes is regulated in a paracrine manner after osteoblast stimulation.
Anti-Osteoporosis Medication Prescriptions and Incidence of Subsequent Fracture Among Primary Hip Fracture Patients in England and Wales: An Interrupted Time-Series Analysis
Among hip fracture patients, publication of NICE guidance and availability of generic alendronic acid was temporally associated with increased prescribing and a significant decline in subsequent fractures.
RESOLUCIÓN Becas ASBMR 2016
Finalizado el plazo para el envío de solicitudes para acceder a las Becas FEIOMM para la presentación de trabajos de investigación en el Congreso de la ASBMR en Atlanta, se adjunta la lista de solicitudes remitidas para su evaluación.
Risk of hip, subtrochanteric, and femoral shaft fractures among mid and long term users of alendronate: nationwide cohort and nested case-control study
These findings support an acceptable balance between benefit and risk with treatment with alendronate in terms of fracture outcomes, even for over 10 years of continuous use.
Transcriptomic Analyses of Adipocyte Differentiation from Human Mesenchymal Stromal-Cells (MSC).
These results shed new light to understand adipose-tissue differentiation and physiology, increasing our knowledge about pathologies like obesity, type-2 diabetes and osteoporosis.
Rationale of the Spanish FRAX model in decision-making for predicting osteoporotic fractures: an update of FRIDEX cohort of Spanish women
The FRAX tool has been found to show a good discriminatory capacity for detecting women at high risk of fragility fracture, and is better for hip fracture than major fracture. The test of sensibility shows that it is, at least, not inferior than when using BMD model alone. The predictive capacity of FRAX tool needs…
Association of Trabecular Bone Score with Inflammation and Adiposity in Patients with Psoriasis: Effect of Adalimumab Therapy
in nondiabetic patients with moderate-to-severe psoriasis, TBS correlates with metabolic syndrome features and inflammation. This association is still present after 6 months of adalimumab therapy.
Anti-senescence and Anti-inflammatory Effects of the C-terminal Moiety of PTHrP Peptides in OA Osteoblasts
Our data support an anti-senescence and anti-inflammatory role for the C-terminal moiety of PTHrP with potential applications in chronic inflammatory conditions such as OA.
Denosumab or Zoledronic Acid in Postmenopausal Women With Osteoporosis Previously Treated With Oral Bisphosphonates
In postmenopausal women with osteoporosis previously treated with oral bisphosphonates, denosumab was associated with greater BMD increases at all measured skeletal sites and greater inhibition of bone remodeling compared with zoledronic acid.
Forearm DXA Increases the Rate of Patients With Asymptomatic Primary Hyperparathyroidism Meeting Surgical Criteria
J Clin Endocrinol Metab. 2016 Jul;101(7):2728-32. doi: 10.1210/jc.2016-1513. Epub 2016 Apr 12. CONCLUSIONS: DXA at 3 sites revealed OP at the forearm, but not at the other sites, in 11.2% of aPHPT patients. Half of these cases met surgical criteria based on this one factor alone. These patients did not show any clinical (except age)…
Therapy of Hypoparathyroidism With PTH(1-84): A Prospective Six Year Investigation of Efficacy and Safety
J Clin Endocrinol Metab. 2016 Jul;101(7):2742-50. doi: 10.1210/jc.2015-4135. Epub 2016 May 4. CONCLUSIONS: Long-term, continuous therapy of hypoparathyroidism for 6 years with rhPTH(1-84) is associated with reductions in supplemental calcium and calcitriol requirements, stable serum calcium concentration, and reduced urinary calcium excretion. The safety profile remains good. These data represent the longest experience with the…
A Longitudinal Study of Skeletal Histomorphometry at 6 and 24 Months Across Four Bone Envelopes in Postmenopausal Women With Osteoporosis Receiving Teriparatide or Zoledronic Acid in the SHOTZ Trial
J Bone Miner Res. 2016 Jul;31(7):1429-39. doi: 10.1002/jbmr.2804. Epub 2016 Mar 8. This study demonstrates for the first time that bone formation indices are higher with TPTD treatment than with ZOL in all four bone envelopes and the difference persists for at least 2 years. Moreover, the magnitude of the effect of TPTD in cortical…
Effect of Adjunctive Raloxifene Therapy on Severity of Refractory Schizophrenia in Women: A Randomized Clinical Trial
JAMA Psychiatry. 2016 Jul 20. doi: 10.1001/jamapsychiatry.2016.1383. [Epub ahead of print] Raloxifene hydrochloride, 120 mg/d, reduces illness severity and increases the probability of a clinical response in women with refractory schizophrenia. This large trial of raloxifene in this patient population offers a promising, well-tolerated agent that has potential application in clinical practice. Autor: Kulkarni J,…
Strains caused by daily loading might be responsible for delayed healing of an incomplete atypical femoral fracture
Bone. 2016 Jul;88:125-30. doi: 10.1016/j.bone.2016.04.020. Epub 2016 Apr 22. In conclusion, the poor healing capacity of incomplete atypical femoral fractures can be explained by biomechanical factors, and daily low impact activities are enough to cause strain magnitudes that prohibit bone formation. Autor: Gustafsson A, Schilcher J, Grassi L, Aspenberg P, Isaksson H.
The management of osteoporosis in children
Osteoporos Int. 2016 Jul;27(7):2147-79. doi: 10.1007/s00198-016-3515-9. Epub 2016 Apr 28. Review. The scope of this article is to review the manifestations of and risk factors for primary and secondary osteoporosis in children, to discuss the definition of pediatric osteoporosis, and to summarize recommendations for monitoring and prevention of bone fragility. As well, this article reviews…
Strains caused by daily loading might be responsible for delayed healing of an incomplete atypical femoral fracture
Bone. 2016 Jul;88:125-30. doi: 10.1016/j.bone.2016.04.020. Epub 2016 Apr 22. In conclusion, the poor healing capacity of incomplete atypical femoral fractures can be explained by biomechanical factors, and daily low impact activities are enough to cause strain magnitudes that prohibit bone formation. Autor: Gustafsson A, Schilcher J, Grassi L, Aspenberg P, Isaksson H.
In vitro lifespan and senescent behaviour of human periosteal derived stem cells
Bone. 2016 Jul;88:1-12. doi: 10.1016/j.bone.2016.04.013. Epub 2016 Apr 19. Overall, our findings suggest the possibility to use early-passage PDPCs for bone regenerative approaches based on the local recruitment of stem cells, whilst the later cell passages could be a suitable in vitro tool to validate scaffolds intended for bone regeneration in elderly subjects. Autor: Vozzi…
Exploring correlation between bone metabolism markers and densitometric traits in extended families from Spain
Strong genetic correlations were observed between osteocalcin and several bone mineral densitometric traits. In addition, suggestive genetic correlations with densitometric traits were observed for leptin and sclerostin. Overall, the few strong and several suggestive genetic correlations point out the existence of a complex underlying genetic architecture for bone metabolism plasma phenotypes.
Genetic Contribution of Femoral Neck Bone Geometry to the Risk of Developing Osteoporosis: A Family-Based Study
Our findings suggest that a relatively simple and easy to use method based on DXA studies can provide useful data on properties of the Hip in clinical practice.
Effects of quercetin, a natural phenolic compound, in the differentiation of human mesenchymal stem cells (MSC) into adipocytes and osteoblasts
Quercetin supplementation inhibited osteoblastic differentiation and promoted adipogenesis at the highest tested concentration. Such possible adverse effects of high quercetin concentrations should be taken into account in nutraceutical or pharmaceutical strategies using such flavonol.
Clinical Course of Bone Metabolism Disorders in Patients with Inflammatory Bowel Disease: A 5-Year Prospective Study
Age, smoking habit, and Inflammatory Bowel Disease activity negatively influence the clinical course of BMD. Treatment with calcium and vitamin D improves hip T-score in patients with osteopenia whereas bisphosphonates improve hip T-score in patients with osteoporosis.
Mineral metabolism disorders, vertebral fractures and aortic calcifications in stable kidney transplant recipients: The role of gender (EMITRAL study)
Vitamin D deficiency is more common among female kidney transplant recipients at earlier CKD-T stages, and it contributes to secondary hyperparathyroidism. Prevalent vertebral fractures are only related to high serum PTH levels in female recipients.
Management of Hypoparathyroidism: Summary Statement and Guidelines
J Clin Endocrinol Metab. 2016 Jun;101(6):2273-83. doi: 10.1210/jc.2015-3907. Epub 2016 Mar 4. CONCLUSIONS: This document not only provides a summary of our current knowledge but also places recent advances in its management into a context that should enhance future advances in our understanding of hypoparathyroidism. Autor: Brandi ML, Bilezikian JP, Shoback D, Bouillon R, Clarke…
Cortical-Bone Fragility–Insights from sFRP4 Deficiency in Pyle’s Disease
N Engl J Med. 2016 Jun 30;374(26):2553-62. doi: 10.1056/NEJMoa1509342. CONCLUSIONS: Our study showed that Pyle’s disease was caused by a deficiency of sFRP4, that cortical-bone and trabecular-bone homeostasis were governed by different mechanisms, and that sFRP4-mediated cross-regulation between Wnt and BMP signaling was critical for achieving proper cortical-bone thickness and stability. Autor: Simsek Kiper PO,Saito…
A systematic review and meta-analysis of the association between eating disorders and bone density
Osteoporos Int. 2016 Jun;27(6):1953-66. doi: 10.1007/s00198-015-3468-4. Epub 2016 Jan 18. Hip, whole body and femoral neck BMD were reduced to a statistically significant level in AN but not BN groups. The meta-regression was limited by the number of included studies and did not find any significant predictors. This meta-analysis confirms the association between low BMD…
How Accurate is Your Sclerostin Measurement? Comparison Between Three Commercially Available Sclerostin ELISA Kits
Calcif Tissue Int. 2016 Jun;98(6):546-55. doi: 10.1007/s00223-015-0105-3. Epub 2016 Jan 9. The variability in values generated from Biomedica, R&D Systems and TECOmedical assays raises questions regarding the accuracy and specificity of the assays. Direct comparison of studies using different kits is not possible and great care should be given to measurement of sclerostin, with traceability…
Identification of a G-Protein Subunit-α11 Gain-of-Function Mutation, Val340Met, in a Family with Autosomal Dominant Hypocalcemia Type 2 (ADH2)
J Bone Miner Res June; 31(6):1167-1176 . doi: 10.1002/jbmr.2797. Epub 2016 Jan 28. In conclusion, our identification of a novel germline gain-of-function Gα11 mutation, Val340Met, causing ADH2 demonstrates the importance of the Gα11 C-terminal region for G-protein function and CaSR signal transduction. Autor: Piret SE, Gorvin CM, Pagnamenta AT, Howles SA, Cranston T, Rust N,…
CONVOCATORIA BECAS FEIOMM ASBMR 2016
FEIOMM convoca 5 BECAS para la presentación de trabajos científicos en ASBMR 2016 Annual Meeting (American Society for Bone and Mineral Research) que se celebrará en Atlanta, Georgia (USA) del 16 al 19 de septiembre de 2016.Dichas becas cubrirán inscripción, viaje y alojamiento. La aceptación de la beca implica la conformidad con las condiciones de…
Osteogenic gene array of osteoblasts cultured on a novel osteoinductive biphasic calcium phosphate bone grafting material
Novel osteoinductive biphasic calcium phosphate particles demonstrate a wide range of significant increases over several key molecules implicated in osteogenesis that may be implicated in their ability to form ectopic bone formation.
Real-Life and RCT Participants: Alendronate Users Versus FITs’ Trial Eligibility Criterion
One in two real-life users of alendronate exhibited one or more clinical characteristics that would have led to them being excluded from the FIT trial.
Vascular Calcification Induced by Chronic Kidney Disease Is Mediated by an Increase of 1α-Hydroxylase Expression in Vascular Smooth Muscle Cells
Local activation of 1α-hydroxylase in the artery mediates vascular calcification observed in uremia
Chondroprotective effects of the combination chondroitin sulfate-glucosamine in a model of osteoarthritis induced by anterior cruciate ligament transection in ovariectomised rats
These results demonstrate the chondroprotective effects of the combination chondroitin sulfate-glucosamine in vivo, in the experimental model of anterior cruciate ligament transection in ovariectomised rats, and suggest that this combination may be useful to control the joint catabolic effects of inflammatory stress.
Preadmission Bisphosphonate and Mortality in Critically Ill Patients
J Clin Endocrinol Metab. 2016 May;101(5):1945-53. doi: 10.1210/jc.2015-3467. Epub 2016 Jan 18. Preadmission bisphosphonate use was associated with superior survival among critically ill patients. Prospective studies examining the effects of bisphosphonate in critical illness are required. Autor: Lee P, Ng C, Slattery A, Nair P, Eisman JA, Center JR.
Cancel the denosumab holiday
Osteoporos Int. 2016 May;27(5):1677-82. doi: 10.1007/s00198-016-3553-3. Epub 2016 Mar 1 Patients should be encouraged to continue denosumab therapy long term. If discontinuation does occur, appropriate steps must be taken to prevent the rapid bone loss and probable acute fracture risk. Autor: Loi F, Córdova LA, Pajarinen J, Lin TH, Yao Z, Goodman SB.
Free 25-Hydroxyvitamin D: Impact of Vitamin D Binding Protein Assays on Racial-Genotypic Associations
J Clin Endocrinol Metab. 2016 May;101(5):2226-34. doi: 10.1210/jc.2016-1104. Epub 2016 Mar 23. Previously reported racial differences in DBP concentration are likely from monoclonal assay bias, as there was no racial difference in DBP concentration by other methods. This confirms the poor vitamin D status of many African-Americans and the utility of total 25OHD in assessing…
Technical Note: Cortical thickness and density estimation from clinical CT using a prior thickness-density relationship
This method might be a promising approach for the quantification of cortical bone thickness and density using clinical routine imaging techniques.
The Proteasome Inhibitor Bortezomib Maintains Osteocyte Viability in Multiple Myeloma Patients by Reducing Both Apoptosis and Autophagy: A New Function for Proteasome Inhibitors.
J Bone Miner Res. 2016 Apr;31(4):815-27. doi: 10.1002/jbmr.2741. Epub 2015 Dec 14. Our data identify osteocyte autophagy as a new potential target in MM bone disease and support the use of PIs to maintain osteocyte viability and improve bone integrity in MM patients. Autor: Toscani D, Palumbo C, Dalla Palma B, Ferretti M, Bolzoni M,…
A Novel Domain-Specific Mutation in a Sclerosteosis Patient Suggests a Role of LRP4 as an Anchor for Sclerostin in Human Bone
J Bone Miner Res. 2016 Apr;31(4):874-81. doi: 10.1002/jbmr.2782. Epub 2016 Jan 24 We demonstrate that impaired sclerostin binding to the mutated LRP4 protein leads to dramatic increase in circulating sclerostin in this patient. With this study, we provide the first evidence suggesting that LRP4 is responsible for the retention of sclerostin in the bone environment…
Differential Effects of Teriparatide and Denosumab on Intact PTH and Bone Formation Indices: AVA Osteoporosis Study
J Clin Endocrinol Metab. 2016 Apr;101(4):1353-63. doi: 10.1210/jc.2015-4181. Epub 2016 Feb 9 We compared effects of teriparatide and denosumab on PTH, bone turnover markers, and bone histomorphometry in osteoporotic postmenopausal women. The findings were inconsistent with an early indirect anabolic effect of denosumab. Autor: Dempster DW, Zhou H, Recker RR, Brown JP, Recknor CP, Lewiecki…
Effect of Teriparatide on Bone Formation in the Human Femoral Neck
J Clin Endocrinol Metab. 2016 Apr;101(4):1498-505. doi: 10.1210/jc.2015-3698. Epub 2016 Feb 22 TPTD stimulates bone formation rapidly in cancellous and endocortical envelopes of the FN. Our findings provide a mechanistic basis for TPTD-mediated improvement in FN bone mass and ultimately hip strength. This study is the first demonstration of the effect of any osteoporosis medication…
The National Osteoporosis Foundation’s position statement on peak bone mass development and lifestyle factors: a systematic review and implementation recommendations
Osteoporos Int. 2016 Apr;27(4):1281-386. doi: 10.1007/s00198-015-3440-3. Epub 2016 Feb 8. Erratum in: Osteoporos Int. 2016 Apr;27(4):1387. The best evidence (grade A) is available for positive effects of calcium intake and physical activity, especially during the late childhood and peripubertal years-a critical period for bone accretion. Good evidence is also available for a role of vitamin…
The National Osteoporosis Foundation’s position statement on peak bone mass development and lifestyle factors: a systematic review and implementation recommendations
Osteoporos Int. 2016 Apr;27(4):1281-386. doi: 10.1007/s00198-015-3440-3. Epub 2016 Feb 8 The best evidence (grade A) is available for positive effects of calcium intake and physical activity, especially during the late childhood and peripubertal years-a critical period for bone accretion. Good evidence is also available for a role of vitamin D and dairy consumption and a…
Osteoporosis in the adult solid organ transplant population: underlying mechanisms and available treatment options
Osteoporos Int. 2016 Apr;27(4):1425-40. doi: 10.1007/s00198-015-3367-8. Epub 2015 Oct 16. Review Supplementation with calcium and vitamin D is often necessary in the SOT population due to a high incidence of vitamin D deficiency. Bisphosphonate therapy is most commonly used for prevention and treatment of osteoporosis, but therapy can be limited by renal dysfunction which is…
Differential Effects of Teriparatide and Denosumab on Intact PTH and Bone Formation Indices: AVA Osteoporosis Study
J Clin Endocrinol Metab. 2016 Apr;101(4):1353-63. doi: 10.1210/jc.2015-4181. Epub 2016 Feb 9. We compared effects of teriparatide and denosumab on PTH, bone turnover markers, and bone histomorphometry in osteoporotic postmenopausal women. The findings were inconsistent with an early indirect anabolic effect of denosumab. Autor: Dempster DW, Zhou H, Recker RR, Brown JP, Recknor CP, Lewiecki…
Sodium Intake and Osteoporosis. Findings From the Women’s Health Initiative
J Clin Endocrinol Metab. 2016 Apr;101(4):1414-21. doi: 10.1210/jc.2015-4017. Epub 2016 Feb 10. In this large, prospective, observational cohort study of postmenopausal women in the WHI, Cox proportional hazard regression models showed that sodium intake at or near recommended levels is not likely to impact bone metabolism. Autor: Carbone L, Johnson KC, Huang Y, Pettinger M,…
Evaluation of efficacy and safety of conjugated estrogens/bazedoxifene in a Latin American population
Conjugated estrogens/bazedoxifene improved vasomotor symptoms, genitourinary syndrome of menopause, and BMD in Latin American women, with efficacy/safety similar to the global population.
The Effects of Body Composition, Dietary Intake, and Physical Activity on Calcaneus Quantitative Ultrasound in Spanish Young Adults
Lifestyle choices and their consequences during early adulthood could influence bone mass, particularly physical activity and lean mass. Furthermore, this study provides novel data about bone mass as indicated by the QUS measurements at the time of PBM acquisition.
Phenolic Compounds in Extra Virgin Olive Oil (EVOO) Stimulate Human Osteoblastic Cell Proliferation
Cell proliferation was increased. The most effective EVOO phenolic extracts were those obtained from the Picual variety, as they significantly increased cell proliferation by 18-22%. Conversely, Arbequina phenolic extracts increased cell proliferation by 9-13%. A decline in osteoblast proliferation was observed in oils obtained from olive fruits collected at the end of the harvest period,…
Convocatoria Becas FEIOMM Movilidad 2016
La Fundación Española de Investigación Ósea y del Metabolismo Mineral (FEIOMM) convoca las BECAS FEIOMM-Movilidad con el fin de proporcionar una ayuda complementaria para la realización de estancias cortas en centros de investigación nacionales e internacionales destinadas a ampliar la formación en investigación, mediante la adquisición de nuevos conocimientos y técnicas experimentales, en el campo…
Differential Effects of Teriparatide and Zoledronic Acid on Bone Mineralization Density Distribution at 6 and 24 Months in the SHOTZ Study
J Bone Miner Res. 2016; 31(8):1527-35. doi: 10.1002/jbmr.2825. Epub 2016 Mar 30. TPTD stimulated new bone formation, producing a mineralized bone matrix that remained relatively heterogeneous with a stable mean mineral content. ZOL slowed bone turnover and prolonged secondary mineralization, producing a progressively more homogeneous and highly mineralized bone matrix. While both TPTD and ZOL…
Mortality After Atypical Femoral Fractures: A Cohort Study
J Bone Miner R 2016 Mar;31(3):491-7. doi: 10.1002/jbmr.2767. Epub 2016 Jan 8 We conclude that in contrast to ordinary subtrochanteric and femoral shaft fractures, atypical femoral fractures are not associated with excess mortalityes. Autor: Kharazmi M, Hallberg P, Schilcher J, Aspenberg P, Michaëlsson K.
Dietary Patterns and Fractures in Postmenopausal Women: Results From the Women’s Health Initiative
JAMA Intern Med. 2016 Mar 28. doi: 10.1001/jamainternmed.2016.0482. [Epub ahead of print] Higher adherence to a Mediterranean diet is associated with a lower risk for hip fractures. These results support that a healthy dietary pattern may play a role in maintaining bone health in postmenopausal women. Autor: Haring B, Crandall CJ, Wu C, LeBlanc ES,…
MicroRNA variants as genetic determinants of bone mass
Bone. 2016 Mar;84:57-68. doi: 10.1016/j.bone.2015.12.016. Epub 2015 Dec 23. Review. Given the polygenic nature of skeletal diseases like osteoporosis and osteoarthritis, validating the function of additional miRNA-associated SNPs has the potential to enhance our understanding of the genetic determinants of bone mass and predisposition to selected skeletal diseases. Autor: Dole NS, Delany AM.
Osteocyte-directed bone demineralization along canaliculi
Bone. 2016 Mar;84:279-88. doi: 10.1016/j.bone.2015.12.006. Epub 2015 Dec 17 These data suggest demineralization can occur from within bone through the canalicular system, and that peri-canalicular demineralization occurs not uniformly but directed by individual osteocytes. Blockade of peri-canalicular demineralization may be a therapeutic strategy to increase bone mass and quality. Autor: Nango N, Kubota S, Hasegawa…
Bisphosphonate drug holidays: we reap what we sow
Osteoporos Int. 2016 Mar;27(3):849-52. doi: 10.1007/s00198-015-3453-y. Epub 2015 Dec 14. No abstract available. Clinicians need to rethink the assumption that a patient who has taken an oral bisphosphonate for 5 years or an intravenous therapy for 3 years should automatically start a drug holiday. The clinician should individualize the decision for each patient based on…
Effect of osteoporosis medications on fracture healing
Osteoporos Int. 2016 Mar;27(3):861-71. doi: 10.1007/s00198-015-3331-7. Epub 2015 Sep 29 Further clinical studies with these medications are needed to fully understand their effects on fracture healing in order to simultaneously treat fragility fractures and underlying osteoporosis. Autor: Hegde V, Jo JE, Andreopoulou P, Lane JM.
Bone mineral density decline according to renal tubular dysfunction and phosphaturia in tenofovir-exposed HIV-infected patients
Chronic abnormal phosphaturia explains, at least in part, progressive bone loss during TDF therapy. These data suggest that tubular dysfunction leads to an altered equilibrium between phosphatemia, phosphaturia and bone as mechanism of progressive BMD decline.
AI-related BMD variation in actual practice conditions: a prospective cohort study
Our data confirm a clinically relevant bone loss associated with aromatase inhibitors (AI) therapy amongst non-users of preventative bisphosphonates. We further report on the importance of BMD monitoring as well as calcium and 25(OH)vitD supplementation in these patients.
Antiresorptive treatment, when initiated after a first hip fracture, may not protect of a second contralateral episode in elderly population: A study with 685 patients
There was no significant difference between suffering a second hip fracture and following osteoporosis treatment, using psychotropic drugs or being institutionalised.
Increase in Fracture Risk Following Unintentional Weight Loss in Postmenopausal Women: The Global Longitudinal Study of Osteoporosis in Women
Unintentional weight loss at baseline was associated with a significantly increased risk of fracture of the clavicle, wrist, spine, rib, hip, and pelvis for up to 5 years following weight loss. This increase is seen as early as 1 year following weight loss, emphasizing the need for prompt fracture risk assessment and appropriate management to…
Vitamin D3 and calcidiol are not equipotent
Calcidiol is faster and 3-6 times more potent to obtain serum levels of 25(OH)D in the medium to long term.
Premios Fundación Lilly de Investigación Biomédica Preclínica y Clínica 2016
La Fundación Lilly, en desarrollo de sus objetivos estatutarios y dentro del programa de Apoyo a la Investigación BIOMÉDICA, convoca los Premios Fundación Lilly de Investigación Biomédica Preclínica y Clínica 2016, para investigadores que hayan contribuido de forma significativa al desarrollo de la Biomedicina y las Ciencias de la Salud en España, y mantengan una…
The Microbiome and Musculoskeletal Conditions of Aging: A Review of Evidence for Impact and Potential Therapeutics
J Bone Miner Res. 2016 Feb;31(2):261-9. doi: 10.1002/jbmr.2765. Review. This perspective discusses evidence to date on the role of the microbiome and the highly prevalent age-related disorders of osteoporosis, osteoarthritis, gout, rheumatoid arthritis, sarcopenia, and frailty. It also reviews data on the effects of probiotics and prebiotic interventions in animal and human models. Despite suggestive…
Contribution of Lumbar Spine BMD to Fracture Risk in Individuals With T-Score Discordance
J Bone Miner Res. 2016 Feb;31(2):274-80. doi: 10.1002/jbmr.2611. Epub 2015 Sep 3. This study shows the significant contribution of lower LS BMD to fracture risk over and above FN BMD in women. A LS BMD lower than FN BMD should be incorporated into fracture risk calculators at least for women in older age-groups. Autor: Alarkawi…
Global Consensus Recommendations on Prevention and Management of Nutritional Rickets
J Clin Endocrinol Metab. 2016 Feb;101(2):394-415. doi: 10.1210/jc.2015-2175. Epub 2016 Jan 8. Rickets, osteomalacia, and vitamin D and calcium deficiencies are preventable global public health problems in infants, children, and adolescents. Implementation of international rickets prevention programs, including supplementation and food fortification, is urgently required. Autor: Munns CF,Shaw N,Kiely M,Specker BL,Thacher TD,Ozono K,MichigamiT,Tiosano D,Mughal MZ,…
FGF23-regulated production of Fetuin-A (AHSG) in osteocytes
Bone. 2016 Feb;83:35-47. doi: 10.1016/j.bone.2015.10.008. Epub 2015 Oct 23. Our data not only confirm that AHSG is produced in bone, mainly in osteocytes, but show for the first time that its production is modulated by FGF23. Since both proteins play important roles in the bone and cardiovascular pathology, these results add new pieces to the…
Monthly High-Dose Vitamin D Treatment for the Prevention of Functional Decline: A Randomized Clinical Trial
JAMA Intern Med. 2016 Feb 1;176(2):175-83. doi: 10.1001/jamainternmed.2015.7148. Although higher monthly doses of vitamin D were effective in reaching a threshold of at least 30 ng/mL of 25-hydroxyvitamin D, they had no benefit on lower extremity function and were associated with increased risk of falls compared with 24 000 IU. Autor: Bischoff-Ferrari HA, Dawson-Hughes B, Orav…
Relationship between spinal osteoarthritis and vertebral fractures in men older than 50 years: data from the Camargo Cohort Study
Our results suggest a positive relationship between radiologic osteoarthritic changes at the thoracic spine and prevalent vertebral fractures in men more than 50 years of age. Osteoarthritis may act as a local risk factor, in addition to other mechanical factors, resulting in a greater propensity to fracture, especially at the mid-thoracic region.
Medication-related osteonecrosis of the jaw associated with bisphosphonates and denosumab in osteoporosis
Most of our cases were in the early stages of MRONJ, and the success rate after conservative treatment was high.
Role of Periostin in Adhesion and Migration of Bone Remodeling Cells
Role of Periostin in Adhesion and Migration of Bone Remodeling Cells
Clinical effectiveness of orthogeriatric and fracture liaison service models of care for hip fracture patients: population-based longitudinal study
The introduction and/or expansion of orthogeriatric and FLS models of post-hip fracture care has a beneficial effect on subsequent mortality. No evidence for a reduction in second hip fracture rate was found.
Balancing benefits and risks of glucocorticoids in rheumatic diseases and other inflammatory joint disorders: new insights from emerging data
An expert consensus paper from the European Society for Clinical and Economic Aspects of Osteoporosis and Osteoarthritis (ESCEO). Within a strategy of a disease modifying approach to inflammatory disease, short durations of moderate doses of GCs are generally well tolerated and have a positive benefit/risk ratio. Patients should be assessed for fracture risk and bone…
The COL1A1 SP1 polymorphism is associated with lower bone mineral density in patients treated with valproic acid
In our study, the presence of the ‘s’ allele of the COL1A1 Sp1 polymorphism in individuals with epilepsy was related to lower bone BMD (lumbar and femoral). This relationship seemed to be further apparent in the patients undergoing treatment with VPA.
Fracture experience among participants from the FROCAT study: what thresholding is appropriate using the FRAX tool?
Our findings support and validate the use of FRIDEX thresholds of FRAX when discussing the risk of fracture and the initiation of therapy with patients.
Bone-density tests
It’s worth getting a bone-density test if you’re older or have other risk factors for weak bones, because without it the first sign of osteoporosis is usually a broken bone. Autor: © 2011 American Medical Association
Clinical Practice. Postmenopausal Osteoporosis
N Engl J Med. 2016 Jan 21;374(3):254-62. doi: 10.1056/NEJMcp1513724. Review. Key Clinical Points Postmenopausal Osteoporosis Fractures and osteoporosis are common, particularly among older women, and hip fractures can be devastating. Treatment is generally recommended in postmenopausal women who have a bone mineral density T score of -2.5 or less, a history of spine or hip…
Myostatin deficiency partially rescues the bone phenotype of osteogenesis imperfecta model mice
Osteoporos Int. 2016 Jan;27(1):161-70. doi: 10.1007/s00198-015-3226-7. Epub 2015 Jul 16. Myostatin deficiency partially improved the reduced femoral bone biomechanical strength of adult +/oim mice by increasing muscle mass with concomitant improvements in bone microarchitecture and physiochemical properties. Autor: Oestreich AK, Carleton SM, Yao X, Gentry BA, Raw CE, Brown M, Pfeiffer FM, Wang Y, Phillips…
Managing Osteoporosis in Patients on Long-Term Bisphosphonate Treatment: Report of a Task Force of the American Society for Bone and Mineral Research
Osteoporos Int. 2016 Jan;27(1):161-70. doi: 10.1007/s00198-015-3226-7. Epub 2015 Jul 16. Myostatin deficiency partially improved the reduced femoral bone biomechanical strength of adult +/oim mice by increasing muscle mass with concomitant improvements in bone microarchitecture and physiochemical properties. Autor: Oestreich AK, Carleton SM, Yao X, Gentry BA, Raw CE, Brown M, Pfeiffer FM, Wang Y, Phillips…
Managing Osteoporosis in Patients on Long-Term Bisphosphonate Treatment: Report of a Task Force of the American Society for Bone and Mineral Research
J Bone Miner Res. 2016 Jan;31(1):16-35. doi: 10.1002/jbmr.2708. Review. Hence, the Task Force suggests that after 5 years of oral BP or 3 years of intravenous BP, reassessment of risk should be considered. In women at high risk, for example, older women, those with a low hip T-score or high fracture risk score, those with…
Contribution of Quadriceps Weakness to Fragility Fracture: A Prospective Study
J Bone Miner Res. 2016 Jan;31(1):208-14. doi: 10.1002/jbmr.2594. Epub 2015 Aug 4. These data indicate that muscle weakness is an independent determinant of fracture risk in men, but not in women. This sex difference suggests that apart from mechanical load effect of muscle on bone, there are other muscle-bone interactions that need to be investigated…
Epidemiology of fractures in type 2 diabetes
Bone. 2016 Jan;82:2-8. doi: 10.1016/j.bone.2015.05.032. Epub 2015 May 29. Review. This article is part of a Special Issue entitled “Bone and diabetes” Autor: Schwartz AV
Implications of exercise-induced adipo-myokines in bone metabolism
The beneficial effects of exercise on bone metabolism depends on the intermittent exposure to myokines which, instead, act as inflammatory/pro-resorptive mediators when chronically elevated; on the other hand, the reduction in the circulating levels of adipokines sustains these effects as well as improves the whole-body metabolic status.
Oxidative stress, autophagy, epigenetic changes and regulation by miRNAs as potential therapeutic targets in osteoarthritis
A deeper knowledge of the mechanisms involved in chondrocyte aging could identify potential targets for the treatment of OA, a prevalent and therapeutic-orphan disease.
New PPARγ partial agonist improves obesity-induced metabolic alterations and atherosclerosis in LDLr-/- mice
GQ-177, a new thiazolidinedione, acts as a partial PPARγ agonist that improves obesity-associated insulin resistance and dyslipidemia with atheroprotective effects in LDLr-/- mice.
Efficacy and safety of alendronic acid in the treatment of osteoporosis in children
Alendronate increased bone mineral density and was well tolerated in all patients, therefore it could be considered as a therapeutic option in the treatment of osteoporosis in children.
Convocatoria BECAS FEIOMM INVESTIGACIÓN 2016
La Fundación Española de Investigación Ósea y del Metabolismo Mineral (FEIOMM), convoca 6 BECAS de 6.000€ cada una para promocionar la investigación básica, clínica y traslacional en el campo del metabolismo mineral y óseo
Hypophosphatasia: an overview of the disease and its treatment
Osteoporos Int. 2015 Dec;26(12):2743-57. doi: 10.1007/s00198-015-3272-1. Epub 2015 Aug 6. This review presents the current knowledge on hypophosphatasia, a rare genetic disease of very variable severity (from lethal to mild) and clinical presentation, caused by defective production of tissue-non-specific alkaline phosphatase (TNSALP). Autor: Bianchi ML.
Are Biochemical Markers of Bone Turnover Representative of Bone Histomorphometry in 370 Postmenopausal Women?
J Clin Endocrinol Metab. 2015 Dec;100(12):4662-8. doi: 10.1210/jc.2015-2957. Epub 2015 Oct 27. Bone turnover markers were significantly but modestly associated with bone turnover parameters measured in iliac cancellous bone. The iliac crest bone may not represent perfectly the whole bone turnover. Autor: Chavassieux P, Portero-Muzy N, Roux JP, Garnero P, Chapurlat R.
Rebound-associated vertebral fractures after discontinuation of denosumab-from clinic and biomechanics
Osteoporos Int. 2015 Dec 22. [Epub ahead of print] Studies are urgently needed to i) prove the underlying pathophysiological processes suggested above, ii) establish the predictive criteria exposing patients to an increased risk of RVF, and iii) determine appropriate treatment regimens to be applied in such patients. Autor: Popp AW, Zysset PK, Lippuner K.
The effect of 8 or 5 years of denosumab treatment in postmenopausal women with osteoporosis: results from the FREEDOM Extension study
Osteoporos Int. 2015 Dec;26(12):2773-83. doi: 10.1007/s00198-015-3234-7. Epub 2015 Jul 23. CONCLUSIONS: Denosumab treatment for up to 8 years was associated with persistent reductions of BTMs, continued BMD gains, low fracture incidence, and a consistent safety profile. Autor: Papapoulos S, Lippuner K, Roux C, Lin CJ, Kendler DL, Lewiecki EM, Brandi ML, Czerwiński E, Franek E,…
Comparative performance of current definitions of sarcopenia against the prospective incidence of falls among community-dwelling seniors age 65 and older
Osteoporos Int. 2015 Dec;26(12):2793-802. doi: 10.1007/s00198-015-3194-y. Epub 2015 Jun 12. CONCLUSION: Among the definitions investigated, the Baumgartner definition and the Cruz-Jentoft definition had the highest validity for predicting the rate of falls. Autor: Bischoff-Ferrari HA, Orav JE, Kanis JA, Rizzoli R, Schlögl M, Staehelin HB, Willett WC, Dawson-Hughes B.
Negative Impact of Aromatase Inhibitors on Proximal Femoral Bone Mass and Geometry in Postmenopausal Women with Breast Cancer
Calcif Tissue Int. 2015 Dec;97(6):551-9. doi: 10.1007/s00223-015-0046-x. Epub 2015 Aug 1. AI treatment in breast cancer patients is associated with deterioration of femoral cortical BMD and geometry, which could contribute in site-specific weakened bone strength and increased incidence of hip fractures. Autor: Lee SJ, Kim KM, Brown JK, Brett A, Roh YH, Kang DR, Park…
Macrophages: Their Emerging Roles in Bone
J Bone Miner Res. 2015 Dec;30 (12):2140-2149. doi: 10.1002/jbmr.2735. Epub 2018 Nov 4. Review. Collectively, this developing area of osteoimmunology raises new questions and promises to provide novel insights into pathophysiologic conditions as well as therapeutic and regenerative approaches vital for skeletal health. Autor: Sinder BP, Pettit AR, McCauley LK.
Trabecular bone score in patients with liver transplants after one year of risedronate treatment
No significant effect in TBS was observed in liver transplant patients treated with RIS or calcium and vitamin D3 after 1 year of follow-up. In these patients the clinical usefulness of this new tool should be established.
Influence of age on rat bone-marrow mesenchymal stem cells potential
Taking together these results indicate for the first time that mesenchymal stem cells have significant differences in their proliferative, pluripotency and metabolism profiles and those differences are age depending.
MiRNA profiling of whole trabecular bone: identification of osteoporosis-related changes in MiRNAs in human hip bones
We identified two osteoblast miRNAs over-expressed in osteoporotic fractures, which opens novel prospects for research and therapy.
The role of CD40 and CD40L in bone mineral density and in osteoporosis risk: A genetic and functional study
Our results suggest that the CD40/CD40L system plays a role in regulating BMD. Effectively, our data suggest that a decreased production of OPG could be the cause of the lower BMD observed in TT women for rs1883832 of the CD40 gene and that the degree of methylation of CpGs in the CD40 promoter could contribute…
Reduction of trabecular and cortical volumetric bone mineral density at the proximal femur in patients with acromegaly
Both cortical and trabecular vBMD are reduced at the proximal femur in ACRO patients, regardless of gender, gonadal status and disease activity. Disease duration is negatively associated with trabecular vBMD at the total hip and intertrochanteric sites.
Premio FHOEMO – SEIOMM 2013
PREVALENCIA DE OSTEOPOROSIS, FRACTURAS VERTEBRALES E HIPOVITAMINOSIS D EN MUJERES POSTMENOPÁUSICAS QUE VIVEN EN UN HÁBITAT RURAL Ver resolución aquí.
Bone Density After Teriparatide Discontinuation in Premenopausal Idiopathic Osteoporosis
J Clin Endocrinol Metab. 2015 Nov;100(11):4208-14. doi: 10.1210/jc.2015-2829. Epub 2015 Sep 10 CONCLUSIONS: These findings lead us to conclude that premenopausal women with IOP, particularly those over 40, may require antiresorptive treatment to prevent bone loss after teriparatide. Autor: Cohen A, Kamanda-Kosseh M, Recker RR, Lappe JM, Dempster DW, Zhou H, Cremers S, Bucovsky M,…
Circulating monocytes: an appropriate model for bone-related study
Osteoporos Int. 2015 Nov;26(11):2561-72. doi: 10.1007/s00198-015-3250-7. Epub 2015 Jul 21. In particular, we discuss the close relationship between PBMs and osteoclasts, and highlight the utility of PBMs in study the pathophysiological mechanisms underlying various skeletal disorders. Autor: Zhou Y, Deng HW, Shen H.
Bone mineral density and inflammatory and bone biomarkers after darunavir-ritonavir combined with either raltegravir or tenofovir-emtricitabine in antiretroviral-naive adults with HIV-1: a substudy of the NEAT001/ANRS143 randomised trial
A raltegravir-based regimen was associated with significantly less loss of bone mineral density than a standard regimen containing tenofovir disoproxil fumarate, and might be a treatment option for patients at high risk of osteopenia or osteoporosis who are not suitable for NtRTIs such as abacavir or tenofovir alafenamide.
Body fat loss induced by calcium in co-supplementation with conjugated linoleic acid is associated with increased expression of bone formation genes in adult mice
Overall, in addition to the weight loss promoting properties of calcium, on its own or co-supplemented with conjugated linoleic acid, our results support beneficial effects on bone metabolism in mice.
Relationship between myostatin and irisin in type 2 diabetes mellitus: a compensatory mechanism to an unfavourable metabolic state?
Our results suggest that serum levels of myostatin and irisin are related in patients with type 2 diabetes. Triglyceride and glucose levels could modulate myostatin and irisin concentrations as a compensatory mechanism to improve the metabolic state in these patients although further studies are needed to elucidate whether the action of these myokines represents an…
The role of serum osteoprotegerin and receptor-activator of nuclear factor-κB ligand in metabolic bone disease of women after obesity surgery
These data show that the osteoprotegerin and receptor-activator of nuclear factor-κB ligand system is associated with bone markers and bone mineral density at the lumbar spine after obesity surgery.
Denosumab increases sublesional bone mass in osteoporotic individuals with recent spinal cord injury.
Treatment with denosumab increases lumbar and femoral BMD and decreases bone turnover markers in individuals with recent SCI. This drug may be a promising therapeutic option in SCI-related osteoporosis.
Resolución Becas FEIOMM Investigación 2015
Para promover la investigación clínica, básica y trasnacional en el campo de la patología metabólica ósea, se ha resuelto la convocatoria de Becas de investigación 2015 de la FEIOMM. Consulte la resolución aquí.
Premio FHOEMO – SEIOMM 2015
RUTA DE LA SALUD, UNA FORMA DE DIFUNDIR EL CONOCIMIENTO DE LA OSTEOPOROSIS. Ver resolución aquí.
PREMIOS ITALFÁRMACO-SEIOMM 2015
XX Congreso SEIOMM – Bilbao: El jurado, compuesto por los moderadores de las sesiones de comunicaciones orales y pósters y el Comité Científico del XX Congreso de la SEIOMM, ha otorgado los Premios Italfármaco 2015 a los siguientes trabajos
Acta Premio Joven Investigador 2015
Mejor comunicación presentada por un investigador socio menor de 35 años: Dra.Blanca Torrubia “EFECTO BENEFICIOSOS DEL ACEITE DE OLIVA SOBRE LA BIOMECÁNICA Y MORFOMETRÍA ÓSEA EN RATAS OVARIECTOMIZADAS.”
A meta-analysis of trabecular bone score in fracture risk prediction and its relationship to FRAX
J Bone Miner Res. 2015 Oct 24. doi: 10.1002/jbmr.2734. [Epub ahead of print] TBS is a significant predictor of fracture risk independently of FRAX. The findings support the use of TBS as a potential adjustment for FRAX probability, though the impact of the adjustment remains to be determined in the context of clinical assessment guidelines….
Severe spontaneous vertebral fractures after denosumab discontinuation: three case reports
Osteoporos Int. 2015 Oct 28. [Epub ahead of print] Osteoporosis treatments are usually given for a limited period of time in order to balance benefits and risks. We report three cases of postmenopausal women without any previous fragility fracture who presented severe spontaneous vertebral fractures after denosumab discontinuation. We think that the occurrence of these…
Risk Assessment Tools for Osteoporosis Screening in Postmenopausal Women: A Systematic Review
Curr Osteoporos Rep. 2015 Oct;13(5):287-301. doi: 10.1007/s11914-015-0282-z. Among women 50-64 years old, a Fracture Risk Assessment Tool (FRAX) threshold ≥9.3 % had a sensitivity of 33 % for identifying BMD T-score ≤-2.5 and 26 % for predicting major osteoporotic fracture (MOF). For predicting MOF, sensitivity was higher for SCORE and Osteoporosis Self-assessment Tool equation (OST),…
FGF23-regulated production of Fetuin-A (AHSG) in osteocytes
Bone. 2015 Oct 20;83:35-47. doi: 10.1016/j.bone.2015.10.008. [Epub ahead of print] CONCLUSIONS: Our data not only confirm that AHSG is produced in bone, mainly in osteocytes, but show for the first time that its production is modulated by FGF23. Since both proteins play important roles in the bone and cardiovascular pathology, these results add new pieces…
Persistence with denosumab and persistence with oral bisphosphonates for the treatment of postmenopausal osteoporosis: a retrospective, observational study, and a meta-analysis
Osteoporos Int. 2015 Oct;26(10):2401-11. doi: 10.1007/s00198-015-3253-4. Epub 2015 Aug 18. These data from the Swedish Prescribed Drug Register and literature review suggest that persistence was higher with denosumab than with oral bisphosphonates. Autor: Karlsson L, Lundkvist J, Psachoulia E, Intorcia M, et al.
Persistence, adherence, and medication-taking behavior in women with postmenopausal osteoporosis receiving denosumab in routine practice in Germany, Austria, Greece, and Belgium: 12-month results from a European non-interventional study
Osteoporos Int. 2015 Oct;26(10):2479-89. doi: 10.1007/s00198-015-3164-4. Epub 2015 May 28. These data extend the real-world evidence regarding persistence with and adherence to denosumab, both of which are critical for favorable clinical outcomes, including fracture risk reduction. Autor: Hadji P, Papaioannou N, Gielen E, Feudjo Tepie M, Zhang E, Frieling I, Geusens P, Makras P, Resch…
Intervention Thresholds and the Diagnosis of Osteoporosis
J Bone Miner Res. 2015 Oct;30(10):1747-53. doi: 10.1002/jbmr.2531. A position paper of the National Bone Health Alliance recently recommended that diagnostic criteria for osteoporosis be redefined. We review the merits and demerits of this proposal and argue that the operational bone mineral density (BMD)-based definition be retained while clarity is brought to bear on the…
Higher Dietary Calcium Intakes Are Associated With Reduced Risks of Fractures, Cardiovascular Events, and Mortality: A Prospective Cohort Study of Older Men and Women
J Bone Miner Res. 2015 Oct;30(10):1758-66. doi: 10.1002/jbmr.2515. Epub 2015 May 10. In summary, for older men and women, calcium intakes of up to 1348 (316) mg/d from food were associated with decreased risks for fracture, non-fatal CVD, stroke, and all-cause mortality. Autor: WILE Khan B, Nowson CA, Daly RM, English DR, Hodge AM, Giles…
Lack of Influence of Vitamin D Receptor BsmI (rs1544410) Polymorphism on the Rate of Bone Loss in a Cohort of Postmenopausal Spanish Women Affected by Osteoporosis and Followed for Five Years
rs1544410 polymorphisms do not account significantly for the changes in bone mass in Spanish women with osteoporosis undergoing treatment.
Adverse Effects of Diabetes Mellitus on the Skeleton of Aging Mice
DM worsens bone alterations of aged mice, related to decreased bone turnover and bone vasculature and increased senescence, independently of the anti-oxidative stress machinery.
Whole-genome sequencing identifies EN1 as a determinant of bone density and fracture
We identified a low-frequency non-coding variant near a novel locus, EN1, with an effect size fourfold larger than the mean of previously reported common variants for lumbar spine BMD (rs11692564) which was also associated with a decreased risk of fracture. Using an En1cre/flox mouse model, we observed that conditional loss of En1 results in low…
Circulating sclerostin and estradiol levels are associated with inadequate response to bisphosphonates in postmenopausal women with osteoporosis
Sclerostin and estradiol levels are associated with the response to bisphosphonate therapy in women with postmenopausal osteoporosis.
Impact of the NOGG and NOF Guidelines on the Indication of Bone Mineral Density in Routine Clinical Practice
The application of the NOGG and NOF guidelines led to a decrease in BMD indications, reducing costs and improving efficiency in the diagnostic management of osteoporosis, although variability exists between the guidelines.
Clinical Expression of Calcium Sensing Receptor Polymorphism (A986S) in Normocalcemic and Asymptomatic Hyperparathyroidism
A986S polymorphism of CaSR is an independent predictor of PTH level in normocalcemic hyperparathyroidism patients, but not in asymptomatic hyperparathyroidism.
Skeletal adverse effects with aromatase inhibitors in early breast cancer: evidence to date and clinical guidance
A target concentration of 40 ng/ml 25(OH)D may prevent development of AIrA. We also demonstrate that AIrA is genetically determined: single nucleotide polymorphisms located in genes encoding key factors for the metabolism of estrogens and vitamin D (CYP17A1, VDR, and CYP27B1) are associated with self-reported arthralgia during AI therapy. We recommend establishing an individualized protocol…
Overuse and Underuse of Antiosteoporotic Treatments According to Highly Influential Osteoporosis Guidelines: A Population-Based Cross-Sectional Study in Spain
In conclusion, we found that the pharmacological management of osteoporosis in women of 50 and over in this population combines an important overuse and, to a lesser extent, underuse, although the level of inappropriateness varied strikingly depending on the CPG used. It seems urgent to reduce treatment overuse without neglecting underuse, as is urgent an…
Bone Mineral Density as a Predictor of Subsequent Wrist Fractures: Findings from the Women’s Health Initiative Study
J Clin Endocrinol Metab. 2015 Sep 14:jc20152568. [Epub ahead of print] CONCLUSIONS: Lumbar spine and femoral neck BMD were associated with incident wrist fracture, but the FRAX threshold recommended to identify screening candidates did not identify the majority of women who subsequently experienced wrist fracture. Improved understanding of determinants of wrist fractures is warranted. Autor:…
Association between Frailty, Osteoporosis, Falls and Hip Fractures among Community-Dwelling People Aged 50 Years and Older in Taiwan: Results from I-Lan Longitudinal Aging Study.
PLoS One. 2015 Sep 8;10(9):e0136968. doi: 10.1371/journal.pone.0136968. eCollection 2015. Frailty and pre-frailty, in Taiwan, was closely associated with recent falls, history of hip fractures and osteoporosis among community-dwelling people 50 years of age and older. Furthermore, frailty intervention programs should take an integrated approach towards strengthening both and muscle mass, as well as prevention of…
Osteoporosis: Treat and Live, or Let Die Twice More Likely
J Bone Miner Res. 2015 Sep;30(9):1551-2. doi: 10.1002/jbmr.2601. The study emphasized that remaining life expectancy is substantial: 13 years for men aged 60 years and 22 years for women aged 60 years. The substantial life expectancy following a fracture exposes patients to increased risk of refracture, which is itself associated with elevated mortality risk. This…
Bone Health and Osteoporosis
Endocrinol Metab Clin North Am. 2015;44:517-30. Osteoporosis is characterized by low bone mass and microarchitectural deterioration of bone tissue leading to decreased bone strength and an increased risk of low-energy fractures. Central dual-energy X-ray absorptiometry measurements are the gold standard for determining bone mineral density. Bone loss is an inevitable consequence of the decrease in…
Foreword: Calcified Tissue International and Musculoskeletal Research Special Issue : Bone Material Properties and Skeletal Fragility
Calcif Tissue Int. 2015 Sep;97(3):199-200. doi: 10.1007/s00223-015-0012-7. Epub 2015 May 13. Autor: Burr DB, Allen MR.
Presentation and management of osteoporosis presenting in association with pregnancy or lactation
Osteoporos Int. 2015 Sep;26(9):2223-41. doi: 10.1007/s00198-015-3149-3. Epub 2015 May 5. In this review, we summarize our current understanding of the pathophysiology of fragility fractures that occur for the first time during pregnancy and lactation, and provide guidance on appropriate investigations and treatment strategies. Autor: Kovacs CS, Ralston SH.
Meeting international standards of secondary fracture prevention: a survey on Fracture Liaison Services in the Netherlands
Osteoporos Int. 2015 Sep;26(9):2257-63. doi: 10.1007/s00198-015-3117-y. Epub 2015 Apr 10. The available data also showed that patients attending the FLSs were evaluated, treated and followed in high compliancy with the IOF standards. Some standards are open to different interpretations and may need further specification. The major shortcoming in FLS practice was that patients invited to…
Efficacy of bisphosphonates against osteoporosis in adult men: a meta-analysis of randomized controlled trials
Osteoporos Int. 2015 Sep;26(9):2355-63. doi: 10.1007/s00198-015-3148-4. Epub 2015 May 6. Compared with placebo, bisphosphonates could decrease the risk of vertebral and non-vertebral fractures, reduce BSAP and CTX, and increase BMD in men with osteoporosis. Autor: Chen L, Wang G, Zheng F, Zhao H, Li H.
Overuse and Underuse of Antiosteoporotic Treatments According to Highly Influential Osteoporosis Guidelines: A Population-Based Cross-Sectional Study in Spain
The pharmacological management of osteoporosis in women of 50 and over in this population combines an important overuse and, to a lesser extent, underuse, although the level of inappropriateness varied strikingly depending on the CPG used. It seems urgent to reduce treatment overuse without neglecting underuse, as is urgent an attempt to reach wider agreement…
Fine mapping of bone structure and strength QTLs in heterogeneous stock rat
We identified quantitative trait loci (QTLs) for structure phenotypes on chromosomes 3, 8, 10, 12, 17 and 20, and QTLs for strength phenotypes on chromosomes 5, 10 and 11 that met a conservative genome-wide empiric significance threshold (FDR=5%; P<3×10-6). Importantly, most QTLs were localized to very narrow genomic regions (as small as 0.3Mb and up…
Parathyroid Hormone-Related Protein Analogs as Osteoporosis Therapies
In this review, we discuss the current concepts about the cellular and molecular mechanisms whereby PTHrP may induce anabolic actions in bone. Pre-clinical studies and clinical data using N-terminal PTHrP analogs are also summarized, pointing to PTHrP as a promising alternative to current bone anabolic therapies.
The accuracy of osteoporotic fracture risk prediction tools: a systematic review and meta-analysis
Most of the 13 tools are feasible in clinical practice. FRAX has the largest number of externally validated and independent studies. The overall accuracy of the different tools is satisfactory (>0.70), with QFracture reaching 0.89 (95% CI 0.88 to 0.89). Significant methodological limitations were observed in many studies, suggesting caution when comparing tools based solely…
Differential Effects of Dabigatran and Warfarin on Bone Volume and Structure in Rats with Normal Renal Function
These findings suggest for the first time that dabigatran has a better bone safety profile than warfarin, as warfarin treatment affects bone by reducing trabecular size and structure, increasing turnover and reducing mineralization. These differences could potentially result in a lower incidence of fractures in dabigatran treated patients
Serum 25-hydroxyvitamin D, parathyroid hormone, calcium intake, and bone mineral density in Spanish adults
Vitamin D insufficiency is very common among Spanish community-dwelling adult subjects. A threshold of serum 25(OH)D around 30 ng/ml would be necessary for the prevention of secondary hyperparathyroidism and hip bone loss in our population, regardless of the dairy calcium ingestion. Programs to improve vitamin D status may be required in our country.
Convocatoria BECAS FEIOMM INVESTIGACIÓN 2015
La Fundación Española de Investigación Ósea y del Metabolismo Mineral (FEIOMM), convoca 6 BECAS de 6.000€ cada una para promocionar la investigación básica, clínica y traslacional en el campo del metabolismo mineral y óseo. Consulte las bases de la convocatoria aquí.
Intestinal Calcium Absorption Decreases Dramatically After Gastric Bypass Surgery Despite Optimization of Vitamin D Status
J Bone Miner Res. 2015 Aug;30(8):1377-85. doi: 10.1002/jbmr.2467. Epub 2015 May 21. In conclusion, FCA decreased dramatically after RYGB, even with most 25OHD levels ≥30 ng/mL and with recommended Ca intake. RYGB patients may need high Ca intake to prevent perturbations in Ca homeostasis, although the approach to Ca supplementation needs further study. Decline in FCA…
Improving Osteoporosis Management in Primary Care: An Audit of the Impact of a Community Based Fracture Liaison Nurse
PLoS One. 2015 Aug 27;10(8):e0132146. doi: 10.1371/journal.pone.0132146. eCollection 2015. CONCLUSION: A fracture liaison nurse in primary care has been associated with a period of improved management. Liaison nurses based in different parts of the health system should be tested in a prospective trial Autor: Chant T, de Lusignan S, Cooper A, Elliott M, et al
Bisphosphonate Treatment of Children and Adults with Osteogenesis Imperfecta: Unanswered Questions
Calcif Tissue Int. 2015 Aug;97(2):101-3. doi: 10.1007/s00223-015-0021-6. Epub 2015 Jun 13. Bisphosphonates are extensively used for treatment of children and adults with osteogenesis imperfecta. Over years, studies have reported the response of BP treatment in individuals with OI but some questions remain still unanswered. Autor: Brizola E, Shapiro JR.
Osteocytes and Homeostasis of Remote Organs : Bone-Buried Osteocytes Talk to Remote Organs
Curr Osteoporos Rep. 2015 Aug;13(4):193-7. doi: 10.1007/s11914-015-0269-9. The study of bones has attracted researchers from many medical fields. To understand bone-organ interactions, hematologists were challenged to investigate bone marrow (BM), the core of bone where hematopoiesis takes place. Through studies of the hematopoietic stem cells niche, hematologists contributed to the discovery of unexpected functions of…
Common allelic variants of the vitamin receptor D gene rs7975232 (ApaI) do not influence bone mineral density figures in postmenopausal osteoporotic women
The VDR gene rs7975232 polymorphism is not related to figures of bone mineral density in postmenopausal osteoporotic Spanish women
Early (1-year) Discontinuation of Different Anti-osteoporosis Medications Compared: A Population-Based Cohort Study
Early discontinuation with available anti-osteoporosis oral drugs is very common. Monthly risedronate, weekly alendronate, and daily teriparatide are the drugs with the best persistence, whilst daily oral drugs have 40-60 % higher first-year discontinuation rates compared to weekly alendronate
Effect of whole-body vibration training on bone mass in adolescents with and without Down syndrome: a randomized controlled trial.
wenty weeks of WBV training may improve BMC and BMD in clinically relevant skeletal sites in both groups. Nevertheless, this type of training seems to provoke a lesser response in adolescents with DS than in those without DS.
MicroRNAs 29b, 133b, and 211 Regulate Vascular Smooth Muscle Calcification Mediated by High Phosphorus
miR-29b, miR-133b, and miR-211 have direct roles in the vascular smooth muscle calcification induced by high phosphorus and may be new therapeutic targets in the management of vascular calcification.
Incidence and Predictors of Multiple Fractures Despite High Adherence to Oral Bisphosphonates: A Binational Population-Based Cohort Study
Even among highly adherent users of oral BP therapy, a minority sustain multiple fractures while on treatment. Older age was predictive of increased risk within both study populations, as was history of recent/old fracture and dementia within one but not both populations
Serum Circulating MicroRNAs as Biomarkers of Osteoporotic Fracture
Several miRNAs may be biomarkers of bone fracture, particularly miR-21-5p.
Exon array analysis reveals genetic heterogeneity in atypical femoral fractures. A pilot study
The results of this pilot study suggest that these fractures are polygenic and are associated with the accumulation of changes in the coding regions of several genes.
Lack of association of vitamin D receptor BsmI gene polymorphism with bone mineral density in Spanish postmenopausal women
The BsmI polymorphism in the VDR gene was not associated with BMD in Spanish postmenopausal women.
Surgical treatment in spine Paget’s disease: a systematic review
The main objective of the review is to find out indications for surgery, outcomes of these patients and also the standard perioperative management.
RESOLUCIÓN Becas ASBMR 2015
Finalizado el plazo para el envío de solicitudes para acceder a las Becas FEIOMM para la presentación de trabajos en el Congreso de la ASBMR en Seattle del 9 al 12 de octubre de 2015, se adjunta la lista de solicitudes remitidas para su evaluación
Serum 25-Hydroxyvitamin D Levels: Variability, Knowledge Gaps, and the Concept of a Desirable Range
J Bone Miner Res. 2015 Jul;30(7):1119-33. doi: 10.1002/jbmr.2536. Epub 2015 May 7. We propose a desirable range of 20 to 40 ng/mL (50 to 100 nmol/L), provided precise and accurate assays are used. Although slightly lower levels, 15 to 20 ng/mL, may be sufficient for some infants and adults, higher levels, 40 to 60 ng/mL, may still be safe….
Effects of Denosumab and Calcitriol on Severe Secondary Hyperparathyroidism in Dialysis Patients With Low Bone Mass
. J Clin Endocrinol Metab. 2015 Jul;100(7):2784-2792. Epub 2015 May 8 Denosumab allows for supra-physiologic doses of calcitriol resulting in decreased parathyroid secretion and parathyroid hyperplasia. Supervised administration and weekly laboratory and clinical monitoring of serum calcium are recommended during the first month to prevent hypocalcemia Autor: Chen CL, Chen NC, Liang HL, Hsu CY,…
Oral Calcidiol Is More Effective Than Cholecalciferol Supplementation to Reach Adequate 25(OH)D Levels in Patients with Autoimmune Diseases Chronically Treated with Low Doses of Glucocorticoids: A “Real-Life” Study
Patients with higher body mass index and those receiving higher doses of glucocorticoids are at increased risk of having lower levels of 25(OH)D. In these patients, calcidiol supplementations are more effective than cholecalciferol to reach adequate 25(OH)D levels.
CYP11A1 expression in bone is associated with aromatase inhibitor-related bone loss.
The genetic association of CYP11A1 gene with AIBL and its expression in bone tissue reveals a potential local function of this enzyme in bone metabolism regulation, offering a new vision of the steroidogenic ability of this tissue and new understanding of aromatase inhibitor-induced bone loss.
Risks and Benefits of Bisphosphonate Therapies
The aims of this review is to compile the basic characteristics of these drugs and outline the most important benefits and side effects and provide a clinical context as well as a research agenda to fill the gaps in knowledge.
Three-dimensional printed PCL-hydroxyapatite scaffolds filled with CNTs for bone cell growth stimulation
The composites show typical hydroxyapatite bioactivity, good cell adhesion and spreading at the scaffolds surface, this combination of properties indicating that the produced 3D, three-phase, scaffolds are promising materials in the field of bone regenerative medicine.
Associations between frailty and serum N-terminal propeptide of type I procollagen and 25-hydroxyvitamin D in older Spanish women: The Toledo Study for Healthy Aging
After adjustment for confounders, high PINP levels (defined by the upper quartile) and low levels of 25(OH)D (lower quartile) remained significantly associated to frailty [OR for PINP: 2.19; OR for 25(OH)D: 1.65]. Women with both high PINP levels and low 25(OH)D levels presented a 5.85-fold increased frailty risk.
Combined effects of interaction between physical activity and nutrition on bone health in children and adolescents: a systematic review
Although the results of cross-sectional studies were inconsistent, the results of randomized controlled trials showed that exercise has the potential to improve bone health under conditions of adequate calcium intake.
Bone changes in alcoholic liver disease
In this review we study the pathogenesis of bone changes in alcoholic liver disease and discuss potential therapies.
Risk factors for the development of osteoporosis after spinal cord injury. A 12-month follow-up study
The evaluation of BMD at the lumbar spine and femur short-term after spinal cord injury (SCI) is a simple, effective method for predicting the development of osteoporosis during the first year after SCI. Our results also indicate the need to evaluate and treat these patients shortly after injury.
Incidence of hip fracture in Spain (1997-2010)
The analysis of the incidence of hip fracture in Spain in people≥65 year old shows a significant variability between AA. CC. Except in Canary Islands, this variability is difficult to explain only by factors such as population age, sun exposure or north-south gradient.
The influence of genetic variability and proinflammatory status on the development of bone disease in patients with Gaucher disease
The data suggest that patients with type 1 Gaucher disease (GD1) have increased susceptibility to developing bone disease owing to the coexistence of genetic variants, and that genetic background in GD1 is fundamental to regulate the impact of proinflammatory status on the development of bone disease.
Comparison of two different strategies of treatment with zoledronate in HIV-infected patients with low bone mineral density: single dose versus two doses in 2 years
The benefits for BMD of a single dose of zoledronate in 2 years may be comparable to those obtained with two doses of the drug after 96 weeks, although this study is insufficiently powered to exclude a real difference.
Convocatoria Becas Feiomm ASBMR 2015
FEIOMM convoca 5 BECAS para la presentación de trabajos científicos en ASBMR 2015 Annual Meeting (American Society for Bone and Mineral Research) que se celebrará en Seattle, Washington (USA) del 9 al 12 de octubre de 2015.FEIOMM convoca 5 BECAS para la presentación de trabajos científicos en ASBMR 2015 Annual Meeting (American Society for Bone…
Does Diet-Induced Weight Loss Lead to Bone Loss in Overweight or Obese Adults? A Systematic Review and Meta-Analysis of Clinical Trials
J Bone Miner Res 201530(12); 2168-2178. doi: 10.1002/jbmr.2564. Epub 2015 May 25. These data show that in overweight and obese individuals, a single diet-induced weight-loss intervention induces a small decrease in total hip BMD, but not lumbar spine BMD. This decrease is small in comparison to known metabolic benefits of losing excess weight. Autor: Zibellini…
Use of proton pump inhibitors is associated with fractures in young adults: a population-based study
Osteoporos Int 19 may 2015 on line. DOI 10.1007/s00198-015-3168-0 PPI use was associated with fracture in young adults, but overall evidence did not support a PPI-fracture relationship in children. Young adults who use PPIs should be cautioned regarding potentially increased risk for fracture, even if they lack traditional fracture risk factors. Autor: D. E. Freedberg,…
Bone strength and muscle properties in postmenopausal women with and without a recent distal radius fracture
Osteoporos Int 19 May online 2015. DOI 10.1007/s00198-015-3160-8 Postmenopausal women aged 50 years and older with a recent DRF had lower bone and muscle strength in both the upper and lower extremities com- pared to the women without a recent DRF, despite no differences in DXA-derived aBMD at the femoral neck or spine and no…
Co-administration of Antiresorptive and Anabolic Agents: A Missed Opportunity
J Bone Miner Res. 2015 May;30(5):753-64. doi: 10.1002/jbmr.2496. Combined therapy remains a potentially valuable approach to therapy. Because studies of antifracture efficacy comparing combined with single therapy are unlikely to be performed in humans, efforts should be directed toward improving methods of quantifying the net effects of combined therapy on bone’s material composition, microarchitecture, and…
Establishing Biomechanical Mechanisms in Mouse Models: Practical Guidelines for Systematically Evaluating Phenotypic Changes in the Diaphyses of Long Bones
Journal of Bone and Mineral Research 2015; Volume 30, Issue 6, pages 951–966 The goal of this review is to clarify the biomechanical mechanisms and to make recommendations for systematically evaluating phenotypic changes in mouse bones, with a focus on long-bone diaphyses and cortical bone. Further, minimum reportable standards for testing conditions and outcome variables…
Hyponatremia and Fractures: Findings From the MrOS Study
Journal of Bone and Mineral Research 2015; Volume 30, Issue 6, pages 970–975 The data show that hyponatremia is associated with up to a doubling in the risk of hip and morphometric spine fractures, independent of BMD. Further studies, to determine how hyponatremia causes fractures and if correction of hyponatremia decreases fractures, are needed. Autor:…
Trabecular bone score (TBS) as a new complementary approach for osteoporosis evaluation in clinical practice
Bone. 2015 May 16. pii: S8756-3282(15)00195-7. doi: 10.1016/j.bone.2015.05.016. Although TBS changes with osteoporosis treatment, the magnitude is less than that of aBMD of the spine, and it is not clear how change in TBS relates to fracture risk reduction. TBS may also have a role in the assessment of fracture risk in some causes of…
Bisphosphonates for the prevention of fractures in osteogenesis imperfecta: meta-analysis of placebo-controlled trials
J Bone Miner Res. 2015 May;30(5):929-33. doi: 10.1002/jbmr.2410. We conclude that the effects of bisphosphonates on fracture prevention in osteogenesis imperfecta are inconclusive. Adequately powered trials with a fracture endpoint are needed to further investigate the risks and benefits of bisphosphonates in this condition. Autor: Hald JD, Evangelou E, Langdahl BL, Ralston SH.
The Effect of 6 versus 9 Years of Zoledronic Acid Treatment in Osteoporosis: A Randomized Second Extension to the HORIZON-Pivotal Fracture Trial (PFT)
J Bone Miner Res. 2015 May;30(5):934-44. doi: 10.1002/jbmr.2442. The results suggest almost all patients who have received six annual ZOL infusions can stop medication for up to 3 years with apparent maintenance of benefits. Autor: Black DM, Reid IR, Cauley JA, Cosman F, Leung PC, Lakatos P, Lippuner K, Cummings SR, Hue TF, Mukhopadhyay A,…
Improvement of mineral and bone metabolism markers is associated with better survival in haemodialysis patients: the COSMOS study
COSMOS provides evidence of the association of serum phosphorus, calcium and PTH and mortality, and suggests survival benefits of controlling chronic kidney disease-mineral and bone disorder biochemical parameters in CKD5D patients.
DLK1 regulates whole body glucose metabolism: A negative feedback regulation of the osteocalcin-insulin loop
Our data suggest that Glu-OCN-controlled production of Delta like-1 (DLK1) by pancreatic β cells acts as a negative feedback mechanism to counteract the stimulatory effects of insulin on osteoblast production of Glu-OCN, a potential mechanism preventing OCN-induced hypoglycemia.
Inappropriate prescribing to the oldest old patients admitted to hospital: prevalence, most frequently used medicines, and associated factors
Prescribed medicines and potentially inappropriate medicines (PIM) and potentially prescribing omissions (PPO) prevalence were high among patients 85 years and over. Benzodiazepine use in those who are prone to falls and omission of calcium and vitamin D in those with osteoporosis were the most frequent PIM and PPO, respectively. Factors associated with PIM and PPO…
Disability-adjusted-life-years losses in postmenopausal women with osteoporosis: a burden of illness study
DALY losses were considerable amongst postmenopausal women with osteoporosis. Not having a prior bone fracture, being older, using a SERM and having less osteoporotic risk factors were all linked to less DALY losses.
Use of oral bisphosphonates in primary prevention of fractures in postmenopausal women: a population-based cohort study
In postmenopausal women, bisphosphonates have not been shown to better decrease risk of first fracture compared with calcium and vitamin D therapy alone.
Estudio Dasio Resultados
Estudio Dasio Resultados
GRABACIÓN de la presentación del Estudio DASIO
El Estudio DASIO es un estudio multicéntrico, prospectivo y observacional que se ha llevado a cabo en cerca de 300 centros de salud de atención primaria en todo el territorio español.
Los objetivos del estudio han sido, en primer lugar, evaluar de la adherencia a las recomendaciones del profesional sanitario en mujeres osteoporóticos y la influencia de la incorporación de un lácteo fermentado enriquecido con calcio y vitamina D en la alimentación diaria sobre esta adherencia. Como objetivo secundario se fijo el evular la adherencia y la satisfacción al consumo diario del mismo. En tercer lugar, se analizaron los posibles cambios en las molestias gastrointestinales.
Efficacy and Safety of Single-Dose Zoledronic Acid for Osteoporosis in Frail Elderly Women: A Randomized Clinical Trial. J
JAMA Intern Med. Published online April 13, 2015. doi:10.1001/jamainternmed.2015.0747. In this group of frail elderly women with osteoporosis, 1 dose of zoledronic acid improved BMD over 2 years. The clinical importance of nonsignificant increases in fracture and mortality rates in the treatment group needs further study. Since it is not known whether such therapy reduces…
MicroRNA-188 regulates age-related switch between osteoblast and adipocyte differentiation
J Clin Invest. 2015 Apr;125(4):1509-22. doi: 10.1172/JCI77716. Epub 2015 Mar 9. Together, our results indicate that miR-188 is a key regulator of the age-related switch between osteogenesis and adipogenesis of BMSCs and may represent a potential therapeutic target for age-related bone loss. Autor: Li CJ, Cheng P, Liang MK, Chen YS, Lu Q, Wang JY,…
Osteoporosis Treatment and Fracture Outcomes
JAMA Intern Med. Published online April 13, 2015. doi:10.1001/jamainternmed.2015.0757 In this issue of JAMA Internal Medicine, Greenspan and colleagues1 present intriguing data on zoledronic acid, one of the most potent drugs in the bisphosphonate family—if not the most potent—approved for treatment of osteoporosis. In a study of frail elderly women living in nursing homes, the…
Screening for Osteoporosis
JAMA. 2015 Apr 14;313(14):1467-1468. doi: 10.1001/jama.2015.1064. This JAMA Clinical Guidelines Synopsis article summarizes the most recent National Osteoporosis Foundation guidelines on screening older men and postmenopausal women for osteoporosis. Autor: Altkorn D, Cifu AS.
Arterialized venous bicarbonate is associated with lower bone mineral density and an increased rate of bone loss in older men and women
J Clin Endocrinol Metab. 2015 Apr;100(4):1343-9. doi: 10.1210/jc.2014-4166. Epub 2015 Feb 2. Arterialized plasma HCO3 was associated positively with cross-sectional BMD and inversely with the rate of bone loss, implying that systemic acid-base status is an important determinant of skeletal health during aging. Ongoing bone loss was linearly related to arterialized HCO3, even after adjustment…
Here comes the sun-is vitamin D a cure for all that ails us?
J Clin Endocrinol Metab. 2015 Apr;100(4):1237-40. doi: 10.1210/jc.2015-1396 Autor: Magge SN.
Switching from tenofovir to abacavir in HIV-1-infected patients with low bone mineral density: changes in bone turnover markers and circulating sclerostin levels
The switch from tenofovir to abacavir seems to induce a positive effect on bone tissue, since bone turnover markers decreased. In addition, circulating sclerostin levels increased, a change associated with improved bone properties.
Bazedoxifene/conjugated estrogens combination for the treatment of the vasomotor symptoms associated with menopause and for prevention of osteoporosis in postmenopausal women
The tissue-selective estrogen complex (TSEC) combines bazedoxifene and conjugated estrogens and is designed not only to improve menopausal symptoms and vulvovaginal atrophy but also to prevent bone loss. Therefore, it maintains the benefits of estrogen therapy while antagonizing the stimulation effects on the endometrium and mammary gland without the effects associated with progestins.
Antiresorptives and anabolic therapy in sequence or combination for postmenopausal osteoporosis
Sequential antiresorptive therapy is recommended to maintain drug increases in bone mass and support secondary mineralization of the newly formed bone. Combination therapies of antiresorptives and anabolic agents have shown a significant increase in bone mineral density compared to monotherapies. However, none of the combinations have been studied for the prevention of fractures. Combination therapy…
Bone Tissue Properties Measurement by Reference Point Indentation in Glucocorticoid-Induced Osteoporosis
Our study is the first to demonstrate that reference point indentation is sensitive enough to reflect changes in cortical bone indentation following treatment with osteoporosis therapies in patients newly exposed to glucocorticoids.
The importance of calciuria as lithogenic factors in patients with osteopenia/osteoporosis.
Patients with osteopenia/osteoporosis without lithiasis present some urinary biochemical alterations. This would explain the lack of lithogenic activity, although low calcium excretion in 24-h urine samples is a protective factor against the loss of bone mineral density.
The effects of swimming training on bone tissue in adolescence.
Although more information is needed for females, it seems that for males, swimming is associated with lower BMC and BMD.
Adjusting Fracture Probability by Trabecular Bone Score
Calcif Tissue Int (2015) 96:500–509 DOI 10.1007/s00223-015-9980-x They have demonstrated that lumbar spine texture analysis using TBS is a risk factor for osteoporotic fracture and also for risk of death. The predictive ability of TBS is independent of FRAX clinical risk factors and femoral neck BMD; finally we have derived an algorithm to adjust probability…
WNT5A Has Anti-Prostate Cancer Effects In Vitro and Reduces Tumor Growth in the Skeleton In Vivo
J Bone Miner Res. 2015 Mar;30(3):488-97- Using different osteotropic human prostate cancer cell lines, the influence of WNT5A overexpression and knock-down on proliferation, migration, and apoptosis was assessed. In vitro, WNT5A overexpression induced prostate cancer cell apoptosis and reduced proliferation and migration, whereas WNT5A knock-down showed opposite effects. In vivo, different xenograft models were used…
Connexin 43 channels are essential for normal bone structure and osteocyte viability
J Bone Miner Res. 2015 Mar;30(3):436-48. doi: 10.1002/jbmr.2374. These findings suggest that osteocytic Cx43 channels play distinctive roles in the bone; hemichannels play a dominant role in regulating osteocyte survival, endocortical bone resorption, and periosteal apposition, and gap junction communication is involved in the process of bone remodeling. Autor: Xu H, Gu S, Riquelme MA,…
The choice of normative pediatric reference database changes spine bone mineral density z-scores but not the relationship between bone mineral density and prevalent vertebral fractures
J Clin Endocrinol Metab. 2015 Mar;100(3):1018-27. doi: 10.1210/jc.2014-3096. Epub 2014 Dec 11. Although the use of a LSBMD Z-score threshold as part of the definition of osteoporosis in a child with VF does not appear valid, the study of relationships between BMD and VF is valid regardless of the BMD database that is used. Autor:…
Serum uric acid is associated with quantitative ultrasound parameters in men: data from the Camargo cohor
Higher serum uric acid levels in men older than 50 years are positively associated with QUS parameters. These data might suggest a better bone quality in men with elevated serum uric acid values.
A 7-year randomized, placebo-controlled trial assessing the long-term efficacy and safety of bazedoxifene in postmenopausal women with osteoporosis: effects on bone density and fracture
At 7 years, the cumulative incidences of new vertebral fractures were significantly lower in the bazedoxifene (6.4%) and bazedoxifene 20 mg (7.6%) groups than in the placebo group (9.9%); the relative risk reductions were 36.5% and 30.4%, respectively (both p < 0.001). Bazedoxifene had no effect on the overall incidence of nonvertebral fractures.
Use of osteoporosis medications after hospitalization for hip fracture: a cross-national study
Regardless of differences in health care delivery systems and medication reimbursement plans, the use of osteoporosis medications for the secondary prevention of osteoporotic fracture was low. Adherence to osteoporosis treatment was also suboptimal with the PDC<0.70 in all three countries.
Serum bicarbonate and bone mineral density in US adults
Am J Kidney Dis. 2015 Feb;65(2):240-8. doi:10.1053/j.ajkd.2014.07.007. Lower serum bicarbonate levels are associated with lower BMD in US adults. Further studies should examine whether serum bicarbonate levels should be incorporated into the diagnostic assessment and management of osteoporosis. Autor: Chen W, Melamed ML, Abramowitz MK.
Low bone mineral density and fractures in stages 3-5 CKD: an updated systematic review and meta-analysis
Osteoporos Int. 2015 Feb;26(2):449-58. doi: 10.1007/s00198-014-2813-3 The meta-analysis indicates that BMD is low in predialysis and dialysis patients with fractures. These findings, considered together with the recent prospective study in CKD, and post hoc analyses of the pivotal fracture trials suggests that BMD may be clinically useful in assessing fracture risk in CKD, different than…
Increased risk of stroke among hip fracture patients: a nationwide cohort study
Osteoporos Int. 2015 Feb;26(2):645-52. doi: 10.1007/s00198-014-2919-7. Hip fracture is independently associated with increased risk of developing stroke. In addition, the risk of stroke following incidence of hip fracture is more prominent in younger patients, men, those with cardiovascular comor- bidities, and in patients using specific medication, such as diuretics and ABRs. Given the subsequent higher…
Why does rate of bone density loss not predict fracture risk?
J Clin Endocrinol Metab. 2015 Feb;100(2):679-83. doi: 10.1210/jc.2014-3777. The low correlation between past and future BMD loss helps explain why the rate of BMD loss is unlikely to be helpful for refining fracture risk. Autor: Leslie WD, Majumdar SR, Morin SN, Lix LM
Trabecular bone score as an indicator for skeletal deterioration in diabetes
Clin Endocrinol Metab. 2015 Feb;100(2):475-82. doi: 10.1210/jc.2014-2047. The inverse association between lumbar spine TBS and insulin resistance may make it an indicator for determining skeletal deterioration in diabetic patients who have high BMD. Autor: Kim JH, Choi HJ, Ku EJ, Kim KM, Kim SW, Cho NH, Shin CS.
A randomized, double-blind phase 2 clinical trial of blosozumab, a sclerostin antibody, in postmenopausal women with low bone mineral density
J Bone Miner Res. 2015 Feb;30(2):216-24. doi: 10.1002/jbmr.2351. These results support further study of blosozumab as a potential anabolic therapy for osteoporosis. Autor: ReckerRR,BensonCT,MatsumotoT,BologneseMA,RobinsDA,A J,ChiangAY,Hu L,Krege JH, Sowa H,Mitlak BH,M SL
Timing of the initiation of bisphosphonates after surgery for fracture healing: a systematic review and meta-analysis of randomized controlled trials
Osteoporos Int. 2015 Feb;26(2):431-41. doi: 10.1007/s00198-014-2903-2. Epub 2014 Sep 30. Early administration of BPs after surgery did not appear to delay fracture healing time either radiologically or clinically. Furthermore, according to the changes in BMD and bone turnover markers, the anti-resorptive efficacy of BPs given immediately after surgical repair should positively affect the rate of…
SPANISH CONSENSUS ON PREMATURE MENOPAUSE
Hormonal therapy (HT) is considered the treatment of choice to alleviate the symptoms of hypoestrogenism and to prevent long-term consequences. We suggest that HT should be continued until at least age 51, the average age at natural menopause.
PREVALENCE OF OSTEOPOROTIC VERTEBRAL FRACTURE IN SPANISH WOMEN OVER AGE 45.
Vertebral osteoporotic fracture in the female Spanish population is frequent. The high prevalence in the Spanish population older than 60 years is probably related to malnutrition in the period from 1936 to 1952.
REGIONAL VARIABILITY IN CHANGES IN THE INCIDENCE OF HIP FRACTURE IN THE SPANISH POPULATION (2000-2012).
Hip fractures continue to increase in absolute numbers, although if the rates are adjusted for age, a downward trend is seen in certain age groups. These findings have various origins, although in the absence of great changes in population structure, we believe that drug treatments for osteoporosis may play a role. There is variability in…
TRENDS IN THE INCIDENCE OF HIP FRACTURE IN GRAN CANARIA, CANARY ISLANDS, SPAIN: 2007-2011 VERSUS 1989-1993.
The findings suggest a trend to stabilize the incidence of hip fracture in the Canary Islands due to a decrease in men, while in women, the incidence increased.
COMPARISON BETWEEN DIFFERENT BONE TREATMENTS ON AREAL BONE MINERAL DENSITY (ABMD) AND BONE MICROARCHITECTURAL TEXTURE AS ASSESSED BY THE TRABECULAR BONE SCORE (TBS).
As expected, TBS of Naive subjects decreased with age. As expected a TBS preservation has been observed under Alendronate and Risedronate. Testosterone and Calcium and Vitamin D effects on TBS were evaluated for the first time: a similar preservation effect has been observed. A significant TBS increase was observed under Denosumab and PTH. TBS could…
ROLE OF THE PARATHYROID HORMONE TYPE 1 RECEPTOR (PTH1R) AS A MECHANOSENSOR IN OSTEOCYTE SURVIVAL.
The novel findings indicate that PTH1R is an important component of mechanical signal transduction in osteocytic MLO-Y4 cells, and PTH1R activation by PTHrP-independent and dependent mechanisms has a relevant role in the pro-survival action of mechanical stimulus in these cells.
Effect of recent spinal cord injury on Wnt signaling antagonists (sclerostin and Dkk-1) and their relationship with bone loss. A 12-month prospective study.
Short-term after spinal cord injury there is a marked increase in bone turnover and bone loss, the latter associated with an increase in Dkk-1 serum levels. The persistence of increased levels of this Wnt antagonist throughout the study and their relationship with the magnitude of bone loss suggests a contributory role of this mediator in…
Treatment Satisfaction in Postmenopausal Women Suboptimally Adherent to Bisphosphonates Who Transitioned to Denosumab Compared with Risedronate or Ibandronate.
Women with low adherence to oral bisphosphonates reported greater treatment satisfaction when transitioned to denosumab versus switching to a monthly oral bisphosphonate
Osteosarcopenic obesity and fall prevention strategies.
A therapeutic approach to osteosarcopenic obesity aimed at the prevention of falls must include several factors, and act on those risk elements which can be effectively modified.
p38α function in osteoblasts influences adipose tissue homeostasis.
Altogether, these results further suggest that, in addition to osteocalcin, other bone-derived signals affect white adipose tissue and energy expenditure contributing to the regulation of energy metabolism.
Socio-economic status and its association with the risk of developing hip fractures: a region-wide ecological study.
Wealthiest areas have an almost 30% increased risk of hip fracture compared to the most deprived. Differences in age-sex composition and a higher prevalence of obesity in deprived areas could explain this higher risk.
Comparative Effects of Teriparatide, Denosumab, and Combination Therapy on Peripheral Compartmental Bone Density, Microarchitecture, and Estimated Strength: the DATA-HRpQCT Study
J Bone Miner Res. 2015 Jan;30(1):39-45. doi: 10.1002/jbmr.2315. Together, these findings suggest that the use of denosumab and teriparatide in combination improves HR-pQCT measures of bone quality more than either drug alone and may be of significant clinical benefit in the treatment of postmenopausal osteoporosis. Autor: Tsai JN, Uihlein AV, Burnett-Bowie SA, Neer RM, Zhu…
The effects of calcium supplementation on verified coronary heart disease hospitalization and death in postmenopausal women: a collaborative meta-analysis of randomized controlled trials
J Bone Miner Res. 2015 Jan;30(1):165-75. doi: 10.1002/jbmr.2311. In conclusion, current evidence does not support the hypothesis that calcium supplementation with or without vitamin D increases coronary heart disease or all-cause mortality risk in elderly women. Autor: Lewis JR,Radavelli-Bagatini S,Rejnmark L,ChenJS, SimpsonJM,Lappe JM,Mosekilde L,Prentice RL,PrinceRL
Erythropoietin directly stimulates osteoclast precursors and induces bone loss
FASEB J. 2015 Jan 28. pii: fj.14-259085. [Epub ahead of print] In summary, our findings demonstrate that EPO negatively regulates bone mass and thus bears significant clinical implications for the potential management of patients with endogenously or therapeutically elevated EPO levels. Autor: Hiram S,Liron T,Desher N,Mittelman M,Gassmann M,Rauner M,Franke K,Wielockx B,Neumann D,Gabet
DIAGNOSIS AND MANAGEMENT OF OSTEONECROSIS OF THE JAW: A SYSTEMATIC REVIEW AND INTERNATIONAL CONSENSUS
J Bone Miner Res. 2015 Jan;30(1):3-23. doi: 10.1002/jbmr.2405. Prevention strategies for ONJ include elimination or stabilization of oral disease prior to initiation of antiresorptive agents, as well as maintenance of good oral hygiene. In those patients at high risk for the development of ONJ, including cancer patients receiving high-dose BP or Dmab therapy, consideration should…
REFERENCE INTERVALS FOR BONE TURNOVER MARKERS AND THEIR ASSOCIATION WITH INCIDENT HIP FRACTURES IN OLDER MEN: THE HEALTH IN MEN STUDY
J Clin Endocrinol Metab. 2015 Jan;100(1):90-9. doi: 10.1210/jc.2014-2646. Reference intervals for BTMs in older men have been defined. tOC may be more informative for hip fracture risk in older men than CTX-I and PINP. Further studies are needed to clarify the utility of BTM reference intervals in the management of aging men at risk of…
STEM CELLS AND BONE: A HISTORICAL PERSPECTIVE
Bone. 2015 Jan;70C:2-9. doi: 10.1016/j.bone.2014.08.011. Current interest in stem cells in bone as in other fields is intertwined with that shift. New opportunities and also new challenges arise. This article is part of a Special Issue entitled “Stem cells and bone”. Autor: Bianco P.
OSTEOCYTES MEDIATE THE ANABOLIC ACTIONS OF CANONICAL Wnt/β-catenin SIGNALING IN BONE
Proc Natl Acad Sci U S A. 2015 Jan 20. pii: 201409857. Thus, activation of osteocytic β-catenin signaling increases both osteoclasts and osteoblasts, leading to bone gain, and is sufficient to activate the Notch pathway. These findings demonstrate disparate outcomes of β-catenin activation in osteocytes versus osteoblasts and identify osteocytes as central target cells of…
GREMLIN 1 IDENTIFIES A SKELETAL STEM CELL WITH BONE, CARTILAGE, AND RETICULAR STROMAL POTENTIAL
Cell. 2015 Jan 15;160(1-2):269-84. doi: 10.1016/j.cell.2014.11.042. Grem1 expression identifies distinct connective tissue stem cells in both the bone (OCR stem cells) and the intestine (iRSCs). Autor: Worthley DL, Churchill M, Compton JT, Tailor Y, Rao M
IS THERE ENOUGH EVIDENCE TO USE BISPHOSPHONATES IN HIV-INFECTED PATIENTS? A SYSTEMATIC REVIEW AND META-ANALYSIS.
In conclusion, administration of oral and intravenous bisphosphonates was associated with increased bone mineral density at the lumbar spine and total hip over two years in HIV-positive patients. However, none of the included trials were long enough to detect the impact of bisphosphonates on a clinically important outcome such as fracture risk.
EFFICACY AND SAFETY OF A PHYTO-SERM AS AN ALTERNATIVE TO HORMONE THERAPY.
Although interesting data on relief of vasomotor symptoms have been reported for DT56a, further clinical studies with a greater number of cases and a longer period of study are required to correctly identify its indications for use as an alternative to hormone therapy, especially in preventing osteoporosis
CURRENT AND FUTURE TREATMENTS OF SECONDARY OSTEOPOROSIS.
For most conditions, the available evidence is limited. Special attention should be paid to possible contraindications of drugs used for the treatment of postmenopausal or senile osteoporosis. Bisphosphonates are the most widely used drugs in secondary osteoporosis, and denosumab or teriparatide have been also assessed in some cases.
SUBGROUP VARIATIONS IN BONE MINERAL DENSITY RESPONSE TO ZOLEDRONIC ACID AFTER HIP FRACTURE
J Bone Miner Res. 2014 Dec;29(12):2545-51. doi: 10.1002/jbmr.2283 Percentage change from baseline in TH and FN BMD at months 12 and 24 was greater (p < 0.05) in ZOL-treated patients compared with placebo in most subgroups. Treatment-by-subgroup interactions (p < 0.05) indicated that a greater effect on BMD was observed for TH BMD at month 12 in females,…
UNVEILING SKELETAL FRAGILITY IN PATIENTS DIAGNOSED WITH MGUS: NO LONGER A CONDITION OF UNDETERMINED SIGNIFICANCE?
J Bone Miner Res. 2014 Dec;29(12):2529-33. doi: 10.1002/jbmr.2387. Accordingly, this Perspective provides evidence that the “undetermined significance” portion of the MGUS acronym may be best replaced in favor of the term “monoclonal gammopathy of skeletal significance” (MGSS) in order to more accurately reflect the enhanced skeletal risks inherent in this condition. Autor: Drake MT.
Structural and Mechanical Repair of Diffuse Damage in Cortical Bone In Vivo
Journal of Bone and Mineral Research, Vol. 29, No. 12, December 2014, pp 2537–2544. doi: 10.1002/jbmr.2309. The studies found that diffuse matrix damage regions in living cortical bone undergo a direct microstructural and mechanically effective repair. The direct repair of these submicron-size cracks in living bone occurs without activating the bone remodeling that are needed…
Prediction of Incident Hip Fracture with the Estimated Femoral Strength by Finite Element Analysis of DXA Scans in the Study of Osteoporotic Fractures
Journal of Bone and Mineral Research, Volume 29, Issue 12, pages 2594–2600. doi: 10.1002/jbmr.2291. In conclusion, the estimated femoral strength from FE analysis of DXA scans is an independent predictor and performs at least as well as FN BMD in predicting incident hip fracture in postmenopausal women. Autor: Yang L,, Palermo L, Black DM, Eastell…
Secular trends in the incidence of primary hyperparathyroidism over five decades (1965–2010)
Bone 2014; 73:1-7. doi: 10.1016/j.bone.2014.12.003. Over time, two periods of increased PHPT incidence occurred, one beginning in 1974 (121.7 per 100,000 person-years) and a second peak (86.2 per 100,000 person-years) starting in 1998. The median age of PHPT subjects has increased significantly from 55 years in 1985–1997 to 60 years of age in 1998–2010 and more patients (36%) had…
BISPHOSPHONATE PRESCRIPTIONS IN MEN WITH ANDROGEN DEPRIVATION THERAPY USE
JAMA. 2014 Dec 3;312(21):2285-6. doi: 10.1001/jama.2014.14038. Although the optimal rate of bisphosphonate use in men on androgen deprivation therapy (ADT) is unknown, it is reasonable that most men with prior osteoporosis or fracture should be taking a bisphosphonate or other effective bone medication. Autor: Gulamhusein H, Yun L, Cheung AM, Sutradhar R, Paszat L, Warde…
Analysis of the Bone MicroRNome in Osteoporotic Fractures.
In this first hypothesis-free study of the bone microRNome we found two miRNAs, miR-187, and miR-518f, differentially regulated in osteoporotic bone. Further studies are needed to elucidate the mechanisms involved in the association of these miRNAs with fractures.
Reference values of bone stiffness index and C-terminal telopeptide in healthy European children.
These reference data lay the ground to evaluate bone growth and metabolism in prepubertal children in epidemiological and clinical settings. They may also inform clinical practice to monitor skeletal development and to assess adverse drug reactions during medical treatments.
IGF-1 and ADMA levels are inversely correlated in nondiabetic ankylosing spondylitis patients undergoing anti-TNF-alpha therapy.
An inverse correlation between IGF-1 levels and asymmetric dimethylarginine (ADMA), an endogenous endothelial nitric oxide synthase inhibitor that impairs nitric oxide production and secretion promoting endothelial dysfunction, was found. No significant association was found between IGF-1 and IGFBP-3 levels with angiopoietin-2, osteopontin, disease activity, systemic inflammation, metabolic syndrome features, or adipokines.
Ursodeoxycholic acid decreases bilirubin-induced osteoblast apoptosis.
Bilirubin and lithocholic acid induce apoptosis in osteoblastic cells. Ursodeoxycholic acid counteracts the apoptotic consequences of these two substances, and therefore, it may have further beneficial effects on the decreased bone formation in the cholestasis.
Comorbidity and healthcare expenditure in women with osteoporosis living in the basque country (Spain).
Most women with osteoporosis have multimorbidity. The variety of conditions emphasises the complexity of clinical management in this group and the importance of maintaining a generalist and multidisciplinary approach to their clinical care.
A New Role For 5-methoxytryptophol On Bone Cells Function In Vitro.
In conclusion, the present study demonstrates a new role of 5-methoxytryptophol inhibiting osteoclastogenesis and promoting osteoblast differentiation.
Relationship of Dickkopf1 (DKK1) with Cardiovascular Disease and Bone Metabolism in Caucasian Type 2 Diabetes Mellitus.
In summary, circulating DKK1 levels are higher in Type 2 Diabetes Mellitus with Cardiovascular Disease and are associated with an abnormal carotid intima media thickness in this cross-sectional study. DKK1 may be involved in vascular disease of Type 2 Diabetes Mellitus patients.
Acta Premios Becas FEIOMM Investigación 2014
Para promover la investigación clínica, básica y traslacional en el campo de la patología metabólica ósea.Reunido el Jurado formado por el Comité Científico de la Seiomm, con el fin de resolver la adjudicación de las Becas FEIOMM de INVESTIGACIÓN 2014 para promover la investigación clínica, básica y traslacional en el campo de la patología metabólica…
Premio FHOEMO – SEIOMM 2014
FACTORES DE RIESGO PREVIOS A UNA FRACTURA POR FRAGILIDAD Y ABORDAJE DE LOS MISMOS DESDE LA ATENCIÓN PRIMARIA DE SALUD. Ver resolución aquí.
ACTA PREMIOS ITALFÁRMACO-SEIOMM 2014 XIX Congreso Santiago de Compostela
El Jurado, compuesto por los moderadores de las sesiones de comunicaciones orales y pósteres y el Comité Científico del XIX Congreso de la SEIOMM, ha otorgado los Premios Italfarmaco 2014 a las siguientes comunicaciones
Acta Premio Joven Investigador 2014
El jurado, compuesto por los moderadores de las sesiones de comunicaciones orales y el Comité Científico del XIX Congreso de la SEIOMM ha otorgado el Premio al Joven Investigador, consistente en la financiación de los gastos de inscripción, viaje y alojamiento del próximo Congreso SEIOMM, Bilbao 2015 a: Araceli Muñoz Garach
Acta Premio Joven Investigador 2014
El jurado, compuesto por los moderadores de las sesiones de comunicaciones orales y el Comité Científico del XIX Congreso de la SEIOMM ha otorgado el Premio al Joven Investigador, consistente en la financiación de los gastos de inscripción, viaje y alojamiento del próximo Congreso SEIOMM, Bilbao 2015 a: Pablo Garmilla.
Gaucher disease and bone manifestations
Calcif Tissue Int. 2014 Dec;95(6):477-94. doi: 10.1007/s00223-014-9923-y We have conducted a systematic review of all the various aspects of Gaucher disease, focusing on different skeletal manifestations, pathophysiology of bone alterations, clinical symptoms, and current diagnostic and therapeutic approaches. Autor: 1. Marcucci G, Zimran A, Bembi B, Kanis J, Reginster JY, Rizzoli R, Cooper C, Brandi…
VII Edición de los Premios de EDUCACIÓN MÉDICA 2014
Cátedra de EDUCACIÓN MÉDICA Fundación Lilly-UCM Estimado/a amigo/a: Además de invitarle a participar en la VII Edición de los Premios de EDUCACIÓN MÉDICA 2014, patrocinados por la Cátedra de EDUCACIÓN MÉDICA Fundación Lilly-UCM, le adjunto una carta del Director de la Cátedra, así como un cartel anunciador con las BASES de la convocatoria al que…
SEMANA MUNDIAL DE LA OSTEOPOROSIS
JORNADAS PARA PACIENTES Coordinación: Dra. Mª Jesús Moro Álvarez Servicio Medicina Interna. SALÓN DE ACTOS – HOSPITAL UNIVERSITARIO INFANTA LEONOR (HUIL) Jornadas
Literature review: The effects of teriparatide therapy at the hip in patients with osteoporosis
Bone 67; 246–256. doi: 10.1016/j.bone.2014.07.014. Epub 2014 Jul 15 Studies using dual-energy X-ray absorptiometry and quantitative computed tomography for longitudinal assessment of changes at the hip have consistently shown increases in areal and volumetric bone mineral density, cortical thickness, and finite element-estimated hip strength in patients treated with teriparatide. Finally, in clinical fracture-outcome trials, treatment…
THE CONVERGENCE OF FRACTURE REPAIR AND STEM CELLS: INTERPLAY OF GENES, AGING, ENVIRONMENTAL FACTORS AND DISEASE
J Bone Miner Res. 2014 Nov;29(11):2307-22. doi: 10.1002/jbmr.2373. Review studies of bone regeneration in genetically modified mouse models, during aging, following environmental exposure, and in the setting of disease that provide insights regarding the role of multipotent cells and their regulation during fracture repair. Complementary animal models and ongoing scientific discoveries define an increasing number…
CONSTITUTIVE EXPRESSION OF GSΑR201C IN MICE PRODUCES A HERITABLE, DIRECT REPLICA OF HUMAN FIBROUS DYSPLASIA BONE PATHOLOGY AND DEMONSTRATES ITS NATURAL HISTORY
J Bone Miner Res. 2014 Nov;29(11):2357-68. doi: 10.1002/jbmr.2267. As in humans, FD lesions in mice developed only in the postnatal life; a defined spatial and temporal pattern characterized the onset and progression of lesions across the skeleton. In individual bones, lesions developed through a sequence of three distinct histopathological stages: a primary modeling phase defined…
VEGF RECEPTOR 2 (VEGFR2) ACTIVATION IS ESSENTIAL FOR OSTEOCYTE SURVIVAL INDUCED BY MECHANOTRANSDUCTION.
These in vitro findings point to caveolin-1-dependent VEGFR2 activation as an important mechanism whereby mechanical stimuli promote osteocyte viability
CALCIUM NEPHROLITHIASIS AND BONE DEMINERALIZATION: PATHOPHYSIOLOGY, DIAGNOSIS, AND MEDICAL MANAGEMENT.
Patients with recurrent calcium nephrolithiasis and fasting hypercalciuria have a higher incidence of osteopenia and osteoporosis. They present increased BTMs (mainly resorptive) and up to 30% have hypocitraturia and increased urinary calcium/citrate ratio (>0.25). Medical therapy is aimed at improving the dietary habits, prescribing combinations of potassium citrate, thiazides, and bisphosphonates, and correcting bone and…
IMPACT OF ESTROGENS ON ATHEROSCLEROSIS AND BONE IN THE APOLIPOPROTEIN E-DEFICIENT MOUSE MODEL.
Endogenous estrogens partially reduce atherogenic burden in female apolipoprotein E-deficient mice. Ovariectomy increases bone resorption, but not under exacerbated proatherogenic conditions induced by high-fat diet. The absence of apolipoprotein E might have an influence on the asymmetric responses of atherogenesis and bone resorption.
ENDOCRINOLOGY IN PREGNANCY: BONE METABOLIC CHANGES DURING PREGNANCY: A PERIOD OF VULNERABILITY TO OSTEOPOROSIS AND FRACTURE.
Osteoporosis and fragility fracture have been diagnosed, although rarely. The condition, however, is transitory because there is no long-term data supporting the deleterious effect of pregnancy on bone mass or fracture risk. Prevention is limited by the lack of identifiable risk factors. When fractures are diagnosed, rest, analgesics, or when indicated, orthopedic intervention, have demonstrated…
Convocatoria BECAS FEIOMM INVESTIGACIÓN 2014
La Fundación Española de Investigación Ósea y del Metabolismo Mineral (FEIOMM), convoca 3 BECAS de 6.000€ cada una para promocionar la investigación básica, clínica y traslacional en el campo del metabolismo mineral y ósea. Consulte las bases aquí.
THE ROLE OF DIETARY PROTEIN AND VITAMIN D IN MAINTAINING MUSCULOSKELETAL HEALTH IN POSTMENOPAUSAL WOMEN: A CONSENSUS STATEMENT FROM THE EUROPEAN SOCIETY FOR CLINICAL AND ECONOMIC ASPECTS OF OSTEOPOROSIS AND OSTEOARTHRITIS (ESCEO).
The European Society for Clinical and Economic Aspects of Osteoporosis and Osteoarthritis (ESCEO) recommends optimal dietary protein intake of 1.0-1.2g/kgbodyweight/d with at least 20-25g of high-quality protein at each main meal, with adequate vitamin D intake at 800IU/d to maintain serum 25-hydroxyvitamin D levels >50nmol/L as well as calcium intake of 1000mg/d, alongside regular physical…
EFFECTS OF NRF2 DEFICIENCY ON BONE MICROARCHITECTURE IN AN EXPERIMENTAL MODEL OF OSTEOPOROSIS.
We have demonstrated in vivo a key role of nuclear factor erythroid derived 2-related factor-2 (Nrf2) in the maintenance of bone microarchitecture.
MICROSTRUCTURAL TRABECULAR BONE FROM PATIENTS WITH OSTEOPOROTIC HIP FRACTURE OR OSTEOARTHRITIS: ITS RELATIONSHIP WITH BONE MINERAL DENSITY AND BONE REMODELLING MARKERS.
Bone turnover markers, BMD and bone microstructural changes in osteoporosis are opposite to those of OA. These findings justify a less resistant bone with higher risk of fragility fractures in OP patients. These histomorphometric and biomechanical changes may be suspected by measuring of BMD and β-CrossLaps levels.
IMPROVEMENT IN BONE MINERAL DENSITY AFTER SWITCHING FROM TENOFOVIR TO ABACAVIR IN HIV-1-INFECTED PATIENTS WITH LOW BONE MINERAL DENSITY: TWO-CENTRE RANDOMIZED PILOT STUDY (OSTEOTDF STUDY).
Switching from tenofovir to abacavir led to a slight improvement in femoral BMD although no differences were detected between groups. Larger studies are necessary before firm recommendations can be made on the discontinuation of tenofovir in patients with a low BMD.
PHARMACOGENOMICS OF OSTEOPOROTIC FRACTURES.
Although scarce data are available, interesting opportunities are open for a better understanding of the pharmacogenetics of osteoporosis and osteoporotic fractures. They include the reanalysis of data already available from epidemiological studies and clinical trials, as well as obtaining pharmacogenetic data in new studies. However, based upon the experience with previous genome-wide association studies, large…
CHANGES IN BONE MINERAL METABOLISM PARAMETERS, INCLUDING FGF23, AFTER DISCONTINUING CINACALCET AT KIDNEY TRANSPLANTATION.
We conclude that patients receiving cinacalcet on dialysis presented similar serum phosphate levels but higher PTH and serum calcium levels during the initial six months after kidney transplantation than cinacalcet non-treated patients. The group previously treated with cinacalcet before transplantation showed higher FGF23 levels without significant differences, so further studies should investigate its relevance in…
HIV INFECTION, BONE METABOLISM, AND FRACTURES.
The European Society of AIDS (EACS), and other societies, have included guidance on management of osteoporosis in HIV-infected patients emphasizing the identification of patients with low bone mass. Supplementation of calcium and vitamin D and the use of alendronate in these individuals should be recommended on a case base.
OSTEOCYTE-DERIVED RANKL IS A CRITICAL MEDIATOR OF THE INCREASED BONE RESORPTION CAUSED BY DIETARY CALCIUM DEFICIENCY
Bone. 2014 Sep;66:146-54 These results demonstrate that RANKL produced by osteocytes contributes to the increased bone resorption and the bone loss caused by secondary hyperparathyroidism, strengthening the evidence that osteocytes are an important target cell for hormonal control of bone remodeling Autor: Xiong J, Piemontese M, Thostenson JD, Weinstein RS, Manolagas SC, O’Brien CA.
BINDING KINETICS OF A FLUORESCENTLY LABELED BISPHOSPHONATE AS A TOOL FOR DYNAMIC MONITORING OF BONE MINERAL DEPOSITION IN VIVO
JBMR 2014; 29(9) 1993-2003 The results suggest monitoring binding kinetics based on fluorescently labeled bisphosphonates represents a highly sensitive, site-specific method for monitoring changes in bone mineral deposition with the potential for translation into human applications in osteoporosis and bone metastatic processes and their treatment Autor: Robert J Tower, Graeme M Campbell, Marc Müller, Olga…
Mineralisation of collagen rich soft tissues and osteocyte lacunae in Enpp1−/− mice
Bone. 2014 Sep 28;69C:139-147. doi: 10.1016/j.bone.2014.09.016. [Epub ahead of print] This study examined the role of NPP1 in osteocytes, osteoclasts and cortical bone, using a mouse model lacking NPP1 (Enpp1−/−) he cortical bone from Enpp1−/− mice was thinner and less porous, with a larger marrow space. Scanning electron microscopy (SEM) revealed a decrease in the…
Association of chronic obstructive pulmonary disease and smoking status with bone density and vertebral fractures in male lung cancer screening participants
J Bone Miner Res. 2014 Oct;29(10):2224-9. doi: 10.1002/jbmr.2248. In conclusion, our study shows that lung cancer screening participants have a substantial vertebral fracture burden. Fractures are more common in current smokers, who also have lower bone density. We could not confirm that COPD is independently associated with vertebral fractures. Autor: Jong WU1,Jong PA,Vliegenthart R,Isgum I,Lammers…
Reproducibility of results in preclinical studies: a perspective from the bone field
J Bone Miner Res. 2014 Oct;29(10):2131-40. doi: 10.1002/jbmr.2293 In this invited perspective, we highlight the magnitude of the problem across biomedical fields and address the relevance of these concerns to the field of bone and mineral metabolism. We also suggest how our specialty journals, our scientific organizations, and our community of bone and mineral researchers…
Osteocyte-derived RANKL is a critical mediator of the increased bone resorption caused by dietary calcium deficiency
Bone 2014;66:147-154 The results demonstrate that RANKL produced by osteocytes contributes to the increased bone resorption and the bone loss caused by secondary hyperparathyroidism, strengthening the evidence that osteocytes are an important target cell for hormonal control of bone remodeling. Autor: Xiong J, Piemontese M, Thostenson JD, Weinstein RS, Manolagas SC, O’Brien CA.
The fracture sites of atypical femoral fractures are associated with the weight-bearing lower limb alignment
Bone. 2014 Jun 14;66C:105-110. doi: 10.1016/j.bone.2014.06.008. [Epub ahead of print]. The femorotibial angle (FTA) of the patients with atypical diaphyseal femoral fracture were significantly larger compared to that of those with not only atypical subtrochanteric fractures (AFFs) but also typical femoral fractures (TFFs). In conclusion, the fracture sites of AFFs are associated with the standing…
Prevalence and predictors of low bone density and fragility fractures in women with systemic lupus erythematosus in a Mediterranean region.
Fragility fractures were seen in 4.4 % of SLE patients. All patients with fragility fractures showed osteopenia at BMD. There is a high prevalence of bone loss in SLE patients, since up to 46 % of SLE patients showed low BMD. Total hip and femoral neck osteopenia were the most frequent findings correlated with low…
Spanish Menopause Society position statement: Use of denosumab in postmenopausal women.
A panel of experts from the Spanish Menopause Society has met to develop usage recommendations based on the best available evidence.
The Association between Nutritional Screening Via The Conut Index And Bone Mineral Density In Chronic Liver Disease of Various Etiologies.
Malnutrition assessed by CONUT was very frequent in patients with liver cirrhosis. CONUT score inversely correlated with liver function, while malnutrition stage directly correlated with BMD, fracture risk, and 25(OH)-D3. Total cholesterol showed a negative association with BMD in this population.
Effect of lysophosphatidic acid receptor inhibition on bone changes in ovariectomized mice.
Pharmacological inhibition of lysophosphatidic acid receptorwas not beneficial for preventing bone loss in ovariectomized mice, indicating that its favorable effect on bone remodeling is less general than hypothesized.
An ex vivo model in human femoral heads for histopathological study and resonance frequency analysis of dental implant primary stability.
Although resonance frequency analysis (RFA)-assessed implant stability (ISQ values) are not correlated with morphometric parameters, they can discriminate bone quality (osteoporosis versus osteoarthritis). This ex vivo model is useful for dental implant studies.
Medical management of primary hyperparathyroidism: proceedings of the fourth International Workshop on the Management of Asymptomatic Primary Hyperparathyroidism
J Clin Endocrinol Metab. 2014 Oct;99(10):3607-18. doi: 10.1210/jc.2014-1417. Epub 2014 Aug 27 The recommended calcium intake in patients with PHPT should follow guidelines established for all individuals. It is not recommended to limit calcium intake in patients with PHPT who do not undergo surgery. Patients with low serum 25-hydroxyvitamin D should be repleted with doses…
Guidelines for the management of asymptomatic primary hyperparathyroidism: summary statement from the Fourth International Workshop
J Clin Endocrinol Metab. 2014 Oct;99(10):3561-9. doi: 10.1210/jc.2014-1413. Epub 2014 Aug 27. In view of new findings since the last International Workshop on the Management of Asymptomatic PHPT, guidelines for management have been revised. The revised guidelines include: 1) recommendations for more extensive evaluation of the skeletal and renal systems; 2) skeletal and/or renal involvement…
CLINICAL PRESENTATION OF PAGET’S DISEASE: EVALUATION OF A CONTEMPORARY COHORT AND SYSTEMATIC REVIEW
Calcif Tissue Int. 2014 Nov;95(5):385-92. doi: 10.1007/s00223-014-9904-1. Epub 2014 Aug 27. While changes in the mode of presentation of PDB have occurred over recent years, many patients present with complications such as fracture and deformity. Further research is required to determine if early detection and therapeutic intervention might be of value in preventing the morbidity…
Effects of eight-month treatment with ONO-5334, a cathepsin K inhibitor, on bone metabolism, strength and microstructure in ovariectomized cynomolgus monkeys
Bone. 2014 Apr 27;65C:1-8. doi: 10.1016/j.bone.2014.04.023. In microstructural analysis, alendronate suppressed OVX-induced increase in femoral mid-shaft osteonal bone formation rate (BFR) to a level below that recorded in the sham group, whereas ONO-5334 (Catepsin K inhibitor) at 30mg/kg did not suppress periosteal, osteonal and endocortical BFR. This finding supports the significant effect of ONO-5334 on…
RESOLUCIÓN Becas ASBMR 2014
Finalizado el plazo con fecha 15 de julio de 2014 a las 00:00 PM, para el envío de solicitudes se adjunta Acta Resolución de los solicitantes admitidos y excluidos. Recuerde revisar el documento adjunto
Convocatoria Premios MEDES 2014
PREMIOS MEDES MEDICINA EN ESPAÑOL Los Premios MEDES se crearon para reconocer en el ámbito de los países de habla hispana aquellas iniciativas que favorecen la utilización del español en la comunicación del conocimiento de las ciencias de la salud en general y del conocimiento médico en particular, así como a las instituciones o entidades…
Convocatoria Premios MEDES 2014
PREMIOS MEDES MEDICINA EN ESPAÑOL. Los Premios MEDES se crearon para reconocer en el ámbito de los países de habla hispana aquellas iniciativas que favorecen la utilización del español en la comunicación del conocimiento de las ciencias de la salud en general y del conocimiento médico en particular, así como a las instituciones o entidades…
AYUDAS FUNDACIÓN BBVA A PROYECTOS DE INVESTIGACIÓN
El apoyo continuado de la Fundación BBVA a la promoción de la ciencia básica se complementa con esta convocatoria de ayudas dirigida a la realización de proyectos de naturaleza aplicada, en una selección de áreas de actuación preferente de la Fundación BBVA: Biomedicina, Ecología y Biología de la Conservación y Socioeconomía.
En el área de Biomedicina, las ayudas irán destinadas a proyectos de investigación de naturaleza clínica y traslacional, preferentemente en Oncología, Cardiología y el abordaje multidisciplinar de las enfermedades neurodegenerativas.
Secular trends in hip fractures worldwide: opposing trends East versus west
J Bone Miner Res. 2014 Aug;29(8):1745-55. doi: 10.1002/jbmr.2218. Data presented here show close parallels between rising rates of urbanization and hip fractures across disparate geographic locations and cultures. Once the proportion of the urban population stabilized, hip fracture rates also stabilize or begin to decrease perhaps due to the influence of other factors such as…
Five Freely Circulating miRNAs and Bone Tissue miRNAs Are Associated With Osteoporotic Fractures
J Bone Miner Res. 2014; 29: 1715‒1717. doi: 10.1002/jbmr.2175. In conclusion, this study profiled serum miRNAs in osteoporosis and identified 9 miRNAs highly associated with osteoporosis in blood serum. In bone tissue, 6 differentially expressed miRNAs were detectable. Five of these were simultaneously upregulated in the serum samples. Those 5 identified, significantly upregulated circulating miRNAs…
Inflammatory factors in the circulation of patients with active rheumatoid arthritis stimulate osteoclastogenesis via endogenous cytokine production by osteoblasts
Osteoporos Int 2014; Oct;25(10):2453-63. doi: 10.1007/s00198-014-2779-1. Epub 2014 Jul 16 The combination of cytokines present in serum of RA patients with active disease might contribute to bone loss by directly inhibiting osteoblast proliferation and differentiation, but especially by enhancing endogenous cyto- kine (i.e., RANKL and IL-6) production by osteoblasts, there- by stimulating osteoclastogenesis. Autor: Pathak…
RECONSIDERATION OF THE RELEVANCE OF MILD WEDGE OR SHORT VERTEBRAL HEIGHT DEFORMITIES ACROSS A BROAD AGE DISTRIBUTION
Osteoporos Int. 2014 Nov;25(11):2609-15. doi: 10.1007/s00198-014-2801-7. Epub 2014 Jul 29. The study demonstrates that mild or wedged vertebral shape changes are rare among younger subjects, suggesting that when these radiographic abnormalities are seen among older adults, they are less likely to be due to normal variation in vertebral body shape or congenital deformities. In light…
Influence of Vitamin D Status on the Effect of Statins on Bone Mineral Density and Bone Turnover Markers in Postmenopausal Women.
Women on statins and serum 25OHD levels above 20 ng/mL have greater BMD and less bone resorption than those without either of the factors. Differences, however, are not significant in women with only one of them. Vitamin D and statins seem to interact positively in their effects on bone metabolism.
ADHERENCE TO MEDITERRANEAN DIET AND BONE HEALTH.
A limited number of studies have examined the relationship between Mediterranean Diet and bone health, and they have reported conflicting results. On the one hand, adherence to a traditional MeDi has been associated with higher bone mineral density and lower fracture risk. The results of these studies could be attributed to the combined beneficial effects…
Quantitative ultrasound measurements of the calcaneus and hand phalanges in elderly spanish men: relationship with peripheral bone mineral density of the hand phalanges.
There is a small correlation between quantitative US measurements at the calcaneus and phalangeal BMD that increases to a moderate level with quantitative US measurements at the phalanges in elderly Spanish men.
Osteocyte control of bone remodeling: is sclerostin a key molecular coordinator of the balanced bone resorption–formation cycles?
Osteoporosis International 2014; 25: 2685-2700. doi: 10.1002/biof.1186. The osteocyte network plays a central role in directing bone response either to mechanical loading, or to unloading, leading correspondingly to bone formation or resorption. This review shows a key role of the osteocyte-produced sclerostin as a major mediator of the molecular mechanisms involved in the process of…
The effect of olive oil on osteoporosis prevention.
Published evidence suggests that olive oil phenols can be beneficial by preventing the loss of bone mass. It has been demonstrated that they can modulate the proliferative capacity and cell maturation of osteoblasts by increasing alkaline phosphatase activity and depositing calcium ions in the extracellular matrix.
Hypophosphatemic osteomalacia induced by tenofovir in HIV-infected patients.
Rheumatologists should be alert to osteomalacia in patients receiving tenofovir. The main complaint reported by these patients is diffuse pain, predominantly in the lower limbs, indicating multiple stress fractures. Serum phosphate and appropriate screening for abnormal proximal tubule function should be monitored. Bone scintigraphy should be carried out in cases of limb pain before the…
Laboratory Abnormalities in CKD-MBD: Markers, Predictors, or Mediators of Disease?
This review summarizes the complex pathophysiology of CKD-MBD and outlines which laboratory abnormalities represent biomarkers of disease severity, which laboratory abnormalities are predictors of cardiovascular disease, and which laboratory abnormalities should be considered (direct) uremic toxins exerting organ damage. This information may help to streamline current and future therapeutic efforts.
Vitamin-D pathway genes and HIV-1 disease progression in injection drug users.
According to our results, VDR locus association follows an additive model in which increased genetic risk score for the VDR is directly correlated with AIDS progression rates. Our data supports a role of vitamin-D pathway gene variability on HIV-1 disease progression.
Regulatory authorities and orthopaedic clinical trials on expanded mesenchymal stem cells.
To further foster this research, the pathway to eventually obtain authorisation from the National Competent Authorities and Research Ethics Committees under the European regulation is reviewed, and the experience of the REBORNE European project offers information and important clues about the current Voluntary Harmonization Procedure and other opportunities that need to be considered by surgeons…
Bone metabolism and adipokines: are there perspectives for bone diseases drug discovery?
There are currently substantial developments being made in the understanding of the interplay between bone metabolism and the metabolic system. These insights could potentially lead to the development of new treatment strategies and interventions with the aim of successful outcomes in many people affected by bone disorders. Specifically, future research should look into the intimate…
The selective estrogen receptor modulator, bazedoxifene, reduces ischemic brain damage in male rat.
Our results demonstrate that: 1) 17β-estradiol (E2) at physiological plasma levels in female rats is neuroprotective in male rats when given at the acute stage of the ischemic challenge; and 2) bazedoxifene acetate at clinically relevant plasma levels mimics the neuroprotective action of E2 and could be, therefore, a candidate in stroke treatment.
Gene expression profile induced by ovariectomy in bone marrow of mice: A functional approach to identify new candidate genes associated to osteoporosis risk in women.
These results reinforce the role of antioxidant pathways and of B-cells in bone metabolism. Furthermore, it shows that a genome-wide gene expression approach in animal models is a useful method for detecting genes associated to BMD and osteoporosis risk in humans.
Bone: a new endocrine organ at the heart of chronic kidney disease and mineral and bone disorders.
Osteocalcin, produced by osteoblasts or released from mineralised bone, interferes with insulin concentrations and sensitivity, and its metabolism is disturbed in kidney disease. These bone-derived humoral factors might place the bone at the centre of cardiovascular disease associated with chronic kidney disease. Most importantly, factors that dictate the regulation of these substances in bone and…
Comparing Bone Microarchitecture by Trabecular Bone Score (TBS) in Caucasian American Women with and Without Osteoporotic Fractures
Calcif Tissue Int. 2014 Sep;95(3):201-8. doi: 10.1007/s00223-014-9882-3. Epub 2014 Jun 20. After adjusting for age, weight, BMD, smoking, and maternal and family history of fracture, TBS (but not BMD) remained a significant predictor of fracture: OR 1.28[1.13–1.46] even after adjustment. In a US female population, TBS again was able to discriminate between those with and…
Lumbar spine texture enhances 10-year fracture probability assessment
Osteoporos Int (2014) 25:2271–2277. doi: 10.1007/s00198-014-2761-y. Epub 2014 Jun 21. Lumbar spine texture analysis using TBS is a risk factor for major osteoporotic fractures and a risk factor for death. Lumbar spine TBS is able to predict incident major osteoporotic fractures independent of FRAX clinical risk factors and femoral neck BMD even after accounting for…
Biochemical markers of bone turnover in diabetes patients-a meta-analysis, and a methodological study on the effects of glucose on bone markers
Osteoporos Int. 2014 Jun 25(6):1697-708. doi: 10.1007/s00198-014-2676-7. In conclusion, we found that diabetes patients have a different bone turnover than non-diabetes patients and the differences in bone turnover are enhanced at menopause. The results from this meta-analysis underscore the need to conduct more re- search within the assessment of fracture risk using bone markers in…
Clinical and Radiographic Findings in Adults With Persistent Hypophosphatasemia
J Bone Miner Res 2014; 29:1651-1660. The clinical and radiographic findings of adult patients with persistent hypophosphatasemia resemble those of the adult form of hypophosphatasia. Clinicians should take notice of persistent hypophosphatasemia, consider the diagnosis of hypophosphatasia, and be cautious when considering potent anti-remodeling therapy in these adults. This population warrants further evaluation. Autor: McKiernan…
Bone metabolism after bariatric surgery
J Bone Miner Res. 2014 Jul;29(7):1507-18. doi: 10.1002/jbmr.2226. Bariatric surgery is a popular and effective treatment for severe obesity but may have negative effects on the skeleton. This review summarizes changes in bone density and bone metabolism from animal and clinical studies of bariatric surgery, with specific attention to Roux-en-Y gastric bypass (RYGB), adjustable gastric…
Glucocorticoids and irreversible damage in patients with systemic lupus erythematosus.
Prednisone causes damage in systemic lupus erythematosus. Doses <7.5 mg/day and methylprednisolone pulses are not associated with damage accrual
Mandibular cortical indices on cone-beam computed tomography images in osteoporotic women on treatment with oral bisphosphonates.
Mandibular cortical width should not be used to predict the risk of bisphosphonate-associated osteonecrosis of the jaws.
Serum sclerostin in hepatitis C virus infected patients.
Serum sclerostin levels were within the normal range in Hepatitis C virus infected patients, and correlated directly with BMD and serum telopeptide. In addition, the relationships of sclerostin and osteocalcin with variables associated with insulin resistance suggested the role of bones for intermediary metabolisms.
Heritability of Bone Mineral Density in a Multivariate Family-Based Study.
Our findings provide additional evidence on the heritability of BMD and a strong genetic correlation between BMD and bone mass/fracture phenotypes in a Spanish population. Our results emphasize the importance of detecting genetic risk factors and the benefit of early diagnosis and especially therapeutic and preventive strategies.
Longitudinal practice patterns of prophylaxis of glucocorticoid-induced osteoporosis in patients with polymyalgia rheumatica.
Although prophylaxis of glucocorticoid-induced osteoporosis in patients with PMR has increased in the recent years, many patients do not receive prophylaxis with bisphosphonate during the first visit.
EMAS position statement: The management of postmenopausal women with vertebral osteoporotic fracture.
The management of women with osteoporotic vertebral fractures includes measures to reduce pain providing early mobility, to support the affected spine ensuring fracture healing, as well as starting treatment for osteoporosis itself. Any other underlying pathology should be sought and treated. Early detection and treatment is essential as there is an increased risk of further…
9ª Edición Bolsas de Investigación L’ORÉAL-UNESCO for women in science
Programa Internacional L’Oréal – UNESCO “For Women in Science” Apoya desde hace años a las científicas de nuestro país, además de promover la vocación por la ciencia, y ofrece 5 becas de investigación de 15.000 euros cada una para jóvenes investigadoras españolas. El Mundo necesita Ciencia, la Ciencia necesita a las Mujeres…
Convocatoria Becas Feiomm ASBMR 2014
FEIOMM convoca 5 BECAS para la presentación de trabajos científicos en ASBMR 2014 Annual Meeting (American Society for Bone and Mineral Research) que se celebrará en Houston, Texas (USA) del 12 al 15 de septiembre de 2014. Bases de la convocatoria.
SKELETAL AND NONSKELETAL EFFECTS OF VITAMIN D: IS VITAMIN D A TONIC FOR BONE AND OTHER TISSUES?
Osteoporos Int (2014) 25:2347–2357 To revisit the question posed in the title of this review, is vitamin D a tonic for bone and soft tissue? Probably not, but levels of <25–40 nmol/L do have significant adverse consequences, so should be prevented. However, as with any potent bioactive compound, more is not necessarily better, and use…
Osteoblast-derived microvesicles: A novel mechanism for communication between osteoblasts and osteoclasts
Bone. 2015 May 24;79:37-42. doi: 10.1016/j.bone.2015.05.022. [Epub ahead of print] The maintenance of bone homeostasis is largely dependent upon cellular communication between osteoclasts and osteoblasts. Microvesicles (MVs) have received a good deal of attention and are increasingly considered as mediators of intercellular communication due to their capacity to merge with and transfer a repertoire of…
Notch1 and Notch2 expression in osteoblast precursors regulates femoral microarchitecture
Bone 2014; 62:22-28 Notch1 and Notch2 inactivation increased porosity and reduced thickness of cortical bone. These effects were modest and more evident in 3 and 6 month old female than in male mice of the same age. In conclusion, Notch1 and Notch2 expression in osteoblast precursors regulates cancellous bone volume and microarchitecture. Autor: Zanotti S, Canali…
Effect of vitamin D3 on asthma treatment failures in adults with symptomatic asthma and lower vitamin D levels: the VIDA randomized clinical trial
JAMA. 2014 May 28;311(20):2083-91. doi: 10.1001/jama.2014.5052. Vitamin D3 did not reduce the rate of first treatment failure or exacerbation in adults with persistent asthma and vitamin D insufficiency. These findings do not support a strategy of therapeutic vitamin D3 supplementation in patients with symptomatic asthma. Autor: Castro M, King TS, Kunselman SJ, Cact.ana MD, Denlinger…
Fracture Prediction After Discontinuation of 4 to 5 Years of Alendronate Therapy: The FLEX Study
JAMA Intern Med. 2014 May 5. doi: 10.1001/jamainternmed.2014.1232. [Epub ahead of print] Among postmenopausal women who discontinue alendronate therapy after 4 to 5 years, age and hip BMD at discontinuation predict clinical fractures during the subsequent 5 years. Follow-up measurements of DXA 1 year after discontinuation and of BAP or NTX 1 to 2 years…
Bone Density and Bone Turnover Marker Monitoring After Discontinuation of Alendronate Therapy: An Evidence-Based Decision to Do Less
JAMA Intern Med. 2014 May 5. doi: 10.1001/jamainternmed.2014.162. [Epub ahead of print] The clinical utility of medication monitoring has been a controversial issue in osteoporosis management. In the 1998 and 20012 coverage rules commonly called the “Bone Mass Measurement Act,” the Centers for Medicare & Medicaid Services (CMS) outlined provisions for bone mineral density (BMD)…
Waning predictive value of serum adiponectin for fracture risk in elderly men
MrOs Sweden. Osteoporos Int 2014;25:1831-1836 Serum adiponectin is a risk factor for fracture. Nevertheless, the predictive value attenuates with time so that its use for the risk assessment in the long term is questionable. This study underlines the importance of testing the long-term stability of potential risk factors that might be used in fracture risk…
Peak bone mass in young HIV-infected patients compared with healthy controls.
Bone mineral density was similar between HIV-infected patients aged 20-30 years than in age- and gender-matched controls. However, lower femoral T-scores and higher rate of osteopenia and osteoporosis were seen in HIV-infected men. Therapy with protease inhibitors, nadir CD4 counts, and fat and lean mass were predictive factors of peak bone mass. Given that these…
Bone mass and vitamin D levels in women with a diagnosis of fibromyalgia.
No differences in BMD were found between patients and controls. As for 25OHD, a lack of its expected summer rise was observed. It is doubtful whether this has any homeostatic consequence. We consider that the association reported in other studies is merely circumstantial, and not due to the intrinsic characteristics of these disorders.
Effects of PTH (1-84) on bone quality in a validated model of osteoporosis due to androgenic deprivation.
PTH (1-84) is able to restore the adverse effects of orchidectomy on bone as measured by BMD, microstructural and biomechanical properties and bone remodeling markers. The purpose of this study was to evaluate the effect of parathyroid hormone (PTH) (1-84) in a model of male osteoporosis induced by orchidectomy in rats. Autor: Martín-Fernández M, Martínez…
Low iron status as a factor of increased bone resorption and effects of an iron and vitamin D-fortified skimmed milk on bone remodelling in young Spanish women.
Iron deficiency is related with higher bone resorption in young women. Consumption of a dairy product that supplies 5 μg/day of vitamin D3 reduces bone turnover and increases circulating 25OHD to nearly reach an optimal vitamin D status, defined as 25OHD over 75 nmol/L. Autor: Toxqui L, Pérez-Granados AM, Blanco-Rojo R, Wright I, de la Piedra…
Effects of a short-term whole body vibration intervention on bone mass and structure in elderly people.
A short-term whole body vibration therapy is not enough to cause any changes on bone mineral content or bone mineral density and it only produces a slight variation on bone structure among elderly people. Autor: Gómez-Cabello A, González-Agüero A, Morales S, Ara I, Casajús JA5, Vicente-Rodríguez G.
Bone turnover markers in patients with prostate carcinoma: influence of sex steroids levels.
In patients with prostate carcinoma, estrogen levels influence bone resorption and bone formation whereas androgens may exert actions only in bone resorption. These results suggest that estradiol is the main sex steroid that regulates bone metabolism in males with prostate carcinoma. Autor: Varsavsky M, Reyes-García R, García-Martín A, Rozas-Moreno P, González-Ramírez R, Muñoz-Torres M.
The effect of five proteins on stem cells used for osteoblast differentiation and proliferation: a current review of the literature.
Bone-tissue engineering is a therapeutic target in the field of dental implant and orthopedic surgery. It is therefore essential to find a microenvironment that enhances the growth and differentiation of osteoblasts both from mesenchymal stem cells (MSCs) and those derived from dental pulp. The aim of this review is to determine the relationship among the…
Lysophosphatidic acid receptor inhibition as a new multipronged treatment for rheumatoid arthritis.
Pharmacological inhibition of LPA1 receptor in the K/BxN serum-transfer arthritis model led to reduction of severity of arthritis involving multiple mechanisms, increased apoptosis, reduced inflammatory mediators and proteins involved in bone remodelling, that show LPA1 as a very promising target in rheumatoid arthritis treatment. Autor: Orosa B, García S, Martínez P, González A, Gómez-Reino JJ, Conde…
Hip fracture in three elderly populations of central Spain: data from the NEDICES study.
Self-reported hip fracture is a common condition among community-living elderly population in Spain, and has a significant impact upon long-term all-cause mortality. There is a paucity of data concerning the specific associations between hip fracture in the elderly and other age-related conditions, as well as its impact on long-term survival. Autor: Fernández-Ruiz M, Guerra-Vales JM,…
Sclerostin serum levels in prostate cancer patients and their relationship with sex steroids.
Circulating sclerostin levels are significantly increased in patients with prostate cancer and particularly in those receiving androgen deprivation therapy. The inverse relationship between serum sclerostin and testosterone in these patients suggests that androgens are key regulators of bone metabolism in this population. Autor: García-Fontana B, Morales-Santana S, Varsavsky M, García-Martín A,…
Linkage and association analyses using families identified a locus affecting an osteoporosis-related trait.
We provide strong and significant evidence from both linkage and association analyses that the SOST gene may affect the strength of the femoral shaft. Future investigations should study the relationship between bone mass formation and strength properties of the bones. Autor: Athanasiadis G1, Malouf J, Hernandez-Sosa N, Martin-Fernandez L,…
Long-term effect of hormone therapy on bone in early menopause: vertebral fractures after 20 years.
In spite of the fact that this study does not have a large enough sample, our data suggest that HT used in the early years of menopause does not present a long-term protective effect on vertebral fracture after discontinuing treatment. Autor: Castelo-Branco C, Davila J, Perelló MF, Peguero A, Ros C, Martínez-Serrano MJ, Balasch J.
Retinoic acid differentially affects in vitro proliferation, differentiation and mineralization of two fish bone-derived cell lines: different gene expression of nuclear receptors and ECM proteins.
Our results show: (i) retinoic acid affects proliferative and mineralogenic activities in two fish skeletal cell types and (ii) that during phenotype transitions, specific retinoic acid nuclear receptors and bone-related genes are differentially expressed in a cell type-dependent manner. Autor: Fernández I, Tiago DM, Laizé V, Leonor Cancela M, Gisbert E.
Association of matrix Gla protein gene functional polymorphisms with loss of bone mineral density and progression of aortic calcification.
The results suggest that matrix Gla protein genetic variations could predict a higher risk of bone loss and progression of vascular calcification in men. Two matrix Gla protein (MGP) polymorphisms were associated with progression of aortic calcification and femoral neck bone loss in men. All these findings were also functionally corroborated in two vascular and…
Calcific periarthritis as the only clinical manifestation of hypophosphatasia in middle-aged sisters.
Multiple juxta-articular deposits of hydroxyapatite causing calcific periarthritis may be a useful sign of hypophosphatasia, especially when the calcific periarthritis is familial. ypophosphatasia (HPP) is the inborn error of metabolism that features low serum alkaline phosphatase (ALP) activity caused by loss-of-function mutation(s) within the gene for the tissue nonspecific isoenzyme of ALP (TNSALP). In HPP,…
Use of an educational support program to assist patients receiving injectable osteoporosis treatment: experience with teriparatide.
The results show that patients from all provinces in Spain with severe osteoporosis receiving teriparatide and enrolled in an educational support program had high persistence and satisfaction with the program. However, no control group was included in these analyses and it is possible that selection bias occurred. It is suggested that patient-based strategies similar to…
Incidence of skeletal fractures after traumatic spinal cord injury: a 10-year follow-up study.
The incidence of fractures after spinal cord injury is high, with severity and time since spinal cord injury being the main determinants for their development. Fractures were frequently associated with clinical complications. However, the use of anti-osteoporotic treatment was uncommon. Autor: Gifre L, Vidal J, Carrasco J, Portell E, Puig J, Monegal A, Guañabens N,…
Prevalence of causes of secondary osteoporosis and contribution to lower bone mineral density in HIV-infected patients.
A high prevalence of secondary causes of osteoporosis is observed in HIV-infected patients, and its type and cumulative number determine a lower BMD, after adjusting by age and body mass index. Eighty-one percent of human immunodeficiency virus (HIV)-infected patients had one or more of seven evaluated causes of secondary osteoporosis, and this rate increases with…
Bone mineral density status and frequency of osteoporosis and clinical fractures in 155 patients with psoriatic arthritis followed in a university hospital.
The magnitude of the problem of osteoporosis in psoriatic arthritis seems to be mild. To assess the bone mineral density (BMD) and the frequency of osteoporosis and clinical fractures in a large group of Spanish patients with psoriatic arthritis (PsA). Autor: Busquets N, Vaquero CG2, Moreno JR, Vilaseca DR, Narváez J, Carmona L4, Nolla JM.
An OA phenotype may obtain major benefit from bone-acting agents.
A particular subset of postmenopausal patients with high remodeling and/or low subchondral bone density may benefit from the treatment with bone-acting agents hindering OA progression. This OA population could be identified with the simultaneous use of subchondral bone dual-energy X-ray absorptiometry and scintigraphy. Autor: Roman-Blas JA, Castañeda S, Largo R, Lems WF, Herrero-Beaumont G.
Prevalence of osteoporosis, vertebral fractures and hypovitaminosis D in postmenopausal women living in a rural environment.
In our study, postmenopausal women who live in rural populations have more poverty, lower values of vitamin D, lower BMD in the lumbar spine and a higher prevalence of vertebral fractures and of osteoporosis. The higher prevalence of obesity, arterial hypertension and diabetes mellitus observed in these women may be adjuvant factors, all fostered by…
Dietary interventions for preventing complications in idiopathic hypercalciuria.
Long-term adherence (five years) to diets that feature normal levels of calcium, low protein and low salt may reduce numbers of stone recurrences, decrease oxaluria and calcium oxalate relative supersaturation indexes in people with idiopathic hypercalciuria who experience recurrent kidney stones. Adherence to a low salt, normal calcium level diet for some months can reduce…
The role of wnt signaling and sclerostin in the pathogenesis of glucocorticoid-induced osteoporosis.
This review describes the most recent data on the effects of glucocorticoids on the Wnt signaling pathway, especially on their antagonists, sclerostin and Dkk-1. Bone formation is suppressed in glucocorticoid-induced osteoporosis. One of the mechanisms by which glucocorticoids depress bone formation is through their effects on the Wnt/β-catenin signaling pathway, a critical regulator of osteoblastogenesis….
HIV infection and its association with an excess risk of clinical fractures and : a nation-wide case-control study.
HIV infection is associated with an almost 3-fold increase in fracture risk compared to that of uninfected age and gender-matched uninfected patients. HIV patients are also at an almost 9-fold higher risk of hip fracture. Autor: Prieto-Alhambra D, Güerri-Fernández R, De Vries F, Lalmohamed A, Bazelier M,…
Empirically Based Composite Fracture Prediction Model from the Global Longitudinal Study of Osteoporosis in Postmenopausal Women (GLOW).
After examining results for 10 different bone fracture sites, advanced age appeared the single best possibility for uniting several different sites, resulting in an empirically based composite fracture risk model. Several fracture prediction models that combine fractures at different sites into a composite outcome are in current use. However, to the extent individual fracture sites…
The relevance of biomaterials to the prevention and treatment of osteoporosis.
Keeping in mind the premise “living longer, living better”, this commentary is the result of the thoughts, proposals and conclusions obtained after one year working in the framework of this network. Osteoporosis is a worldwide disease with a very high prevalence in humans older than 50. The main clinical consequences are bone fractures, which often…
Replication study of three functional polymorphisms associated with bone mineral density in a cohort of Spanish women.
Gene candidate and genome-wide association studies have revealed tens of loci of susceptibility for osteoporosis. The results underscore the significance of the LRP5 gene in bone metabolism and emphasize the significance of the replication of previous results in independent cohorts. Autor: Panach L, Mifsut D, Tarín JJ, Cano A, García-Pérez MA.
Effects of arachidonic acid on the concentration of hydroxyeicosatetraenoic acids in culture media of mesenchymal stromal cells differentiating into adipocytes or osteoblasts.
The results highlight the PUFA metabolism differences between uninduced and induced MSC to differentiate into adipocytes and osteoblasts, besides the relevant role of the lipoxygenase gene expression in adipogenesis induction. Autor: Casado-Díaz A, Ferreiro-Vera C, Priego-Capote F, Dorado G, Luque-de-Castro MD, Quesada-Gómez JM.
A genome-wide copy number association study of osteoporotic fractures points to the 6p25.1 locus.
The results suggest that deletions in the 6p25.1 locus may predispose to higher risk of fracture in a subset of populations of European origin; larger and geographically restricted studies will be needed to confirm this regional association. This is a first step towards the evaluation of the role of rare CNVs in osteoporosis. Autor: Oei…
Impact on the population of different bone mineral density testing criteria and appropriateness of densitometries in the ESOSVAL cohort, Spain.
The impact on the population of the different recommendations is enormous, varying from 17% to 80% of the population over 50 who would be tested Although in men it seems that a clinical rationale exists between the presence of risk factors and the rates of BMD testing, this pattern does not seem to exist in…
Association of Simvastatin and Hyperlipidemia with Periodontal Status and Bone Metabolism Markers.
Within the limits of this study, our findings suggest that the intake of simvastatin is associated with increasing serum OPG concentrations and this could have a protective effect against bone destruction and periodontal clinical attachment loss. The baseline systemic inflammatory state of hyperlipidemic patients is indicated by their increased erythrocyte sedimentation rate. Autor: Magán-Fernández A,…
Prevalence of vertebral fractures and minor vertebral deformities evaluated by DXA-assisted vertebral fracture assessment (VFA) in a population-based study of postmenopausal women: the FRODOS study.
Although the VFA approach showed a lower than expected prevalence of VF in our cohort, its association with clinical and densitometric parameters may be useful to identify women at risk for developing fragility fractures and may therefore justify its use in longitudinal studies. The high prevalence of minor vertebral deformities detected in patients with VF…
Alternative treatments for oral bisphosphonate-related osteonecrosis of the jaws: A pilot study comparing fibrin rich in growth factors and teriparatide.
In our series, the plasma rich in growth factors showed better results than the teriparatide in the treatment of recurrent oral bisphosphonate-related osteonecrosis. The aim of this study is to describe and compare the evolution of recurrent bisphosphonate-related osteonecrosis of the jaws (BRONJ) in patients treated with plasma rich in growth factors or teriparatide. Material…
Bone mass behavior after 1 year of different treatment strategies in prostate cancer patients subjected to androgen deprivation therapy.
Denosumab increased significantly bone mass in all three dual X-ray absorptiometry standard sites, while alendronate did not at total hip. No benefit was observed in men previously treated with alendronate who switched to denosumab treatment. Autor: Planas Morin J, Celma Domenech A, Placer Santos J, Trilla Herrera E, Salvador Lacambra C,…
Comparative effects of gastric bypass and sleeve gastrectomy on plasma osteopontin concentrations in humans.
Roux-en-Y gastric bypass increased circulating osteopontin levels, while they remained unaltered after sleeve gastrectomy. The increase in osteopontin levels after Roux-en-Y gastric bypass could be related to the increased bone resorption in relation to its well-known effects on bone of this malabsorptive procedure in comparison to the merely restrictive sleeve gastrectomy. Autor: Lancha A1, Moncada…
Bone mineral density and bone turnover in non-cirrhotic patients with chronic hepatitis C and sustained virological response to antiviral therapy with peginterferon-alfa and ribavirin.
Patients with chronic hepatitis C have low bone mass associated with increased bone resorption, and some relationship can be expected between serum aminotransferase levels and the degree of bone mass loss. Bone mass may be improved and bone turnover normalized in patients who respond to antiviral therapy. Elevated serum sTRFR-55 levels may play a role…
The fragile elderly hip: Mechanisms associated with age-related loss of strength and toughness
Bone 61 (2014) 138–148. This review examines recent developments in the understanding of why the elderly hip becomes fragile. This growing understanding is suggesting novel testable approaches for reducing risk of hip fracture that might translate into control of the growing worldwide impact of hip fractures on our ageing populations. Autor: Reeve J, Loveridge N.
Physiological effects of microgravity on bone cells
Calcif Tissue Int. 2014 Jun;94(6):569-79. doi: 10.1007/s00223-014-9851-x. Epub 2014 Apr 1. The objective of this review is to summarize the recent research on bone cells under microgravity conditions based on advances in the field. Autor: Arfat Y, Xiao WZ, Iftikhar S, Zhao F, Li DJ, Sun YL, Zhang G, Shang P, Qian AR.
The relationship between proton pump inhibitor adherence and fracture risk in the elderly
Calcif Tissue Int. 2014 Jun;94(6):597-607. doi: 10.1007/s00223-014-9855-6. Epub 2014 Apr 6. These results provide further evidence that PPI use may increase fracture risk in the elderly and highlight the need for clinicians to periodically reassess elderly patients’ individualized needs for ongoing PPI therapy, while weighing potential risks and benefits Autor: Ding J, Heller DA, Ahern…
THE OSTEOBLAST TO OSTEOCYTE TRANSITION: EPIGENETIC CHANGES AND RESPONSE TO THE VITAMIN D3 HORMONE
Mol Endocrinol. 2014 Jul;28(7):1150-65 We conclude that osteocytogenesis is accompanied by changes in gene expression that may be driven by both genetic and epigenetic components. These changes are likely responsible for the osteocyte phenotype and may contribute to reduced sensitivity to 1,25(OH)(2)D(3). Autor: St John HC, Bishop KA, Meyer MB, Benkusky NA, Leng N, Kendziorski…
Single- and Multiple-Dose Randomized Studies of Blosozumab, a Monoclonal Antibody Against Sclerostin, in Healthy Postmenopausal Women
J. Bone Miner Res 2014; 29: 935–943. DOI: 10.1002/jbmr.2092 Conclusions: These findings support further investigation of blosozumab as a potential anabolic therapy for osteoporosis. Autor: McColm J, Hu L, Womack T, Cai Tang C, Chiang AY
La Fundación BIAL abre las candidaturas para la 16ª edición del Premio BIAL
Los Premios BIAL apoyan y premian la investigación médica con 340.000 euros.• Uno de los objetivos principales del Premio BIAL, que cumple su 30 aniversario, es aumentar el número de candidaturas internacionales • El Premio BIAL contempla dos categorías: el “Gran Premio BIAL de Medicina” y el “Premio BIAL de Medicina Clínica”. Con un importe…
Leukaemogenesis induced by an activating β-catenin mutation in osteoblasts
Nature. 2014 Feb 13;506(7487):240-4. doi: 10.1038/nature12883. Epub 2014 Jan 15 These findings demonstrate that genetic alterations in osteoblasts can induce acute myeloid leukaemia, identify molecular signals leading to this transformation and suggest a potential novel pharmacotherapeutic approach to acute myeloid leukaemia. Autor: Kode A, Manavalan JS, Mosialou I, Bhagat G, Rathinam CV, Luo N, Khiabanian…
The Effects of 3 Years of Calcium Supplementation on Common Carotid Artery Intimal Medial Thickness and Carotid Atherosclerosis in Older Women: An Ancillary Study of the CAIFOS Randomized Controlled Trial
In conclusion, our study does not support the hypothesis that calcium supplementation increases either carotid artery intimal medial thickness or carotid atherosclerosis. In addition, calcium supplementation and high total calcium intake may indeed reduce carotid atherosclerosis. Autor: Joshua R Lewis, Kun Zhu, Peter L Thompson and Richard L Prince
Premios Fundación Lilly de Investigación Biomédica Preclínica y Clínica 2014
La Fundación Lilly, en desarrollo de sus objetivos estatutarios y dentro del programa de Apoyo a la Investigación, convoca los Premios Fundación Lilly de Investigación Biomédica Preclínica y Clínica 2014, para investigadores que hayan contribuido de forma significativa al desarrollo de la Biomedicina y las Ciencias de la Salud en España, y mantengan una actividad…
MHC Class II Transactivator Is an In Vivo Regulator of Osteoclast Differentiation and Bone Homeostasis Co-opted From Adaptive Immunity
In conclusion, despite the huge impact of osteoporosis worldwide, our knowledge of bone genetics and biology remains remarkably incomplete. Our findings and models provide compelling genetic evidence of a novel molecular network regulating adult skeletal homeostasis in vivo, which may help identify new specific therapeutic targets against involution- al, inflammatory, or cancer‐induced bone wasting. Autor:…
Trabecular Bone Score: A Noninvasive Analytical Method Based Upon the DXA Image
The trabecular bone score (TBS) is a gray‐level textural metric that can be extracted from the two‐dimensional lumbar spine dual‐energy X‐ray absorptiometry (DXA) image. TBS is related to bone microarchitecture and provides skeletal information that is not captured from the standard bone mineral density (BMD) measurement. Based on these data, lumbar spine TBS holds promise…
Bone-specific insulin resistance disrupts whole-body glucose homeostasis via decreased osteocalcin activation
J Clin Invest. 2014 Apr 1;124(4):1-13. doi: 10.1172/JCI72323. Epub 2014 Mar 18. Together, these results underscore the involvement of bone, among other tissues, in the disruption of whole-body glucose homeostasis resulting from a HFD and the involvement of insulin and osteocalcin cross-talk in glucose intolerance. Furthermore, our data indicate that insulin resistance develops in bone…
Reversing LRP5-Dependent Osteoporosis and SOST Deficiency–Induced Sclerosing Bone Disorders by Altering WNT Signaling Activity
In conclusion, our data highlight the potential for novel drug targeting approaches in rare skeletal disorders ranging from severe skeletal fragility to sclerosing bone overgrowth through selective modulation of canonical WNT signaling. These approaches should also be beneficial in the context of other medical conditions with much less severe phenotypes, such as postmenopausal osteoporosis, given…
Ischaemic cardiac events and use of strontium ranelate in postmenopausal osteoporosis: a nested case–control study in the CPRD
The results of this nested case–control study in the CPRD indicate no evidence for a higher risk of MI or cardiovascular death associated with the use of strontium ranelate in women treated for osteoporosis compared with non-use of this agent in routine medical practice in the UK. Autor: C. Cooper, K. M. Fox, J. S….
Changing trends in the epidemiology of hip fracture in Spain
Osteoporos Int (2014) 25:1267–1274. DOI 10.1007/s00198-013-2586-0. Conclusions This study supports other international studies by showing changes in the incidence of hip fractures after age population adjustment, which denotes a decrease in the younger age groups and among women and shows an increase in both groups over 85 years. The increase in the crude incidence rate…
Modulation of Strain-Specific Differences in Gene Expression by Cannabinoid Type 2 Receptor Deficiency
Calcified Tissue International (2014) 94:4: 423-432 They conclude that Cnr2 deficiency affects expression of a large number of genes in different strains of mice, and that these differences are likely to be responsible in part for the differences in skeletal phenotype that they and others have observed in mice with defective cannabinoid receptor signalling in…
Acta BECAS FEIOMM Investigación Tarragona 2013
Relación de Becas entregadas por FEIOMM tras el Congreso SEIOMM 2013 celebrado en Tarragona. Consulte aquí.
ACTA PREMIOS ITALFÁRMACO-SEIOMM 2013 XVIII Congreso Tarragona
El Jurado, compuesto por los moderadores de las sesiones de comunicaciones orales y pósteres y el Comité Científico del XVIII Congreso de la SEIOMM, ha otorgado los Premios Italfarmaco 2013 a las siguientes comunicaciones
Acta Premio Joven Investigador 2013
Mejor comunicación presentada por un investigador socio menor de 35 años.El jurado, compuesto por los moderadores de las sesiones de comunicaciones orales y pósters y el Comité Científico del XVIII Congreso de la SEIOMM, ha otorgado el Premio al Joven Investigador
Comparative gastrointestinal safety of bisphosphonates in primary osteoporosis: a network meta-analysis
Osteoporos Int (2014) 25:1225–1235 This is the first network meta-analysis to assess the comparative GI safety of bisphosphonates for primary osteoporosis. Our results identify zoledronic acid as having the highest probability of having the greatest number of GI adverse events and nausea. Discontinuation due to adverse events may be a more clinically relevant outcome, with…
Rueda de prensa DIA MUNDIAL DE LA OSTEOPOROSIS
Con motivo de la celebración Intervenciones de: Dr. Manuel Díaz Curiel, Presidente FHOEMO. Incidencia de la Osteoporosis y análisis de su máxima consecuencia, la fractura osteoporótica. Dr. Javier del Pino, Presidente SEIOMM. Impacto Económico de la Osteoporosis en el Sistema Nacional de Salud. Dra. Carmen Sánchez Chicharro. Calidad de Vida del paciente con Osteoporosis.
Convocatoria Beca Biología Molecular Ósea FEIOMM 2013
FEIOMM convoca una beca de 10.000 euros brutos para promocionar la investigación en el campo de Biología Molecular Ósea. Podrán optar a ella todos los asociados de la SEIOMM con experiencia investigadora en el campo de la patología metabólica ósea. Consulte Convocatoria aquí.
Convocatoria Beca Investigación Clínica FEIOMM 2013
FEIOMM convoca una beca de 3.000 euros brutos para promocionar la investigación clínica en el campo de la patología metabólica ósea. Podrán optar a ella todos los asociados de la SEIOMM con experiencia investigadora en el campo de la patología metabólica ósea. Consulte las bases de la convocatoria aquí.
Convocatoria Beca Investigación Básica FEIOMM 2013
FEIOMM convoca una beca de 3.000 euros brutos para promocionar la investigación básica en el campo de la patología metabólica ósea. Podrán optar a ella todos los asociados de la SEIOMM con experiencia investigadora en el campo de la patología metabólica ósea. Consulte las bases aquí.
Resolución 2ª Becas ASBMR 2013
Finalizado el plazo con fecha 06 de Septiembre de 2013 a las 12:00 A.M., para el envío de solicitudes se adjunta la lista de solicitantes admitidos y excluidos para su evaluación.El Comité Científico considera que todos los trabajos presentados han tenido un alto interés científico y dado que el nº de solicitantes es menor al…
In Vivo Assessment of Bone Quality in Postmenopausal Women With Type 2 Diabetes
J Bone Miner Res, (2014) 29; 787–795 The findings represent the first demonstration, using a direct in vivo measure of BMS, of compromised bone material properties in patients with T2D. Further, our results confirm previous studies demonstrating low bone turnover in patients with T2D and highlight the potential detrimental effects of prolonged hyperglycemia on bone…
Premiado Jesús Delgado-Calle Socio de la SEIOMM y Joven Investigador
Felicitaciones a nuestro 2013 Sevgi y Gideon Rodan Fellowship Winner
Nationwide registry- based analysis of cardiovascular risk factors and adverse outcomes in patients treated with stronium ranelate
In conclusion, baseline cardiovascular diseases are common in patients treated with strontium ranelate, with more than half of strontium ranelate users being current users of antiplatelet drugs or having a history of cerebrovascular disease, peripheral vascular disease or myocardial infarction. Moreover, this observational study shows an increased confounder-adjusted mortality risk in patients treated with strontium ranelate…
Huesos artificiales mediante células madres y carbón
Científicos españoles han patentado un nuevo biomaterial para desarrollar tejido óseo, conocido como huesos artificiales, a partir de células madre procedentes de cordón umbilical. Este material consiste en una tela de carbón activado sobre la que se soportan y se diferencian las células dando origen a un producto capaz de promover el crecimiento del hueso….
Dr. Neyro intervino como invitado especial en el programa “En buenas manos”
Dentro de su labor de divulgación sanitaria de la que este web es un buen ejemplo, el Dr. Neyro intervino como invitado especial en el programa “En buenas manos”
Dentro de su labor de divulgación sanitaria de la que este web es un buen ejemplo, el Dr. Neyro intervino como invitado especial en el programa “En buenas manos” que presenta y dirige el afamado divulgador sanitario Dr. Bartolomé Beltrán, el pasado sábado 22 de junio de 2013.
Expertos ISFR-IOF proponen medidas estandarizadas de los resultados clínicos de las fracturas de muñ
Siete principales recomendaciones hechas; consenso internacional podría beneficiarse enormemente la práctica clínica y el diseño del estudio en la investigación fractura de radio distal
VIII Premio Banco Sabadell a la investigación biomédica
El premio consiste en una dotación de 50.000 euros y una obra de un escultor español contemporáneo.Banco Sabadell otorga este premio con objeto de reconocer la excelencia de personas jóvenes, con una importante trayectoria en el campo de la búsqueda biomédica y ciencias de la salud, que destaquen en su especialidad por su capacidad de…
ISFR-IOF experts propose standardized measurements of clinical outcomes in wrist fractures
Seven core recommendations made; international consensus could immensely benefit clinical practice and study design in distal radius fracture
Distal radius fractures (often simply termed wrist or Colles’ fractures) are the second most common fractures in the elderly. Beyond the immediate impact on the patient, wrist fractures in older adults often indicate underlying osteoporosis and high risk of subsequent fragility fractures.
Despite their clinical significance, evidence-based practice and clinical research on wrist fractures are hampered by the lack of standardized methods of outcome measurement. A new publication* by the Distal Radius Working Group of the International Society for Fracture Repair (ISFR) and the International Osteoporosis Foundation (IOF) makes important new recommendations in an effort to promote international consensus.
“In regard to distal radius fractures there is currently no agreed-upon definition of what should be measured in a clinical trial. As a result, researchers are faced with heterogeneous information – a serious barrier to high-quality research in the evaluation of outcomes or definition of intervention thresholds,” said Dr. Jörg Goldhahn, Lecturer at the Institute for Biomechanics of the Swiss Federal Institute of Technology (ETH), Zurich and President-Elect of the ISFR.
The IOF-ISFR Working Group used a methodological approach to arrive at a comprehensive foundation of content for outcomes. The absence of pain and restoration of function was agreed as the common treatment goals and foci for clinical measures. There was also a consensus that symptom and function should be measured as separate domains in the WHO International Classification of Functioning, Disability and Health (ICF)
The impact of osteoporosis prevention programs on calcium intake: a systematic review
Froedtert Healthcare, Patient Care Services, Milwaukee, WI, USA, ryanpa@uwm.edu. Ryan P, Schlidt A, Ryan C Froedtert Healthcare, Patient Care Services, Milwaukee, WI, USA, ryanpa@uwm.edu. Osteoporosis International : a Journal Established as Result of Cooperation Between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA [2013] Autor: Journal Established as Result of…
ERA-EDTA Award for outstanding contributions to ERA-EDTA
Jorge B. Cannata-Andia is the recipient of the 2013 ERA-EDTA award for contributions to ERA-EDTA.
He became a member of ERA-EDTA in 1982 and served his first term in the Council of the Association from 1993 to 1997 as an ordinary Council member. In 2002, he became Secretary-Treasurer till 2005, after which he became President up to 2008.
In his first term he collaborated with Jacques Bernheim on the successful re-launching of the ERA-EDTA Registry by making a number of adaptations according to the new needs and objectives of the Association. His main contributions, however, came during the periods he was Secretary-Treasurer and President. He played a crucial role in many of the Society’s activities such as making the ERA-EDTA administrative offices versatile and flexible to deal with all aspects of the Society, the creation of “Follow us”, setting up Post-Congress Council Meetings and creating the title of “Chairperson of the Administrative Offices”.
Thanks to his initiative the ERA-EDTA started supporting collaborative clinical trials and observational studies, as well as supporting translational research projects. Furthermore, during his terms as an Officer in the ERA-EDTA Council, he played a crucial role in improving or initiating a number of scientific and educative activities such as increasing the number of CME Courses, the launch of Fellowship Programs in 2006, the creation of NDT-Educational in 2004 and NDT-Plus in 2008, the installation of the first Scientific Advisory Board (SAB) in 2006, the establishment of ERA-EDTA Registry Courses in 2005 and starting lobbying for financial support for the QUEST project, and, now, thanks to this amount kept aside the ERA-EDTA has been able to finance the EQUAL project. In 2006 the ERA-EDTA Registry obtained, for the first time in the ERA-EDTA history, funds from the European Union for a project called “NephroQUEST” led by Carmine Zoccali and Kitty Jager. He was also instrumental in ERA-EDTA becoming part of EKHA, which is currently very active lobbying the European Community both for funds for renal diseases, but also for awareness issues. Currently he is the representative for ERA-EDTA at the European Union of Medical Specialists (UEMS).
10º CURSO DE FORMACIÓN CONTINUADA EN SALUD DE LA MUJER
Coordinado por el Dr. José Luis Neyro, experto Ginecólogo del Hospital de Cruces de Bilbao
Bienvenido al 10º Curso de Formación Continuda en Salud de la Mujer
Un año más, coordinado por el Dr. José Luis Neyro, experto Ginecólogo del Hospital de Cruces de Bilbao, se reunirá a ginecólogos y expertos de otras especialidades para revisar y actualizar patologías asociadas a la Menopausia. Este encuentro, cuyo objetivo se centra en formar a los especialistas en salud de la mujer, se ha convertido en todo un referente en la ciudad de Bilbao.
European guidance for the diagnosis and management of osteoporosis in postmenopausal women
Abstract: Summary Guidance is provided in a European setting on the assessment and treatment of postmenopausal women at risk of fractures due to osteoporosis.
Introduction
In 1997, the European Foundation for Osteoporosis and Bone Disease (subsequently the International Osteoporosis Foundation, IOF) published guidelines for the diagnosis and management of osteoporosis [1], subsequently updated in 2008 by the IOF and European Society for Clinical and Economic Evaluation of Osteoporosis and Osteoarthritis (ESCEO) [2]. Since then, there have been significant advances in the field of osteoporosis. These include the development of new techniques for measuring bone mineral, improved methods of assessing fracture risk and new treatments that have been shown to significantly reduce the risk
of fractures at vulnerable sites. Against this background, the Scientific Advisory Board of the ESCEO, in collaboration with the IOF, has recognised a need to update the guidance which is detailed below. The high societal and personal costs of osteoporosis pose challenges to public health and physicians, particularly since most patients with osteoporosis remain untreated. Indeed, less than 20 % of patients with a fragility fracture receive therapy to reduce future fracture within the year following fracture [3–5]. The aim of this guidance is to stimulate a cohesive approach to the management of osteoporosis in Europe. The term guidance rather than guidelines is used, to avoid any prescriptive connotations since country- or region-specific guidelines are now widely available in many European countries and continue to evolve. Rather, the guidance can inform the development of new guidelines or the revision of existing guidelines.
Vitamin D supplementation in elderly or postmenopausal women: a 2013 update of the 2008 recommendati
Vitamin D insufficiency has deleterious consequences on health outcomes. In elderly or postmenopausal women, it may exacerbate osteoporosis.
Introduction
Few subjects have been the source of as much discussion in the medical community in recent years as vitamin D. Lack of vitamin D has well known direct effects on bone health. This occurs via the deregulation of calcium homeostasis and increased serum parathyroid hormone (PTH), which negatively affects bone remodeling by increasing bone resorption1–3. In elderly or postmenopausal women, this may exacerbate osteoporosis. Vitamin D insufficiency has a variety of causes (Table 1)4,5, including reduced endogenous synthesis, decreased availability, and concomitant diseases. The risk factors for vitamin D insufficiency are related to race, latitude, exposure to sunlight and ability to tan, and cultural attitudes to supplementation and general health6. The indications for screening include bone diseases, old age (particularly in case of falls or fracture), malabsorption syndromes, and certain medications (Table 1)4,5.
Risk factors for the development of vertebral fractures after percutaneous vertebroplasty – Martinez
Angels Martinez-Ferrer MD1, Jordi Blasco MD2, Josep L Carrasco3, Juan Macho PhD2, Luis San Román MD2, Antonio López Rueda MD2, Ana Monegal PhD1, Nuria Guañabens PhD4, Pilar Peris PhD4, Abstract We have recently observed an increased risk for vertebral fractures (VF) in a randomized controlled trial comparing the analgesic effect of vertebroplasty (VP) versus conservative…
Cómo prevenir la osteoporosis gracias al Pilates
Para los afectados por enfermedades óseas, como la osteoporosis, es fundamental la práctica de ejercicio físico tanto para prevenir su avance como para minimizar los riesgos de fractura.
Un ejercicio físico adaptado a sus especiales necesidades, como el que les brinda el método Pilates, que les procura múltiples beneficios. “Se trata de una actividad física sin riesgo de caídas o golpes, que hace trabajar los músculos y ayuda a compensar el desequilibrio entre reabsorción y formación del tejido óseo”, explica Emilie Baudoin, experta en Pilates en Divina Pastora Seguros.
Un estudio asocia el ciclismo de competición con mayor riesgo de osteoporosis
Zaragoza, 13 feb (EFE).- Un estudio de la Universidad de Zaragoza vincula la práctica competitiva de ciclismo con mayor riesgo de osteoporosis y el decrecimiento en salud ósea,
Premio Banco Sabadell a la Investigación Biomédica
El premio consiste en una dotación de 50.000 euros y una obra de un escultor español contemporáneo.
Banco Sabadell otorga este premio con objeto de reconocer la excelencia de personas jóvenes, con una importante trayectoria en el campo de la búsqueda biomédica y ciencias de la salud, que destaquen en su especialidad por su capacidad de innovación. El premio consiste en una dotación de 50.000 euros y una obra de un escultor español contemporáneo. La de esta edición es del barcelonés Sergi Aguilar, considerado uno de los principales artistas españoles de su generación.
Premios Fundación Pfizer de Investigación
Se abre el plazo de presentación de candidaturas para la nueva edición de los Premios Fundación Pfizer de Investigación en las siguientes categorías:
Investigación Básica.
Investigación Clínica o Salud Pública.
Investigación para profesionales sanitarios en fase de especialización
Podrán optar aquellos trabajos de investigación biomédica que hayan sido publicados durante 2012, en revistas contenidas en el Science Citation Index. Los trabajos deberán haberse realizado en instituciones españolas públicas o privadas. También se aceptarán trabajos realizados en entidades españolas en colaboración con instituciones extranjeras.
Premios Fundación Pfizer de Investigación
Se abre el plazo de presentación de candidaturas para la nueva edición de los Premios Fundación Pfizer de InvestigaciónPremios Fundación Pfizer de Investigación en las siguientes categorías: Investigación Básica. Investigación Clínica o Salud Pública. Investigación para profesionales sanitarios en fase de especialización
Cost-Effectiveness of Osteoporosis Interventions for ‘Incidental’ Vertebral Fractures
Vertebral fractures detected “incidentally” by chest radiograph usually do not trigger osteoporosis treatment in older patients. Background Vertebral fractures detected “incidentally” by chest radiograph usually do not trigger osteoporosis treatment in older patients. In a 3-arm controlled trial we reported that both physician-directed and enhanced (physician plus patient activation) interventions increased treatment rates more than…
Improvement in Bone Properties by Using Risedronate Adsorbed Hydroxyapatite Novel Nanoparticle Based
Authors: Sahana, H.; Khajuria, Deepak Kumar; Razdan, Rema; Mahapatra, D. Roy; Bhat, M.R.; Suresh, Sarasija; Rao, R. Ramachandra; Mariappan, L. Abstract: A superior drug formulation capable of achieving efficient osteogenesis is in imperative demand for the treatment of osteoporosis. In the present study we investigated the potential of using novel risedronate-hydroxyapatite (HA) nanoparticle based formulation…
Becas Fundación Ramón Areces para Estudios Postdoctorales
XXV Convocatoria de Becas para Ampliación de Estudios en el Extranjero en Ciencias de la Vida y de la Materia
Presentación
La Fundación Ramón Areces tiene como objetivo fundamental el patrocinio de proyectos de investigación científica y técnica en España a través de Concursos Nacionales, la formación de jóvenes investigadores, así como el fomento y desarrollo de la educación y de la cultura en general.
European Calcified Tissue Society Congress 2013
Opportunities for ECTS to communicate information about their 50th Annivesary Congress. Abstract deadline: 28 January 2013 To ensure that your research is part of ECTS 2013, you will need to submit your abstract by the 28 January 2013 via the ECTS website. http://www.ectscongress.org/2013/prog/abstract.htm Why submit your abstract to ECTS 2013? Long-standing congress of highest scientific quality…
BiologicsSpineTrauma Features
Could wood be a practical replacement for bone? Researchers from the National Research Council of Italy (CNR) writing in a forthcoming issue of the International Journal of Healthcare Technology and Management …
Biloine W. Young • Fri, December 21st, 2012
Could wood be a practical replacement for bone? Researchers from the National Research Council of Italy (CNR) writing in a forthcoming issue of the International Journal of Healthcare Technology and Management suggest that it can. It turns out that the structure of some woods at the microscopic level is very close to that of natural bone; both have unique biomechanical properties such as high strength and lightness.
Two researchers in Italy, Ugo Finardi (Institute for Economic Research on Firms and Growth-CERIS-CNR, and University of Torino), and Simone Sprio (Institute of Science and Technology for Ceramics – ISTEC-CNR), have carried out a case study on the implications of a new technology recently developed by the Research Group on Biomaterials of ISTEC. In that work, the researchers, Anna Tampieri, Simone Sprio and Andrea Ruffini, used a nanotechnological approach to transform rattan wood into hierarchically organized implants.
La osteoporosis repunta en Navarra por el cambio de dieta y el sedentarismo
ESTA DOLENCIA, QUE SUFREN 37.000 MUJERES Y 9.000 HOMBRES, DEBILITA EL HUESO Y CAUSA FRACTURAS
Los dietistas-nutricionistas apuestan por prevenirla con una dieta que incluya menos carne, sal y alcohol, y más verdura
M. GONZÁLEZ – Sábado, 27 de Octubre de 2012 – Actualizado a las 05:09h
Osteoporosis detección: una entrevista con el profesor Ciro Cooper
Lea esta entrevista detallada con el Presidente del Comité de la IOF de Asesores Científicos “Debemos tratar la osteoporosis como tratamiento de cualquier enfermedad crónica: en la enfermedad cardiovascular que evaluar los factores de riesgo e intervenir con estatinas en el ictus se evalúa la presión arterial e intervenir para quienes están en el extremo…
Las chicas adolescentes que fuman pueden aumentar su riesgo de enfermedades óseas futuras
La mitad de la formación del tejido óseo de las mujeres tiene lugar durante estos primeros años, afirman los investigadores
MARTES, 4 de diciembre (HealthDay News) — Las adolescentes que fuman pueden tener un riesgo mayor de osteoporosis, según un estudio reciente que halló que los huesos de las chicas que fuman se desarrollan menos en este periodo fundamental de sus vidas.
El Hospital de Torrevieja aborda de la osteoporosis en atención primaria
El Hospital de Torrevieja ha realizado recientemente una sesión formativa bajo el título “Osteoporosis y práctica clínica en atención primaria”.
Este curso se encuentra enmarcado en el II Plan de Prevención y Control de la Osteoporosis de la Comunidad Valenciana y en el Plan Estratégico de la Consellería: ESOSVAL, que tiene como objetivo principal mejorar la atención al paciente con Osteoporosis o con riesgo de presentarla (se adjunta programa). El curso está acreditado por la Comisión de Formación Continuada de la Comunidad Valenciana del Sistema Nacional de Salud.
La actualización de conocimientos y la mejora de habilidades son una necesidad permanente de los profesionales sanitarios para un adecuado ejercicio de su profesión, contribuye a la mejora del funcionamiento del sistema sanitario, a la satisfacción del paciente y a la de los propios profesionales.
La osteoporosis o mejor, su consecuencia natural, la fractura osteoporótica, es un problema de salud, que genera morbilidad y mortalidad, y que tiene repercusiones sanitarias, sociales y económicas, de gran calado.
La jornada formativa contó con la participación de casi medio centenar de médicos y enfermeras de las diferentes zonas básicas de salud que integran el Departamento. El objetivo es actualizar la formación de dichos profesionales en áreas detectadas de mejora y que ellos a su vez trasladen a los profesionales de sus respectivas áreas el conjunto de aprendizajes adquiridos.
Columna vertebral y los efectos de la adición
Por Nancy Walsh, escritor de personal, MedPage Today. Comentado por Zalman S. Agus, MD , Profesor Emérito de la Escuela Perelman de Medicina de la Universidad de Pennsylvania y Dorothy Caputo, MA, BSN, RN, enfermera de Planificación.
MINNEAPOLIS – Las mujeres que se quedaron en alto riesgo de fractura de cadera en la osteoporosis a pesar del tratamiento previo con alendronato (Fosamax) se beneficiaron de la adición de teriparatida (Forteo) en lugar de simplemente cambiar a él, un investigador dice aquí.
A los 6 meses, las mujeres que agregaron teriparatida al alendronato (Fosamax), la terapia mostraron aumentos significativos en la densidad mineral ósea volumétrica (DMO) de la cadera en comparación con aquellos que cambiaron a la teriparatida solo (0,9% frente a -0,5%, P = 0,004), de acuerdo a Felicia Cosman, MD, del Hospital Helen Hayes en West Haverstraw, NY
Esos aumentos se mantuvieron significativas a los 18 meses (2,2% versus ningún cambio, P = 0,002), dijo en la reunión anual de la Sociedad Americana de Investigación Ósea y Mineral.
Investigaciones anteriores han sugerido que la DMO diferente y respuestas bioquímicas pueden ocurrir entre las mujeres previamente tratadas con alendronato o raloxifine (Evista) que, o bien añadir o cambiar a la teriparatida, una formulación de hormona paratiroidea, pero los efectos sobre la resistencia ósea eran desconocidos.
La osteoporosis causa 90.000 fracturas de cadera cada año en España
Se producen principalmente en mujeres de bajo peso
MADRID, 30 Nov. (EUROPA PRESS)
Factores de riesgo de osteoporosis después de la menopausia
ScienceDaily (13 de noviembre de 2012) – Un estudio preliminar de 127 mujeres post-menopáusicas con terapia de reemplazo hormonal en Portugal sugiere que hay varios factores de riesgo asociados con la osteoporosis y las fracturas óseas que incluyen la edad, la baja densidad mineral ósea, un estilo de vida sedentario, el consumo de café y…
Método de evaluación de la densidad ósea
ScienceDaily (19 de noviembre de 2012) – Un nuevo estudio del Instituto Karolinska en Suecia muestra que una técnica para medir la densidad de los huesos llamada radiología digital radiogrammetry (o DXR) que se utiliza en las radiografías manuales puede ayudar a identificar a los pacientes con mayor riesgo de fractura de cadera. Los investigadores creen que DXR, que es totalmente comparable con otros métodos más costosos, se puede utilizar de forma preventiva para identificar a las personas en la zona de riesgo para la osteoporosis – una enfermedad estimado para llevar a cabo unos 200 millones de mujeres en todo el mundo.
Cada año, aproximadamente 1,7 millones de fracturas de cadera se producen en todo el mundo (alrededor de 18.000 sólo en Suecia), sobre todo en personas de edad avanzada y las mujeres con osteoporosis. Una fractura de cadera puede ser particularmente grave para las personas mayores, sino que a menudo implica la rehabilitación largo y deja muchos pacientes no pueden llevar una vida independiente. Además, entre el 10 y el 20 por ciento de los pacientes mueren de complicaciones. Además del sufrimiento humano que causan, las fracturas de cadera son también muy costosa para los servicios sanitarios de la cantidad de atención que requieren.
“Si podemos identificar a las personas con osteoporosis y tratarlos con medicamentos, se puede reducir el riesgo de fractura de cadera”, dice el investigador principal, profesor asociado del Departamento de Torkel Brismar Instituto Karolinska de Ciencias Clínicas, Intervención y Tecnología. “Nuestra investigación muestra que DXR es una técnica que se presta bien a este, a lo mejor en la salud general chequeos o exámenes, por ejemplo, o cuando las personas buscan tratamiento para un lado o sospecha de fractura de muñeca.”
Medicamentos para la osteoporosis asociada a las fracturas de fémur
Los bifosfonatos son medicamentos que se usan para prevenir o retrasar el proceso de la osteoporosis.
Los bifosfonatos son medicamentos que se usan para prevenir o retrasar el proceso de la osteoporosis. Son ampliamente utilizados para las mujeres mayores de 45 años. Recientemente, se ha publicado información que indica que el 1% de los que tomaron el medicamento podría experimentar un efecto secundario grave que da lugar a fracturas por estrés espontáneos.
Uno de mis pacientes ha experimentado esta situación de primera mano. Ella nos ha pedido que comparta su historia y recursos educativos con otros pacientes y nuestros lectores del blog.
Los hombres podrían beneficiarse de medicamento para la osteoporosis: Estudio
Varones con mayor riesgo que tomaron Reclast vieron un 67 por ciento de disminución en las fracturas Miércoles, 31 de octubre (HealthDay News) – Los hombres mayores con riesgo de fracturas por osteoporosis pueden cosechar los mismos beneficios que las mujeres de los medicamentos que fortalecen los huesos llamados bifosfonatos, un nuevo estudio sugiere. En…
Acuerdo con la Conselleria de Sanitat para fomentar la investigación en osteoporosis
El Centro Superior de Investigación en Salud Pública de la Generalitat Valenciana ha firmado un acuerdo para seguir avanzando en la prevención y el tratamiento de la osteoporosis.
Madrid, 19 de noviembre de 2012. El Centro Superior de Investigación en Salud Pública de la Generalitat Valenciana ha firmado un acuerdo con la compañía biotecnológica Amgen y la farmacéutica GlaxoSmithKline (GSK) para seguir avanzando en la prevención y el tratamiento de la osteoporosis.
Esta colaboración servirá para ampliar el programa Esosval, una iniciativa estratégica de la Conselleria de Sanitat, en el marco del II Plan de Prevención y Control de la Osteoporosis de la Comunidad Valenciana, que tiene como objetivo fomentar la formación, investigación y asistencia sanitaria para mejorar la atención a los pacientes con osteoporosis o con riesgo de presentarla. Amgen y GSK están aunando esfuerzos para beneficiar a los pacientes que padecen esta patología
Premios Congreso Cuenca 2012 – FEIOMM
BECAS FEIOMM 2012 AL MEJOR TRABAJO DE INVESTIGACIÓN CLÍNICA EN EL CAMPO DE: LA PATOLOGIA METABOLICA OSEA dotada con 3.000. € y EN EL ÁREA DE BIOLOGÍA MOLECULAR ÓSEA dotada con 10.000 €.
Carta abierta firmada por Premios Nobel Europeos
Momento en que nosotros, la comunidad científica, debe actuar de forma conjunta
Estimado colega,
Las discusiones en la próxima cumbre de Jefes de Estado de la Unión Europea y los gobiernos de las naciones miembro, prevista para el 22 y 23 de noviembre de 2012, serán decisivas en la determinación del presupuesto de investigación de la UE para los próximos siete años. Los 80 millones de euros para la investigación, según lo propuesto por la Comisión Europea, aún no están garantizados. Varios Estados miembros están exigiendo recortes severos en el presupuesto total de la UE, por lo que la investigación tendrá que competir con otras prioridades políticas.
Tomando carrera fuera de la ecuación en la medición de riesgo de las mujeres de la osteoporosis
Para las mujeres con varios tipos de orígenes raciales o étnicos, un nuevo método para medir la salud ósea puede mejorar las probabilidades de diagnosticar correctamente el riesgo de osteoporosis y fracturas óseas.
Panel de Llamadas de Reemplazo Hormonal demasiado arriesgado
Un grupo influyente de salud nacional confirmó el lunes una recomendación anterior contra a largo plazo la terapia de reemplazo hormonal para mujeres menopáusicas, diciendo que sus riesgos superan a los beneficios para la mayoría de los pacientes.
Por THOMAS M. BURTON
El hallazgo de la Fuerza de Tareas de Servicios Preventivos EE.UU. no se espera que traiga cambios importantes para los médicos y las mujeres ya que el uso preventivo de la terapia de reemplazo hormonal se ha vuelto menos común, ya que un importante estudio hace una década se desanime. Por otra parte, las conclusiones publicadas el lunes son similares a los del mismo panel alcanzado en 2005.
El grupo de trabajo recomendó que el uso de la combinación de estrógeno y progestina para la prevención de enfermedades crónicas en mujeres posmenopáusicas. El grupo también recomendó que el uso a largo plazo de estrógenos en mujeres posmenopáusicas que han tenido una histerectomía.
El grupo tomó ninguna posición a corto plazo el uso de estrógenos y otras terapias de reemplazo hormonal para tratar los síntomas de la menopausia temporales, como los sofocos y los sudores nocturnos.
Un estudio publicado a principios de este mes sugiere que la terapia hormonal después de la menopausia comenzó poco puede ayudar a aliviar la depresión, la ansiedad y los sofocos sin aumentar los riesgos de enfermedades cardiovasculares. Sin embargo, el estudio se ha visto como un apoyo a corto plazo el uso de hormonas, no a largo plazo.
A partir antihipertensivos vinculados a la fractura de cadera en ancianos
La Sociedad Americana de Investigación Ósea y Mineral 2012 Reunión Anual, Minneapolis, Minnesota, EE.UU:
medwireNews: El riesgo de fractura de cadera en los individuos mayores aumentos durante los primeros 45 días después de iniciar el tratamiento antihipertensivo, y de forma significativa para los que empiezan la angiotensina II enzima convertidora de angiotensina y los bloqueadores beta-adrenérgicos, informan investigadores canadienses.
El estudio incluyó datos de más de 300.000 nuevos tratados comunidad que habita en ancianos con una media de 81 años, de los cuales 1.463 fracturas de cadera experimentados durante el período de observación de 450 días.
“Se debe tener precaución cuando se inicia el tratamiento antihipertensivo en pacientes de edad avanzada para minimizar el riesgo de los resultados potencialmente devastadores de las fracturas de cadera”, comentó Debra Butt, de la Universidad de Toronto, en un comunicado de prensa.
Los hallazgos del estudio fueron presentados en la Sociedad Americana de Investigación Ósea y Mineral de la Reunión Anual 2012 en Minneapolis, Minnesota.
La deficiencia de vitamina D relacionada con las fracturas vertebrales en hombres con diabetes melli
Kim YJ Kwandong de University College de Medicina, Hospital Myongji Koyang, Corea y sus colegas realizaron el estudio y encontró que los hombres con diabetes mellitus tipo 2 e inferior a 20 ng suero de vitamina d / mL se encontraban en casi 8 veces más propensos que los que tenían mayor los niveles de…
Sin riesgo cardiaco para mujeres de calcio
Por Nancy Walsh, escritor de personal, MedPage Today. Comentado por Robert Jasmer, MD , Profesor Clínico Asociado de Medicina de la Universidad de California, San Francisco y Dorothy Caputo, MA, BSN, RN, enfermera de Planificación
MINNEAPOLIS – Los suplementos de calcio ampliamente prescritos para la salud ósea en las mujeres no parecen estar asociados con un mayor riesgo cardiovascular, los investigadores encontraron.
Con más de 2 décadas de seguimiento de una cohorte de casi 75.000 mujeres, el riesgo relativo de enfermedad cardiovascular fue de 0,86 (IC del 95%: 0,65 a 0,88), Julie Paik, MD, de la Harvard Medical School en Boston, informó aquí, en el reunión anual de la Sociedad Americana de Investigación Ósea y Mineral.
A pesar de la popularidad de los suplementos de calcio – una estimación dice que el 60% de las mujeres mayores de 60 años que uso – ha habido un creciente interés por una posible relación con problemas cardiovasculares, con datos contradictorios haber surgido.
En un análisis secundario de un estudio, el uso de calcio se asoció con un mayor riesgo de infarto de miocardio (MI) y de un criterio de valoración combinado de IM, ictus y muerte súbita.
Y en un meta-análisis de ensayos aleatorios, hubo un aumento en el riesgo de infarto de miocardio con o sin suplemento de vitamina D, mientras que otro meta-análisis encontró efectos neutros para los suplementos.
Debido a que los estudios prospectivos hasta ahora han sido de corta duración, Paik y sus colegas analizaron datos del Estudio de Salud de las Enfermeras, que comenzó en 1976 registró mujeres en edades de 30 a 55.
Este análisis se basó en los resultados de 74.272 mujeres que completaron un cuestionario sobre alimentación en 1984, en el que los participantes se detalla su ingesta habitual de alimentos, bebidas y suplementos dietéticos.
El calcio se informó cada 4 años.
Becas todavía disponibles – IOF Curso de formación avanzada sobre Osteoporosis
Se comunica a todos los Asociados que por ser miembro de la SEIOM pueden nominar a cualuqier miembro o sociedad a las becas propuestas por la IOF. El informe anual Curso de Formación Avanzada IOF sobre la Osteoporosis (para ser acreditado CME) se llevará a cabo a partir de enero 30 hasta febrero 1, 2013…
Asociados SEIOMM: Cómo acceder a su cuenta de la IBMS!!!
International Bone and Mineral Society Como miembro de la IBMS, tendrá los beneficios que le corresponden como socio de la IBMS! A través de su cuenta de socio de la IBMS tendrá acceso completo al Entorno de Conocimento BoneKey y liber acceso a BoneKEy Reports. Necesita su usuario y clave? Lea estas instrucciones sobre como…
Effects of strontium on the quality of bone apatite crystals: a paired biopsy study in postmenopausa
In paired biopsies of osteoporotic women treated with either strontium ranelate or a placebo for 36 months, characteristics of bone apatite crystals were not influenced by the presence of strontium. Summary In paired biopsies of osteoporotic women treated with either strontium ranelate or a placebo for 36 months, characteristics of bone apatite crystals were not influenced…
Beca para el 22nd IOF Advanced Training Course on Osteoporosis
Beca para el 22nd IOF Advanced Training Course on Osteoporosis en Ginebra (Suiza) 30 de enero y 1 de febrero de 2013). Fecha límite para formalizar la solicitud, 2 de noviembre de 2012. Información en http://www.iofbonehealth.org/cns-information Para la carta de recomendación de la SEIOMM contactar con la Secretaría. Paseo de la Castellana, 135–7ªPlta. 28046-Madrid Telefono: 91 790…
Día Mundial de la Osteoporosis
Cada año, millones de adultos mayores -en su mayoría- sufrirán una fractura de cadera devastadora como resultado de una caída simple desde su propia altura. Muchos millones más sufrirán fracturas de columna, muñeca, hombro y pelvis… Estas fracturas no son un accidente. Es probable que la osteoporosis sea la causa subyacente. Una persona que haya…
La Fundación Internacional de Osteoporosis unida por un mundo sin fracturas por osteoporosis
Oficialmente lanzado en marzo de 2012 por la Fundación Internacional de Osteoporosis la campaña Fractura Global.
Su interés en la captura de la fractura contribuye a la visión de la Fundación Internacional de Osteoporosis de la unida de un mundo sin fracturas por osteoporosis – que puede ser facilitado mediante la aplicación de base de coordinador-, fractura post-sistemas / modelos de atención: www.iofbonehealth.org/capture- fracturarse .
La Campaña a la Captura de la fractura tiene como objetivo
- Sensibilizar a base de coordinador-, fractura post-sistemas para la prevención de fracturas segundos
- Proporcionar normas internacionalmente aprobadas para las mejores prácticas
- Facilitar el cambio a nivel nacional
Vamos a hacer esto
- El desarrollo de un marco de mejores prácticas
- La organización de una coalición internacional de asociados y endosantes
- El desarrollo de un sitio web y un mapa interactivo para albergar a toda la información
- Crear y compartir guías de implementación y herramientas
- Marketing y comunicación de la campaña a nivel mundial
- Pilotar un programa de subvenciones para el desarrollo de sistemas de
¿Dónde estamos ahora?
Parkinson’s disease and osteoporosis
Frederiek van den Bos1,2, Arlene D. Speelman3, Monique Samson1, Marten Munneke4,5, Bastiaan R. Bloem6 and, Harald J. J. Verhaar1 Conclusion: bone loss in PD is multifactorial. It is clinically important because of the concomitant risk of fractures. Screening for osteoporosis should be considered more often, and therapeutic interventions should be initiated. Autor: F. van den…
V Simposio de Biología y patología del hueso y cartílago
Los próximos 22 y 23 de Junio se celebrará en Toledo el V Simposio de Biología y patología del hueso y cartílago Os informamos que los próximos días 22 y 23 de Junio se celebrará en Toledo el V Simposio de Biología y patología del hueso y cartílago. Disponen de más información y del programa…
Inhibition of osteoclast differentiation and matrix metalloproteinase production by CD4+CD25+ T cell
To reveal the mechanism of inflammation-accompanied osteoporosis, mouse CD11b cells and CD4+CD25+ T cells were cocultured. Our results showed that CD11b+ monocytes cocultured with CD4+CD25+ T cells generated significantly less osteoclasts than those cocultured with CD4+CD25− T cells. The levels of MMP-7 and 9 in coculture supernatant were decreased significantly when CD11b+ monocytes and CD4+CD25+…
The rhPTH treatment elevates plasma secreted protein acidic and rich in cysteine levels in patients
The secreted protein acidic and rich in cysteine (SPARC), also known as osteonectin, plays an important role in osteoblast formation, maturation, and survival. Summary The secreted protein acidic and rich in cysteine (SPARC), also known as osteonectin, plays an important role in osteoblast formation, maturation, and survival. Here, we report the effects of recombinant human…
Sclerostin: an Emerging Target for the Treatment of Cancer-Induced Bone Disease
Curr Osteoporos Rep. 2017 Dec;15(6):532-541. doi:10.1007/s11914-017-0403-y McDonald MM, Delgado-Calle J. Más información
Premio FHOEMO – SEIOMM 2011
PREVALENCIA DE HIPOVITAMINOSIS D EN UNA POBLACIÓN CON FRACTURA OSTEOPORÓTICA ATENDIDA EN LA ATENCIÓN PRIMARIA DE SALUD Ver resolución aquí.
Actas Resolución Becas FEIOMM 2011 Molecular
Resolución Beca Investigación Molecular. Puede consultar la Resolución aquí.
Actas Resolución Becas FEIOMM 2011 Clínica
Resolución Beca Investigación Cínica. Puede consultar la resolución aquí.
Actas Resolución Becas FEIOMM 2011 Básica
Resolución Beca Investigación Básica. Puede consultar la resolución aquí.
Acta resolución Beca investigacion clínica FEIOMM 2010
Resolución Beca Investigación Clínica. Puede consultar la resolución aquí.
Acta resolución Beca investigacion básica FEIOMM 2010
Resolución Beca Investigación Básica Puede consultar la resolución aquí.