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“Métodos de determinación y valores deseables de la Vitamina D”, disponible el vídeo

El Dr. José Manuel Quesada Gómez (Servicio de Endocrinología. Hospital Reina Sofía. Córdoba) y el profesor Feliciano Priego Capote (Profesor Titular del Departamento de Química Analítica de la Universidad de Córdoba) han impartido la hasta el momento última sesión en línea de la SEIOMM. Con la colaboración del Dr. José Luis Pérez Castrillón como moderador,…

Lo mejor del año en investigación clínica sobre metabolismo óseo, con la Dra. Pilar Peris en el podcast “Somos la SEIOMM”

En esta tercera entrega del podcast “Somos la SEIOMM” hablamos con la doctora Pilar Peris. Especialista en Reumatología del Servicio de Reumatología del Hospital Clínico de Barcelona, la doctora Peris nos resumirá Lo Mejor del Año en Metabolismo Óseo. Las comunicaciones de Investigación CLÍNICA presentadas en el XXVI Congreso de la SEIOMM. Puede descargar aquí…

Registro REFRA (Proyecto FLS Excellence): lo más relevante de los pacientes incorporados al Registro

La SEIOMM les ofrece en esta infografía un resumen de lo más relevante de los pacientes incorporados al Registro REFRA, como parte del Proyecto FLS Excellence. Toda la información se irá actualizando periódicamente. Puede descargar la infografía en este enlace: ÚLTIMA ACTUALIZACIÓN Actualización 3 de octubre de 2022. 5.393 pacientes incluidos en nuestro registro REFRA.

El Bone Site 2022 reúne a expertos en metabolismo óseo los días 3 y 4 de junio en Madrid de forma presencial y por streaming

Llega el Bone Site 2022, una iniciativa que cumple este año su segunda edición y que está pensada para debatir los retos y avances en el manejo de la osteoporosis. El Bone Site 2022 contará con un programa científico de actualidad y con la participación de expertos nacionales e internacionales en metabolismo óseo. SEIOMM avala…

Cuida tu Salud, un proyecto europeo que busca promover un envejecimiento saludable

CuidaTuSalud es un proyecto europeo que busca concienciar sobre la importancia de promover un envejecimiento saludable “especialmente a partir de los 65 años”, según AMGEN, promotor de esta plataforma educativa sobre salud ósea y cardiovascular. Todos los materiales educativos de #ProtectYourLife #CuidaTuSalud se encuentran disponibles en este enlace: http://bit.ly/PULCuidaTuSalud Aquí, desde un enfoque científico validado, se…

La Vitamina D a partir de los 65 años, podcast “ÓSEO MARTES” de SEIOMM con la Dra. Cristina Carbonell

En mayores de 65 años el mantenimiento de ciertos niveles de Vitamina D es fundamental para el adecuado metabolismo del hueso. Ese es el mensaje central del primer ÓSEO MARTES, una iniciativa que SEIOMM ha puesto en marcha, con la colaboración de Gebro Pharma, y con la Dra. Cristina Carbonell (Especialista en Medicina Familiar y…

Radiofrequency echographic multi-spectrometry for the in-vivo assessment of bone strength: state of the art-outcomes of an expert consensus meeting organized by the European Society for Clinical and Economic Aspects of Osteoporosis,Osteoarthritis and Musculoskeletal Diseases (ESCEO)

Radiofrequency echographic multi-spectrometry for the in-vivo assessment of bone strength: state of the art-outcomes of an expert consensus meeting organized by the European Society for Clinical and Economic Aspects of Osteoporosis,Osteoarthritis and Musculoskeletal Diseases (ESCEO)

Determinants, consequences and potential solutions to poor adherence to anti-osteoporosis treatment: results of an expert group meeting organized by the European Society for Clinical and Economic Aspects of Osteoporosis, Osteoarthritis and Musculoskeletal Diseases (ESCEO) and the International Osteoporosis Foundation (IOF).

Determinants, consequences and potential solutions to poor adherence to anti-osteoporosis treatment: results of an expert group meeting organized by the European Society for Clinical and Economic Aspects of Osteoporosis, Osteoarthritis and Musculoskeletal Diseases (ESCEO) and the International Osteoporosis Foundation (IOF).

CONVOCATORIA BECAS FEIOMM INSCRIPCIÓN 2019

CONVOCATORIA 10 Becas FEIOMM INSCRIPCIÓN al XXIV CONGRESO GIRONA 2019 Madrid, a 10 de septiembre de 2019 La Fundación Española de Investigación Ósea y del Metabolismo Mineral (FEIOMM) convoca 10 Becas como ayuda a jóvenes investigadores para la asistencia al XXIV CONGRESO NACIONAL SEIOMM que se celebrará en Girona del 16 al 18 de octubre de 2019. Pueden consultar las bases…

PROLIA® (DENOSUMAB): POSIBLE RIESGO DE FRACTURAS VERTEBRALES MÚLTIPLES TRAS LA SUSPENSIÓN DEL TRATAMIENTO

Se han notificado casos de fracturas, algunas múltiples, tras la suspensión del tratamiento con Prolia® (denosumab). LINK a AEMPS LINK PDF Nota informativa Se recuerda que Prolia® únicamente se debe de utilizar en pacientes con elevado riesgo de fracturas y se recomienda a los profesionales sanitarios considerar, antes de comenzar a tratar al paciente, la posible aparición…

CONVOCATORIA BECAS FEIOMM INVESTIGACIÓN 2019

La Fundación Española de Investigación Ósea y del Metabolismo Mineral (FEIOMM), convoca 6 BECAS de 7.000 € cada una para promocionar la investigación básica, clínica y traslacional en el campo del metabolismo mineral y óseo. BASES de la CONVOCATORIA aquí Fecha Límite domingo 29 de septiembre de 2019 REQUISÍTOS Ser miembro asociado ordinario o de pleno derecho de la…

RESOLUCIÓN BECAS FEIOMM ASBMR 2019

Puedes descargar el ACTA aquí. Dado que el número de solicitantes admitidos es superior al de becas ofertadas y siguiendo las bases establecidas, las BECAS han sido ADJUDICADAS a: GONZALO ALLO MIGUEL, por su trabajo: “Serum 25 hydroxyvitamin D levels, Trabecular Bone Score and Bone Mineral Density in patients with Differentiated Thyroid Cancer and TSH suppression therapy” EDUARDO MARTÍN GUERRERO, por su…

The impact of hip fracture on health-related quality of life and activities of daily living: the SPARE-HIP prospective cohort study.

Arch Osteoporos. 2019 May 29;14(1):56. doi: 10.1007/s11657-019-0607-0. Prieto-Alhambra D, Moral-Cuesta D, Palmer A, Aguado-Maestro I, Bardaji MFB, Brañas F, Bueno GA, Caeiro-Rey JR, Cano IA, Barres-Carsi M, Delgado LG, Salomó-Domènech M, Etxebarria-Foronda I, Ferrer BL, Mills S, Herrando LE, Mifsut  D, Evangelista LDR, Nogués X, Perez-Coto I, Blasco JM, Martín-Hernández C, Kessel H, Serra JT,…

CONVOCATORIA BECAS FEIOMM ASBMR 2019

La Fundación Española de Investigación Ósea y del Metabolismo Mineral FEIOMM convoca 5 Becas para la presentación de trabajos científicos en ASBMR 2019 que se celebrará en Orlando, Florida, (USA) del 20 al 23 de septiembre de 2019. Puedes consultar las bases de la convocatoria en el siguiente link: “BECAS y PREMIOS” BASES DE LA CONVOCATORIA ASBMR 2019 *Las solicitudes se…

Calcimimetics maintain bone turnover in uremic rats despite the concomitant decrease in parathyroid hormone concentration.

Kidney Int. 2019 Mar 12. pii:S0085-2538(19)30043-2. doi: 10.1016/j.kint.2018.12.015. Díaz-Tocados JM, Rodríguez-Ortiz ME, Almadén Y, Pineda C, Martínez-Moreno JM, Herencia C, Vergara N, Pendón-Ruiz de Mier MV, Santamaría R, Rodelo-Haad C,Casado-Díaz A, Lorenzo V, Carvalho C, Frazão JM, Felsenfeld AJ, Richards WG, Aguilera-Tejero E, Rodríguez M, López I, Muñoz-Castañeda JR.

Screening for Osteoporosis to Prevent Fractures: US Preventive Services Task Force Recommendation Statement.

JAMA. 2018 Jun 26;319(24):2521-2531. doi: 10.1001/jama.2018.7498. DOI: 10.1001/jama.2018.7498  -PMID: 29946735  [Indexed for MEDLINE] US Preventive Services Task Force, Curry SJ(1), Krist AH(2)(3), Owens DK(4)(5), Barry MJ(6), Caughey AB(7), Davidson KW(8), Doubeni CA(9), Epling JW Jr(10), Kemper AR(11), Kubik M(12), Landefeld CS(13), Mangione CM(14), Phipps MG(15), Pignone M(16)(17), Silverstein M(18), Simon MA(19), Tseng CW(20)(21), WongJB(22).

Teriparatide Treatment Increases Mineral Content and Volume in Cortical and Trabecular Bone of Iliac Crest: A Comparison of Infrared Imaging With X-Ray-Based Bone Assessment Techniques.

J Bone Miner Res. 2018 Aug 13. doi: 10.1002/jbmr.3565. DOI: 10.1002/jbmr.3565  -PMID: 30102789 Paschalis EP(1), Krege JH(2), Gamsjaeger S(1), Eriksen EF(3), Burr DB(4), Disch DP(2), Stepan JJ(5), Fahrleitner-Pammer A(6), Klaushofer K(1), Marin F(2), PavoI(2). https://www.ncbi.nlm.nih.gov/pubmed/30102789

Activation of RANK/RANKL/OPG Pathway Is Involved in the Pathophysiology of Fibrous Dysplasia and Associated With Disease Burden.

J Bone Miner Res. 2018 Nov 29. doi: 10.1002/jbmr.3602. [Epub ahead of print] de Castro LF(1), Burke AB(1)(2), Wang HD(1)(3), Tsai J(1)(2), Florenzano P(1)(4), Pan KS(1)(3), Bhattacharyya N(1), Boyce AM(1), Gafni RI(1), Molinolo AA(5), Robey PG(6), Collins MT(1). DOI: 10.1002/jbmr.3602  -PMID: 30496606 https://www.ncbi.nlm.nih.gov/pubmed/30496606

Comparative anti-fracture effectiveness of different oral anti-osteoporosis therapies based on “real-world” data: a meta-analysis of propensity-matched cohort findings from the UK Clinical Practice

Clin Epidemiol. 2018  Oct 9;10:1417-1431. doi: 10.2147/CLEP.S164112. eCollection 2018. Khalid S, Calderon-Larrañaga S, Hawley S, Ali MS, Judge A, Arden N, van Staa T, Cooper C, Javaid MK, Prieto-Alhambra D. Research Database and the Catalan SIDIAP Database. https://www.ncbi.nlm.nih.gov/pubmed/30349390

In-hospital care, complications, and 4-month mortality following a hip or proximal femur fracture: the Spanish registry of osteoporotic femur fractures prospective cohort study.

Osteoporos. 2018 Sep 14;13(1):96. doi: 10.1007/s11657-018-0515-8. Prieto-Alhambra D, Reyes C, Sainz MS, González-Macías J, Delgado LG, Bouzón CA, Gañan SM, Miedes DM, Vaquero-Cervino E, Bardaji MFB, Herrando LE, Baztán FB, Ferrer BL, Perez-Coto I, Bueno GA, Mora-Fernandez J, Doñate TE, Blasco JM,Aguado-Maestro I, Sáez-López P, Doménech MS, Climent-Peris V, Rodríguez ÁD,Sardiñas HK, Gómez ÓT, Serra…

2018_PREMIOS ITALFARMACO

El Jurado, compuesto por los Moderadores de las sesiones de comunicaciones orales y posters y el Comité Científico del XXIII Congreso de la SEIOMM celebrado en Granada, del 7 al 9 de noviembre de 2018; Ha otorgado los Premios Italfarmaco 2018 a las mejores comunicaciones Orales y Póster. Descarga ACTA

PROGRAMA Pre_Congreso HOT TOPICS ASBMR 2018

MIÉRCOLES 7 NOVIEMBRE 10.30 – 14.00 h  Palacio de Congresos de Granada Os presentamos el PROGRAMA HOT TOPICS ASBMR 2018 Descarga el PROGRAMA En esta actividad, que tendrá lugar durante el próximo congreso anual de nuestra sociedad en Granada, se resumirán los principales simposiums plenarios así como las comunicaciones orales y pósters más relevantes que se…

Trends in hip fracture in patients with rheumatoid arthritis: results from the Spanish National Inpatient Registry over a 17-year period (1999-2015)

RMD Open. 2018 Jun  4;4(1):e000671. Mazzucchelli R, Pérez Fernandez E, Crespí-Villarías N, Quirós-Donate J, García Vadillo A, Espinosa M, Peña M, Macía-Villa C, Morell-Hita JL, Martinez-Prada C,Villaverde V, Morado Quiroga I, Guzón-Illescas O, Barbadillo C, Fernández Prada M, Godoy H, Herranz Varela A, Galindo Izquierdo M, Rodriguez Caravaca G. TREND-AR study. https://www.ncbi.nlm.nih.gov/pubmed/29955384

CONVOCATORIA BECAS FEIOMM INVESTIGACIÓN 2018

La Fundación Española de Investigación Ósea y del Metabolismo Mineral (FEIOMM), convoca 6 BECAS de 6.000€ cada una para promocionar la investigación básica, clínica y traslacional en el campo del metabolismo mineral y óseo. BASES de la CONVOCATORIA. Las solicitudes se remitirán a la secretaría de la FEIOMM / SEIOMM, por correo electrónico (seiomm@seiomm.org) en un único archivo pdf antes del miércoles 10 de octubre…

Vitamin D, Calcium, or Combined Supplementation for the Primary Prevention of Fractures in Community-Dwelling Adults: US Preventive Services Task Force Recommendation Statement.

JAMA. 2018 Apr 17;319(15):1592-1599. doi: 10.1001/jama.2018.3185. PubMed PMID: 29677309. US Preventive Services Task Force, Grossman DC, Curry SJ, Owens DK, Barry MJ, Caughey AB, Davidson KW, Doubeni CA, Epling JW Jr, Kemper AR, Krist AH, Kubik M, Landefeld S, Mangione CM, Silverstein M, Simon MA, Tseng CW.

RESOLUCIÓN CONVOCATORIA BECAS FEIOMM ASBMR 2018

Madrid, a 17 de julio de 2018 Finalizado el plazo para el envío de solicitudes para acceder a las Becas FEIOMM ASBMR 2018 para la presentación de trabajos de investigación en el Congreso de la ASBMR 2018 que se celebrará en Montréal, Quebec, (CANADA) del 28 de septiembre al 1 de octubre de 2018. Descarga el Acta resolución…

10.1002/jbmr.3350. Epub 2018 Feb 23. PubMed PMID: 29194749. Longitudinal Effects of Teriparatide or Zoledronic Acid on Bone Modeling- and Remodeling-Based Formation in the SHOTZ Study.  Dempster DW, Zhou H, Ruff VA, Melby TE, Alam J, Taylor KA. J Bone Miner Res. 2018 Apr;33(4):627-633. doi:

Sábado 7 de julio fin_CONVOCATORIA BECAS FEIOMM ASBMR 2018

La Fundación Española de Investigación Ósea y del Metabolismo Mineral FEIOMM convoca 5 Becas para la presentación de trabajos científicos en ASBMR 2018 que se celebrará en Montréal, Quebec, (CANADA) del 28 de septiembre al 1 de octubre de 2018. Dichas becas cubrirán inscripción, viaje y alojamiento. La aceptación de la beca implica la conformidad…

Twelve years of experience with miglustat in the treatment of type 1 Gaucher disease: The Spanish ZAGAL project

Blood Cells Mol Dis. 2018 Feb;68:173-179. doi:10.1016/j.bcmd.2016.10.017 Giraldo P, Andrade-Campos M, Alfonso P, Irun P, Atutxa K, Acedo A, Barez A, Blanes M, Diaz-Morant V, Fernández-Galán MA, Franco R, Gil-Cortes C, Giner V, Ibañez A, Latre P, Loyola I, Luño E, Hernández-Martin R, Medrano-Engay B, Puerta  J, Roig I, de la Serna J, Salamero O,…

Spanish National Hip Fracture Registry (SNHFR): a description of its objectives, methodology and implementation

Rev Esp Geriatr Gerontol. 2018 Feb 6.pii: S0211-139X(18)30001-5. doi:10.1016/j.regg.2017.12.001 Sáez-López P, González-Montalvo JI, Ojeda-Thies C, Mora-Fernández J,Muñoz-Pascual A, Cancio JM, Tarazona FJ, Pareja T, Gómez-Campelo P,Montero-Fernández N, Alarcón T, Mesa-Lampre P, Larrainzar R, Duaso E, Gil-Garay E, Diéz-Pérez A, Prieto-Alhambra D, Queipo-Matas R, Otero-Puime A; participantsin the RNFC.

RESOLUCIÓN solicitudes PROYECTO SEIOMM_FLS EXCELLENCE

RESOLUCIÓN solicitudes PROYECTO SEIOMM_FLS EXCELLENCE Finalizado el plazo del envío de solicitudes para acceder al Proyecto FLS Excellence y una vez reunido el Comité Científico del Proyecto para su valoración, en función de los criterios especificados en la convocatoria, según baremo, han sido adjudicadas las 6 FLS que a continuación se detallan: Descarga aquí la…

Effects of Teriparatide Compared with Risedronate on the Risk of Fractures in Subgroups of Postmenopausal Women with Severe Osteoporosis: The VERO Trial. 

J Bone Miner Res. 2018 Jan 12. doi: 10.1002/jbmr.3384. [Epub ahead of print] Geusens P, Marin F, Kendler DL, Russo LA, Zerbini CA, Minisola S, Body JJ, Lespessailles E, Greenspan SL, Bagur A, Stepan JJ, Lakatos P, Casado E, Moericke R, López-Romero P, Fahrleitner-Pammer A. https://www.ncbi.nlm.nih.gov/pubmed/29329484

PROYECTOS SEIOMM

RESOLUCIÓN solicitudes PROYECTO SEIOMM_FLS EXCELLENCE_

Finalizado el plazo del envío de solicitudes para acceder al Proyecto FLS Excellence y una vez reunido el Comité Científico del Proyecto para su valoración, en función de los criterios especificados en la convocatoria, según baremo, han sido adjudicadas las 6 FLS que a continuación se detallan:

1.- FLS ANOIA D´IGUALADA _ Consorcio Sanitario del Anoia – Igualada – Barcelona
     Solicitante: Dr. Enric Duaso Magaña
2.- FLS BADALONA SERVEIS ASSISTENCIALS_ Centre Sociosaniatrio El Carme. Badalona Serveis Assistencials – Badalona – Barcelona
      Solicitante: Dr. Jose Manuel Cancio Trujillo
3.- FLS HOSPITAL DEL MAR_ Hospital del Mar _ Barcelona
     Solicitante: Dr. Xavier Nogues Solan
4.- FLS HOSPITAL UNIVERSITARIO VIRGEN MACARENA_ Hospital Virgen Macarena _ Sevilla
     Solicitantes: Dra. Mª José Montoya García – Dr. F. Jesús Olmo Montes
5.- FLS CLÍNICO SAN CARLOS_ Hospital clínico San Carlos _ Madrid
     Solicitante: Dr. Jesus Mora Fernández
6.- FLS HOSPITAL SON LLÀTZER_ Hospital de Son Llàtzer _ Palma _Islas Baleares
Solicitante: Dr. Bartolomé Lladó Ferrer

Descarga aquí la RESOLUCIÓN

Y para que así conste, en Madrid, a 10 de abril de 2018.

Comité Científico Proyecto FLS Excellence


Normativa para Proyectos SEIOMM

Un Proyecto SEIOMM es aquel proyecto de investigación diseñado por socios de la SEIOMM, por la Junta Directiva o por agentes externos a la misma, cuyo contenido o desarrollo es juzgado por la Junta Directiva como de interés para la Sociedad.

Quality of life for up to 18 months after low-energy hip, vertebral, and distal forearm fractures-results from the ICUROS.

Osteoporos Int. 2017 Dec 11. doi: 10.1007/s00198-017-4317-4. Svedbom A, Borgstöm F, Hernlund E, Ström O, Alekna V, Bianchi ML, Clark P,Curiel MD, Dimai HP, Jürisson M, Kallikorm R, Lember M, Lesnyak O, McCloskey E,Sanders KM, Silverman S, Solodovnikov A, Tamulaitiene M, Thomas T, Toroptsova N, Uusküla A, Tosteson ANA, Jönsson B, Kanis JA. Más información

The Effect of Intentional Weight Loss on Fracture Risk in Persons With Diabetes: Results From the Look AHEAD Randomized Clinical Trial.

J Bone Miner Res. 2017 Nov;32(11):2278-2287. doi: 10.1002/jbmr.3214 Johnson KC, Bray GA, Cheskin LJ, Clark JM, Egan CM, Foreyt JP, Garcia KR, Glasser S, Greenway FL, Gregg EW, Hazuda HP, Hergenroeder A, Hill JO, Horton ES, Jakicic JM, Jeffery RW, Kahn SE, Knowler WC, Lewis CE, Miller M, Montez MG, Nathan DM, Patricio JL, Peters…

Identification of a novel locus on chromosome 2q13, which predisposes to clinical vertebral fractures independently of bone density.

Ann Rheum Dis. 2017 Nov 23. pii: annrheumdis-2017-212469. doi: 10.1136/annrheumdis-2017-212469 Alonso N, Estrada K, Albagha OME, Herrera L, Reppe S, Olstad OK, Gautvik KM,Ryan NM, Evans KL, Nielson CM, Hsu YH, Kiel DP, Markozannes G, Ntzani EE, Evangelou E, Feenstra B, Liu X, Melbye M, Masi L, Brandi ML, Riches P, Daroszewska A, Olmos JM,…

8ºARC EN OSTEOPOROSIS 2018

www.arcosteoporosis.com Una vez más, un grupo de reconocidos expertos en osteoporosis presentarán las comunicaciones más relevantes de los principales congresos del año 2017 y aportarán todos sus conocimientos para responder a las preguntas planteadas por los asistentes. A través de esta web y de nuestra cuenta de Twitter (@arcosteoporosis) iremos actualizando todas las novedades de…

Parathyroid hormone inhibits Notch signaling in osteoblasts and osteocytes

Bone. 2017 Oct;103:159-167. doi: 10.1016/j.bone.2017.06.027 Parathyroid hormone (PTH) and Notch receptors regulate bone formation by governing the function of osteoblastic cells. To determine whether PTH interacts with Notch signaling as a way to control osteoblast function, we tested the effects of PTH on Notch activity in osteoblast- and osteocyte-enriched cultures. Induction of Notch signaling in…

Vertebral Fractures Following Discontinuation of Denosumab: a Post-hoc Analysis of the Randomized Placebo-controlled FREEDOM Trial and its Extension

J Bone Miner Res. 2017 Nov 4. doi: 10.1002/jbmr.3337 Denosumab reduces bone resorption and vertebral and nonvertebral fracture risk. Denosumab discontinuation increases BTMs 3 months after a scheduled dose is omitted, reaching above-baseline levels by 6 months, and decreases BMD to baseline levels by 12 months. We analyzed the risk of new or worsening vertebral…

Muscle functions and bone strength are impaired in adolescents with type 1 diabetes

Bone. 2018 Jan;106:22-27. doi: 10.1016/j.bone.2017.10.005 Sarcopenia and osteoporosis are among the late complications of type 1 diabetes (T1D) in adults. The aim of this study was to assess volumetric bone mineral density (BMD) and dynamic muscle function in adolescents with T1D and to assess the clinical and biochemical predictors of their musculoskeletal system. METHODS: Ninety-five…

Concise Review: Musculoskeletal Stem Cells to Treat Age-Related Osteoporosis

Stem Cells Transl Med. 2017 Oct;6(10):1930-1939. doi: 10.1002/sctm.17-0054 Age-related (type-II) osteoporosis is a common and debilitating condition driven in part by the loss of bone marrow (BM) mesenchymal stromal cells (MSC) and their osteoblast progeny, leading to reduced bone formation. Current pharmacological regiments targeting age-related osteoporosis do not directly treat the disease by increasing bone…

Effect of Surgery Versus Observation: Skeletal 5-Year Outcomes in a Randomized Trial of Patients With Primary HPT (the SIPH Study)

J Bone Miner Res. 2017 Sep;32(9):1907-1914. doi: 10.1002/jbmr.3177. Epub 2017 Jul 7. The objective was to study the effect of parathyroidectomy (PTX) compared with observation (OBS) on bone mineral density (BMD) in g/cm2 and T-scores and on biochemical markers of bone turnover (P1NP and CTX-1) in a prospective randomized controlled study of patients with mild…

Targeting cellular senescence prevents age-related bone loss in mice

Nat Med. 2017 Sep;23(9):1072-1079. doi: 10.1038/nm.4385. Epub 2017 Aug 21. Aging is associated with increased cellular senescence, which is hypothesized to drive the eventual development of multiple comorbidities. Here we investigate a role for senescent cells in age-related bone loss through multiple approaches. In particular, we used either genetic (i.e., the INK-ATTAC ‘suicide’ transgene encoding…

Discontinuation of Denosumab therapy for osteoporosis: A systematic review and position statement by ECTS

2017 Aug 5;105:11-17. doi: 10.1016/j.bone.2017.08.003. [Epub ahead of print] Review. CONCLUSION: There appears to be an increased risk of multiple vertebral fractures after discontinuation of denosumab although strong evidence for such an effect and for measures to prevent the occurring bone loss is lacking. Clinicians and patients should be aware of this potential risk. Based…

Comparison of total, free and bioavailable 25-OH vitamin D determinations to evaluate its biological activity in healthy adults: the LabOscat study

Osteoporos Int. 2017 Aug;28(8):2457-2464. doi: 10.1007/s00198-017-4062-8. Peris P, Filella X, Monegal A, Guañabens N( Foj L, Bonet M,Boquet D, Casado E, Cerdá D, Erra A, Gómez-Vaquero C, Martínez S, Montalá N, Pittarch C, Kanterewicz E, Sala M, Suris X, Carrasco JL; LabOscat Study Group. Collaborators: Larrosa M, Nolla JM, Roig-Vilaseca D. Más información

El 20 de octubre se celebra el Día Mundial de la Osteoporosis

El 20% de las personas con fractura de cadera fallece al cabo de un año

  • De las personas que no fallecen, el 40 por ciento tiene problemas para caminar por sí mismas y el 59 por ciento todavía requiere de ayuda pasado un año
  • Una de cada seis mujeres y uno de cada diez hombres mayores de 70 años sufrirá una fractura osteoporótica
  • El tratamiento de la osteoporosis reduce entre un 50 y un 70 por ciento el riesgo de fractura 
  • Más información y vídeo de la campaña en http://www.amgen.es/osteoporosis/

Sesión científica. SEIOMM-SERPE

www.seiommalexionlive.com Miércoles 25 de octubre de 2017 17:00-18:15     SESIÓN CIENTÍFICA. SEIOMM-SERPE: ENFERMEDADES METABÓLICAS ÓSEAS RARAS EN NIÑOS Y ADULTOS Moderadores:   Roger Bouillon, Esmeralda Núñez Cuadros                              Diagnóstico y tratamiento del hipoparatiroidismo. Claudio Marcocci                              Nuevas…

Comparison of total, free and bioavailable 25-OH vitamin D determinations to evaluate its biological activity in healthy adults: the LabOscat study

Osteoporos Int. 2017 Aug;28(8):2457-2464. doi: 10.1007/s00198-017-4062-8 Peris P, Filella X, Monegal A, Guañabens N( Foj L, Bonet M,Boquet D, Casado E, Cerdá D, Erra A, Gómez-Vaquero C, Martínez S, Montalá N, Pittarch C, Kanterewicz E, Sala M, Suris X, Carrasco JL; LabOscat Study Group. Collaborators: Larrosa M, Nolla JM, Roig-Vilaseca D. Más Información

Effect of Surgery Versus Observation: Skeletal 5-Year Outcomes in a Randomized Trial of Patients With Primary HPT (the SIPH Study)

J Bone Miner Res. 2017 Sep;32(9):1907-1914. doi: 10.1002/jbmr.3177. Epub 2017 Jul 7. The objective was to study the effect of parathyroidectomy (PTX) compared with observation (OBS) on bone mineral density (BMD) in g/cm2 and T-scores and on biochemical markers of bone turnover (P1NP and CTX-1) in a prospective randomized controlled study of patients with mild…

Romosozumab (sclerostin monoclonal antibody) versus teriparatide in postmenopausal women with osteoporosis transitioning from oral bisphosphonate therapy: a randomised, open-label, phase 3 trial.

Lancet. 2017 Jul 26. doi: 10.1016/S0140-6736(17)31613-6. Más información Langdahl BL, Libanati C, Crittenden DB, Bolognese MA, Brown JP, Daizadeh NS,Dokoupilova E, Engelke K, Finkelstein JS, Genant HK, Goemaere S, Hyldstrup L, Jodar-Gimeno E, Keaveny TM, Kendler D, Lakatos P, Maddox J, Malouf J, Massari FE,Molina JF, Ulla MR, Grauer A.

10 years of denosumab treatment in postmenopausal women with osteoporosis:results from the phase 3 randomised FREEDOM trial and open-label extension

Lancet Diabetes Endocrinol. 2017 Jul;5(7):513-523. doi:10.1016/S2213-8587(17)30138-9. Epub 2017 May 22 Más información Bone HG, Wagman RB, Brandi ML, Brown JP, Chapurlat R, Cummings SR, Czerwiński E, Fahrleitner-Pammer A, Kendler DL, Lippuner K, Reginster JY, Roux C, Malouf J, Bradley MN, Daizadeh NS, Wang A, Dakin P, Pannacciulli N, Dempster DW, Papapoulos S.

European Society for Clinical and Economic Aspects of Osteoporosis, Osteoarthritis and Musculoskeletal Diseases (ESCEO). Identification and management of patients at increased risk of osteoporotic fracture: outcomes of an ESCEO expert consensus meeting

Osteoporos Int. 2017 Jul;28(7):2023-2034. doi: 10.1007/s00198-017-4009-0. Epub 2017 Apr 27 Más información Kanis JA, Cooper C, Rizzoli R, Abrahamsen B, Al-Daghri NM, Brandi ML,Cannata-Andia J, Cortet B, Dimai HP, Ferrari S, Hadji P, Harvey NC, Kraenzlin M, Kurth A, McCloskey E, Minisola S, Thomas T, Reginster JY

Targeting cellular senescence prevents age-related bone loss in mice

Nat Med. 2017 Sep;23(9):1072-1079. doi: 10.1038/nm.4385. Epub 2017 Aug 21. Aging is associated with increased cellular senescence, which is hypothesized to drive the eventual development of multiple comorbidities. Here we investigate a role for senescent cells in age-related bone loss through multiple approaches. In particular, we used either genetic (i.e., the INK-ATTAC ‘suicide’ transgene encoding…

Discontinuation of Denosumab therapy for osteoporosis: A systematic review and position statement by ECTS

2017 Aug 5;105:11-17. doi: 10.1016/j.bone.2017.08.003. [Epub ahead of print] Review. CONCLUSION: There appears to be an increased risk of multiple vertebral fractures after discontinuation of denosumab although strong evidence for such an effect and for measures to prevent the occurring bone loss is lacking. Clinicians and patients should be aware of this potential risk. Based…

The Effect of Abaloparatide-SC on Fracture Risk Is Independent of Baseline FRAX Fracture Probability: A Post Hoc Analysis of the ACTIVE Study.

Daily subcutaneous (SC) injections of the investigational drug abaloparatide-SC (80 mcg) for 18 months significantly decrease the risk of vertebral and nonvertebral fracture compared with placebo in postmenopausal women. We examined the efficacy of abaloparatide-SC as a function of baseline fracture risk, assessed using the FRAX tool. A total of 821 women randomized to placebo…

Treatment of Low Bone Density or Osteoporosis to Prevent Fractures in Men and Women: A Clinical Practice Guideline Update From the American College of Physicians.

This guideline updates the 2008 American College of Physicians (ACP) recommendations on treatment of low bone density and osteoporosis to prevent fractures in men and women. This guideline is endorsed by the American Academy of Family Physicians. The ACP Clinical Guidelines Committee based these recommendations on a systematic review of randomized controlled trials; systematic reviews;…

Osteoporosis Treatment Efficacy for Men: A Systematic Review and Meta-Analysis.

Randomized clinical trials that evaluated the efficacy of a treatment for osteoporosis or low bone mineral density for adult men and reported fracture outcomes. Twenty-four articles reporting results for 22 studies (including 4,868 male participants) met strict inclusion criteria. Fixed-effects meta-analyses using the Mantel-Haenszel method demonstrated significantly lower risk of vertebral fractures with alendronate (relative…

Long-Term Randomized Trial of Intensive Versus Symptomatic Management in Paget’s Disease of Bone: The PRISM-EZ Study.

It has been suggested that normalization of bone turnover may improve clinical outcome in Paget’s disease of bone (PDB) by preventing complications such as fractures and the development of osteoarthritis. Here we investigated the long-term effects of a treatment strategy that aimed to normalize bone turnover in PDB with that of symptomatic treatment. The study…

Imminent fracture risk.

The clinical significance of osteoporosis is in the occurrence of fractures and re-fractures. The main risk factor of sustaining a fracture is a previous one, but a recent fracture is a better fracture risk factor than fracture history. The role of the recency of fracture has been shown for both vertebral and non-vertebral fracture risk….

Pain, quality of life and safety outcomes of kyphoplasty for vertebral compression fractures: report of a task force of the American Society for Bone and Mineral Research

The relative efficacy and harms of balloon kyphoplasty (BK) for treating vertebral compression fractures (VCF) are uncertain. The clinical importance of the greater improvements with BK versus NSM is unclear, may be due to placebo effect, and may not counterbalance short-term AE risks. Outcomes appeared similar between BK and other surgical interventions.Well-conducted randomized trials comparing…

Anti-senescence and Anti-inflammatory Effects of the C-terminal Moiety of PTHrP Peptides in OA Osteoblasts.

Osteoarthritis (OA) is characterized by degenerative changes in the whole joint leading to physical disability in the elderly population. This condition is associated with altered bone metabolism in subchondral areas suggesting that therapeutic strategies aimed at modifying bone cell metabolism may be of interest. The three PTHrP peptides favored osteoblastic function although the C-terminal domain…

Responses to Treatment With Teriparatide in Patients With Atypical Femur Fractures Previously Treated With Bisphosphonates

If oversuppression of bone turnover explained the association between bisphosphonate use and atypical subtrochanteric femur fractures (AFF), this could be reversed with anabolic treatment such as teriparatide. They conducted a prospective, open-label study in patients previously treated with bisphosphonates who sustained AFF, examining the response to 24-month treatment with teriparatide on bone mineral density (BMD),…

Bone Loss After Denosumab: Only Partial Protection with Zoledronate

A case series of six women with postmenopausal osteoporosis who had received continuous denosumab for 7 years and were then given a single infusion of zoledronate (5 mg) is reported. During denosumab treatment, bone mineral density (BMD) in the spine increased 18.5% (P = 0.006), and total hip BMD by 6.9% (P = 0.03). Post-zoledronate BMDs were measured 18-23 months after treatment,…

Evaluation of the Dietary Intake of Cadmium, Lead and Mercury and Its Relationship with Bone Health among Postmenopausal Women in Spain.

Few studies have investigated the extent to which dietary heavy metals are associated with low bone mineral density. They did not find associations between bone health and the dietary intake of three heavy metals in postmenopausal women. Dietary intake of the measured heavy metals were within the recommended values. Int J Environ Res Public Health….

Mind the (treatment) gap: a global perspective on current and future strategies for prevention of fragility fractures

This narrative review considers the key challenges facing healthcare professionals and policymakers responsible for providing care to populations in relation to bone health. These challenges broadly fall into four distinct themes: (1) case finding and management of individuals at high risk of fracture, (2) public awareness of osteoporosis and fragility fractures, (3) reimbursement and health…

Bone health in Down syndrome

Patients with Down syndrome have a number of risk factors that theoretically could predispose them to osteoporosis. In addition, the bone mass of these people may be affected by their anthropometric and body composition peculiarities. In general terms, studies in adults with Down syndrome reported that these people have lower areal bone mineral density (g/cm(2))…

Extracellular calcium promotes bone formation from bone marrow mesenchymal stem cells by amplifying the effects of BMP-2 on SMAD signalling.

Understanding the molecular events that regulate osteoblast differentiation is essential for the development of effective approaches to bone regeneration. In this study, they analysed the osteoinductive properties of extracellular calcium in bone marrow-derived mesenchymal stem cell (BM-MSC) differentiation. Data suggest that Ca2+ and BMP-2 cooperate and promote an autocrine/paracrine osteogenic feed-forward loop.  On the whole,…

Bone density, microarchitecture, and material strength in chronic kidney disease patients at the time of kidney transplantation.

Bone health is assessed by bone mineral density (BMD). Other techniques such as trabecular bone score and microindentation could improve the risk of fracture’s estimation. Our chronic kidney disease (CKD) patients presented worse bone health (density, microarchitecture, mechanical properties) than controls. More than BMD  should be done to evaluate patients at risk of fracture. CONCLUSIONS:…

Association of physical fitness, body composition, cardiometabolic markers and adherence to the Mediterranean diet with bone mineral density in perimenopausal women. The FLAMENCO project.

This study aimed to analyse the association of different components of physical fitness, body composition, cardiometabolic markers and the Mediterranean diet with bone mineral density (BMD) in perimenopausal women, and to test which of these components are independently associated with BMD. The sample comprised 197  perimenopausal women (52.6 ± 4.5 years). Sports Sci. 2017 May;35(9):880-887. doi: 10.1080/02640414.2016.1196825. Más…

Executive summary of the consensus document on osteoporosis in HIV-infected individuals.

Osteoporosis has become an emerging comorbid condition in people living with HIV (PLWH). The increase in survival and the progressive aging of PLWH will make this complication more frequent in the near future. In addition to the traditional risk factors affecting the general population, factors directly or indirectly associated with HIV infection, including antiretroviral therapy,…

BRCA1 haploinsufficiency cell-autonomously activates RANKL expression and generates denosumab-responsive breast cancer-initiating cells.

Denosumab, a monoclonal antibody to the receptor activator of nuclear factor-κB ligand (RANKL), might be a novel preventative therapy for BRCA1-mutation carriers at high risk of developing breast cancer. They propose that breast epithelium-specific mono-allelic inactivation of BRCA1 might suffice to cell-autonomously generate RANKL-addicted, denosumab-responsive CSC-like states.  The convergent addiction to a hyperactive RANKL/RANK axis…

Effect of age and gender on serum periostin: Relationship to cortical measures, bone turnover and hormones.

Periostin is an extracellular matrix protein, and in bone is expressed most highly in the periosteum. It increases bone formation through osteoblast differentiation, cell adhesion, Wnt signalling and collagen cross-linking. We hypothesised that serum periostin would be high at times of life when cortical modeling is active, in early adulthood and in older age, and…

MC4R-dependent suppression of appetite by bone-derived lipocalin 2.

Bone has recently emerged as a pleiotropic endocrine organ that secretes at least two hormones, FGF23 and osteocalcin, which regulate kidney function and glucose homeostasis, respectively. These findings have raised the question of whether other bone-derived hormones exist and what their potential functions are. Here we identify, through molecular and genetic analyses in mice, lipocalin…

Patients’ preferences for anti-osteoporosis drug treatment: a cross-European discrete choice experiment.

This study has as objectives: To estimate the preferences of osteoporotic patients for medication attributes, and analyse data from seven European countries. In total, 1124 patients completed the experiment, with a sample of between 98 and 257 patients per country. They found statistically significant differences in patients’ preferences for anti-osteoporosis medications between countries, especially for…

Bone density, microarchitecture and tissue quality following long-term treatment with tenofovir/emtricitabine or abacavir/lamivudine.

HIV infection has been associated with reduced bone mineral density (BMD). Antiretroviral therapy has a deleterious effect on BMD, but its effect on bone fragility is not clear. Long-term treatment with TDF-FTC leads to impaired bone health, not only in terms of BMD, but also in terms of bone quality, another determinant of overall bone…

Swimming and peak bone mineral density: A systematic review and meta-analysis.

This meta-analysis aims to determine the effects of regular swimming on bone mineral density (BMD) in young adults (18-30 years). Young adult swimmers present similar BMD values than CG and lower values than HIGH. J Sports Sci. 2017 Apr 10:1-13. doi: 10.1080/02640414.2017.1307440 Más información Gomez-Bruton A, Montero-Marín J, González-Agüero A, Gómez-Cabello A, García-Campayo J, Moreno…

Cytocompatibility assessment of Ti-Zr-Pd-Si-(Nb) alloys with low Young’s modulus, increased hardness, and enhanced osteoblast differentiation for biomedical applications.

Ti-based alloys have increased importance for biomedical applications due to their excellent properties. In particular, the two recently developed TiZrPdSi(Nb) alloys, with a predominant β-Ti phase microstructure, have good mechanical properties, such as a relatively low Young’s modulus and high hardness.  Results suggest that the TiZrPdSi(Nb) alloys can be considered  as excellent candidates for orthopaedical…

The Usefulness of Bone Biomarkers for Monitoring Treatment Disease: A Comparative Study in Osteolytic and Osteosclerotic Bone Metastasis Models.

The skeleton is the most common site of colonization by metastatic cancers. Zoledronic acid (ZA) has been shown to be effective for the treatment of bone metastases regardless of whether the bone lesions are osteolytic or osteoblastic. Biochemical markers of bone turnover may be useful tools to quantify the degree of bone remodeling in the…

The Use of the Fracture Risk Assessment (FRAX®) Tool in Predicting Risk of Fractures in Patients With Inflammatory Bowel Disease: A Systematic Review.

Inflammatory bowel disease (IBD), which includes Crohn’s disease and ulcerative colitis, is associated with an increased prevalence of osteoporosis and osteopenia. They aim to evaluate the use of the World Health Organization Fracture  Risk Assessment (FRAX®) tool in these patients to assess 10-yr risk of fracture. J Clin Densitom. 2017 Apr – Jun;20(2):180-187. doi: 10.1016/j.jocd.2016.08.010….

A retrospective cohort study of concomitant ipsilateral extra-capsular and intra-capsular fractures of the proximal femur. Are they casual findings or an undervalued reality?

Fractures of the proximal femur constitute a major public health problem, with an annual incidence in Spain of 7.6 cases per 1000 inhabitants over 65 years of age. Between May 2010  and December 2016, 33 (median age, 86 years-old) of the 2625 hip fractures were classified as simultaneous extra- and intra-capsular ipsilateral fractures. CONCLUSION: The…

Adequacy of treatment for osteoporosis in primary prevention. Quantitative and qualitative study

Quantitative study: To assess the prevalence of inadequacy of treatment for osteoporosis in primary prevention (OPP) in women aged 60-74years. Aten Primaria. 2017 Apr 14. pii: S0212-6567(16)30378-X. doi:10.1016/j.aprim.2017.01.007. Más información Vedia Urgell C, Massot Mesquida M, Valles Fernandez R, Garcia Vicente JA, Franzi Siso A, Muñoz Ortiz L, Vilaró Jaques L, Bosch Peligero M.

Behavior of Human Osteoblast Cells Cultured on Titanium Discs in Relation to Surface Roughness and Presence of Melatonin.

The aim of this work was to observe the behavior of osteoblast cells cultured in vitro on titanium discs in relation to disc surface roughness and the addition of melatonin to the culture medium. Among the genes studied, a significant increase in phosphate-regulating neutral endopeptidase, X-linked (PHEX) expression was observed in cells cultured on EP…

Watch Movie Online Home Again (2017)

Home Again (2017) Duration 97 mins Genre Comedy, Drama. In Cinemas September 7, 2017 Language English. Country United States of America. Plot For Home Again Movie ‘Home Again’ was released in September 7, 2017 in genre Comedy. Hallie Meyers-Shyer was directed this movie and starring by Reese Witherspoon. This movie tell story about Life for…

Streaming Full Movie Home Again (2017)

Home Again (2017) Duration 97 mins Genre Comedy, Drama. In Cinemas September 7, 2017 Language English. Country United States of America. Plot For Home Again Movie ‘Home Again’ was released in September 7, 2017 in genre Comedy. Hallie Meyers-Shyer was directed this movie and starring by Reese Witherspoon. This movie tell story about Life for…

Streaming Full Movie Home Again (2017) Online

Home Again (2017) Duration 97 mins Genre Comedy, Drama. In Cinemas September 7, 2017 Language English. Country United States of America. Plot For Home Again ‘Home Again’ is a movie genre Comedy, was released in September 7, 2017. Hallie Meyers-Shyer was directed this movie and starring by Reese Witherspoon. This movie tell story about Life…

Molecular gates in mesoporous bioactive glasses for the treatment of bone tumors and infection.

Mesoporous bioactive glasses are recently gaining importance thanks to their bone regenerative properties.Moreover, the mesoporous nature of these materials makes them suitable for drug delivery applications, opening new lines in the field of bone therapies. Acta Biomater. 2017 Mar 1;50:114-126. Más información Polo L Gómez-Cerezo N, Aznar E, Vivancos JL, Sancenón F, Arcos D, Vallet-Regí…

Lithogenic factors in postmenopausal women with osteoporotic fracture.

The aim of this study was to show the presence of phosphorus and calcium metabolism disorders and the presence of urine lithogenic factors in women with osteoporotic fracture without previous urinary lithiasis. A cross-sectional study including 55 women with osteoporotic fracture surgically treated in the Trauma Department. CONCLUSIONS: Women with osteoporotic fracture showed several lithogenic…

Generation and characterization of two immortalized human osteoblastic cell lines useful for epigenetic studies.

Different model systems using osteoblastic cell lines have been developed to help understand the process of bone formation. Here, we report the establishment of two human osteoblastic cell lines obtained from primary cultures upon transduction of immortalizing genes. The resulting cell lines had no major J Bone Miner Metab. 2017 Mar;35(2):150-160. doi: 10.1007/s00774-016-0753-z. Epub 2016…

BRCA1 haploinsufficiency cell-autonomously activates RANKL expression and generates denosumab-responsive breast cancer-initiating cells.

Denosumab, a monoclonal antibody to the receptor activator of nuclear factor-κB ligand (RANKL), might be a novel preventative therapy for BRCA1-mutation carriers at high risk of developing breast cancer. They tested the alternative but not mutually exclusive hypothesis that BRCA1 deficiency might cell-autonomously activate RANKL expression to generate cellular states with cancer stem cell (CSC)-like…

The effectiveness of a basic exercise intervention to improve strength and balance in women with osteoporosis.

OBJECTIVE: To determine the effects of a simple exercise program on the balance and strength of postmenopausal women with osteoporosis.CONCLUSION: The present study demonstrates that a physical exercise program based on balance and strength exercises, carried out with simple and readily available  equipment, is capable of significantly improving the strength and balance of women with…

Opportunistic screening for osteoporosis by routine CT in Southern Europe.

Abdominal CT images obtained for other reasons can identify patients with osteoporosis BMD without additional radiation exposure or cost. Uncalibrated values at L1 can detect more osteoporosis patients with spinal compression fractures than DXA in oncologic patients. Osteoporos Int. 2017 Mar;28(3):983-990. doi: 10.1007/s00198-016-3804-3. Epub 2017 Jan 20. Más información Alacreu E, Moratal D, Arana E

MicroRNAs in bone diseases.

MicroRNAs are small, noncoding single-stranded RNAs that have emerged as important posttranscriptional regulators of gene expression, with an essential role in vertebrate development and different biological processes. This review highlights the recent advances in the function of miRNAs and their roles in bone remodeling and bone diseases. MicroRNAs (miRNAs) are a class of small (∼22…

Hypophosphatasia: An overview For 2017.

Hypophosphatasia (HPP) is the inborn-error-of-metabolism that features low serum alkaline phosphatase (ALP) activity (hypophosphatasemia) caused by loss-of-function mutation(s) of the gene that encodes the tissue-nonspecific isoenzyme of ALP (TNSALP). Autosomal recessive or autosomal dominant inheritance from among >300 TNSALP (ALPL) mutations largely explains HPP’s remarkably broad-ranging severity. TNSALP mutation analysis BlueHost优惠码 is essential for recurrence…

The effect of patient age at intervention on risk of implant revision after total replacement of the hip or knee: a population-based cohort study.

Total joint replacements for end-stage osteoarthritis of the hip and knee are cost-effective and demonstrate significant clinical improvement.However, robust population based lifetime-risk data for implant revision are not available to aid patient decision making, which is a particular problem in young  patient groups deciding on best-timing for surgery. The study used novel methodology to investigate…

Effects of Sex and Notch Signaling on the Osteocyte Cell Pool.

Osteocytes play a fundamental role in mechanotransduction and skeletal remodeling. Sex is a determinant of skeletal structure, and female C57BL/6J mice  have increased osteoblast number in cancellous bone when compared to male mice. Activation of Notch in the skeleton causes profound cell-context dependent changes in skeletal 嘉盛外汇 physiology. the aim of this study was to…

Cost-Effectiveness of Orthogeriatric and Fracture Liaison Service Models of Care for Hip Fracture Patients: A Population-Based Study.

Fracture liaison services are recommended as a model of best practice for organizing patient care and secondary fracture prevention for hip fracture patients, although variation exists in how such services are structured. There is considerable uncertainty as to which model is most cost-effective and should therefore be mandated. This study evaluated the cost- effectiveness of…

Reducing Undercarboxylated Osteocalcin With Vitamin K Supplementation Does Not Promote Lean Tissue Loss or Fat Gain Over 3 Years in Older Women and Men: A Randomized Controlled Trial.

Osteocalcin (OC) is a vitamin K-dependent protein synthesized during bone formation. Mice injected with the undercarboxylated form of OC (ucOC) had more skeletal muscle mass and less fat mass than sham-treated controls, suggesting a unique metabolic role for ucOC. UcOC decreases in response to vitamin K supplementation. Our objective was to determine the effect of…

Anti-citrullinated protein antibodies are associated with decreased bone mineral density: baseline data from a register of early arthritis patients

Since the previous studies showed that anti-citrullinated protein antibodies (ACPA) can induce osteoclasts differentiation and activation, even before arthritis onset, the aim of their study was to determine 嘉盛外汇 whether ACPA-positivity is associated with lower bone mineral density (BMD) at baseline visit of a register of early arthritis (EA) patients. The study population comprised 578…

Transcriptomic analyses of the anti-adipogenic effects of oleuropein in human mesenchymal stem cells.

Extra virgin olive oil has positive effects on health. Oleuropein is a polyphenolic compound present in olive-tree leaves, fruits (olives) and olive oil. The effects of oleuropein on the adipogenesis of human bone-marrow mesenchymal stem cells were studied by transcriptomics and differential gene-expression analyses. Their data suggest that mitochondrial activity is reduced by oleuropein, mostly…

Serum from postmenopausal women treated with a by-product of olive-oil extraction process stimulates osteoblastogenesis and inhibits adipogenesis in human mesenchymal stem-cells (MSC).

Aging may enhance both oxidative stress and bone-marrow mesenchymal stem-cell (MSC) differentiation into adipocytes. That reduces osteoblastogenesis, thus favoring bone-mass loss and fracture, representing an important worldwide health-issue, mainly in countries with aging populations. Intake of antioxidant products may help to retain bone-mass density. Exp Gerontol. 2017 Feb 3;90:71-78. doi: 10.1016/j.exger.2017.01.024. Más información Casado-Díaz A,…

Clinical experience with microindentation in vivo in humans.

Densitometry and imaging techniques are currently used in clinical settings to measure bone quantity and spatial structure. Recently, Reference Point Indentation has opened the  possibility of directly assessing the mechanical characteristics of cortical bone in living individuals, adding a new dimension to the assessment of bone strength. Bone. 2017 Feb;95:175-182. doi: 10.1016/j.bone.2016.11.003. Más información Herrera…

Age-Related Loss in Bone Mineral Density of Rats Fed Lifelong on a Fish Oil-Based Diet Is Avoided by Coenzyme Q10 Addition.

Oxidative stress has been related to this bone loss, making dietary compounds with antioxidant properties a promising weapon. Male Wistar rats were maintained on diets with fish oil as unique fat source, supplemented or not with coenzyme Q10 (CoQ10). BMD was evaluated in the femur. Serum osteocalcin, osteopontin, receptor activator of nuclear factor-κB ligand, ostroprotegerin,…

Effect of vanadium on calcium homeostasis, osteopontin mRNA expression, and bone microarchitecture in diabetic rats.

The aim of this study was to examine whether alterations caused by diabetes in calcium homeostasis, expression of osteopontin and the microarchitecture of bone are corrected by exposure to vanadium. They conclude that treatment with 3 mg V per d of the glucose lowering agent bis(maltolato)oxovanadium(iv) causes a decrease in osteopontin mRNA, which could favour…

Risk of bone tumors in children and residential proximity to industrial and urban areas: New findings from a case-control study.

Few epidemiologic studies have explored risk factors for bone tumors in children, and the role of environmental factors needs to be analyzed. The objective of this study was to  ascertain the association between residential proximity to vigrx plus official website industrial plants and  urban areas and risk of bone tumors in children, taking into account…

Connexin37 deficiency alters organic bone matrix, cortical bone geometry, and increases Wnt/β-catenin signaling

Deletion of connexin (Cx) 37 in mice leads to increased cancellous bone mass due to defective osteoclast differentiation. Paradoxically; however, Cx37-deficient mice exhibit reduced cortical thickness accompanied by higher bone strength,suggesting a contribution of Cx37 to bone matrix composition. Thus, we investigated whether global deletion of Cx37 alters the composition of phentermine organic bone extracellular…

Evidence on the analgesic role of bisphosphonates and denosumab in the treatment of pain due to bone metastases: A systematic review within the European Association for Palliative Care guidelines project

Bisphosphonates and denosumab are well-established therapies to reduce the frequency and severity of skeletal-related events in patients with bone metastasis. However, the analgesic effect of these medications on bone pain is uncertain.Watch movie online The Transporter Refueled (2015) Evidence to support an analgesic role for bisphosphonates and denosumab is weak. Bisphosphonates and denosumab appear to…

Bone Structure and Geometric Properties at the Radius and Tibia in Adolescent Endurance-Trained Cyclists.

OBJECTIVE: To describe cortical and trabecular volumetric bone mineral density (vBMD), bone mineral content (BMC), cross-sectional area (CSA), and bone strength indexes (BSIs) in adolescent endurance-trained cyclists (CYC) and compare them with controls (CON). CONCLUSIONS: Adolescent CYC in this study showed lower values of BMC and vBMD at determined sites of the radius and tibia…

3D-DXA: Assessing the Femoral Shape, the Trabecular Macrostructure and the Cortex in 3D from DXA images

The 3D distribution of the cortical and trabecular bone mass in the proximal femur is a critical component in determining fracture resistance that is not taken into account in clinical routine Dual-energy X-ray Absorptiometry (DXA) examination. Models and measurements provided by the “3D-DXA” software algorithm were evaluated using a database of 157 study subjects, by…

Prevalence of vertebral fracture and densitometric osteoporosis in Spanish adult men: The Camargo Cohort Study.

The aim of this study was to assess the prevalence of densitometric osteoporosis and vertebral fractures in Spanish men aged ≥50 years, and to study how the relationship between them may change depending on how osteoporosis is diagnosed. A community-based population of 1003 men aged ≥50 years was studied. Bone mineral density (BMD) was measured by DXA…

Primary and Secondary Prevention of Hip Fragility Fracture in Teruel Health Sector, Aragon, Spain

The objective was to analyze primary and secondary interventions carried out in individuals diagnosed with femur fragility fracture at Teruel in 2014. CONCLUSIONS: Primary pharmacologic prevention and assessment of osteoporosis or risk of fracture are unfrequent in our health district.. Although pharmacologic treatment is prescribed more frequently in Teruel than in other areas after a…

Deprescribing long-term treatments with bisphosphonates for osteoporosis in primary care in the Basque Country (Spain)

To evaluate the impact of a multifactorial intervention to promote bisphosphonate deprescription after over 5 years of use (BF5y) in a health care organisation (HCO) in Gipuzkoa (Spain) and to compare it with the standard intervention in other HCOs in the Basque Health Service-Osakidetza.CONCLUSIONS: Standard and multifactorial interventions are very effective in reducing unnecessary treatments…

High Glucose Alters the Secretome of Mechanically Stimulated Osteocyte-like Cells Affecting Osteoclast Precursor Recruitment and Differentiation

Diabetes mellitus (DM) induces bone deterioration, while mechanical stimulation promotes osteocyte-driven bone formation. We aimed to evaluate the interaction of acute exposure (24h) to high glucose (HG) with both the pro-survival effect conferred to osteocytic MLO-Y4 cells and osteoblastic MC3T3-E1 cells by mechanical stimulation and the interaction of these cells with osteoclast precursor RAW264.7 cells….

Relationship between spinal osteoarthritis and vertebral fractures in men older than 50 years: data from the Camargo Cohort Study

Spinal osteoarthritis has been suggested as a risk factor for vertebral fractures. However, results are conflicting: most of the data are focused on the lumbar region, and referred to postmenopausal women, whereas data for men are scarce. The aim of this study is to assess the relationship between spinal osteoarthritis and vertebral fractures in men…

Geographic variation in secondary fracture prevention after a hip fracture during

Fragility fractures of the hip have a major impact on the lives of patients and their families. This study highlights significant geographical variation in secondary fracture prevention with even the highest performing regions failing the majority of patients despite robust evidence supporting the benefits of diagnosis and treatment. CONCLUSIONS: Significant geographic differences exist in prescribing…

Primary hyperparathyroidism: review and recommendations on evaluation, diagnosis, and management. A Canadian and international consensus.

This review presents the current state of the art in the diagnosis and management of PHPT and updates the Canadian Position paper on PHPT. An overview of the impact of PHPT on the skeleton and other target organs is presented with international consensus. Differences in the international presentation of this condition are also summarized. Más…

Effect of Longer-Interval vs Standard Dosing of Zoledronic Acid on Skeletal Events in Patients With Bone Metastases: A Randomized Clinical Trial.

Among patients with bone metastases due to breast cancer, prostate cancer, or multiple myeloma, the use of zoledronic acid every 12 weeks compared with the standard dosing interval of every 4 weeks did not result in an increased risk of skeletal events over 2 years. This longer interval may be an acceptable treatment option. Más…

Effects of Romosozumab Compared With Teriparatide on Bone Density and Mass at the Spine and Hip in Postmenopausal Women With Low Bone Mass.

Results: romosozumab significantly increased integral vBMD and BMC at the lumbar spine and total hip from baseline, and compared with placebo and teriparatide (all p < 0.05). Trabecular vertebral vBMD improved significantly and similarly from baseline (p < 0.05) with both romosozumab (18.3%) and teriparatide (20.1%), whereas cortical vertebral vBMD gains were larger with romosozumab compared with teriparatide (13.7% versus 5.7%, p < 0.0001). Trabecular hip…

Molecular mechanisms in bone mechanotransduction

Histol Histopathol. 2016 Dec 16:11858. Bone is one of the most adaptable tissues in the body as it is continuously subjected to load bearing. Mechanical stimulation is necessary for the development of the skeleton.In this review, we discuss the complexity and well-orchestrated events that occur in bone mechanotransduction, focusing on osteocyte viability as an important…

Impact of obesity on bone metabolism

Endocrinol Nutr. 2016 Dec;63(10):551-559. High weight is a protective factor against osteoporosis and risk of fracture. In obesity, however, where overweight is associated to excess fat, this relationship does not appear to be so clear, excess weight has sometimes been associated to decreased bone mass. Autor: López-Gómez JJ, Pérez Castrillón JL, de Luis Román DA

Parathyroid Hormone Polymorphism RS6254 is Associated with the Development and Severity of Osteoporosis in Asymptomatic but not Normocalcemic Hyperthyroidism

Horm Metab Res. 2016 Dec;48(12):828-833. Although normocalcemic and asymptomatic hyperparathyroidism (HPT) are becoming more common, they remain only partially understood. Parathyroid hormone (PTH) polymorphisms have been associated with disease severity in classical HPT. The aim of the present study was to evaluate the clinical effect of PTH polymorphism  (rs6254) in normocalcemic and asymptomatic HPT. A…

Gender-associated comorbidities in rheumatoid arthritis and their impact on outcome: data from GENIRA

Rheumatol Int. 2016 Dec 16. GENIRA [Gender in Rheumatoid Arthritis (RA)] is a comprehensive project aimed at  studying gender differences in RA patients and how these differences impact on these patient outcomes. Women with RA present significantly worse disability and QOL outcomes than men; these differences can be explained by female gender-associated comorbidities such as…

Switching from a ritonavir-boosted PI to dolutegravir as an alternative strategy in virologically suppressed HIV-infected individuals

Antimicrob Chemother. 2016 Dec 20. pii: dkw504. doi: 10.1093/jac/dkw504. Switching from PIs to dolutegravir in virologically suppressed HIV-infected individuals has not been assessed. The principal aim was to assess the evolution of bone mineral density (BMD) when switching from a ritonavir-boosted PI to dolutegravir in HIV-infected  patients with osteopenia or osteoporosis. CONCLUSIONS: Dolutegravir + Kivexa(®) was safe…

The Activity of Adiponectin in Bone

Calcif Tissue Int. 2016 Dec 7Watch Full Movie Online Streaming Online and Download The adipokine adiponectin affects multiple target tissues and plays important roles in glucose metabolism and whole-body energy homeostasis. Circulating adiponectin levels in obese people are lower than in non-obese, and increased serum adiponectin is associated with weight loss. Results of these studies…

Treatment Sequence Matters: Anabolic and Antiresorptive Therapy for Osteoporosis

J Bone Miner Res. 2016 Dec 7. doi: 10.1002/jbmr.3051.Watch movie online The Transporter Refueled (2015) The majority of osteoporosis medications are antiresorptive agents, which reduce the rate of bone remodeling. Within this group are the bisphosphonates, which inhibit protein prenylation in the mature osteoclast, reducing osteoclast capacity to resorb bone(1) and denosumab, a monoclonal antibody…

Genetic Variants Associated with Circulating Parathyroid Hormone

J Am Soc Nephrol. 2016 Dec 7 Parathyroid hormone (PTH) is a primary calcium regulatory hormone. Elevated serum PTH concentrations in primary and secondary hyperparathyroidism have been associated with bone disease, hypertension, and in some studies, cardiovascular mortality. Genetic causes of variation in circulating PTH concentrations are incompletely understood. This study performed a genome-wide association…

Circulating microRNA Signatures in Patients With Idiopathic and Postmenopausal Osteoporosis and Fragility Fractures

J Clin Endocrinol Metab. 2016 Nov;101(11):4125-4134 Specific serum miRNA profiles are strongly related to bone pathologies. Therefore miRNAs might be directly linked to bone tissue homeostasis. In particular, miR-29b-3p has previously been reported as regulator of osteogenic differentiation and could serve as a novel marker of bone turnover in osteoporotic patients as a member of…

Diabetes Drug effects on the skeleton

PUMBE – Calcif Tissue Int (2016). doi:10.1007/s00223-016-0203-x Anti-diabetes medications are crucial for maintaining glucose control and for preventing micro- and macrovascular complications in diabetes. However, they may modulate fracture risk in diabetes in different ways. The purpose of this review is to provide a comprehensive overview of the effect of these medications on bone metabolism…

Effects of Teriparatide Compared with Risedronate on Recovery After Pertrochanteric Hip Fracture: Results of a Randomized, Active-Controlled,Double-Blind Clinical Trial at 26 Weeks

J Bone Joint Surg Am. 2016 Nov 16;98(22):1868-1878. Osteoporosis drugs might affect fracture-healing. We therefore studied the effects of teriparatide in comparison with risedronate on recovery after pertrochanteric hip fractures. Teriparatide was associated with less pain and a shorter time to complete the TUG test between 6 and 26 weeks compared with risedronate. Other fracture-recovery…

A reproducible method for the isolation and expansion of ovine mesenchymal stromal cells from bone marrow for use in regenerative medicine preclinical studies

J Tissue Eng Regen Med. 2016 Nov 18. doi: 10.1002/term.2254 The use of multipotent mesenchymal stromal cells (MSCs) as candidate medicines for treating a variety of pathologies is based on their qualities as either progenitors for the regeneration of damaged tissue or producers of a number of molecules with pharmacological properties. The osteogenic potential of…

Oxidation inhibits PTH receptor signaling and trafficking

Biochem Biophys Res Commun. 2016 Nov 28.Watch Full Movie Online Streaming Online and Download Reactive Oxygen Species (ROS) increase during aging, potentially affecting many tissues including brain, heart, and bone.  ROS alter signaling pathways and constitute potential therapeutic targets to limit oxidative damaging effects in aging-associated diseases.  The role of oxidation on PTHR signaling and…

CathepsinKCre mediated deletion of βcatenin results in dramatic loss of bone mass by targeting both osteoclasts and osteoblastic cells

Sci Rep. 2016 Nov 2;6:36201. doi: 10.1038/srep36201 This study examines the effects of Wnt/βcatenin signaling in mature osteoclasts by generating mice lacking βcatenin in CathepsinK-expressing cells (Ctnnb1(f/f);CtsKCre mice). Their results indicate that the bone phenotype of Ctnnb1(f/f);CtsKCre animals combines a cell-autonomous effect in the mature osteoclast with indirect effects  due to the additional targeting of…

Distinct Osteomimetic Response of Androgen-Dependent and Independent Human Prostate Cancer Cells to Mechanical Action of Fluid Flow: Prometastatic Implications

Prostate. 2016 Nov 3. doi: 10.1002/pros.23270. Prostate cancer frequently expresses an osteomimetic phenotype, but it is unclear how it is regulated and what biological and clinical implications it confers.  MAFF activated osteoblast-like phenotype of prostate cancer cells and altered their responses to osteocyte soluble factors. Autor: González Á, García de Durango C, Alonso V, Bravo…

Effects of chronic lead exposure on bone mineral properties in femurs of growing rats

Toxicology. 2016 Nov 30. pii: S0300-483X(16)30303-1. doi:10.1016/j.tox.2016.11.017. The aim of the present study is to make a more detailed description of the toxic effects of lead intoxication on bone intrinsic material properties as mineral composition, morphology and microstructural characteristics. Autor: Álvarez-Lloret P, Lee CM, Conti MI, Terrizzi AR, González-López S,Martínez MP.

The role of serum osteoprotegerin and receptor-activator of nuclear factor-Κb ligand in metabolic bone disease of women after obesity surgery

J Bone Miner Metab. 2016 Nov;34(6):655-661.Watch Full Movie Online Streaming Online and Download Metabolic bone disease may appear as a complication of obesity surgery. These data show that the osteoprotegerin and receptor-activator of nuclear factor-κB ligand system is  associated with bone markers and bone mineral density at the lumbar spine after obesity surgery Autor: Balsa…

Can acetazolamide be used to treat diseases involving increased bone mineral density?

DOI: 10.5582/irdr.2016.01067 PMCID: PMC5116865 PMID: 27904825 Sclerosing bone dysplasias are a series of clinically and genetically heterogeneous diseases characterized by functional failure of the osteoclasts in  bone resorption, leading to an excessive amount of bone mineral density (BMD) which could have serious clinical consequences. We treated three children affected with seriously high levels of BMD…

Goal-Directed Treatment for Osteoporosis: A Progress Report from the ASBMR-NOF Working Group on Goal-Directed Treatment for Osteoporosis

J Bone Miner Res. 2016 Nov 19. doi: 10.1002/jbmr.3039. The American Society for Bone and Mineral Research and the United States National Osteoporosis Foundation (NOF) formed a working group to develop principles of goal-directed treatment and identify gaps that need to be filled to implement this approach. With goal-directed treatment, a treatment goal would first…

Association of Muscle Weakness with Post-Fracture Mortality in Older Men and Women: A 25 Year Prospective Study

J Bone Miner Res. 2016 Nov 11. doi: 10.1002/jbmr.3037. Osteoporotic fracture increases the risk of premature mortality. Muscle weakness  is associated with both increased fracture risk and low BMD. However, the role of muscle strength in post-fracture mortality is not well understood. This study examines the change of muscle strength measured at quadriceps (QS) before…

Nanocrystallinity effects on osteoblast and osteoclast response to silicon substituted hydroxyapatite (SiHA)

Nanocrystallinity of SiHA affects the cell/biomaterial interface inducing bone cell apoptosis by loss of cell anchorage (anoikis), delaying osteoclast-like cell differentiation and decreasing the resorptive activity of this cell type. These results suggest the potential use of nano-SiHA biomaterial for preventing bone resorption in treatment of osteoporotic bone.

Oral Microbiota, Periodontal Status and Osteoporosis in Postmenopausal Women

Osteoporosis did not influence the prevalence of periodontitis among postmenopausal women. The presence of periodontopathogenic bacteria was not sufficient to confirm disease. A preventive maintenance program for postmenopausal women, particularly osteoporotic women, who are at greater risk of tooth loss, could minimize the potential effects of bone loss on periodontal tissues.Watch Cyberbully (2015) Full Movie…

Protection From Glucocorticoid-Induced Osteoporosis by Anti-Catabolic Signaling in the Absence of Sost/Sclerostin

J Bone Miner Res 2016, 31: 1791–1802. doi: 10.1002/jbmr.2869 PubMed PMID: 27163932Watch Full Movie Online Streaming Online and Download In the context of glucocorticoid excess, activation of Wnt/β-catenin signaling by Sost/sclerostin deficiency sustains bone integrity by opposing bone catabolism despite markedly reduced bone formation and increased apoptosis. This crosstalk between glucocorticoids and Wnt/β-catenin signaling could…

Cortical Bone Porosity: What Is It, Why Is It Important, and How Can We Detect It?

Curr Osteoporos Rep. 2016 Oct;14(5):187-98. doi: 10.1007/s11914-016-0319-y. DOI: 10.1007/s11914-016-0319-y PMID: 27623679 [PubMed – in process] Cortical porosity is important because of its impact on bone material and mechanical properties as well as its role in the remodeling process. This review aims to provide an overview of what this level of porosity is, why it is…

Potentially inappropriate prescribing in older Spanish population according to STOPP/START criteria (STARTREC study)

n our Health Region, at least 50% of the population aged 70 or older has one or more potentially inappropriate prescribing (PIP), according to STOPP/START criteria. According to STOPP, the most common drugs identified are benzodiazepines, non-steroidal anti-inflammatory drugs and proton pump inhibitors; according to START, osteoporosis treatments, antiplatelet agents, statins, metformin and beta blockers….

Cost-effectiveness of orthogeriatric and fracture liaison service models of care for hip fracture patients: A population based study

Irrespective of how patients were stratified in terms of their age, sex, and Charlson co-morbidity score at index hip fracture, our results suggest that introducing an orthogeriatrician-led or a nurse-led FLS is cost-effective when compared to usual care. Although, considerable uncertainty remains concerning which of the models of care should be preferred, introducing an orthogeriatrician-led…

The Use of the WHO Facture Risk Assessment (FRAX®) Tool in Predicting Risk of Fractures in Patients With Inflammatory Bowel Disease: A Systematic Review

The FRAX tool has been limitedly used in patients with IBD; however, the evidence currently available only shows a modest increase in the 10-yr risks of bone fracture and does not support unequivocally the need for specific interventions.Roblox HackBigo Live Beans HackYUGIOH DUEL LINKS HACKPokemon Duel HackRoblox HackPixel Gun 3d HackGrowtopia HackClash Royale Hackmy cafe…

Novel biological markers of bone: from bone metabolism to bone physiology

Rheumatology (Oxford). 2016 Oct;55(10):1714-25. Epub 2016 Jan 20. DOI: 10.1093/rheumatology/kev410 PMID: 26790456 [PubMed – in process] Traditional BTMs have been used for years to help with fracture risk prediction and in particular for treatment monitoring. Clinical use of the new biochemical markers has not been established so far. Their relationship with fracture risk is still…

Osteocytic signalling pathways as therapeutic targets for bone fragility

Nat Rev Endocrinol. 2016 Oct;12(10):593-605. Epub 2016 May 27. DOI: 10.1038/nrendo.2016.71 PMID: 27230951 [PubMed – in process] Osteocytes are differentiated osteoblasts that become surrounded by matrix during the process of bone formation. Acquisition of the osteocyte phenotype is achieved by profound changes in gene expression. The discovery of mutations in human osteocytic genes has contributed,…

Bisphosphonates for steroid-induced osteoporosis

Cochrane Database Syst Rev. 2016 Oct 5;10:CD001347. Review. PMID: 27706804Watch Full Movie Online Streaming Online and Download There was high-certainty evidence that bisphosphonates are beneficial in reducing the risk of vertebral fractures with data extending to 24 months of use. There was low-certainty evidence that bisphosphonates may make little or no difference in preventing nonvertebral…

HIV infection and bone disease

J Intern Med. 2016 Oct;280(4):350-8. doi: 10.1111/joim.12520. Epub 2016 Jun 6. DOI: 10.1111/joim.12520 PMID: 27272530 [PubMed – in process] The success of antiretroviral therapy in treating HIV infection has greatly prolonged life expectancy in affected individuals, transforming the disease into a chronic condition. A number of HIV-associated non-AIDS comorbidities have emerged in the ageing HIV-infected…

Safety and efficacy of vertebroplasty for acute painful osteoporotic fractures (VAPOUR): a multicentre, randomised, double-blind, placebo-controlled trial

Lancet. 2016 Oct 1;388(10052):1408-1416. doi: 10.1016/S0140-6736(16)31341-1. PMID: 27544377 Vertebroplasty is superior to placebo intervention for pain reduction in patients with acute osteoporotic spinal fractures of less than 6 weeks’ in duration. These findings will allow patients with acute painful fractures to have an additional means of pain management that is known to be effective. Autor:…

The roles of vascular endothelial growth factor in bone repair and regeneration

Bone. 2016 Oct;91:30-8. doi: 10.1016/j.bone.2016.06.013. Epub 2016 Jun 25. Review. This review (i) summarizes the roles of VEGF at different stages of bone repair, including the phases of inflammation, endochondral ossification, intramembranous ossification during callus formation and bone remodeling; (ii) discusses different mechanisms underlying the effects of VEGF on osteoblast function, including paracrine, autocrine and…

A randomized, double-blind, multicenter, placebo-controlled study to evaluate the efficacy and safety of oral salmon calcitonin in the treatment of osteoporosis in postmenopausal women taking calcium and vitamin D

Bone. 2016 Oct;91:122-9. doi: 10.1016/j.bone.2016.07.019. Epub 2016 Jul 25. Due to the lack of efficacy in preventing fractures, the development of the orally formulated calcitonin was terminated despite the promising results in earlier studies. Autor: Henriksen K, Byrjalsen I, Andersen JR, Bihlet AR, Russo LA, Alexandersen P, Valter I, Qvist P, Lau E, Riis BJ,…

Longer Duration of Diabetes Strongly Impacts Fracture Risk Assessment: The Manitoba BMD Cohort

J Clin Endocrinol Metab. 2016 Nov;101(11):4489-4496. Diabetes is a FRAX-independent risk factor for MOF only in women with a long duration of diabetes, but diabetes increases hip fracture risk, regardless of duration. Those with diabetes longer than 10 years are at particularly high risk of fracture, and this elevated risk is currently underestimated by FRAX….

Objectively Verified Parental Hip Fracture Is an Independent Risk Factor for Fracture: a Linkage Analysis of 478,792 Parents and 261,705 Offspring

J Bone Miner Res. 2016 Sep;31(9):1753-9. doi: 10.1002/jbmr.2849. Epub 2016 Apr 30. Parental Hip Fracture (HF) increased the risk for offspring Major Osteoporotic Fracture (MOF) and HF but not when parental HF occurred after age 80 years. This suggests a more nuanced approach for clinicians trying to stratify fracture risk, and illustrates the enormous potential…

Triglyceride Levels and Fracture Risk in Midlife Women: Study of Women’s Health Across the Nation (SWAN)

J Clin Endocrinol Metab. 2016 Sep;101(9):3297-305. doi: 10.1210/jc.2016-1366. Epub 2016 Jun 13. CONCLUSIONS:  Midlife women with high fasting plasma TG had an increased risk of incident nontraumatic fracture. Secondary Abstract: Midlife women with fasting plasma triglyceride (TG) of at least 300 mg/dl had 2.5-fold greater hazards of fracture in 2 years later and onward, compared…

Links Between the Microbiome and Bone

J Bone Miner Res. 2016 Sep;31(9):1638-46. doi: 10.1002/jbmr.2887. Epub 2016 Jul 26. Despite these challenges, an understanding of the mechanisms by which the gut microbiome affects bone has the potential to provide insights into the dissociation between fracture risk and bone mineral density in patients including those with obesity, diabetes, or inflammatory bowel disease. In…

Potential Usefulness of BMD and Bone Turnover Monitoring of Zoledronic Acid Therapy Among Women With Osteoporosis: Secondary Analysis of Randomized Controlled Trial Data

J Bone Miner Res. 2016 Sep;31(9):1767-73. doi: 10.1002/jbmr.2847. Epub 2016 Apr 25. In conclusion, serum PINP is potentially useful in monitoring response to zoledronic acid. Further research is needed to evaluate the effects of monitoring PINP on treatment decisions and other clinically relevant outcomes. Autor: Bell KJ, Hayen A, Glasziou P, Irwig L, Eastell R,…

Effect of Abaloparatide vs Placebo on New Vertebral Fractures in Postmenopausal Women With Osteoporosis: A Randomized Clinical Trial

JAMA. 2016 Aug 16;316(7):722-33. doi: 10.1001/jama.2016.11136. Among postmenopausal women with osteoporosis, the use of subcutaneous abaloparatide, compared with placebo, reduced the risk of new vertebral and nonvertebral fractures over 18 months. Further research is needed to understand the clinical importance of RD, the risks and benefits of abaloparatide treatment, and the efficacy of abaloparatide vs…

Sun Exposure Behavior, Seasonal Vitamin D Deficiency, and Relationship to Bone Health in Adolescents

J Clin Endocrinol Metab. 2016 Aug;101(8):3105-13. doi: 10.1210/jc.2016-1559. Epub 2016 May 26. Sun exposure levels failed to provide adequate vitamin D, with approximately one-quarter of adolescents insufficient even at summer peak. Seasonal vitamin D deficiency was prevalent and those affected had low BMD. Recommendations on vitamin D acquisition are indicated in this age-group. Autor: Farrar…

Denosumab or Zoledronic Acid in Postmenopausal Women With Osteoporosis Previously Treated With Oral Bisphosphonates

J Clin Endocrinol Metab. 2016 Aug;101(8):3163-70. doi: 10.1210/jc.2016-1801. Epub 2016 Jun 6 In postmenopausal women with osteoporosis previously treated with oral bisphosphonates, denosumab was associated with greater BMD increases at all measured skeletal sites and greater inhibition of bone remodeling compared with ZOL. Autor: Miller PD, Pannacciulli N, Brown JP, Czerwinski E, Nedergaard BS, Bolognese…

Effects of antidepressants on postmenopausal bone loss – A 5-year longitudinal study from the OSTPRE cohort

Bone. 2016 Aug;89:25-31. doi: 10.1016/j.bone.2016.05.003. Epub 2016 May 11. In conclusion, the use of SSRIs seems to accelerate postmenopausal bone loss in a dose-response manner. Associations between TCA and other antidepressant use and bone loss may also exist. Thus, the possibility of increased risk of osteoporosis should be considered when prescribing antidepressants for postmenopausal women….

Daily Intake of Milk Enriched with n-3 Fatty Acids, Oleic Acid, and Calcium Improves Metabolic and Bone Biomarkers in Postmenopausal Women

In postmenopausal women with moderate cardiovascular risk, dietary supplementation with a dairy drink enriched with fatty acids (EPA+DHA), oleic acid, minerals, and vitamins induces a positive effect on cardiovascular risk and parameters of bone metabolism. Its regular consumption may be a useful nutritional support for postmenopausal women.

RESOLUCIÓN Becas ASBMR 2016

Finalizado el plazo para el envío de solicitudes para acceder a las Becas FEIOMM para la presentación de trabajos de investigación en el Congreso de la ASBMR en Atlanta, se adjunta la lista de solicitudes remitidas para su evaluación.

Therapy of Hypoparathyroidism With PTH(1-84): A Prospective Six Year Investigation of Efficacy and Safety

J Clin Endocrinol Metab. 2016 Jul;101(7):2742-50. doi: 10.1210/jc.2015-4135. Epub 2016 May 4. CONCLUSIONS: Long-term, continuous therapy of hypoparathyroidism for 6 years with rhPTH(1-84) is associated with reductions in supplemental calcium and calcitriol requirements, stable serum calcium concentration, and reduced urinary calcium excretion. The safety profile remains good. These data represent the longest experience with the…

A Longitudinal Study of Skeletal Histomorphometry at 6 and 24 Months Across Four Bone Envelopes in Postmenopausal Women With Osteoporosis Receiving Teriparatide or Zoledronic Acid in the SHOTZ Trial

J Bone Miner Res. 2016 Jul;31(7):1429-39. doi: 10.1002/jbmr.2804. Epub 2016 Mar 8. This study demonstrates for the first time that bone formation indices are higher with TPTD treatment than with ZOL in all four bone envelopes and the difference persists for at least 2 years. Moreover, the magnitude of the effect of TPTD in cortical…

Effect of Adjunctive Raloxifene Therapy on Severity of Refractory Schizophrenia in Women: A Randomized Clinical Trial

JAMA Psychiatry. 2016 Jul 20. doi: 10.1001/jamapsychiatry.2016.1383. [Epub ahead of print] Raloxifene hydrochloride, 120 mg/d, reduces illness severity and increases the probability of a clinical response in women with refractory schizophrenia. This large trial of raloxifene in this patient population offers a promising, well-tolerated agent that has potential application in clinical practice. Autor: Kulkarni J,…

Strains caused by daily loading might be responsible for delayed healing of an incomplete atypical femoral fracture

Bone. 2016 Jul;88:125-30. doi: 10.1016/j.bone.2016.04.020. Epub 2016 Apr 22. In conclusion, the poor healing capacity of incomplete atypical femoral fractures can be explained by biomechanical factors, and daily low impact activities are enough to cause strain magnitudes that prohibit bone formation. Autor: Gustafsson A, Schilcher J, Grassi L, Aspenberg P, Isaksson H.

The management of osteoporosis in children

Osteoporos Int. 2016 Jul;27(7):2147-79. doi: 10.1007/s00198-016-3515-9. Epub 2016 Apr 28. Review. The scope of this article is to review the manifestations of and risk factors for primary and secondary osteoporosis in children, to discuss the definition of pediatric osteoporosis, and to summarize recommendations for monitoring and prevention of bone fragility. As well, this article reviews…

Strains caused by daily loading might be responsible for delayed healing of an incomplete atypical femoral fracture

Bone. 2016 Jul;88:125-30. doi: 10.1016/j.bone.2016.04.020. Epub 2016 Apr 22. In conclusion, the poor healing capacity of incomplete atypical femoral fractures can be explained by biomechanical factors, and daily low impact activities are enough to cause strain magnitudes that prohibit bone formation. Autor: Gustafsson A, Schilcher J, Grassi L, Aspenberg P, Isaksson H.

In vitro lifespan and senescent behaviour of human periosteal derived stem cells

Bone. 2016 Jul;88:1-12. doi: 10.1016/j.bone.2016.04.013. Epub 2016 Apr 19. Overall, our findings suggest the possibility to use early-passage PDPCs for bone regenerative approaches based on the local recruitment of stem cells, whilst the later cell passages could be a suitable in vitro tool to validate scaffolds intended for bone regeneration in elderly subjects. Autor: Vozzi…

Exploring correlation between bone metabolism markers and densitometric traits in extended families from Spain

Strong genetic correlations were observed between osteocalcin and several bone mineral densitometric traits. In addition, suggestive genetic correlations with densitometric traits were observed for leptin and sclerostin. Overall, the few strong and several suggestive genetic correlations point out the existence of a complex underlying genetic architecture for bone metabolism plasma phenotypes.

Cortical-Bone Fragility–Insights from sFRP4 Deficiency in Pyle’s Disease

N Engl J Med. 2016 Jun 30;374(26):2553-62. doi: 10.1056/NEJMoa1509342. CONCLUSIONS: Our study showed that Pyle’s disease was caused by a deficiency of sFRP4, that cortical-bone and trabecular-bone homeostasis were governed by different mechanisms, and that sFRP4-mediated cross-regulation between Wnt and BMP signaling was critical for achieving proper cortical-bone thickness and stability. Autor: Simsek Kiper PO,Saito…

A systematic review and meta-analysis of the association between eating disorders and bone density

Osteoporos Int. 2016 Jun;27(6):1953-66. doi: 10.1007/s00198-015-3468-4. Epub 2016 Jan 18. Hip, whole body and femoral neck BMD were reduced to a statistically significant level in AN but not BN groups. The meta-regression was limited by the number of included studies and did not find any significant predictors. This meta-analysis confirms the association between low BMD…

How Accurate is Your Sclerostin Measurement? Comparison Between Three Commercially Available Sclerostin ELISA Kits

Calcif Tissue Int. 2016 Jun;98(6):546-55. doi: 10.1007/s00223-015-0105-3. Epub 2016 Jan 9. The variability in values generated from Biomedica, R&D Systems and TECOmedical assays raises questions regarding the accuracy and specificity of the assays. Direct comparison of studies using different kits is not possible and great care should be given to measurement of sclerostin, with traceability…

Identification of a G-Protein Subunit-α11 Gain-of-Function Mutation, Val340Met, in a Family with Autosomal Dominant Hypocalcemia Type 2 (ADH2)

J Bone Miner Res June; 31(6):1167-1176 . doi: 10.1002/jbmr.2797. Epub 2016 Jan 28. In conclusion, our identification of a novel germline gain-of-function Gα11 mutation, Val340Met, causing ADH2 demonstrates the importance of the Gα11 C-terminal region for G-protein function and CaSR signal transduction. Autor: Piret SE, Gorvin CM, Pagnamenta AT, Howles SA, Cranston T, Rust N,…

CONVOCATORIA BECAS FEIOMM ASBMR 2016

FEIOMM convoca 5 BECAS para la presentación de trabajos científicos en ASBMR 2016 Annual Meeting (American Society for Bone and Mineral Research) que se celebrará en Atlanta, Georgia (USA) del 16 al 19 de septiembre de 2016.Dichas becas cubrirán inscripción, viaje y alojamiento. La aceptación de la beca implica la conformidad con las condiciones de…

Chondroprotective effects of the combination chondroitin sulfate-glucosamine in a model of osteoarthritis induced by anterior cruciate ligament transection in ovariectomised rats

These results demonstrate the chondroprotective effects of the combination chondroitin sulfate-glucosamine in vivo, in the experimental model of anterior cruciate ligament transection in ovariectomised rats, and suggest that this combination may be useful to control the joint catabolic effects of inflammatory stress.

Cancel the denosumab holiday

Osteoporos Int. 2016 May;27(5):1677-82. doi: 10.1007/s00198-016-3553-3. Epub 2016 Mar 1 Patients should be encouraged to continue denosumab therapy long term. If discontinuation does occur, appropriate steps must be taken to prevent the rapid bone loss and probable acute fracture risk. Autor: Loi F, Córdova LA, Pajarinen J, Lin TH, Yao Z, Goodman SB.

Free 25-Hydroxyvitamin D: Impact of Vitamin D Binding Protein Assays on Racial-Genotypic Associations

J Clin Endocrinol Metab. 2016 May;101(5):2226-34. doi: 10.1210/jc.2016-1104. Epub 2016 Mar 23. Previously reported racial differences in DBP concentration are likely from monoclonal assay bias, as there was no racial difference in DBP concentration by other methods. This confirms the poor vitamin D status of many African-Americans and the utility of total 25OHD in assessing…

The Proteasome Inhibitor Bortezomib Maintains Osteocyte Viability in Multiple Myeloma Patients by Reducing Both Apoptosis and Autophagy: A New Function for Proteasome Inhibitors.

J Bone Miner Res. 2016 Apr;31(4):815-27. doi: 10.1002/jbmr.2741. Epub 2015 Dec 14. Our data identify osteocyte autophagy as a new potential target in MM bone disease and support the use of PIs to maintain osteocyte viability and improve bone integrity in MM patients. Autor: Toscani D, Palumbo C, Dalla Palma B, Ferretti M, Bolzoni M,…

A Novel Domain-Specific Mutation in a Sclerosteosis Patient Suggests a Role of LRP4 as an Anchor for Sclerostin in Human Bone

J Bone Miner Res. 2016 Apr;31(4):874-81. doi: 10.1002/jbmr.2782. Epub 2016 Jan 24 We demonstrate that impaired sclerostin binding to the mutated LRP4 protein leads to dramatic increase in circulating sclerostin in this patient. With this study, we provide the first evidence suggesting that LRP4 is responsible for the retention of sclerostin in the bone environment…

Differential Effects of Teriparatide and Denosumab on Intact PTH and Bone Formation Indices: AVA Osteoporosis Study

J Clin Endocrinol Metab. 2016 Apr;101(4):1353-63. doi: 10.1210/jc.2015-4181. Epub 2016 Feb 9 We compared effects of teriparatide and denosumab on PTH, bone turnover markers, and bone histomorphometry in osteoporotic postmenopausal women. The findings were inconsistent with an early indirect anabolic effect of denosumab. Autor: Dempster DW, Zhou H, Recker RR, Brown JP, Recknor CP, Lewiecki…

The National Osteoporosis Foundation’s position statement on peak bone mass development and lifestyle factors: a systematic review and implementation recommendations

Osteoporos Int. 2016 Apr;27(4):1281-386. doi: 10.1007/s00198-015-3440-3. Epub 2016 Feb 8. Erratum in: Osteoporos Int. 2016 Apr;27(4):1387. The best evidence (grade A) is available for positive effects of calcium intake and physical activity, especially during the late childhood and peripubertal years-a critical period for bone accretion. Good evidence is also available for a role of vitamin…

The National Osteoporosis Foundation’s position statement on peak bone mass development and lifestyle factors: a systematic review and implementation recommendations

Osteoporos Int. 2016 Apr;27(4):1281-386. doi: 10.1007/s00198-015-3440-3. Epub 2016 Feb 8 The best evidence (grade A) is available for positive effects of calcium intake and physical activity, especially during the late childhood and peripubertal years-a critical period for bone accretion. Good evidence is also available for a role of vitamin D and dairy consumption and a…

Osteoporosis in the adult solid organ transplant population: underlying mechanisms and available treatment options

Osteoporos Int. 2016 Apr;27(4):1425-40. doi: 10.1007/s00198-015-3367-8. Epub 2015 Oct 16. Review Supplementation with calcium and vitamin D is often necessary in the SOT population due to a high incidence of vitamin D deficiency. Bisphosphonate therapy is most commonly used for prevention and treatment of osteoporosis, but therapy can be limited by renal dysfunction which is…

Differential Effects of Teriparatide and Denosumab on Intact PTH and Bone Formation Indices: AVA Osteoporosis Study

J Clin Endocrinol Metab. 2016 Apr;101(4):1353-63. doi: 10.1210/jc.2015-4181. Epub 2016 Feb 9. We compared effects of teriparatide and denosumab on PTH, bone turnover markers, and bone histomorphometry in osteoporotic postmenopausal women. The findings were inconsistent with an early indirect anabolic effect of denosumab. Autor: Dempster DW, Zhou H, Recker RR, Brown JP, Recknor CP, Lewiecki…

Phenolic Compounds in Extra Virgin Olive Oil (EVOO) Stimulate Human Osteoblastic Cell Proliferation

Cell proliferation was increased. The most effective EVOO phenolic extracts were those obtained from the Picual variety, as they significantly increased cell proliferation by 18-22%. Conversely, Arbequina phenolic extracts increased cell proliferation by 9-13%. A decline in osteoblast proliferation was observed in oils obtained from olive fruits collected at the end of the harvest period,…

Convocatoria Becas FEIOMM Movilidad 2016

La Fundación Española de Investigación Ósea y del Metabolismo Mineral (FEIOMM) convoca las BECAS FEIOMM-Movilidad con el fin de proporcionar una ayuda complementaria para la realización de estancias cortas en centros de investigación nacionales e internacionales destinadas a ampliar la formación en investigación, mediante la adquisición de nuevos conocimientos y técnicas experimentales, en el campo…

Differential Effects of Teriparatide and Zoledronic Acid on Bone Mineralization Density Distribution at 6 and 24 Months in the SHOTZ Study

J Bone Miner Res. 2016; 31(8):1527-35. doi: 10.1002/jbmr.2825. Epub 2016 Mar 30. TPTD stimulated new bone formation, producing a mineralized bone matrix that remained relatively heterogeneous with a stable mean mineral content. ZOL slowed bone turnover and prolonged secondary mineralization, producing a progressively more homogeneous and highly mineralized bone matrix. While both TPTD and ZOL…

MicroRNA variants as genetic determinants of bone mass

Bone. 2016 Mar;84:57-68. doi: 10.1016/j.bone.2015.12.016. Epub 2015 Dec 23. Review. Given the polygenic nature of skeletal diseases like osteoporosis and osteoarthritis, validating the function of additional miRNA-associated SNPs has the potential to enhance our understanding of the genetic determinants of bone mass and predisposition to selected skeletal diseases. Autor: Dole NS, Delany AM.

Osteocyte-directed bone demineralization along canaliculi

Bone. 2016 Mar;84:279-88. doi: 10.1016/j.bone.2015.12.006. Epub 2015 Dec 17 These data suggest demineralization can occur from within bone through the canalicular system, and that peri-canalicular demineralization occurs not uniformly but directed by individual osteocytes. Blockade of peri-canalicular demineralization may be a therapeutic strategy to increase bone mass and quality. Autor: Nango N, Kubota S, Hasegawa…

Bisphosphonate drug holidays: we reap what we sow

Osteoporos Int. 2016 Mar;27(3):849-52. doi: 10.1007/s00198-015-3453-y. Epub 2015 Dec 14. No abstract available. Clinicians need to rethink the assumption that a patient who has taken an oral bisphosphonate for 5 years or an intravenous therapy for 3 years should automatically start a drug holiday. The clinician should individualize the decision for each patient based on…

Increase in Fracture Risk Following Unintentional Weight Loss in Postmenopausal Women: The Global Longitudinal Study of Osteoporosis in Women

Unintentional weight loss at baseline was associated with a significantly increased risk of fracture of the clavicle, wrist, spine, rib, hip, and pelvis for up to 5 years following weight loss. This increase is seen as early as 1 year following weight loss, emphasizing the need for prompt fracture risk assessment and appropriate management to…

The Microbiome and Musculoskeletal Conditions of Aging: A Review of Evidence for Impact and Potential Therapeutics

J Bone Miner Res. 2016 Feb;31(2):261-9. doi: 10.1002/jbmr.2765. Review. This perspective discusses evidence to date on the role of the microbiome and the highly prevalent age-related disorders of osteoporosis, osteoarthritis, gout, rheumatoid arthritis, sarcopenia, and frailty. It also reviews data on the effects of probiotics and prebiotic interventions in animal and human models. Despite suggestive…

Global Consensus Recommendations on Prevention and Management of Nutritional Rickets

J Clin Endocrinol Metab. 2016 Feb;101(2):394-415. doi: 10.1210/jc.2015-2175. Epub 2016 Jan 8. Rickets, osteomalacia, and vitamin D and calcium deficiencies are preventable global public health problems in infants, children, and adolescents. Implementation of international rickets prevention programs, including supplementation and food fortification, is urgently required. Autor: Munns CF,Shaw N,Kiely M,Specker BL,Thacher TD,Ozono K,MichigamiT,Tiosano D,Mughal MZ,…

Monthly High-Dose Vitamin D Treatment for the Prevention of Functional Decline: A Randomized Clinical Trial

JAMA Intern Med. 2016 Feb 1;176(2):175-83. doi: 10.1001/jamainternmed.2015.7148. Although higher monthly doses of vitamin D were effective in reaching a threshold of at least 30 ng/mL of 25-hydroxyvitamin D, they had no benefit on lower extremity function and were associated with increased risk of falls compared with 24 000 IU. Autor: Bischoff-Ferrari HA, Dawson-Hughes B, Orav…

Relationship between spinal osteoarthritis and vertebral fractures in men older than 50 years: data from the Camargo Cohort Study

Our results suggest a positive relationship between radiologic osteoarthritic changes at the thoracic spine and prevalent vertebral fractures in men more than 50 years of age. Osteoarthritis may act as a local risk factor, in addition to other mechanical factors, resulting in a greater propensity to fracture, especially at the mid-thoracic region.

Balancing benefits and risks of glucocorticoids in rheumatic diseases and other inflammatory joint disorders: new insights from emerging data

An expert consensus paper from the European Society for Clinical and Economic Aspects of Osteoporosis and Osteoarthritis (ESCEO). Within a strategy of a disease modifying approach to inflammatory disease, short durations of moderate doses of GCs are generally well tolerated and have a positive benefit/risk ratio. Patients should be assessed for fracture risk and bone…

Clinical Practice. Postmenopausal Osteoporosis

N Engl J Med. 2016 Jan 21;374(3):254-62. doi: 10.1056/NEJMcp1513724. Review. Key Clinical Points Postmenopausal Osteoporosis Fractures and osteoporosis are common, particularly among older women, and hip fractures can be devastating. Treatment is generally recommended in postmenopausal women who have a bone mineral density T score of -2.5 or less, a history of spine or hip…

Myostatin deficiency partially rescues the bone phenotype of osteogenesis imperfecta model mice

Osteoporos Int. 2016 Jan;27(1):161-70. doi: 10.1007/s00198-015-3226-7. Epub 2015 Jul 16. Myostatin deficiency partially improved the reduced femoral bone biomechanical strength of adult +/oim mice by increasing muscle mass with concomitant improvements in bone microarchitecture and physiochemical properties. Autor: Oestreich AK, Carleton SM, Yao X, Gentry BA, Raw CE, Brown M, Pfeiffer FM, Wang Y, Phillips…

Managing Osteoporosis in Patients on Long-Term Bisphosphonate Treatment: Report of a Task Force of the American Society for Bone and Mineral Research

Osteoporos Int. 2016 Jan;27(1):161-70. doi: 10.1007/s00198-015-3226-7. Epub 2015 Jul 16. Myostatin deficiency partially improved the reduced femoral bone biomechanical strength of adult +/oim mice by increasing muscle mass with concomitant improvements in bone microarchitecture and physiochemical properties. Autor: Oestreich AK, Carleton SM, Yao X, Gentry BA, Raw CE, Brown M, Pfeiffer FM, Wang Y, Phillips…

Managing Osteoporosis in Patients on Long-Term Bisphosphonate Treatment: Report of a Task Force of the American Society for Bone and Mineral Research

J Bone Miner Res. 2016 Jan;31(1):16-35. doi: 10.1002/jbmr.2708. Review. Hence, the Task Force suggests that after 5 years of oral BP or 3 years of intravenous BP, reassessment of risk should be considered. In women at high risk, for example, older women, those with a low hip T-score or high fracture risk score, those with…

Are Biochemical Markers of Bone Turnover Representative of Bone Histomorphometry in 370 Postmenopausal Women?

J Clin Endocrinol Metab. 2015 Dec;100(12):4662-8. doi: 10.1210/jc.2015-2957. Epub 2015 Oct 27. Bone turnover markers were significantly but modestly associated with bone turnover parameters measured in iliac cancellous bone. The iliac crest bone may not represent perfectly the whole bone turnover. Autor: Chavassieux P, Portero-Muzy N, Roux JP, Garnero P, Chapurlat R.

Rebound-associated vertebral fractures after discontinuation of denosumab-from clinic and biomechanics

Osteoporos Int. 2015 Dec 22. [Epub ahead of print] Studies are urgently needed to i) prove the underlying pathophysiological processes suggested above, ii) establish the predictive criteria exposing patients to an increased risk of RVF, and iii) determine appropriate treatment regimens to be applied in such patients. Autor: Popp AW, Zysset PK, Lippuner K.

The effect of 8 or 5 years of denosumab treatment in postmenopausal women with osteoporosis: results from the FREEDOM Extension study

Osteoporos Int. 2015 Dec;26(12):2773-83. doi: 10.1007/s00198-015-3234-7. Epub 2015 Jul 23. CONCLUSIONS: Denosumab treatment for up to 8 years was associated with persistent reductions of BTMs, continued BMD gains, low fracture incidence, and a consistent safety profile. Autor: Papapoulos S, Lippuner K, Roux C, Lin CJ, Kendler DL, Lewiecki EM, Brandi ML, Czerwiński E, Franek E,…

Comparative performance of current definitions of sarcopenia against the prospective incidence of falls among community-dwelling seniors age 65 and older

Osteoporos Int. 2015 Dec;26(12):2793-802. doi: 10.1007/s00198-015-3194-y. Epub 2015 Jun 12. CONCLUSION: Among the definitions investigated, the Baumgartner definition and the Cruz-Jentoft definition had the highest validity for predicting the rate of falls. Autor: Bischoff-Ferrari HA, Orav JE, Kanis JA, Rizzoli R, Schlögl M, Staehelin HB, Willett WC, Dawson-Hughes B.

Negative Impact of Aromatase Inhibitors on Proximal Femoral Bone Mass and Geometry in Postmenopausal Women with Breast Cancer

Calcif Tissue Int. 2015 Dec;97(6):551-9. doi: 10.1007/s00223-015-0046-x. Epub 2015 Aug 1. AI treatment in breast cancer patients is associated with deterioration of femoral cortical BMD and geometry, which could contribute in site-specific weakened bone strength and increased incidence of hip fractures. Autor: Lee SJ, Kim KM, Brown JK, Brett A, Roh YH, Kang DR, Park…

Macrophages: Their Emerging Roles in Bone

J Bone Miner Res. 2015 Dec;30 (12):2140-2149. doi: 10.1002/jbmr.2735. Epub 2018 Nov 4. Review. Collectively, this developing area of osteoimmunology raises new questions and promises to provide novel insights into pathophysiologic conditions as well as therapeutic and regenerative approaches vital for skeletal health. Autor: Sinder BP, Pettit AR, McCauley LK.

Bone Density After Teriparatide Discontinuation in Premenopausal Idiopathic Osteoporosis

J Clin Endocrinol Metab. 2015 Nov;100(11):4208-14. doi: 10.1210/jc.2015-2829. Epub 2015 Sep 10 CONCLUSIONS: These findings lead us to conclude that premenopausal women with IOP, particularly those over 40, may require antiresorptive treatment to prevent bone loss after teriparatide. Autor: Cohen A, Kamanda-Kosseh M, Recker RR, Lappe JM, Dempster DW, Zhou H, Cremers S, Bucovsky M,…

Bone mineral density and inflammatory and bone biomarkers after darunavir-ritonavir combined with either raltegravir or tenofovir-emtricitabine in antiretroviral-naive adults with HIV-1: a substudy of the NEAT001/ANRS143 randomised trial

A raltegravir-based regimen was associated with significantly less loss of bone mineral density than a standard regimen containing tenofovir disoproxil fumarate, and might be a treatment option for patients at high risk of osteopenia or osteoporosis who are not suitable for NtRTIs such as abacavir or tenofovir alafenamide.

Relationship between myostatin and irisin in type 2 diabetes mellitus: a compensatory mechanism to an unfavourable metabolic state?

Our results suggest that serum levels of myostatin and irisin are related in patients with type 2 diabetes. Triglyceride and glucose levels could modulate myostatin and irisin concentrations as a compensatory mechanism to improve the metabolic state in these patients although further studies are needed to elucidate whether the action of these myokines represents an…

Risk Assessment Tools for Osteoporosis Screening in Postmenopausal Women: A Systematic Review

Curr Osteoporos Rep. 2015 Oct;13(5):287-301. doi: 10.1007/s11914-015-0282-z. Among women 50-64 years old, a Fracture Risk Assessment Tool (FRAX) threshold ≥9.3 % had a sensitivity of 33 % for identifying BMD T-score ≤-2.5 and 26 % for predicting major osteoporotic fracture (MOF). For predicting MOF, sensitivity was higher for SCORE and Osteoporosis Self-assessment Tool equation (OST),…

FGF23-regulated production of Fetuin-A (AHSG) in osteocytes

Bone. 2015 Oct 20;83:35-47. doi: 10.1016/j.bone.2015.10.008. [Epub ahead of print] CONCLUSIONS: Our data not only confirm that AHSG is produced in bone, mainly in osteocytes, but show for the first time that its production is modulated by FGF23. Since both proteins play important roles in the bone and cardiovascular pathology, these results add new pieces…

Persistence with denosumab and persistence with oral bisphosphonates for the treatment of postmenopausal osteoporosis: a retrospective, observational study, and a meta-analysis

Osteoporos Int. 2015 Oct;26(10):2401-11. doi: 10.1007/s00198-015-3253-4. Epub 2015 Aug 18. These data from the Swedish Prescribed Drug Register and literature review suggest that persistence was higher with denosumab than with oral bisphosphonates. Autor: Karlsson L, Lundkvist J, Psachoulia E, Intorcia M, et al.

Persistence, adherence, and medication-taking behavior in women with postmenopausal osteoporosis receiving denosumab in routine practice in Germany, Austria, Greece, and Belgium: 12-month results from a European non-interventional study

Osteoporos Int. 2015 Oct;26(10):2479-89. doi: 10.1007/s00198-015-3164-4. Epub 2015 May 28. These data extend the real-world evidence regarding persistence with and adherence to denosumab, both of which are critical for favorable clinical outcomes, including fracture risk reduction. Autor: Hadji P, Papaioannou N, Gielen E, Feudjo Tepie M, Zhang E, Frieling I, Geusens P, Makras P, Resch…

Higher Dietary Calcium Intakes Are Associated With Reduced Risks of Fractures, Cardiovascular Events, and Mortality: A Prospective Cohort Study of Older Men and Women

J Bone Miner Res. 2015 Oct;30(10):1758-66. doi: 10.1002/jbmr.2515. Epub 2015 May 10. In summary, for older men and women, calcium intakes of up to 1348 (316) mg/d from food were associated with decreased risks for fracture, non-fatal CVD, stroke, and all-cause mortality. Autor: WILE Khan B, Nowson CA, Daly RM, English DR, Hodge AM, Giles…

Skeletal adverse effects with aromatase inhibitors in early breast cancer: evidence to date and clinical guidance

A target concentration of 40 ng/ml 25(OH)D may prevent development of AIrA. We also demonstrate that AIrA is genetically determined: single nucleotide polymorphisms located in genes encoding key factors for the metabolism of estrogens and vitamin D (CYP17A1, VDR, and CYP27B1) are associated with self-reported arthralgia during AI therapy. We recommend establishing an individualized protocol…

Overuse and Underuse of Antiosteoporotic Treatments According to Highly Influential Osteoporosis Guidelines: A Population-Based Cross-Sectional Study in Spain

In conclusion, we found that the pharmacological management of osteoporosis in women of 50 and over in this population combines an important overuse and, to a lesser extent, underuse, although the level of inappropriateness varied strikingly depending on the CPG used. It seems urgent to reduce treatment overuse without neglecting underuse, as is urgent an…

Bone Mineral Density as a Predictor of Subsequent Wrist Fractures: Findings from the Women’s Health Initiative Study

J Clin Endocrinol Metab. 2015 Sep 14:jc20152568. [Epub ahead of print] CONCLUSIONS: Lumbar spine and femoral neck BMD were associated with incident wrist fracture, but the FRAX threshold recommended to identify screening candidates did not identify the majority of women who subsequently experienced wrist fracture. Improved understanding of determinants of wrist fractures is warranted. Autor:…

Association between Frailty, Osteoporosis, Falls and Hip Fractures among Community-Dwelling People Aged 50 Years and Older in Taiwan: Results from I-Lan Longitudinal Aging Study.

PLoS One. 2015 Sep 8;10(9):e0136968. doi: 10.1371/journal.pone.0136968. eCollection 2015. Frailty and pre-frailty, in Taiwan, was closely associated with recent falls, history of hip fractures and osteoporosis among community-dwelling people 50 years of age and older. Furthermore, frailty intervention programs should take an integrated approach towards strengthening both and muscle mass, as well as prevention of…

Osteoporosis: Treat and Live, or Let Die Twice More Likely

J Bone Miner Res. 2015 Sep;30(9):1551-2. doi: 10.1002/jbmr.2601. The study emphasized that remaining life expectancy is substantial: 13 years for men aged 60 years and 22 years for women aged 60 years. The substantial life expectancy following a fracture exposes patients to increased risk of refracture, which is itself associated with  elevated mortality risk. This…

Bone Health and Osteoporosis

Endocrinol Metab Clin North Am. 2015;44:517-30. Osteoporosis is characterized by low bone mass and microarchitectural deterioration of bone tissue leading to decreased bone strength and an increased risk of low-energy fractures. Central dual-energy X-ray absorptiometry measurements are the gold standard for determining bone mineral density. Bone loss is an inevitable consequence of the decrease in…

Presentation and management of osteoporosis presenting in association with pregnancy or lactation

Osteoporos Int. 2015 Sep;26(9):2223-41. doi: 10.1007/s00198-015-3149-3. Epub 2015 May 5. In this review, we summarize our current understanding of the pathophysiology of fragility fractures that occur for the first time during pregnancy and lactation, and provide guidance on appropriate investigations and treatment strategies. Autor: Kovacs CS, Ralston SH.

Meeting international standards of secondary fracture prevention: a survey on Fracture Liaison Services in the Netherlands

Osteoporos Int. 2015 Sep;26(9):2257-63. doi: 10.1007/s00198-015-3117-y. Epub 2015 Apr 10. The available data also showed that patients attending the FLSs were evaluated, treated and followed in high compliancy with the IOF standards. Some standards are open to different interpretations and may need further specification. The major shortcoming in FLS practice was that patients invited to…

Overuse and Underuse of Antiosteoporotic Treatments According to Highly Influential Osteoporosis Guidelines: A Population-Based Cross-Sectional Study in Spain

The pharmacological management of osteoporosis in women of 50 and over in this population combines an important overuse and, to a lesser extent, underuse, although the level of inappropriateness varied strikingly depending on the CPG used. It seems urgent to reduce treatment overuse without neglecting underuse, as is urgent an attempt to reach wider agreement…

The accuracy of osteoporotic fracture risk prediction tools: a systematic review and meta-analysis

Most of the 13 tools are feasible in clinical practice. FRAX has the largest number of externally validated and independent studies. The overall accuracy of the different tools is satisfactory (>0.70), with QFracture reaching 0.89 (95% CI 0.88 to 0.89). Significant methodological limitations were observed in many studies, suggesting caution when comparing tools based solely…

Serum 25-hydroxyvitamin D, parathyroid hormone, calcium intake, and bone mineral density in Spanish adults

Vitamin D insufficiency is very common among Spanish community-dwelling adult subjects. A threshold of serum 25(OH)D around 30 ng/ml would be necessary for the prevention of secondary hyperparathyroidism and hip bone loss in our population, regardless of the dairy calcium ingestion. Programs to improve vitamin D status may be required in our country.

Intestinal Calcium Absorption Decreases Dramatically After Gastric Bypass Surgery Despite Optimization of Vitamin D Status

J Bone Miner Res. 2015 Aug;30(8):1377-85. doi: 10.1002/jbmr.2467. Epub 2015 May 21. In conclusion, FCA decreased dramatically after RYGB, even with most 25OHD levels ≥30 ng/mL and with recommended Ca intake. RYGB patients may need high Ca intake to prevent perturbations in Ca homeostasis, although the approach to Ca supplementation needs further study. Decline in FCA…

Improving Osteoporosis Management in Primary Care: An Audit of the Impact of a Community Based Fracture Liaison Nurse

PLoS One. 2015 Aug 27;10(8):e0132146. doi: 10.1371/journal.pone.0132146. eCollection 2015. CONCLUSION: A fracture liaison nurse in primary care has been associated with a period of improved management. Liaison nurses based in different parts of the health system should be tested in a prospective trial Autor: Chant T, de Lusignan S, Cooper A, Elliott M, et al

Osteocytes and Homeostasis of Remote Organs : Bone-Buried Osteocytes Talk to Remote Organs

Curr Osteoporos Rep. 2015 Aug;13(4):193-7. doi: 10.1007/s11914-015-0269-9. The study of bones has attracted researchers from many medical fields. To understand bone-organ interactions, hematologists were challenged to investigate bone marrow (BM), the core of bone where hematopoiesis takes place. Through studies of the hematopoietic stem cells niche, hematologists contributed to the discovery of unexpected functions of…

RESOLUCIÓN Becas ASBMR 2015

Finalizado el plazo para el envío de solicitudes para acceder a las Becas FEIOMM para la presentación de trabajos en el Congreso de la ASBMR en Seattle del 9 al 12 de octubre de 2015, se adjunta la lista de solicitudes remitidas para su evaluación

Effects of Denosumab and Calcitriol on Severe Secondary Hyperparathyroidism in Dialysis Patients With Low Bone Mass

. J Clin Endocrinol Metab. 2015 Jul;100(7):2784-2792. Epub 2015 May 8 Denosumab allows for supra-physiologic doses of calcitriol resulting in decreased parathyroid secretion and parathyroid hyperplasia. Supervised administration and weekly laboratory and clinical monitoring of serum calcium are recommended during the first month to prevent hypocalcemia Autor: Chen CL, Chen NC, Liang HL, Hsu CY,…

Oral Calcidiol Is More Effective Than Cholecalciferol Supplementation to Reach Adequate 25(OH)D Levels in Patients with Autoimmune Diseases Chronically Treated with Low Doses of Glucocorticoids: A “Real-Life” Study

Patients with higher body mass index and those receiving higher doses of glucocorticoids are at increased risk of having lower levels of 25(OH)D. In these patients, calcidiol supplementations are more effective than cholecalciferol to reach adequate 25(OH)D levels.

Associations between frailty and serum N-terminal propeptide of type I procollagen and 25-hydroxyvitamin D in older Spanish women: The Toledo Study for Healthy Aging

After adjustment for confounders, high PINP levels (defined by the upper quartile) and low levels of 25(OH)D (lower quartile) remained significantly associated to frailty [OR for PINP: 2.19; OR for 25(OH)D: 1.65]. Women with both high PINP levels and low 25(OH)D levels presented a 5.85-fold increased frailty risk.

Convocatoria Becas Feiomm ASBMR 2015

FEIOMM convoca 5 BECAS para la presentación de trabajos científicos en ASBMR 2015 Annual Meeting (American Society for Bone and Mineral Research) que se celebrará en Seattle, Washington (USA) del 9 al 12 de octubre de 2015.FEIOMM convoca 5 BECAS para la presentación de trabajos científicos en ASBMR 2015 Annual Meeting (American Society for Bone…

Does Diet-Induced Weight Loss Lead to Bone Loss in Overweight or Obese Adults? A Systematic Review and Meta-Analysis of Clinical Trials

J Bone Miner Res 201530(12); 2168-2178. doi: 10.1002/jbmr.2564. Epub 2015 May 25. These data show that in overweight and obese individuals, a single diet-induced weight-loss intervention induces a small decrease in total hip BMD, but not lumbar spine BMD. This decrease is small in comparison to known metabolic benefits of losing excess weight. Autor: Zibellini…

Use of proton pump inhibitors is associated with fractures in young adults: a population-based study

Osteoporos Int 19 may 2015 on line. DOI 10.1007/s00198-015-3168-0 PPI use was associated with fracture in young adults, but overall evidence did not support a PPI-fracture relationship in children. Young adults who use PPIs should be cautioned regarding potentially increased risk for fracture, even if they lack traditional fracture risk factors. Autor: D. E. Freedberg,…

Co-administration of Antiresorptive and Anabolic Agents: A Missed Opportunity

J Bone Miner Res. 2015 May;30(5):753-64. doi: 10.1002/jbmr.2496. Combined therapy remains a potentially valuable approach to therapy. Because studies of antifracture efficacy comparing combined with single therapy are unlikely to be performed in humans, efforts should be directed toward improving methods of quantifying the net effects of combined therapy on bone’s material composition, microarchitecture, and…

Establishing Biomechanical Mechanisms in Mouse Models: Practical Guidelines for Systematically Evaluating Phenotypic Changes in the Diaphyses of Long Bones

Journal of Bone and Mineral Research 2015; Volume 30, Issue 6, pages 951–966 The goal of this review is to clarify the biomechanical mechanisms and to make recommendations for systematically evaluating phenotypic changes in mouse bones, with a focus on long-bone diaphyses and cortical bone. Further, minimum reportable standards for testing conditions and outcome variables…

Bisphosphonates for the prevention of fractures in osteogenesis imperfecta: meta-analysis of placebo-controlled trials

J Bone Miner Res. 2015 May;30(5):929-33. doi: 10.1002/jbmr.2410. We conclude that the effects of bisphosphonates on fracture prevention in osteogenesis imperfecta are inconclusive. Adequately powered trials with a fracture endpoint are needed to further investigate the risks and benefits of bisphosphonates in this condition. Autor: Hald JD, Evangelou E, Langdahl BL, Ralston SH.

The Effect of 6 versus 9 Years of Zoledronic Acid Treatment in Osteoporosis: A Randomized Second Extension to the HORIZON-Pivotal Fracture Trial (PFT)

J Bone Miner Res. 2015 May;30(5):934-44. doi: 10.1002/jbmr.2442. The results suggest almost all patients who have received six annual ZOL infusions can stop medication for up to 3 years with apparent maintenance of benefits. Autor: Black DM, Reid IR, Cauley JA, Cosman F, Leung PC, Lakatos P, Lippuner K, Cummings SR, Hue TF, Mukhopadhyay A,…

Inappropriate prescribing to the oldest old patients admitted to hospital: prevalence, most frequently used medicines, and associated factors

Prescribed medicines and potentially inappropriate medicines (PIM) and potentially prescribing omissions (PPO) prevalence were high among patients 85 years and over. Benzodiazepine use in those who are prone to falls and omission of calcium and vitamin D in those with osteoporosis were the most frequent PIM and PPO, respectively. Factors associated with PIM and PPO…

Estudio Dasio Resultados

Estudio Dasio Resultados

GRABACIÓN de la presentación del Estudio DASIO

El Estudio DASIO es un estudio multicéntrico, prospectivo y observacional que se ha llevado a cabo en cerca de 300 centros de salud de atención primaria en todo el territorio español.

Los objetivos del estudio han sido, en primer lugar, evaluar de la adherencia a las recomendaciones del profesional sanitario en mujeres osteoporóticos y la influencia de la incorporación de un lácteo fermentado enriquecido con calcio y vitamina D en la alimentación diaria sobre esta adherencia. Como objetivo secundario se fijo el evular la adherencia y la satisfacción al consumo diario del mismo. En tercer lugar, se analizaron los posibles cambios en las molestias gastrointestinales.

Efficacy and Safety of Single-Dose Zoledronic Acid for Osteoporosis in Frail Elderly Women: A Randomized Clinical Trial. J

JAMA Intern Med. Published online April 13, 2015. doi:10.1001/jamainternmed.2015.0747. In this group of frail elderly women with osteoporosis, 1 dose of zoledronic acid improved BMD over 2 years. The clinical importance of nonsignificant increases in fracture and mortality rates in the treatment group needs further study. Since it is not known whether such therapy reduces…

Osteoporosis Treatment and Fracture Outcomes

JAMA Intern Med. Published online April 13, 2015. doi:10.1001/jamainternmed.2015.0757 In this issue of JAMA Internal Medicine, Greenspan and colleagues1 present intriguing data on zoledronic acid, one of the most potent drugs in the bisphosphonate family—if not the most potent—approved for treatment of osteoporosis. In a study of frail elderly women living in nursing homes, the…

Screening for Osteoporosis

JAMA. 2015 Apr 14;313(14):1467-1468. doi: 10.1001/jama.2015.1064. This JAMA Clinical Guidelines Synopsis article summarizes the most recent National Osteoporosis Foundation guidelines on screening older men and postmenopausal women for osteoporosis. Autor: Altkorn D, Cifu AS.

Arterialized venous bicarbonate is associated with lower bone mineral density and an increased rate of bone loss in older men and women

J Clin Endocrinol Metab. 2015 Apr;100(4):1343-9. doi: 10.1210/jc.2014-4166. Epub 2015 Feb 2. Arterialized plasma HCO3 was associated positively with cross-sectional BMD and inversely with the rate of bone loss, implying that systemic acid-base status is an important determinant of skeletal health during aging. Ongoing bone loss was linearly related to arterialized HCO3, even after adjustment…

Bazedoxifene/conjugated estrogens combination for the treatment of the vasomotor symptoms associated with menopause and for prevention of osteoporosis in postmenopausal women

The tissue-selective estrogen complex (TSEC) combines bazedoxifene and conjugated estrogens and is designed not only to improve menopausal symptoms and vulvovaginal atrophy but also to prevent bone loss. Therefore, it maintains the benefits of estrogen therapy while antagonizing the stimulation effects on the endometrium and mammary gland without the effects associated with progestins.

Antiresorptives and anabolic therapy in sequence or combination for postmenopausal osteoporosis

Sequential antiresorptive therapy is recommended to maintain drug increases in bone mass and support secondary mineralization of the newly formed bone. Combination therapies of antiresorptives and anabolic agents have shown a significant increase in bone mineral density compared to monotherapies. However, none of the combinations have been studied for the prevention of fractures. Combination therapy…

Adjusting Fracture Probability by Trabecular Bone Score

Calcif Tissue Int (2015) 96:500–509 DOI 10.1007/s00223-015-9980-x They have demonstrated that lumbar spine texture analysis using TBS is a risk factor for osteoporotic fracture and also for risk of death. The predictive ability of TBS is independent of FRAX clinical risk factors and femoral neck BMD; finally we have derived an algorithm to adjust probability…

WNT5A Has Anti-Prostate Cancer Effects In Vitro and Reduces Tumor Growth in the Skeleton In Vivo

J Bone Miner Res. 2015 Mar;30(3):488-97- Using different osteotropic human prostate cancer cell lines, the influence of WNT5A overexpression and knock-down on proliferation, migration, and apoptosis was assessed. In vitro, WNT5A overexpression induced prostate cancer cell apoptosis and reduced proliferation and migration, whereas WNT5A knock-down showed opposite effects. In vivo, different xenograft models were used…

Connexin 43 channels are essential for normal bone structure and osteocyte viability

J Bone Miner Res. 2015 Mar;30(3):436-48. doi: 10.1002/jbmr.2374. These findings suggest that osteocytic Cx43 channels play distinctive roles in the bone; hemichannels play a dominant role in regulating osteocyte survival, endocortical bone resorption, and periosteal apposition, and gap junction communication is involved in the process of bone remodeling. Autor: Xu H, Gu S, Riquelme MA,…

The choice of normative pediatric reference database changes spine bone mineral density z-scores but not the relationship between bone mineral density and prevalent vertebral fractures

J Clin Endocrinol Metab. 2015 Mar;100(3):1018-27. doi: 10.1210/jc.2014-3096. Epub 2014 Dec 11. Although the use of a LSBMD Z-score threshold as part of the definition of osteoporosis in a child with VF does not appear valid, the study of relationships between BMD and VF is valid regardless of the BMD database that is used. Autor:…

A 7-year randomized, placebo-controlled trial assessing the long-term efficacy and safety of bazedoxifene in postmenopausal women with osteoporosis: effects on bone density and fracture

At 7 years, the cumulative incidences of new vertebral fractures were significantly lower in the bazedoxifene (6.4%) and bazedoxifene 20 mg (7.6%) groups than in the placebo group (9.9%); the relative risk reductions were 36.5% and 30.4%, respectively (both p < 0.001). Bazedoxifene had no effect on the overall incidence of nonvertebral fractures.

Low bone mineral density and fractures in stages 3-5 CKD: an updated systematic review and meta-analysis

Osteoporos Int. 2015 Feb;26(2):449-58. doi: 10.1007/s00198-014-2813-3 The meta-analysis indicates that BMD is low in predialysis and dialysis patients with fractures. These findings, considered together with the recent prospective study in CKD, and post hoc analyses of the pivotal fracture trials suggests that BMD may be clinically useful in assessing fracture risk in CKD, different than…

Increased risk of stroke among hip fracture patients: a nationwide cohort study

Osteoporos Int. 2015 Feb;26(2):645-52. doi: 10.1007/s00198-014-2919-7. Hip fracture is independently associated with increased risk of developing stroke. In addition, the risk of stroke following incidence of hip fracture is more prominent in younger patients, men, those with cardiovascular comor- bidities, and in patients using specific medication, such as diuretics and ABRs. Given the subsequent higher…

Timing of the initiation of bisphosphonates after surgery for fracture healing: a systematic review and meta-analysis of randomized controlled trials

Osteoporos Int. 2015 Feb;26(2):431-41. doi: 10.1007/s00198-014-2903-2. Epub 2014 Sep 30. Early administration of BPs after surgery did not appear to delay fracture healing time either radiologically or clinically. Furthermore, according to the changes in BMD and bone turnover markers, the anti-resorptive efficacy of BPs given immediately after surgical repair should positively affect the rate of…

COMPARISON BETWEEN DIFFERENT BONE TREATMENTS ON AREAL BONE MINERAL DENSITY (ABMD) AND BONE MICROARCHITECTURAL TEXTURE AS ASSESSED BY THE TRABECULAR BONE SCORE (TBS).

As expected, TBS of Naive subjects decreased with age. As expected a TBS preservation has been observed under Alendronate and Risedronate. Testosterone and Calcium and Vitamin D effects on TBS were evaluated for the first time: a similar preservation effect has been observed. A significant TBS increase was observed under Denosumab and PTH. TBS could…

Effect of recent spinal cord injury on Wnt signaling antagonists (sclerostin and Dkk-1) and their relationship with bone loss. A 12-month prospective study.

Short-term after spinal cord injury there is a marked increase in bone turnover and bone loss, the latter associated with an increase in Dkk-1 serum levels. The persistence of increased levels of this Wnt antagonist throughout the study and their relationship with the magnitude of bone loss suggests a contributory role of this mediator in…

Comparative Effects of Teriparatide, Denosumab, and Combination Therapy on Peripheral Compartmental Bone Density, Microarchitecture, and Estimated Strength: the DATA-HRpQCT Study

J Bone Miner Res. 2015 Jan;30(1):39-45. doi: 10.1002/jbmr.2315. Together, these findings suggest that the use of denosumab and teriparatide in combination improves HR-pQCT measures of bone quality more than either drug alone and may be of significant clinical benefit in the treatment of postmenopausal osteoporosis. Autor: Tsai JN, Uihlein AV, Burnett-Bowie SA, Neer RM, Zhu…

The effects of calcium supplementation on verified coronary heart disease hospitalization and death in postmenopausal women: a collaborative meta-analysis of randomized controlled trials

J Bone Miner Res. 2015 Jan;30(1):165-75. doi: 10.1002/jbmr.2311. In conclusion, current evidence does not support the hypothesis that calcium supplementation with or without vitamin D increases coronary heart disease or all-cause mortality risk in elderly women. Autor: Lewis JR,Radavelli-Bagatini S,Rejnmark L,ChenJS, SimpsonJM,Lappe JM,Mosekilde L,Prentice RL,PrinceRL

Erythropoietin directly stimulates osteoclast precursors and induces bone loss

FASEB J. 2015 Jan 28. pii: fj.14-259085. [Epub ahead of print] In summary, our findings demonstrate that EPO negatively regulates bone mass and thus bears significant clinical implications for the potential management of patients with endogenously or therapeutically elevated EPO levels. Autor: Hiram S,Liron T,Desher N,Mittelman M,Gassmann M,Rauner M,Franke K,Wielockx B,Neumann D,Gabet

DIAGNOSIS AND MANAGEMENT OF OSTEONECROSIS OF THE JAW: A SYSTEMATIC REVIEW AND INTERNATIONAL CONSENSUS

J Bone Miner Res. 2015 Jan;30(1):3-23. doi: 10.1002/jbmr.2405. Prevention strategies for ONJ include elimination or stabilization of oral disease prior to initiation of antiresorptive agents, as well as maintenance of good oral hygiene. In those patients at high risk for the development of ONJ, including cancer patients receiving high-dose BP or Dmab therapy, consideration should…

REFERENCE INTERVALS FOR BONE TURNOVER MARKERS AND THEIR ASSOCIATION WITH INCIDENT HIP FRACTURES IN OLDER MEN: THE HEALTH IN MEN STUDY

J Clin Endocrinol Metab. 2015 Jan;100(1):90-9. doi: 10.1210/jc.2014-2646. Reference intervals for BTMs in older men have been defined. tOC may be more informative for hip fracture risk in older men than CTX-I and PINP. Further studies are needed to clarify the utility of BTM reference intervals in the management of aging men at risk of…

OSTEOCYTES MEDIATE THE ANABOLIC ACTIONS OF CANONICAL Wnt/β-catenin SIGNALING IN BONE

Proc Natl Acad Sci U S A. 2015 Jan 20. pii: 201409857. Thus, activation of osteocytic β-catenin signaling increases both osteoclasts and osteoblasts, leading to bone gain, and is sufficient to activate the Notch pathway. These findings demonstrate disparate outcomes of β-catenin activation in osteocytes versus osteoblasts and identify osteocytes as central target cells of…

IS THERE ENOUGH EVIDENCE TO USE BISPHOSPHONATES IN HIV-INFECTED PATIENTS? A SYSTEMATIC REVIEW AND META-ANALYSIS.

In conclusion, administration of oral and intravenous bisphosphonates was associated with increased bone mineral density at the lumbar spine and total hip over two years in HIV-positive patients. However, none of the included trials were long enough to detect the impact of bisphosphonates on a clinically important outcome such as fracture risk.

SUBGROUP VARIATIONS IN BONE MINERAL DENSITY RESPONSE TO ZOLEDRONIC ACID AFTER HIP FRACTURE

J Bone Miner Res. 2014 Dec;29(12):2545-51. doi: 10.1002/jbmr.2283 Percentage change from baseline in TH and FN BMD at months 12 and 24 was greater (p < 0.05) in ZOL-treated patients compared with placebo in most subgroups. Treatment-by-subgroup interactions (p <  0.05) indicated that a greater effect on BMD was observed for TH BMD at month 12 in females,…

UNVEILING SKELETAL FRAGILITY IN PATIENTS DIAGNOSED WITH MGUS: NO LONGER A CONDITION OF UNDETERMINED SIGNIFICANCE?

J Bone Miner Res. 2014 Dec;29(12):2529-33. doi: 10.1002/jbmr.2387. Accordingly, this Perspective provides evidence that the “undetermined significance” portion of the MGUS acronym may be best replaced in favor of the term “monoclonal gammopathy of skeletal significance” (MGSS) in order to more accurately reflect the enhanced skeletal risks inherent in this condition. Autor: Drake MT.

Structural and Mechanical Repair of Diffuse Damage in Cortical Bone In Vivo

Journal of Bone and Mineral Research, Vol. 29, No. 12, December 2014, pp 2537–2544. doi: 10.1002/jbmr.2309. The studies found that diffuse matrix damage regions in living cortical bone undergo a direct microstructural and mechanically effective repair. The direct repair of these submicron-size cracks in living bone occurs without activating the bone remodeling that are needed…

Prediction of Incident Hip Fracture with the Estimated Femoral Strength by Finite Element Analysis of DXA Scans in the Study of Osteoporotic Fractures

Journal of Bone and Mineral Research, Volume 29, Issue 12, pages 2594–2600. doi: 10.1002/jbmr.2291. In conclusion, the estimated femoral strength from FE analysis of DXA scans is an independent predictor and performs at least as well as FN BMD in predicting incident hip fracture in postmenopausal women. Autor: Yang L,, Palermo L, Black DM, Eastell…

Secular trends in the incidence of primary hyperparathyroidism over five decades (1965–2010)

Bone 2014; 73:1-7. doi: 10.1016/j.bone.2014.12.003. Over time, two periods of increased PHPT incidence occurred, one beginning in 1974 (121.7 per 100,000 person-years) and a second peak (86.2 per 100,000 person-years) starting in 1998. The median age of PHPT subjects has increased significantly from 55 years in 1985–1997 to 60 years of age in 1998–2010 and more patients (36%) had…

IGF-1 and ADMA levels are inversely correlated in nondiabetic ankylosing spondylitis patients undergoing anti-TNF-alpha therapy.

An inverse correlation between IGF-1 levels and asymmetric dimethylarginine (ADMA), an endogenous endothelial nitric oxide synthase inhibitor that impairs nitric oxide production and secretion promoting endothelial dysfunction, was found. No significant association was found between IGF-1 and IGFBP-3 levels with angiopoietin-2, osteopontin, disease activity, systemic inflammation, metabolic syndrome features, or adipokines.

Acta Premio Joven Investigador 2014

El jurado, compuesto por los moderadores de las sesiones de comunicaciones orales y el Comité Científico del XIX Congreso de la SEIOMM ha otorgado el Premio al Joven Investigador, consistente en la financiación de los gastos de inscripción, viaje y alojamiento del próximo Congreso SEIOMM, Bilbao 2015 a: Araceli Muñoz Garach

Acta Premio Joven Investigador 2014

El jurado, compuesto por los moderadores de las sesiones de comunicaciones orales y el Comité Científico del XIX Congreso de la SEIOMM ha otorgado el Premio al Joven Investigador, consistente en la financiación de los gastos de inscripción, viaje y alojamiento del próximo Congreso SEIOMM, Bilbao 2015 a: Pablo Garmilla.

Gaucher disease and bone manifestations

Calcif Tissue Int. 2014 Dec;95(6):477-94. doi: 10.1007/s00223-014-9923-y We have conducted a systematic review of all the various aspects of Gaucher disease, focusing on different skeletal manifestations, pathophysiology of bone alterations, clinical symptoms, and current diagnostic and therapeutic approaches. Autor: 1. Marcucci G, Zimran A, Bembi B, Kanis J, Reginster JY, Rizzoli R, Cooper C, Brandi…

VII Edición de los Premios de EDUCACIÓN MÉDICA 2014

Cátedra de EDUCACIÓN MÉDICA Fundación Lilly-UCM Estimado/a  amigo/a: Además de invitarle a participar en la VII Edición de los Premios de EDUCACIÓN MÉDICA 2014, patrocinados por la Cátedra de EDUCACIÓN MÉDICA Fundación Lilly-UCM, le adjunto una carta del Director de la Cátedra, así como un cartel anunciador con las BASES de la convocatoria al que…

Literature review: The effects of teriparatide therapy at the hip in patients with osteoporosis

Bone 67; 246–256. doi: 10.1016/j.bone.2014.07.014. Epub 2014 Jul 15 Studies using dual-energy X-ray absorptiometry and quantitative computed tomography for longitudinal assessment of changes at the hip have consistently shown increases in areal and volumetric bone mineral density, cortical thickness, and finite element-estimated hip strength in patients treated with teriparatide. Finally, in clinical fracture-outcome trials, treatment…

THE CONVERGENCE OF FRACTURE REPAIR AND STEM CELLS: INTERPLAY OF GENES, AGING, ENVIRONMENTAL FACTORS AND DISEASE

J Bone Miner Res. 2014 Nov;29(11):2307-22. doi: 10.1002/jbmr.2373. Review studies of bone regeneration in genetically modified mouse models, during aging, following environmental exposure, and in the setting of disease that provide insights regarding the role of multipotent cells and their regulation during fracture repair. Complementary animal models and ongoing scientific discoveries define an increasing number…

CONSTITUTIVE EXPRESSION OF GSΑR201C IN MICE PRODUCES A HERITABLE, DIRECT REPLICA OF HUMAN FIBROUS DYSPLASIA BONE PATHOLOGY AND DEMONSTRATES ITS NATURAL HISTORY

J Bone Miner Res. 2014 Nov;29(11):2357-68. doi: 10.1002/jbmr.2267. As in humans, FD lesions in mice developed only in the postnatal life; a defined spatial and temporal pattern characterized the onset and progression of lesions across the skeleton. In individual bones, lesions developed through a sequence of three distinct histopathological stages: a primary modeling phase defined…

CALCIUM NEPHROLITHIASIS AND BONE DEMINERALIZATION: PATHOPHYSIOLOGY, DIAGNOSIS, AND MEDICAL MANAGEMENT.

Patients with recurrent calcium nephrolithiasis and fasting hypercalciuria have a higher incidence of osteopenia and osteoporosis. They present increased BTMs (mainly resorptive) and up to 30% have hypocitraturia and increased urinary calcium/citrate ratio (>0.25). Medical therapy is aimed at improving the dietary habits, prescribing combinations of potassium citrate, thiazides, and bisphosphonates, and correcting bone and…

ENDOCRINOLOGY IN PREGNANCY: BONE METABOLIC CHANGES DURING PREGNANCY: A PERIOD OF VULNERABILITY TO OSTEOPOROSIS AND FRACTURE.

Osteoporosis and fragility fracture have been diagnosed, although rarely. The condition, however, is transitory because there is no long-term data supporting the deleterious effect of pregnancy on bone mass or fracture risk. Prevention is limited by the lack of identifiable risk factors. When fractures are diagnosed, rest, analgesics, or when indicated, orthopedic intervention, have demonstrated…

THE ROLE OF DIETARY PROTEIN AND VITAMIN D IN MAINTAINING MUSCULOSKELETAL HEALTH IN POSTMENOPAUSAL WOMEN: A CONSENSUS STATEMENT FROM THE EUROPEAN SOCIETY FOR CLINICAL AND ECONOMIC ASPECTS OF OSTEOPOROSIS AND OSTEOARTHRITIS (ESCEO).

The European Society for Clinical and Economic Aspects of Osteoporosis and Osteoarthritis (ESCEO) recommends optimal dietary protein intake of 1.0-1.2g/kgbodyweight/d with at least 20-25g of high-quality protein at each main meal, with adequate vitamin D intake at 800IU/d to maintain serum 25-hydroxyvitamin D levels >50nmol/L as well as calcium intake of 1000mg/d, alongside regular physical…

MICROSTRUCTURAL TRABECULAR BONE FROM PATIENTS WITH OSTEOPOROTIC HIP FRACTURE OR OSTEOARTHRITIS: ITS RELATIONSHIP WITH BONE MINERAL DENSITY AND BONE REMODELLING MARKERS.

Bone turnover markers, BMD and bone microstructural changes in osteoporosis are opposite to those of OA. These findings justify a less resistant bone with higher risk of fragility fractures in OP patients. These histomorphometric and biomechanical changes may be suspected by measuring of BMD and β-CrossLaps levels.

IMPROVEMENT IN BONE MINERAL DENSITY AFTER SWITCHING FROM TENOFOVIR TO ABACAVIR IN HIV-1-INFECTED PATIENTS WITH LOW BONE MINERAL DENSITY: TWO-CENTRE RANDOMIZED PILOT STUDY (OSTEOTDF STUDY).

Switching from tenofovir to abacavir led to a slight improvement in femoral BMD although no differences were detected between groups. Larger studies are necessary before firm recommendations can be made on the discontinuation of tenofovir in patients with a low BMD.

PHARMACOGENOMICS OF OSTEOPOROTIC FRACTURES.

Although scarce data are available, interesting opportunities are open for a better understanding of the pharmacogenetics of osteoporosis and osteoporotic fractures. They include the reanalysis of data already available from epidemiological studies and clinical trials, as well as obtaining pharmacogenetic data in new studies. However, based upon the experience with previous genome-wide association studies, large…

CHANGES IN BONE MINERAL METABOLISM PARAMETERS, INCLUDING FGF23, AFTER DISCONTINUING CINACALCET AT KIDNEY TRANSPLANTATION.

We conclude that patients receiving cinacalcet on dialysis presented similar serum phosphate levels but higher PTH and serum calcium levels during the initial six months after kidney transplantation than cinacalcet non-treated patients. The group previously treated with cinacalcet before transplantation showed higher FGF23 levels without significant differences, so further studies should investigate its relevance in…

OSTEOCYTE-DERIVED RANKL IS A CRITICAL MEDIATOR OF THE INCREASED BONE RESORPTION CAUSED BY DIETARY CALCIUM DEFICIENCY

Bone. 2014 Sep;66:146-54 These results demonstrate that RANKL produced by osteocytes contributes to the increased bone resorption and the bone loss caused by secondary hyperparathyroidism, strengthening the evidence that osteocytes are an important target cell for hormonal control of bone remodeling Autor: Xiong J, Piemontese M, Thostenson JD, Weinstein RS, Manolagas SC, O’Brien CA.

BINDING KINETICS OF A FLUORESCENTLY LABELED BISPHOSPHONATE AS A TOOL FOR DYNAMIC MONITORING OF BONE MINERAL DEPOSITION IN VIVO

JBMR 2014; 29(9) 1993-2003 The results suggest monitoring binding kinetics based on fluorescently labeled bisphosphonates represents a highly sensitive, site-specific method for monitoring changes in bone mineral deposition with the potential for translation into human applications in osteoporosis and bone metastatic processes and their treatment Autor: Robert J Tower, Graeme M Campbell, Marc Müller, Olga…

Mineralisation of collagen rich soft tissues and osteocyte lacunae in Enpp1−/− mice

Bone. 2014 Sep 28;69C:139-147. doi: 10.1016/j.bone.2014.09.016. [Epub ahead of print] This study examined the role of NPP1 in osteocytes, osteoclasts and cortical bone, using a mouse model lacking NPP1 (Enpp1−/−) he cortical bone from Enpp1−/− mice was thinner and less porous, with a larger marrow space. Scanning electron microscopy (SEM) revealed a decrease in the…

Association of chronic obstructive pulmonary disease and smoking status with bone density and vertebral fractures in male lung cancer screening participants

J Bone Miner Res. 2014 Oct;29(10):2224-9. doi: 10.1002/jbmr.2248. In conclusion, our study shows that lung cancer screening participants have a substantial vertebral fracture burden. Fractures are more common in current smokers, who also have lower bone density. We could not confirm that COPD is independently associated with vertebral fractures. Autor: Jong WU1,Jong PA,Vliegenthart R,Isgum I,Lammers…

Reproducibility of results in preclinical studies: a perspective from the bone field

J Bone Miner Res. 2014 Oct;29(10):2131-40. doi: 10.1002/jbmr.2293 In this invited perspective, we highlight the magnitude of the problem across biomedical fields and address the relevance of these concerns to the field of bone and mineral metabolism. We also suggest how our specialty journals, our scientific organizations, and our community of bone and mineral researchers…

Osteocyte-derived RANKL is a critical mediator of the increased bone resorption caused by dietary calcium deficiency

Bone 2014;66:147-154 The results demonstrate that RANKL produced by osteocytes contributes to the increased bone resorption and the bone loss caused by secondary hyperparathyroidism, strengthening the evidence that osteocytes are an important target cell for hormonal control of bone remodeling. Autor: Xiong J, Piemontese M, Thostenson JD, Weinstein RS, Manolagas SC, O’Brien CA.

The fracture sites of atypical femoral fractures are associated with the weight-bearing lower limb alignment

Bone. 2014 Jun 14;66C:105-110. doi: 10.1016/j.bone.2014.06.008. [Epub ahead of print]. The femorotibial angle (FTA) of the patients with atypical diaphyseal femoral fracture were significantly larger compared to that of those with not only atypical subtrochanteric fractures (AFFs) but also typical femoral fractures (TFFs). In conclusion, the fracture sites of AFFs are associated with the standing…

Prevalence and predictors of low bone density and fragility fractures in women with systemic lupus erythematosus in a Mediterranean region.

Fragility fractures were seen in 4.4 % of SLE patients. All patients with fragility fractures showed osteopenia at BMD. There is a high prevalence of bone loss in SLE patients, since up to 46 % of SLE patients showed low BMD. Total hip and femoral neck osteopenia were the most frequent findings correlated with low…

Medical management of primary hyperparathyroidism: proceedings of the fourth International Workshop on the Management of Asymptomatic Primary Hyperparathyroidism

J Clin Endocrinol Metab. 2014 Oct;99(10):3607-18. doi: 10.1210/jc.2014-1417. Epub 2014 Aug 27 The recommended calcium intake in patients with PHPT should follow guidelines established for all individuals. It is not recommended to limit calcium intake in patients with PHPT who do not undergo surgery. Patients with low serum 25-hydroxyvitamin D should be repleted with doses…

Guidelines for the management of asymptomatic primary hyperparathyroidism: summary statement from the Fourth International Workshop

J Clin Endocrinol Metab. 2014 Oct;99(10):3561-9. doi: 10.1210/jc.2014-1413. Epub 2014 Aug 27. In view of new findings since the last International Workshop on the Management of Asymptomatic PHPT, guidelines for management have been revised. The revised guidelines include: 1) recommendations for more extensive evaluation of the skeletal and renal systems; 2) skeletal and/or renal involvement…

CLINICAL PRESENTATION OF PAGET’S DISEASE: EVALUATION OF A CONTEMPORARY COHORT AND SYSTEMATIC REVIEW

Calcif Tissue Int. 2014 Nov;95(5):385-92. doi: 10.1007/s00223-014-9904-1. Epub 2014 Aug 27. While changes in the mode of presentation of PDB have occurred over recent years, many patients present with complications such as fracture and deformity. Further research is required to determine if early detection and therapeutic intervention might be of value in preventing the morbidity…

Effects of eight-month treatment with ONO-5334, a cathepsin K inhibitor, on bone metabolism, strength and microstructure in ovariectomized cynomolgus monkeys

Bone. 2014 Apr 27;65C:1-8. doi: 10.1016/j.bone.2014.04.023. In microstructural analysis, alendronate suppressed OVX-induced increase in femoral mid-shaft osteonal bone formation rate (BFR) to a level below that recorded in the sham group, whereas ONO-5334 (Catepsin K inhibitor) at 30mg/kg did not suppress periosteal, osteonal and endocortical BFR. This finding supports the significant effect of ONO-5334 on…

Convocatoria Premios MEDES 2014

PREMIOS MEDES MEDICINA EN ESPAÑOL Los Premios MEDES se crearon para reconocer en el ámbito de los países de habla hispana aquellas iniciativas que favorecen la utilización del español en la comunicación del conocimiento de las ciencias de la salud en general y del conocimiento médico en particular, así como a las instituciones o entidades…

Convocatoria Premios MEDES 2014

PREMIOS MEDES MEDICINA EN ESPAÑOL. Los Premios MEDES se crearon para reconocer en el ámbito de los países de habla hispana aquellas iniciativas que favorecen la utilización del español en la comunicación del conocimiento de las ciencias de la salud en general y del conocimiento médico en particular, así como a las instituciones o entidades…

AYUDAS FUNDACIÓN BBVA A PROYECTOS DE INVESTIGACIÓN

El apoyo continuado de la Fundación BBVA a la promoción de la ciencia básica se complementa con esta convocatoria de ayudas dirigida a la realización de proyectos de naturaleza aplicada, en una selección de áreas de actuación preferente de la Fundación BBVA: Biomedicina, Ecología y Biología de la Conservación y Socioeconomía.

En el área de Biomedicina, las ayudas irán destinadas a proyectos de investigación de naturaleza clínica y traslacional, preferentemente en Oncología, Cardiología y el abordaje multidisciplinar de las enfermedades neurodegenerativas.

Five Freely Circulating miRNAs and Bone Tissue miRNAs Are Associated With Osteoporotic Fractures

J Bone Miner Res. 2014; 29: 1715‒1717. doi: 10.1002/jbmr.2175. In conclusion, this study profiled serum miRNAs in osteoporosis and identified 9 miRNAs highly associated with osteoporosis in blood serum. In bone tissue, 6 differentially expressed miRNAs were detectable. Five of these were simultaneously upregulated in the serum samples. Those 5 identified, significantly upregulated circulating miRNAs…

Inflammatory factors in the circulation of patients with active rheumatoid arthritis stimulate osteoclastogenesis via endogenous cytokine production by osteoblasts

Osteoporos Int 2014; Oct;25(10):2453-63. doi: 10.1007/s00198-014-2779-1. Epub 2014 Jul 16 The combination of cytokines present in serum of RA patients with active disease might contribute to bone loss by directly inhibiting osteoblast proliferation and differentiation, but especially by enhancing endogenous cyto- kine (i.e., RANKL and IL-6) production by osteoblasts, there- by stimulating osteoclastogenesis. Autor: Pathak…

RECONSIDERATION OF THE RELEVANCE OF MILD WEDGE OR SHORT VERTEBRAL HEIGHT DEFORMITIES ACROSS A BROAD AGE DISTRIBUTION

Osteoporos Int. 2014 Nov;25(11):2609-15. doi: 10.1007/s00198-014-2801-7. Epub 2014 Jul 29. The study demonstrates that mild or wedged vertebral shape changes are rare among younger subjects, suggesting that when these radiographic abnormalities are seen among older adults, they are less likely to be due to normal variation in vertebral body shape or congenital deformities. In light…

ADHERENCE TO MEDITERRANEAN DIET AND BONE HEALTH.

A limited number of studies have examined the relationship between Mediterranean Diet and bone health, and they have reported conflicting results. On the one hand, adherence to a traditional MeDi has been associated with higher bone mineral density and lower fracture risk. The results of these studies could be attributed to the combined beneficial effects…

Osteocyte control of bone remodeling: is sclerostin a key molecular coordinator of the balanced bone resorption–formation cycles?

Osteoporosis International 2014; 25: 2685-2700. doi: 10.1002/biof.1186. The osteocyte network plays a central role in directing bone response either to mechanical loading, or to unloading, leading correspondingly to bone formation or resorption. This review shows a key role of the osteocyte-produced sclerostin as a major mediator of the molecular mechanisms involved in the process of…

Laboratory Abnormalities in CKD-MBD: Markers, Predictors, or Mediators of Disease?

This review summarizes the complex pathophysiology of CKD-MBD and outlines which laboratory abnormalities represent biomarkers of disease severity, which laboratory abnormalities are predictors of cardiovascular disease, and which laboratory abnormalities should be considered (direct) uremic toxins exerting organ damage. This information may help to streamline current and future therapeutic efforts.

Regulatory authorities and orthopaedic clinical trials on expanded mesenchymal stem cells.

To further foster this research, the pathway to eventually obtain authorisation from the National Competent Authorities and Research Ethics Committees under the European regulation is reviewed, and the experience of the REBORNE European project offers information and important clues about the current Voluntary Harmonization Procedure and other opportunities that need to be considered by surgeons…

Bone metabolism and adipokines: are there perspectives for bone diseases drug discovery?

There are currently substantial developments being made in the understanding of the interplay between bone metabolism and the metabolic system. These insights could potentially lead to the development of new treatment strategies and interventions with the aim of successful outcomes in many people affected by bone disorders. Specifically, future research should look into the intimate…

Bone: a new endocrine organ at the heart of chronic kidney disease and mineral and bone disorders.

Osteocalcin, produced by osteoblasts or released from mineralised bone, interferes with insulin concentrations and sensitivity, and its metabolism is disturbed in kidney disease. These bone-derived humoral factors might place the bone at the centre of cardiovascular disease associated with chronic kidney disease. Most importantly, factors that dictate the regulation of these substances in bone and…

Comparing Bone Microarchitecture by Trabecular Bone Score (TBS) in Caucasian American Women with and Without Osteoporotic Fractures

Calcif Tissue Int. 2014 Sep;95(3):201-8. doi: 10.1007/s00223-014-9882-3. Epub 2014 Jun 20. After adjusting for age, weight, BMD, smoking, and maternal and family history of fracture, TBS (but not BMD) remained a significant predictor of fracture: OR 1.28[1.13–1.46] even after adjustment. In a US female population, TBS again was able to discriminate between those with and…

Biochemical markers of bone turnover in diabetes patients-a meta-analysis, and a methodological study on the effects of glucose on bone markers

Osteoporos Int. 2014 Jun 25(6):1697-708. doi: 10.1007/s00198-014-2676-7. In conclusion, we found that diabetes patients have a different bone turnover than non-diabetes patients and the differences in bone turnover are enhanced at menopause. The results from this meta-analysis underscore the need to conduct more re- search within the assessment of fracture risk using bone markers in…

Clinical and Radiographic Findings in Adults With Persistent Hypophosphatasemia

J Bone Miner Res 2014; 29:1651-1660. The clinical and radiographic findings of adult patients with persistent hypophosphatasemia resemble those of the adult form of hypophosphatasia. Clinicians should take notice of persistent hypophosphatasemia, consider the diagnosis of hypophosphatasia, and be cautious when considering potent anti-remodeling therapy in these adults. This population warrants further evaluation. Autor: McKiernan…

Bone metabolism after bariatric surgery

J Bone Miner Res. 2014 Jul;29(7):1507-18. doi: 10.1002/jbmr.2226. Bariatric surgery is a popular and effective treatment for severe obesity but may have negative effects on the skeleton. This review summarizes changes in bone density and bone metabolism from animal and clinical studies of bariatric surgery, with specific attention to Roux-en-Y gastric bypass (RYGB), adjustable gastric…

EMAS position statement: The management of postmenopausal women with vertebral osteoporotic fracture.

The management of women with osteoporotic vertebral fractures includes measures to reduce pain providing early mobility, to support the affected spine ensuring fracture healing, as well as starting treatment for osteoporosis itself. Any other underlying pathology should be sought and treated. Early detection and treatment is essential as there is an increased risk of further…

Osteoblast-derived microvesicles: A novel mechanism for communication between osteoblasts and osteoclasts

Bone. 2015 May 24;79:37-42. doi: 10.1016/j.bone.2015.05.022. [Epub ahead of print] The maintenance of bone homeostasis is largely dependent upon cellular communication between osteoclasts and osteoblasts. Microvesicles (MVs) have received a good deal of attention and are increasingly considered as mediators of intercellular communication due to their capacity to merge with and transfer a repertoire of…

Effect of vitamin D3 on asthma treatment failures in adults with symptomatic asthma and lower vitamin D levels: the VIDA randomized clinical trial

JAMA. 2014 May 28;311(20):2083-91. doi: 10.1001/jama.2014.5052. Vitamin D3 did not reduce the rate of first treatment failure or exacerbation in adults with persistent asthma and vitamin D insufficiency. These findings do not support a strategy of therapeutic vitamin D3 supplementation in patients with symptomatic asthma. Autor: Castro M, King TS, Kunselman SJ, Cact.ana MD, Denlinger…

Bone Density and Bone Turnover Marker Monitoring After Discontinuation of Alendronate Therapy: An Evidence-Based Decision to Do Less

JAMA Intern Med. 2014 May 5. doi: 10.1001/jamainternmed.2014.162. [Epub ahead of print] The clinical utility of medication monitoring has been a controversial issue in osteoporosis management. In the 1998 and 20012 coverage rules commonly called the “Bone Mass Measurement Act,” the Centers for Medicare & Medicaid Services (CMS) outlined provisions for bone mineral density (BMD)…

Low iron status as a factor of increased bone resorption and effects of an iron and vitamin D-fortified skimmed milk on bone remodelling in young Spanish women.

Iron deficiency is related with higher bone resorption in young women. Consumption of a dairy product that supplies 5 μg/day of vitamin D3 reduces bone turnover and increases circulating 25OHD to nearly reach an optimal vitamin D status, defined as 25OHD over 75 nmol/L. Autor: Toxqui L, Pérez-Granados AM, Blanco-Rojo R, Wright I, de la Piedra…

Bone turnover markers in patients with prostate carcinoma: influence of sex steroids levels.

In patients with prostate carcinoma, estrogen levels influence bone resorption and bone formation whereas androgens may exert actions only in bone resorption. These results suggest that estradiol is the main sex steroid that regulates bone metabolism in males with prostate carcinoma. Autor: Varsavsky M, Reyes-García R, García-Martín A, Rozas-Moreno P, González-Ramírez R, Muñoz-Torres M.

The effect of five proteins on stem cells used for osteoblast differentiation and proliferation: a current review of the literature.

Bone-tissue engineering is a therapeutic target in the field of dental implant and orthopedic surgery. It is therefore essential to find a microenvironment that enhances the growth and differentiation of osteoblasts both from mesenchymal stem cells (MSCs) and those derived from dental pulp. The aim of this review is to determine the relationship among the…

Lysophosphatidic acid receptor inhibition as a new multipronged treatment for rheumatoid arthritis.

Pharmacological inhibition of LPA1 receptor in the K/BxN serum-transfer arthritis model led to reduction of severity of arthritis involving multiple mechanisms, increased apoptosis, reduced inflammatory mediators and proteins involved in bone remodelling, that show LPA1 as a very promising target in rheumatoid arthritis treatment. Autor: Orosa B, García S, Martínez P, González A, Gómez-Reino JJ, Conde…

Hip fracture in three elderly populations of central Spain: data from the NEDICES study.

Self-reported hip fracture is a common condition among community-living elderly population in Spain, and has a significant impact upon long-term all-cause mortality. There is a paucity of data concerning the specific associations between hip fracture in the elderly and other age-related conditions, as well as its impact on long-term survival. Autor: Fernández-Ruiz M, Guerra-Vales JM,…

Sclerostin serum levels in prostate cancer patients and their relationship with sex steroids.

Circulating sclerostin levels are significantly increased in patients with prostate cancer and particularly in those receiving androgen deprivation therapy. The inverse relationship between serum sclerostin and testosterone in these patients suggests that androgens are key regulators of bone metabolism in this population. Autor: García-Fontana B, Morales-Santana S, Varsavsky M, García-Martín A,…

Retinoic acid differentially affects in vitro proliferation, differentiation and mineralization of two fish bone-derived cell lines: different gene expression of nuclear receptors and ECM proteins.

Our results show: (i) retinoic acid affects proliferative and mineralogenic activities in two fish skeletal cell types and (ii) that during phenotype transitions, specific retinoic acid nuclear receptors and bone-related genes are differentially expressed in a cell type-dependent manner. Autor: Fernández I, Tiago DM, Laizé V, Leonor Cancela M, Gisbert E.

Association of matrix Gla protein gene functional polymorphisms with loss of bone mineral density and progression of aortic calcification.

The results suggest that matrix Gla protein genetic variations could predict a higher risk of bone loss and progression of vascular calcification in men. Two matrix Gla protein (MGP) polymorphisms were associated with progression of aortic calcification and femoral neck bone loss in men. All these findings were also functionally corroborated in two vascular and…

Calcific periarthritis as the only clinical manifestation of hypophosphatasia in middle-aged sisters.

Multiple juxta-articular deposits of hydroxyapatite causing calcific periarthritis may be a useful sign of hypophosphatasia, especially when the calcific periarthritis is familial. ypophosphatasia (HPP) is the inborn error of metabolism that features low serum alkaline phosphatase (ALP) activity caused by loss-of-function mutation(s) within the gene for the tissue nonspecific isoenzyme of ALP (TNSALP). In HPP,…

Use of an educational support program to assist patients receiving injectable osteoporosis treatment: experience with teriparatide.

The results show that patients from all provinces in Spain with severe osteoporosis receiving teriparatide and enrolled in an educational support program had high persistence and satisfaction with the program. However, no control group was included in these analyses and it is possible that selection bias occurred. It is suggested that patient-based strategies similar to…

Prevalence of causes of secondary osteoporosis and contribution to lower bone mineral density in HIV-infected patients.

A high prevalence of secondary causes of osteoporosis is observed in HIV-infected patients, and its type and cumulative number determine a lower BMD, after adjusting by age and body mass index. Eighty-one percent of human immunodeficiency virus (HIV)-infected patients had one or more of seven evaluated causes of secondary osteoporosis, and this rate increases with…

Bone mineral density status and frequency of osteoporosis and clinical fractures in 155 patients with psoriatic arthritis followed in a university hospital.

The magnitude of the problem of osteoporosis in psoriatic arthritis seems to be mild. To assess the bone mineral density (BMD) and the frequency of osteoporosis and clinical fractures in a large group of Spanish patients with psoriatic arthritis (PsA). Autor: Busquets N, Vaquero CG2, Moreno JR, Vilaseca DR, Narváez J, Carmona L4, Nolla JM.

An OA phenotype may obtain major benefit from bone-acting agents.

A particular subset of postmenopausal patients with high remodeling and/or low subchondral bone density may benefit from the treatment with bone-acting agents hindering OA progression. This OA population could be identified with the simultaneous use of subchondral bone dual-energy X-ray absorptiometry and scintigraphy. Autor: Roman-Blas JA, Castañeda S, Largo R, Lems WF, Herrero-Beaumont G.

Prevalence of osteoporosis, vertebral fractures and hypovitaminosis D in postmenopausal women living in a rural environment.

In our study, postmenopausal women who live in rural populations have more poverty, lower values of vitamin D, lower BMD in the lumbar spine and a higher prevalence of vertebral fractures and of osteoporosis. The higher prevalence of obesity, arterial hypertension and diabetes mellitus observed in these women may be adjuvant factors, all fostered by…

The role of wnt signaling and sclerostin in the pathogenesis of glucocorticoid-induced osteoporosis.

This review describes the most recent data on the effects of glucocorticoids on the Wnt signaling pathway, especially on their antagonists, sclerostin and Dkk-1. Bone formation is suppressed in glucocorticoid-induced osteoporosis. One of the mechanisms by which glucocorticoids depress bone formation is through their effects on the Wnt/β-catenin signaling pathway, a critical regulator of osteoblastogenesis….

Empirically Based Composite Fracture Prediction Model from the Global Longitudinal Study of Osteoporosis in Postmenopausal Women (GLOW).

After examining results for 10 different bone fracture sites, advanced age appeared the single best possibility for uniting several different sites, resulting in an empirically based composite fracture risk model. Several fracture prediction models that combine fractures at different sites into a composite outcome are in current use. However, to the extent individual fracture sites…

Replication study of three functional polymorphisms associated with bone mineral density in a cohort of Spanish women.

Gene candidate and genome-wide association studies have revealed tens of loci of susceptibility for osteoporosis. The results underscore the significance of the LRP5 gene in bone metabolism and emphasize the significance of the replication of previous results in independent cohorts. Autor: Panach L, Mifsut D, Tarín JJ, Cano A, García-Pérez MA.

Effects of arachidonic acid on the concentration of hydroxyeicosatetraenoic acids in culture media of mesenchymal stromal cells differentiating into adipocytes or osteoblasts.

The results highlight the PUFA metabolism differences between uninduced and induced MSC to differentiate into adipocytes and osteoblasts, besides the relevant role of the lipoxygenase gene expression in adipogenesis induction. Autor: Casado-Díaz A, Ferreiro-Vera C, Priego-Capote F, Dorado G, Luque-de-Castro MD, Quesada-Gómez JM.

Association of Simvastatin and Hyperlipidemia with Periodontal Status and Bone Metabolism Markers.

Within the limits of this study, our findings suggest that the intake of simvastatin is associated with increasing serum OPG concentrations and this could have a protective effect against bone destruction and periodontal clinical attachment loss. The baseline systemic inflammatory state of hyperlipidemic patients is indicated by their increased erythrocyte sedimentation rate. Autor: Magán-Fernández A,…

Prevalence of vertebral fractures and minor vertebral deformities evaluated by DXA-assisted vertebral fracture assessment (VFA) in a population-based study of postmenopausal women: the FRODOS study.

Although the VFA approach showed a lower than expected prevalence of VF in our cohort, its association with clinical and densitometric parameters may be useful to identify women at risk for developing fragility fractures and may therefore justify its use in longitudinal studies. The high prevalence of minor vertebral deformities detected in patients with VF…

Alternative treatments for oral bisphosphonate-related osteonecrosis of the jaws: A pilot study comparing fibrin rich in growth factors and teriparatide.

In our series, the plasma rich in growth factors showed better results than the teriparatide in the treatment of recurrent oral bisphosphonate-related osteonecrosis. The aim of this study is to describe and compare the evolution of recurrent bisphosphonate-related osteonecrosis of the jaws (BRONJ) in patients treated with plasma rich in growth factors or teriparatide. Material…

Bone mass behavior after 1 year of different treatment strategies in prostate cancer patients subjected to androgen deprivation therapy.

Denosumab increased significantly bone mass in all three dual X-ray absorptiometry standard sites, while alendronate did not at total hip. No benefit was observed in men previously treated with alendronate who switched to denosumab treatment. Autor: Planas Morin J, Celma Domenech A, Placer Santos J, Trilla Herrera E, Salvador Lacambra C,…

Comparative effects of gastric bypass and sleeve gastrectomy on plasma osteopontin concentrations in humans.

Roux-en-Y gastric bypass increased circulating osteopontin levels, while they remained unaltered after sleeve gastrectomy. The increase in osteopontin levels after Roux-en-Y gastric bypass could be related to the increased bone resorption in relation to its well-known effects on bone of this malabsorptive procedure in comparison to the merely restrictive sleeve gastrectomy. Autor: Lancha A1, Moncada…

Bone mineral density and bone turnover in non-cirrhotic patients with chronic hepatitis C and sustained virological response to antiviral therapy with peginterferon-alfa and ribavirin.

Patients with chronic hepatitis C have low bone mass associated with increased bone resorption, and some relationship can be expected between serum aminotransferase levels and the degree of bone mass loss. Bone mass may be improved and bone turnover normalized in patients who respond to antiviral therapy. Elevated serum sTRFR-55 levels may play a role…

The relationship between proton pump inhibitor adherence and fracture risk in the elderly

Calcif Tissue Int. 2014 Jun;94(6):597-607. doi: 10.1007/s00223-014-9855-6. Epub 2014 Apr 6. These results provide further evidence that PPI use may increase fracture risk in the elderly and highlight the need for clinicians to periodically reassess elderly patients’ individualized needs for ongoing PPI therapy, while weighing potential risks and benefits Autor: Ding J, Heller DA, Ahern…

THE OSTEOBLAST TO OSTEOCYTE TRANSITION: EPIGENETIC CHANGES AND RESPONSE TO THE VITAMIN D3 HORMONE

Mol Endocrinol. 2014 Jul;28(7):1150-65 We conclude that osteocytogenesis is accompanied by changes in gene expression that may be driven by both genetic and epigenetic components. These changes are likely responsible for the osteocyte phenotype and may contribute to reduced sensitivity to 1,25(OH)(2)D(3). Autor: St John HC, Bishop KA, Meyer MB, Benkusky NA, Leng N, Kendziorski…

Leukaemogenesis induced by an activating β-catenin mutation in osteoblasts

Nature. 2014 Feb 13;506(7487):240-4. doi: 10.1038/nature12883. Epub 2014 Jan 15 These findings demonstrate that genetic alterations in osteoblasts can induce acute myeloid leukaemia, identify molecular signals leading to this transformation and suggest a potential novel pharmacotherapeutic approach to acute myeloid leukaemia. Autor: Kode A, Manavalan JS, Mosialou I, Bhagat G, Rathinam CV, Luo N, Khiabanian…

The Effects of 3 Years of Calcium Supplementation on Common Carotid Artery Intimal Medial Thickness and Carotid Atherosclerosis in Older Women: An Ancillary Study of the CAIFOS Randomized Controlled Trial

In conclusion, our study does not support the hypothesis that calcium supplementation increases either carotid artery intimal medial thickness or carotid atherosclerosis. In addition, calcium supplementation and high total calcium intake may indeed reduce carotid atherosclerosis. Autor: Joshua R Lewis, Kun Zhu, Peter L Thompson and Richard L Prince

MHC Class II Transactivator Is an In Vivo Regulator of Osteoclast Differentiation and Bone Homeostasis Co-opted From Adaptive Immunity

In conclusion, despite the huge impact of osteoporosis worldwide, our knowledge of bone genetics and biology remains remarkably incomplete. Our findings and models provide compelling genetic evidence of a novel molecular network regulating adult skeletal homeostasis in vivo, which may help identify new specific therapeutic targets against involution- al, inflammatory, or cancer‐induced bone wasting. Autor:…

Trabecular Bone Score: A Noninvasive Analytical Method Based Upon the DXA Image

The trabecular bone score (TBS) is a gray‐level textural metric that can be extracted from the two‐dimensional lumbar spine dual‐energy X‐ray absorptiometry (DXA) image. TBS is related to bone microarchitecture and provides skeletal information that is not captured from the standard bone mineral density (BMD) measurement. Based on these data, lumbar spine TBS holds promise…

Bone-specific insulin resistance disrupts whole-body glucose homeostasis via decreased osteocalcin activation

J Clin Invest. 2014 Apr 1;124(4):1-13. doi: 10.1172/JCI72323. Epub 2014 Mar 18. Together, these results underscore the involvement of bone, among other tissues, in the disruption of whole-body glucose homeostasis resulting from a HFD and the involvement of insulin and osteocalcin cross-talk in glucose intolerance. Furthermore, our data indicate that insulin resistance develops in bone…

Reversing LRP5-Dependent Osteoporosis and SOST Deficiency–Induced Sclerosing Bone Disorders by Altering WNT Signaling Activity

In conclusion, our data highlight the potential for novel drug targeting approaches in rare skeletal disorders ranging from severe skeletal fragility to sclerosing bone overgrowth through selective modulation of canonical WNT signaling. These approaches should also be beneficial in the context of other medical conditions with much less severe phenotypes, such as postmenopausal osteoporosis, given…

Modulation of Strain-Specific Differences in Gene Expression by Cannabinoid Type 2 Receptor Deficiency

Calcified Tissue International (2014) 94:4: 423-432 They conclude that Cnr2 deficiency affects expression of a large number of genes in different strains of mice, and that these differences are likely to be responsible in part for the differences in skeletal phenotype that they and others have observed in mice with defective cannabinoid receptor signalling in…

Comparative gastrointestinal safety of bisphosphonates in primary osteoporosis: a network meta-analysis

Osteoporos Int (2014) 25:1225–1235 This is the first network meta-analysis to assess the comparative GI safety of bisphosphonates for primary osteoporosis. Our results identify zoledronic acid as having the highest probability of having the greatest number of GI adverse events and nausea. Discontinuation due to adverse events may be a more clinically relevant outcome, with…

Rueda de prensa DIA MUNDIAL DE LA OSTEOPOROSIS

Con motivo de la celebración Intervenciones de: Dr. Manuel Díaz Curiel, Presidente FHOEMO. Incidencia de la Osteoporosis y análisis de su máxima consecuencia, la fractura osteoporótica. Dr. Javier del Pino, Presidente SEIOMM. Impacto Económico de la Osteoporosis en el Sistema Nacional de Salud. Dra. Carmen Sánchez Chicharro. Calidad de Vida del paciente con Osteoporosis.

Resolución 2ª Becas ASBMR 2013

Finalizado el plazo con fecha 06 de Septiembre de 2013 a las 12:00 A.M., para el envío de solicitudes se adjunta la lista de solicitantes admitidos y excluidos para su evaluación.El Comité Científico considera que todos los trabajos presentados han tenido un alto interés científico y dado que el nº de solicitantes es menor al…

Premiado Jesús Delgado-Calle Socio de la SEIOMM y Joven Investigador

Felicitaciones a nuestro 2013 Sevgi y Gideon Rodan Fellowship Winner

El Comité de Premios IBMS revisó las solicitudes pendientes que hemos recibido para el Rodan Fellowship 2013. Jesús Delgado-Calle obtuvo su Ph.D. en 2012 por la Universidad de Cantabria, España. Ha publicado 11 artículos (8 como primer autor) en revistas como Bone, JBMR, CTI y AJP. Más recientemente, se ha estado trabajando en un programa de post-doctorado en la Escuela de Medicina de la Universidad de Indiana.

Nationwide registry- based analysis of cardiovascular risk factors and adverse outcomes in patients treated with stronium ranelate

In conclusion, baseline cardiovascular diseases are common in patients treated with strontium ranelate, with more than half of strontium ranelate users being current users of antiplatelet drugs or having a history of cerebrovascular disease, peripheral vascular disease or myocardial infarction. Moreover, this observational study shows an increased confounder-adjusted mortality risk in patients treated with strontium ranelate…

Huesos artificiales mediante células madres y carbón

Científicos españoles han patentado un nuevo biomaterial para desarrollar tejido óseo, conocido como huesos artificiales, a partir de células madre procedentes de cordón umbilical. Este material consiste en una tela de carbón activado sobre la que se soportan y se diferencian las células dando origen a un producto capaz de promover el crecimiento del hueso….

Dr. Neyro intervino como invitado especial en el programa “En buenas manos”

Dentro de su labor de divulgación sanitaria de la que este web es un buen ejemplo, el Dr. Neyro intervino como invitado especial en el programa “En buenas manos”

Dentro de su labor de divulgación sanitaria de la que este web es un buen ejemplo, el Dr. Neyro intervino como invitado especial en el programa “En buenas manos” que presenta y dirige el afamado divulgador sanitario Dr. Bartolomé Beltrán, el pasado sábado 22 de junio de 2013.

Expertos ISFR-IOF proponen medidas estandarizadas de los resultados clínicos de las fracturas de muñ

Siete principales recomendaciones hechas; consenso internacional podría beneficiarse enormemente la práctica clínica y el diseño del estudio en la investigación fractura de radio distal

Fracturas del radio distal (muñeca a menudo simplemente llamado o fracturas de Colles) son los segundos más común de fracturas en los ancianos. Más allá del impacto inmediato en el paciente, las fracturas de muñeca en los adultos mayores a menudo indican la osteoporosis subyacente y alto riesgo de posteriores fracturas por fragilidad.

ISFR-IOF experts propose standardized measurements of clinical outcomes in wrist fractures

Seven core recommendations made; international consensus could immensely benefit clinical practice and study design in distal radius fracture

Distal radius fractures (often simply termed wrist or Colles’ fractures) are the second most common fractures in the elderly. Beyond the immediate impact on the patient, wrist fractures in older adults often indicate underlying osteoporosis and high risk of subsequent fragility fractures.

Despite their clinical significance, evidence-based practice and clinical research on wrist fractures are hampered by the lack of standardized methods of outcome measurement. A new publication* by the Distal Radius Working Group of the International Society for Fracture Repair (ISFR) and the International Osteoporosis Foundation (IOF) makes important new recommendations in an effort to promote international consensus.

“In regard to distal radius fractures there is currently no agreed-upon definition of what should be measured in a clinical trial. As a result, researchers are faced with heterogeneous information – a serious barrier to high-quality research in the evaluation of outcomes or definition of intervention thresholds,” said Dr. Jörg Goldhahn, Lecturer at the Institute for Biomechanics of the Swiss Federal Institute of Technology (ETH), Zurich and President-Elect of the ISFR.

The IOF-ISFR Working Group used a methodological approach to arrive at a comprehensive foundation of content for outcomes. The absence of pain and restoration of function was agreed as the common treatment goals and foci for clinical measures. There was also a consensus that symptom and function should be measured as separate domains in the WHO International Classification of Functioning, Disability and Health (ICF)

The impact of osteoporosis prevention programs on calcium intake: a systematic review

Froedtert Healthcare, Patient Care Services, Milwaukee, WI, USA, ryanpa@uwm.edu. Ryan P, Schlidt A, Ryan C Froedtert Healthcare, Patient Care Services, Milwaukee, WI, USA, ryanpa@uwm.edu. Osteoporosis International : a Journal Established as Result of Cooperation Between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA [2013] Autor: Journal Established as Result of…

ERA-EDTA Award for outstanding contributions to ERA-EDTA

Jorge B. Cannata-Andia is the recipient of the 2013 ERA-EDTA award for contributions to ERA-EDTA.

He became a member of ERA-EDTA in 1982 and served his first term in the Council of the Association from 1993 to 1997 as an ordinary Council member. In 2002, he became Secretary-Treasurer till 2005, after which he became President up to 2008.

In his first term he collaborated with Jacques Bernheim on the successful re-launching of the ERA-EDTA Registry by making a number of adaptations according to the new needs and objectives of the Association. His main contributions, however, came during the periods he was Secretary-Treasurer and President. He played a crucial role in many of the Society’s activities such as making the ERA-EDTA administrative offices versatile and flexible to deal with all aspects of the Society, the creation of “Follow us”, setting up Post-Congress Council Meetings and creating the title of “Chairperson of the Administrative Offices”.
Thanks to his initiative the ERA-EDTA started supporting collaborative clinical trials and observational studies, as well as supporting translational research projects. Furthermore, during his terms as an Officer in the ERA-EDTA Council, he played a crucial role in improving or initiating a number of scientific and educative activities such as increasing the number of CME Courses, the launch of Fellowship Programs in 2006, the creation of NDT-Educational in 2004 and NDT-Plus in 2008, the installation of the first Scientific Advisory Board (SAB) in 2006, the establishment of ERA-EDTA Registry Courses in 2005 and starting lobbying for financial support for the QUEST project, and, now, thanks to this amount kept aside the ERA-EDTA has been able to finance the EQUAL project. In 2006 the ERA-EDTA Registry obtained, for the first time in the ERA-EDTA history, funds from the European Union for a project called “NephroQUEST” led by Carmine Zoccali and Kitty Jager. He was also instrumental in ERA-EDTA becoming part of EKHA, which is currently very active lobbying the European Community both for funds for renal diseases, but also for awareness issues. Currently he is the representative for ERA-EDTA at the European Union of Medical Specialists (UEMS).

10º CURSO DE FORMACIÓN CONTINUADA EN SALUD DE LA MUJER

Coordinado por el Dr. José Luis Neyro, experto Ginecólogo del Hospital de Cruces de Bilbao

Bienvenido al 10º Curso de Formación Continuda en Salud de la Mujer

Un año más, coordinado por el Dr. José Luis Neyro, experto Ginecólogo del Hospital de Cruces de Bilbao, se reunirá a ginecólogos y expertos de otras especialidades para revisar y actualizar patologías asociadas a la Menopausia. Este encuentro, cuyo objetivo se centra en formar a los especialistas en salud de la mujer, se ha convertido en todo un referente en la ciudad de Bilbao.

European guidance for the diagnosis and management of osteoporosis in postmenopausal women

Abstract: Summary Guidance is provided in a European setting on the assessment and treatment of postmenopausal women at risk of fractures due to osteoporosis.

Introduction
In 1997, the European Foundation for Osteoporosis and Bone Disease (subsequently the International Osteoporosis Foundation, IOF) published guidelines for the diagnosis and management of osteoporosis [1], subsequently updated in 2008 by the IOF and European Society for Clinical and Economic Evaluation of Osteoporosis and Osteoarthritis (ESCEO) [2]. Since then, there have been significant advances in the field of osteoporosis. These include the development of new techniques for measuring bone mineral, improved methods of assessing fracture risk and new treatments that have been shown to significantly reduce the risk
of fractures at vulnerable sites. Against this background, the Scientific Advisory Board of the ESCEO, in collaboration with the IOF, has recognised a need to update the guidance which is detailed below. The high societal and personal costs of osteoporosis pose challenges to public health and physicians, particularly since most patients with osteoporosis remain untreated. Indeed, less than 20 % of patients with a fragility fracture receive therapy to reduce future fracture within the year following fracture [3–5]. The aim of this guidance is to stimulate a cohesive approach to the management of osteoporosis in Europe. The term guidance rather than guidelines is used, to avoid any prescriptive connotations since country- or region-specific guidelines are now widely available in many European countries and continue to evolve. Rather, the guidance can inform the development of new guidelines or the revision of existing guidelines.

Vitamin D supplementation in elderly or postmenopausal women: a 2013 update of the 2008 recommendati

Vitamin D insufficiency has deleterious consequences on health outcomes. In elderly or postmenopausal women, it may exacerbate osteoporosis.

Introduction

Few subjects have been the source of as much discussion in the medical community in recent years as vitamin D. Lack of vitamin D has well known direct effects on bone health. This occurs via the deregulation of calcium homeostasis and increased serum parathyroid hormone (PTH), which negatively affects bone remodeling by increasing bone resorption1–3. In elderly or postmenopausal women, this may exacerbate osteoporosis. Vitamin D insufficiency has a variety of causes (Table 1)4,5, including reduced endogenous synthesis, decreased availability, and concomitant diseases. The risk factors for vitamin D insufficiency are related to race, latitude, exposure to sunlight and ability to tan, and cultural attitudes to supplementation and general health6. The indications for screening include bone diseases, old age (particularly in case of falls or fracture), malabsorption syndromes, and certain medications (Table 1)4,5.

Risk factors for the development of vertebral fractures after percutaneous vertebroplasty – Martinez

Angels Martinez-Ferrer MD1, Jordi Blasco MD2, Josep L Carrasco3, Juan Macho PhD2, Luis San Román MD2, Antonio López Rueda MD2, Ana Monegal PhD1, Nuria Guañabens PhD4, Pilar Peris PhD4, Abstract We have recently observed an increased risk for vertebral fractures (VF) in a randomized controlled trial comparing the analgesic effect of vertebroplasty (VP) versus conservative…

Cómo prevenir la osteoporosis gracias al Pilates

Para los afectados por enfermedades óseas, como la osteoporosis, es fundamental la práctica de ejercicio físico tanto para prevenir su avance como para minimizar los riesgos de fractura.

Un ejercicio físico adaptado a sus especiales necesidades, como el que les brinda el método Pilates, que les procura múltiples beneficios. “Se trata de una actividad física sin riesgo de caídas o golpes, que hace trabajar los músculos y ayuda a compensar el desequilibrio entre reabsorción y formación del tejido óseo”, explica Emilie Baudoin, experta en Pilates en Divina Pastora Seguros.

Un estudio asocia el ciclismo de competición con mayor riesgo de osteoporosis

Zaragoza, 13 feb (EFE).- Un estudio de la Universidad de Zaragoza vincula la práctica competitiva de ciclismo con mayor riesgo de osteoporosis y el decrecimiento en salud ósea,

El trabajo, desarrollado por el grupo de investigación Genud (Growth, Exercise, Nutrition and Development) de la Universidad de Zaragoza, ha sido publicado recientemente en la revista “BMC medicine” y también incluido en el compendio “Advances in Sport Nutrition, Exercise and Medicine”.

Premio Banco Sabadell a la Investigación Biomédica

El premio consiste en una dotación de 50.000 euros y una obra de un escultor español contemporáneo.

Banco Sabadell otorga este premio con objeto de reconocer la excelencia de personas jóvenes, con una importante trayectoria en el campo de la búsqueda biomédica y ciencias de la salud, que destaquen en su especialidad por su capacidad de innovación. El premio consiste en una dotación de 50.000 euros y una obra de un escultor español contemporáneo. La de esta edición es del barcelonés Sergi Aguilar, considerado uno de los principales artistas españoles de su generación.

Premios Fundación Pfizer de Investigación

Se abre el plazo de presentación de candidaturas para la nueva edición de los Premios Fundación Pfizer de Investigación en las siguientes categorías:

Investigación Básica.
Investigación Clínica o Salud Pública.
Investigación para profesionales sanitarios en fase de especialización

Podrán optar aquellos trabajos de investigación biomédica que hayan sido publicados durante 2012, en revistas contenidas en el Science Citation Index. Los trabajos deberán haberse realizado en instituciones españolas públicas o privadas. También se aceptarán trabajos realizados en entidades españolas en colaboración con instituciones extranjeras.

Premios Fundación Pfizer de Investigación

Se abre el plazo de presentación de candidaturas para la nueva edición de los Premios Fundación Pfizer de InvestigaciónPremios Fundación Pfizer de Investigación en las siguientes categorías: Investigación Básica. Investigación Clínica o Salud Pública. Investigación para profesionales sanitarios en fase de especialización

Cost-Effectiveness of Osteoporosis Interventions for ‘Incidental’ Vertebral Fractures

Vertebral fractures detected “incidentally” by chest radiograph usually do not trigger osteoporosis treatment in older patients. Background Vertebral fractures detected “incidentally” by chest radiograph usually do not trigger osteoporosis treatment in older patients. In a 3-arm controlled trial we reported that both physician-directed and enhanced (physician plus patient activation) interventions increased treatment rates more than…

Improvement in Bone Properties by Using Risedronate Adsorbed Hydroxyapatite Novel Nanoparticle Based

Authors: Sahana, H.; Khajuria, Deepak Kumar; Razdan, Rema; Mahapatra, D. Roy; Bhat, M.R.; Suresh, Sarasija; Rao, R. Ramachandra; Mariappan, L. Abstract: A superior drug formulation capable of achieving efficient osteogenesis is in imperative demand for the treatment of osteoporosis. In the present study we investigated the potential of using novel risedronate-hydroxyapatite (HA) nanoparticle based formulation…

Becas Fundación Ramón Areces para Estudios Postdoctorales

XXV Convocatoria de Becas para Ampliación de Estudios en el Extranjero en Ciencias de la Vida y de la Materia

Presentación

La Fundación Ramón Areces tiene como objetivo fundamental el patrocinio de proyectos de investigación científica y técnica en España a través de Concursos Nacionales, la formación de jóvenes investigadores, así como el fomento y desarrollo de la educación y de la cultura en general.

European Calcified Tissue Society Congress 2013

Opportunities for ECTS to communicate information about their 50th Annivesary Congress. Abstract deadline: 28 January 2013 To ensure that your research is part of ECTS 2013, you will need to submit your abstract by the 28 January 2013 via the ECTS website. http://www.ectscongress.org/2013/prog/abstract.htm Why submit your abstract to ECTS 2013? Long-standing congress of highest scientific quality…

BiologicsSpineTrauma Features

Could wood be a practical replacement for bone? Researchers from the National Research Council of Italy (CNR) writing in a forthcoming issue of the International Journal of Healthcare Technology and Management …

Biloine W. Young • Fri, December 21st, 2012

Could wood be a practical replacement for bone? Researchers from the National Research Council of Italy (CNR) writing in a forthcoming issue of the International Journal of Healthcare Technology and Management suggest that it can. It turns out that the structure of some woods at the microscopic level is very close to that of natural bone; both have unique biomechanical properties such as high strength and lightness.

Two researchers in Italy, Ugo Finardi (Institute for Economic Research on Firms and Growth-CERIS-CNR, and University of Torino), and Simone Sprio (Institute of Science and Technology for Ceramics – ISTEC-CNR), have carried out a case study on the implications of a new technology recently developed by the Research Group on Biomaterials of ISTEC. In that work, the researchers, Anna Tampieri, Simone Sprio and Andrea Ruffini, used a nanotechnological approach to transform rattan wood into hierarchically organized implants.

Las chicas adolescentes que fuman pueden aumentar su riesgo de enfermedades óseas futuras

La mitad de la formación del tejido óseo de las mujeres tiene lugar durante estos primeros años, afirman los investigadores

MARTES, 4 de diciembre (HealthDay News) — Las adolescentes que fuman pueden tener un riesgo mayor de osteoporosis, según un estudio reciente que halló que los huesos de las chicas que fuman se desarrollan menos en este periodo fundamental de sus vidas.

El Hospital de Torrevieja aborda de la osteoporosis en atención primaria

El Hospital de Torrevieja ha realizado recientemente una sesión formativa bajo el título “Osteoporosis y práctica clínica en atención primaria”.

Este curso se encuentra enmarcado en el II Plan de Prevención y Control de la Osteoporosis de la Comunidad Valenciana y en el Plan Estratégico de la Consellería: ESOSVAL, que tiene como objetivo principal mejorar la atención al paciente con Osteoporosis o con riesgo de presentarla (se adjunta programa). El curso está acreditado por la Comisión de Formación Continuada de la Comunidad Valenciana del Sistema Nacional de Salud.

La actualización de conocimientos y la mejora de habilidades son una necesidad permanente de los profesionales sanitarios para un adecuado ejercicio de su profesión, contribuye a la mejora del funcionamiento del sistema sanitario, a la satisfacción del paciente y a la de los propios profesionales.

La osteoporosis o mejor, su consecuencia natural, la fractura osteoporótica, es un problema de salud, que genera morbilidad y mortalidad, y que tiene repercusiones sanitarias, sociales y económicas, de gran calado.

La jornada formativa contó con la participación de casi medio centenar de médicos y enfermeras de las diferentes zonas básicas de salud que integran el Departamento. El objetivo es actualizar la formación de dichos profesionales en áreas detectadas de mejora y que ellos a su vez trasladen a los profesionales de sus respectivas áreas el conjunto de aprendizajes adquiridos.

Columna vertebral y los efectos de la adición

Por Nancy Walsh, escritor de personal, MedPage Today. Comentado por Zalman S. Agus, MD , Profesor Emérito de la Escuela Perelman de Medicina de la Universidad de Pennsylvania y Dorothy Caputo, MA, BSN, RN, enfermera de Planificación.

MINNEAPOLIS – Las mujeres que se quedaron en alto riesgo de fractura de cadera en la osteoporosis a pesar del tratamiento previo con alendronato (Fosamax) se beneficiaron de la adición de teriparatida (Forteo) en lugar de simplemente cambiar a él, un investigador dice aquí.

A los 6 meses, las mujeres que agregaron teriparatida al alendronato (Fosamax), la terapia mostraron aumentos significativos en la densidad mineral ósea volumétrica (DMO) de la cadera en comparación con aquellos que cambiaron a la teriparatida solo (0,9% frente a -0,5%, P = 0,004), de acuerdo a Felicia Cosman, MD, del Hospital Helen Hayes en West Haverstraw, NY

Esos aumentos se mantuvieron significativas a los 18 meses (2,2% versus ningún cambio, P = 0,002), dijo en la reunión anual de la Sociedad Americana de Investigación Ósea y Mineral.

Investigaciones anteriores han sugerido que la DMO diferente y respuestas bioquímicas pueden ocurrir entre las mujeres previamente tratadas con alendronato o raloxifine (Evista) que, o bien añadir o cambiar a la teriparatida, una formulación de hormona paratiroidea, pero los efectos sobre la resistencia ósea eran desconocidos.

Método de evaluación de la densidad ósea

ScienceDaily (19 de noviembre de 2012) – Un nuevo estudio del Instituto Karolinska en Suecia muestra que una técnica para medir la densidad de los huesos llamada radiología digital radiogrammetry (o DXR) que se utiliza en las radiografías manuales puede ayudar a identificar a los pacientes con mayor riesgo de fractura de cadera. Los investigadores creen que DXR, que es totalmente comparable con otros métodos más costosos, se puede utilizar de forma preventiva para identificar a las personas en la zona de riesgo para la osteoporosis – una enfermedad estimado para llevar a cabo unos 200 millones de mujeres en todo el mundo.

Cada año, aproximadamente 1,7 millones de fracturas de cadera se producen en todo el mundo (alrededor de 18.000 sólo en Suecia), sobre todo en personas de edad avanzada y las mujeres con osteoporosis. Una fractura de cadera puede ser particularmente grave para las personas mayores, sino que a menudo implica la rehabilitación largo y deja muchos pacientes no pueden llevar una vida independiente. Además, entre el 10 y el 20 por ciento de los pacientes mueren de complicaciones. Además del sufrimiento humano que causan, las fracturas de cadera son también muy costosa para los servicios sanitarios de la cantidad de atención que requieren.

“Si podemos identificar a las personas con osteoporosis y tratarlos con medicamentos, se puede reducir el riesgo de fractura de cadera”, dice el investigador principal, profesor asociado del Departamento de Torkel Brismar Instituto Karolinska de Ciencias Clínicas, Intervención y Tecnología. “Nuestra investigación muestra que DXR es una técnica que se presta bien a este, a lo mejor en la salud general chequeos o exámenes, por ejemplo, o cuando las personas buscan tratamiento para un lado o sospecha de fractura de muñeca.”

Medicamentos para la osteoporosis asociada a las fracturas de fémur

Los bifosfonatos son medicamentos que se usan para prevenir o retrasar el proceso de la osteoporosis.

Los bifosfonatos son medicamentos que se usan para prevenir o retrasar el proceso de la osteoporosis. Son ampliamente utilizados para las mujeres mayores de 45 años. Recientemente, se ha publicado información que indica que el 1% de los que tomaron el medicamento podría experimentar un efecto secundario grave que da lugar a fracturas por estrés espontáneos.

Uno de mis pacientes ha experimentado esta situación de primera mano. Ella nos ha pedido que comparta su historia y recursos educativos con otros pacientes y nuestros lectores del blog.

Acuerdo con la Conselleria de Sanitat para fomentar la investigación en osteoporosis

El Centro Superior de Investigación en Salud Pública de la Generalitat Valenciana ha firmado un acuerdo para seguir avanzando en la prevención y el tratamiento de la osteoporosis.

Madrid, 19 de noviembre de 2012. El Centro Superior de Investigación en Salud Pública de la Generalitat Valenciana ha firmado un acuerdo con la compañía biotecnológica Amgen y la farmacéutica GlaxoSmithKline (GSK) para seguir avanzando en la prevención y el tratamiento de la osteoporosis.

Esta colaboración servirá para ampliar el programa Esosval, una iniciativa estratégica de la Conselleria de Sanitat, en el marco del II Plan de Prevención y Control de la Osteoporosis de la Comunidad Valenciana, que tiene como objetivo fomentar la formación, investigación y asistencia sanitaria para mejorar la atención a los pacientes con osteoporosis o con riesgo de presentarla. Amgen y GSK están aunando esfuerzos para beneficiar a los pacientes que padecen esta patología

Carta abierta firmada por Premios Nobel Europeos

Momento en que nosotros, la comunidad científica, debe actuar de forma conjunta

Estimado colega,

Las discusiones en la próxima cumbre de Jefes de Estado de la Unión Europea y los gobiernos de las naciones miembro, prevista para el 22 y 23 de noviembre de 2012, serán decisivas en la determinación del presupuesto de investigación de la UE para los próximos siete años. Los 80 millones de euros para la investigación, según lo propuesto por la Comisión Europea, aún no están garantizados. Varios Estados miembros están exigiendo recortes severos en el presupuesto total de la UE, por lo que la investigación tendrá que competir con otras prioridades políticas.

Tomando carrera fuera de la ecuación en la medición de riesgo de las mujeres de la osteoporosis

Para las mujeres con varios tipos de orígenes raciales o étnicos, un nuevo método para medir la salud ósea puede mejorar las probabilidades de diagnosticar correctamente el riesgo de osteoporosis y fracturas óseas.

Actualmente, la evaluación de la osteoporosis y el riesgo de fracturas de pequeños accidentes como caídas requiere una prueba de densidad ósea. Pero debido a que estos análisis no proporcionan otra información relevante relacionada con las fracturas, como el tamaño del hueso y la cantidad de fuerza que se somete a un hueso en una caída, la densidad ósea de cada paciente es examinado en contra de una base de datos nacional de personas con la misma edad y raza u origen étnico.
Este enfoque, sin embargo, no funciona para las personas de raza u origen étnico mixto, porque las bases de datos de comparación no puede dar cuenta de herencia mixta. Un problema similar existe para los más pequeños de los grupos raciales o étnicos para los que no son bases de datos de comparación.
“Todas las formas actuales de determinar el riesgo de fracturas requieren conocer su raza y origen étnico correctamente, y pasan por alto el hecho de que los grupos raciales y étnicos no son homogéneas”, dijo el coautor del estudio, el Dr. Arun Karlamangla, profesor de medicina en la geriatría división en la Escuela David Geffen de Medicina en UCLA. “También va en contra de la realidad actual en el sur de California, donde tantas personas son de origen étnico mixto”.

Panel de Llamadas de Reemplazo Hormonal demasiado arriesgado

Un grupo influyente de salud nacional confirmó el lunes una recomendación anterior contra a largo plazo la terapia de reemplazo hormonal para mujeres menopáusicas, diciendo que sus riesgos superan a los beneficios para la mayoría de los pacientes.

El hallazgo de la Fuerza de Tareas de Servicios Preventivos EE.UU. no se espera que traiga cambios importantes para los médicos y las mujeres ya que el uso preventivo de la terapia de reemplazo hormonal se ha vuelto menos común, ya que un importante estudio hace una década se desanime. Por otra parte, las conclusiones publicadas el lunes son similares a los del mismo panel alcanzado en 2005.

El grupo de trabajo recomendó que el uso de la combinación de estrógeno y progestina para la prevención de enfermedades crónicas en mujeres posmenopáusicas. El grupo también recomendó que el uso a largo plazo de estrógenos en mujeres posmenopáusicas que han tenido una histerectomía.

El grupo tomó ninguna posición a corto plazo el uso de estrógenos y otras terapias de reemplazo hormonal para tratar los síntomas de la menopausia temporales, como los sofocos y los sudores nocturnos.

Un estudio publicado a principios de este mes sugiere que la terapia hormonal después de la menopausia comenzó poco puede ayudar a aliviar la depresión, la ansiedad y los sofocos sin aumentar los riesgos de enfermedades cardiovasculares. Sin embargo, el estudio se ha visto como un apoyo a corto plazo el uso de hormonas, no a largo plazo.

A partir antihipertensivos vinculados a la fractura de cadera en ancianos

La Sociedad Americana de Investigación Ósea y Mineral 2012 Reunión Anual, Minneapolis, Minnesota, EE.UU:

medwireNews: El riesgo de fractura de cadera en los individuos mayores aumentos durante los primeros 45 días después de iniciar el tratamiento antihipertensivo, y de forma significativa para los que empiezan la angiotensina II enzima convertidora de angiotensina y los bloqueadores beta-adrenérgicos, informan investigadores canadienses.

El estudio incluyó datos de más de 300.000 nuevos tratados comunidad que habita en ancianos con una media de 81 años, de los cuales 1.463 fracturas de cadera experimentados durante el período de observación de 450 días.

“Se debe tener precaución cuando se inicia el tratamiento antihipertensivo en pacientes de edad avanzada para minimizar el riesgo de los resultados potencialmente devastadores de las fracturas de cadera”, comentó Debra Butt, de la Universidad de Toronto, en un comunicado de prensa.

Los hallazgos del estudio fueron presentados en la Sociedad Americana de Investigación Ósea y Mineral de la Reunión Anual 2012 en Minneapolis, Minnesota.

Sin riesgo cardiaco para mujeres de calcio

Por Nancy Walsh, escritor de personal, MedPage Today. Comentado por Robert Jasmer, MD , Profesor Clínico Asociado de Medicina de la Universidad de California, San Francisco y Dorothy Caputo, MA, BSN, RN, enfermera de Planificación

MINNEAPOLIS – Los suplementos de calcio ampliamente prescritos para la salud ósea en las mujeres no parecen estar asociados con un mayor riesgo cardiovascular, los investigadores encontraron.

Con más de 2 décadas de seguimiento de una cohorte de casi 75.000 mujeres, el riesgo relativo de enfermedad cardiovascular fue de 0,86 (IC del 95%: 0,65 a 0,88), Julie Paik, MD, de la Harvard Medical School en Boston, informó aquí, en el reunión anual de la Sociedad Americana de Investigación Ósea y Mineral.

A pesar de la popularidad de los suplementos de calcio – una estimación dice que el 60% de las mujeres mayores de 60 años que uso – ha habido un creciente interés por una posible relación con problemas cardiovasculares, con datos contradictorios haber surgido.

En un análisis secundario de un estudio, el uso de calcio se asoció con un mayor riesgo de infarto de miocardio (MI) y de un criterio de valoración combinado de IM, ictus y muerte súbita.

Y en un meta-análisis de ensayos aleatorios, hubo un aumento en el riesgo de infarto de miocardio con o sin suplemento de vitamina D, mientras que otro meta-análisis encontró efectos neutros para los suplementos.

Debido a que los estudios prospectivos hasta ahora han sido de corta duración, Paik y sus colegas analizaron datos del Estudio de Salud de las Enfermeras, que comenzó en 1976 registró mujeres en edades de 30 a 55.

Este análisis se basó en los resultados de 74.272 mujeres que completaron un cuestionario sobre alimentación en 1984, en el que los participantes se detalla su ingesta habitual de alimentos, bebidas y suplementos dietéticos.

El calcio se informó cada 4 años.

Effects of strontium on the quality of bone apatite crystals: a paired biopsy study in postmenopausa

In paired biopsies of osteoporotic women treated with either strontium ranelate or a placebo for 36 months, characteristics of bone apatite crystals were not influenced by the presence of strontium. Summary In paired biopsies of osteoporotic women treated with either strontium ranelate or a placebo for 36 months, characteristics of bone apatite crystals were not influenced…

Beca para el 22nd IOF Advanced Training Course on Osteoporosis

Beca para el 22nd IOF Advanced Training Course on Osteoporosis en Ginebra (Suiza) 30 de enero y 1 de febrero de 2013). Fecha límite para formalizar la solicitud, 2 de noviembre de 2012. Información en http://www.iofbonehealth.org/cns-information Para la carta de recomendación de la SEIOMM contactar con la Secretaría. Paseo de la Castellana, 135–7ªPlta. 28046-Madrid  Telefono: 91 790…

Día Mundial de la Osteoporosis

Cada año, millones de adultos mayores -en su mayoría- sufrirán una fractura de cadera devastadora como resultado de una caída simple desde su propia altura. Muchos millones más sufrirán fracturas de columna, muñeca, hombro y pelvis… Estas fracturas no son un accidente. Es probable que la osteoporosis sea la causa subyacente. Una persona que haya…

La Fundación Internacional de Osteoporosis unida por un mundo sin fracturas por osteoporosis

Oficialmente lanzado en marzo de 2012 por la Fundación Internacional de Osteoporosis la campaña Fractura Global.
Su interés en la captura de la fractura contribuye a la visión de la Fundación Internacional de Osteoporosis de la unida de un mundo sin fracturas por osteoporosis – que puede ser facilitado mediante la aplicación de base de coordinador-, fractura post-sistemas / modelos de atención: www.iofbonehealth.org/capture- fracturarse .

La Campaña a la Captura de la fractura tiene como objetivo

  • Sensibilizar a base de coordinador-, fractura post-sistemas para la prevención de fracturas segundos
  • Proporcionar normas internacionalmente aprobadas para las mejores prácticas
  • Facilitar el cambio a nivel nacional

Vamos a hacer esto

  • El desarrollo de un marco de mejores prácticas
  • La organización de una coalición internacional de asociados y endosantes
  • El desarrollo de un sitio web y un mapa interactivo para albergar a toda la información
  • Crear y compartir guías de implementación y herramientas
  • Marketing y comunicación de la campaña a nivel mundial
  • Pilotar un programa de subvenciones para el desarrollo de sistemas de

¿Dónde estamos ahora?

Parkinson’s disease and osteoporosis

Frederiek van den Bos1,2, Arlene D. Speelman3, Monique Samson1, Marten Munneke4,5, Bastiaan R. Bloem6 and, Harald J. J. Verhaar1  Conclusion: bone loss in PD is multifactorial. It is clinically important because of the concomitant risk of fractures. Screening for osteoporosis should be considered more often, and therapeutic interventions should be initiated. Autor: F. van den…

Inhibition of osteoclast differentiation and matrix metalloproteinase production by CD4+CD25+ T cell

To reveal the mechanism of inflammation-accompanied osteoporosis, mouse CD11b cells and CD4+CD25+ T cells were cocultured. Our results showed that CD11b+ monocytes cocultured with CD4+CD25+ T cells generated significantly less osteoclasts than those cocultured with CD4+CD25− T cells. The levels of MMP-7 and 9 in coculture supernatant were decreased significantly when CD11b+ monocytes and CD4+CD25+…

The rhPTH treatment elevates plasma secreted protein acidic and rich in cysteine levels in patients

The secreted protein acidic and rich in cysteine (SPARC), also known as osteonectin, plays an important role in osteoblast formation, maturation, and survival. Summary The secreted protein acidic and rich in cysteine (SPARC), also known as osteonectin, plays an important role in osteoblast formation, maturation, and survival. Here, we report the effects of recombinant human…

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